CA1090813A - Preparation of cis-1-hydroxy-3-substituted-6,6- dimethyl-6,6a-7,8,10,10a-hexahydro-9h-dibenzo ¬b, d| pyran-9-ones and intermediates therefor - Google Patents

Preparation of cis-1-hydroxy-3-substituted-6,6- dimethyl-6,6a-7,8,10,10a-hexahydro-9h-dibenzo ¬b, d| pyran-9-ones and intermediates therefor

Info

Publication number
CA1090813A
CA1090813A CA281,764A CA281764A CA1090813A CA 1090813 A CA1090813 A CA 1090813A CA 281764 A CA281764 A CA 281764A CA 1090813 A CA1090813 A CA 1090813A
Authority
CA
Canada
Prior art keywords
hydroxy
catalyst
dimethyl
temperature
stannic chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA281,764A
Other languages
English (en)
French (fr)
Inventor
William B. Blanchard
Charles W. Ryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to CA356,593A priority Critical patent/CA1100979A/en
Application granted granted Critical
Publication of CA1090813A publication Critical patent/CA1090813A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
CA281,764A 1976-07-06 1977-06-30 Preparation of cis-1-hydroxy-3-substituted-6,6- dimethyl-6,6a-7,8,10,10a-hexahydro-9h-dibenzo ¬b, d| pyran-9-ones and intermediates therefor Expired CA1090813A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA356,593A CA1100979A (en) 1976-07-06 1980-07-18 Preparation of cis-1-hydroxy-3-substituted-6,6- dimethyl-6,6a-7,8,10,10a-hexahydro-9h-dibenzo[b, d]pyran-9-ones and intermediates therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/702,804 US4054581A (en) 1976-07-06 1976-07-06 Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor
US702,804 1976-07-06

Publications (1)

Publication Number Publication Date
CA1090813A true CA1090813A (en) 1980-12-02

Family

ID=24822669

Family Applications (1)

Application Number Title Priority Date Filing Date
CA281,764A Expired CA1090813A (en) 1976-07-06 1977-06-30 Preparation of cis-1-hydroxy-3-substituted-6,6- dimethyl-6,6a-7,8,10,10a-hexahydro-9h-dibenzo ¬b, d| pyran-9-ones and intermediates therefor

Country Status (30)

Country Link
US (2) US4054581A (cg-RX-API-DMAC7.html)
JP (2) JPS5943465B2 (cg-RX-API-DMAC7.html)
AR (1) AR221210A1 (cg-RX-API-DMAC7.html)
AT (2) AT353268B (cg-RX-API-DMAC7.html)
AU (1) AU509540B2 (cg-RX-API-DMAC7.html)
BE (1) BE856408A (cg-RX-API-DMAC7.html)
BG (2) BG28062A3 (cg-RX-API-DMAC7.html)
CA (1) CA1090813A (cg-RX-API-DMAC7.html)
CH (1) CH633791A5 (cg-RX-API-DMAC7.html)
CS (1) CS196374B2 (cg-RX-API-DMAC7.html)
DD (2) DD137228A5 (cg-RX-API-DMAC7.html)
DE (2) DE2729846C2 (cg-RX-API-DMAC7.html)
DK (1) DK144885C (cg-RX-API-DMAC7.html)
ES (2) ES460381A1 (cg-RX-API-DMAC7.html)
FR (1) FR2361384A1 (cg-RX-API-DMAC7.html)
GB (1) GB1582565A (cg-RX-API-DMAC7.html)
GR (1) GR66413B (cg-RX-API-DMAC7.html)
HU (2) HU177307B (cg-RX-API-DMAC7.html)
IE (1) IE45242B1 (cg-RX-API-DMAC7.html)
IL (1) IL52423A (cg-RX-API-DMAC7.html)
NL (1) NL180316C (cg-RX-API-DMAC7.html)
NZ (1) NZ184530A (cg-RX-API-DMAC7.html)
PH (2) PH12637A (cg-RX-API-DMAC7.html)
PL (1) PL105356B1 (cg-RX-API-DMAC7.html)
PT (1) PT66742B (cg-RX-API-DMAC7.html)
RO (1) RO78107A (cg-RX-API-DMAC7.html)
SE (2) SE428016B (cg-RX-API-DMAC7.html)
SU (2) SU910121A3 (cg-RX-API-DMAC7.html)
YU (1) YU163277A (cg-RX-API-DMAC7.html)
ZA (1) ZA773955B (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor
US4133816A (en) * 1977-07-12 1979-01-09 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor
US4171315A (en) * 1978-03-31 1979-10-16 Eli Lilly And Company Preparation of cis-hexahydrodibenzopyranones
US4395560A (en) * 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
JPH0681571B2 (ja) * 1989-11-29 1994-10-19 株式会社備文 解し芝の連続定量供給装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576887A (en) * 1967-05-01 1971-04-27 American Home Prod Process for the preparation of oxaphenanthrenes and intermediates therefor
US3906047A (en) * 1971-06-14 1975-09-16 Hoffmann La Roche 8-(2,6,6-Trimethyl-4-oxo-2-cyclohexen-1-ylidene-2-methylene-6-methyl-4,6-octadien-3-ol
US3929835A (en) * 1973-08-29 1975-12-30 Sharps Ass Alkyl substituted cyclopenta benzopyrans
US3968125A (en) * 1973-11-05 1976-07-06 Eli Lilly And Company Dihydroxyhexahydrodibenzo[b,d]pyrans
US3928598A (en) * 1973-11-05 1975-12-23 Lilly Co Eli Hexahydro-dibenzo{8 b,d{9 pyran-9-ones as an anti-anxiety drug
US4054581A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor

