CA1104566A - Process for the manufacture of azatetracyclic compounds - Google Patents

Process for the manufacture of azatetracyclic compounds

Info

Publication number
CA1104566A
CA1104566A CA278,990A CA278990A CA1104566A CA 1104566 A CA1104566 A CA 1104566A CA 278990 A CA278990 A CA 278990A CA 1104566 A CA1104566 A CA 1104566A
Authority
CA
Canada
Prior art keywords
lower alkyl
formula
mole
dibenzo
azepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA278,990A
Other languages
English (en)
French (fr)
Inventor
Angelo Storni
Hans Blattner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Investments Ltd filed Critical Ciba Geigy Investments Ltd
Application granted granted Critical
Publication of CA1104566A publication Critical patent/CA1104566A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA278,990A 1976-05-21 1977-05-24 Process for the manufacture of azatetracyclic compounds Expired CA1104566A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6650/76 1976-05-21
CH665076A CH624105A5 (en) 1976-05-26 1976-05-26 Process for the preparation of novel azatetracyclic compounds

Publications (1)

Publication Number Publication Date
CA1104566A true CA1104566A (en) 1981-07-07

Family

ID=4312888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA278,990A Expired CA1104566A (en) 1976-05-21 1977-05-24 Process for the manufacture of azatetracyclic compounds

Country Status (30)

Country Link
JP (1) JPS52144687A (de)
AR (2) AR227608A1 (de)
AT (1) AT356114B (de)
AU (1) AU510471B2 (de)
BE (1) BE855009A (de)
CA (1) CA1104566A (de)
CH (2) CH624105A5 (de)
CS (2) CS225103B2 (de)
CY (1) CY1211A (de)
DD (1) DD131169A5 (de)
DE (1) DE2723105A1 (de)
DK (1) DK150301C (de)
ES (1) ES459070A1 (de)
FI (1) FI64582C (de)
FR (1) FR2352816A1 (de)
GB (1) GB1578266A (de)
GR (1) GR72092B (de)
HK (1) HK8784A (de)
HU (1) HU177417B (de)
IE (1) IE45204B1 (de)
IL (1) IL52168A (de)
KE (1) KE3339A (de)
MY (1) MY8500099A (de)
NL (1) NL7705707A (de)
NO (1) NO148489C (de)
NZ (1) NZ184191A (de)
PT (1) PT66588B (de)
SE (1) SE427354B (de)
SG (1) SG63683G (de)
ZA (1) ZA773161B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE9159T1 (de) * 1979-12-10 1984-09-15 Ciba-Geigy Ag Azatetracyclische carbonitrile.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178593C (nl) * 1974-01-31 1986-04-16 Akzo Nv Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen.
CH592095A5 (de) * 1974-02-22 1977-10-14 Ciba Geigy Ag

Also Published As

Publication number Publication date
KE3339A (en) 1983-11-25
IE45204L (en) 1977-11-26
CS225103B2 (en) 1984-02-13
IE45204B1 (en) 1982-07-14
AR228124A1 (es) 1983-01-31
NZ184191A (en) 1979-12-11
IL52168A (en) 1981-07-31
ATA372577A (de) 1979-09-15
NO148489B (no) 1983-07-11
HU177417B (en) 1981-10-28
AR227608A1 (es) 1982-11-30
DE2723105A1 (de) 1977-12-15
FI771651A (de) 1977-11-27
GB1578266A (en) 1980-11-05
AU2547377A (en) 1978-11-30
GR72092B (de) 1983-09-13
ES459070A1 (es) 1978-04-16
CH624106A5 (en) 1981-07-15
JPS52144687A (en) 1977-12-02
CS225106B2 (en) 1984-02-13
SG63683G (en) 1984-07-27
SE427354B (sv) 1983-03-28
CH624105A5 (en) 1981-07-15
NL7705707A (nl) 1977-11-29
ZA773161B (en) 1978-04-26
AU510471B2 (en) 1980-06-26
PT66588B (en) 1978-10-23
FI64582C (fi) 1983-12-12
FI64582B (fi) 1983-08-31
CY1211A (en) 1984-04-06
FR2352816B1 (de) 1980-01-18
BE855009A (fr) 1977-11-25
DD131169A5 (de) 1978-06-07
IL52168A0 (en) 1977-07-31
SE7706120L (sv) 1977-11-27
JPH0141627B2 (de) 1989-09-06
PT66588A (en) 1977-06-01
NO771830L (no) 1977-11-29
MY8500099A (en) 1985-12-31
DE2723105C2 (de) 1987-03-12
DK150301C (da) 1988-01-04
DK229977A (da) 1977-11-27
AT356114B (de) 1980-04-10
FR2352816A1 (fr) 1977-12-23
HK8784A (en) 1984-02-10
DK150301B (da) 1987-02-02
NO148489C (no) 1983-10-19

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