Also Published As

Publication number Publication date
DK301177A (da) 1978-01-07
DD137228A5 (de) 1979-08-22
ES460381A1 (es) 1978-04-01
SU778712A3 (ru) 1980-11-07
PT66742B (en) 1978-11-27
AT355019B (de) 1980-02-11
IE45242L (en) 1978-01-06
DE2759994C2 (de) 1984-09-20
ES460382A1 (es) 1978-04-01
PT66742A (en) 1977-07-01
US4115403A (en) 1978-09-19
ZA773955B (en) 1979-02-28
YU163277A (en) 1982-10-31
BG28062A3 (en) 1980-02-25
IE45242B1 (en) 1982-07-14
FR2361384A1 (fr) 1978-03-10
BE856408A (fr) 1978-01-04
SE435060B (sv) 1984-09-03
SE8005373L (sv) 1980-07-24
PL199365A1 (pl) 1978-04-24
FR2361384B1 (cg-RX-API-DMAC7.html) 1980-02-01
NL180316B (nl) 1986-09-01
CS196374B2 (en) 1980-03-31
HU177307B (en) 1981-09-28
DK144885B (da) 1982-06-28
JPS537676A (en) 1978-01-24
PL105356B1 (pl) 1979-10-31
RO78107A (ro) 1982-02-01
DE2729846C2 (de) 1982-08-19
IL52423A (en) 1980-09-16
JPS6049196B2 (ja) 1985-10-31
GB1582565A (en) 1981-01-14
ATA908478A (de) 1979-07-15
NL180316C (nl) 1987-02-02
PH13260A (en) 1980-02-25
AU2668077A (en) 1979-01-04
IL52423A0 (en) 1977-08-31
DD132495A5 (de) 1978-10-04
PH12637A (en) 1979-07-05
CH633791A5 (de) 1982-12-31
NZ184530A (en) 1979-03-28
DE2729846A1 (de) 1978-01-19
DK144885C (da) 1982-11-22
ATA483277A (de) 1979-04-15
AT353268B (de) 1979-11-12
SU910121A3 (ru) 1982-02-28
SE7707629L (sv) 1978-01-07
US4054581A (en) 1977-10-18
AR221210A1 (es) 1981-01-15
NL7707465A (nl) 1978-01-10
JPS5943465B2 (ja) 1984-10-22
BG28564A4 (en) 1980-05-15
HU183288B (en) 1984-04-28
GR66413B (cg-RX-API-DMAC7.html) 1981-03-20
AU509540B2 (en) 1980-05-15
SE428016B (sv) 1983-05-30
JPS56167683A (en) 1981-12-23

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