CA1088944A - Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same - Google Patents

Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same

Info

Publication number
CA1088944A
CA1088944A CA274,696A CA274696A CA1088944A CA 1088944 A CA1088944 A CA 1088944A CA 274696 A CA274696 A CA 274696A CA 1088944 A CA1088944 A CA 1088944A
Authority
CA
Canada
Prior art keywords
compound
formula
carried out
group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA274,696A
Other languages
English (en)
French (fr)
Inventor
Hiroyuki Nagano
Takashi Mori
Isao Matsunaga
Sakae Takaku
Tatsuo Kujirai
Toshichika Ogasawara
Shigeru Sugano
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP51036101A external-priority patent/JPS5817463B2/ja
Priority claimed from JP8245876A external-priority patent/JPS6052685B2/ja
Priority claimed from JP8352276A external-priority patent/JPS539775A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of CA1088944A publication Critical patent/CA1088944A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA274,696A 1976-04-02 1977-03-24 Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same Expired CA1088944A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (ja) 1976-04-02 1976-04-02 ニコチン酸アミド誘導体
JP36101/1976 1976-04-02
JP82458/1976 1976-07-13
JP8245876A JPS6052685B2 (ja) 1976-07-13 1976-07-13 循環器疾患治療剤
JP8352276A JPS539775A (en) 1976-07-15 1976-07-15 Pyridine derivatives and their preparation
JP83522/1976 1976-07-15

Publications (1)

Publication Number Publication Date
CA1088944A true CA1088944A (en) 1980-11-04

Family

ID=27288973

Family Applications (1)

Application Number Title Priority Date Filing Date
CA274,696A Expired CA1088944A (en) 1976-04-02 1977-03-24 Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same

Country Status (13)

Country Link
AR (2) AR217423A1 (de)
AT (1) AT360532B (de)
AU (1) AU509591B2 (de)
CA (1) CA1088944A (de)
CH (1) CH633535A5 (de)
DE (1) DE2714713C3 (de)
DK (1) DK145608C (de)
ES (2) ES457421A1 (de)
FI (1) FI66598C (de)
FR (1) FR2346334A1 (de)
MX (1) MX5534E (de)
NL (2) NL176674C (de)
SE (1) SE436029B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579431B2 (en) * 1984-12-17 1988-11-24 Chugai Seiyaku Kabushiki Kaisha Method for production of stable nicorandil preparation
WO2010000673A1 (en) * 2008-07-01 2010-01-07 Politechnika Lódzka N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986006960A2 (en) * 1985-05-22 1986-12-04 Beecham Group P.L.C. Use of nicorandil or pinacidil for the treatment of peripheral vascular disease
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
US4973565A (en) * 1989-07-17 1990-11-27 Corning Incorporated Fluoroborosilicate glass and clad article
ZA91291B (en) * 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
AU4841700A (en) * 1999-05-12 2000-11-21 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
IT1403890B1 (it) 2010-12-28 2013-11-08 Procos Spa Processo per la produzione di nicorandil

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU579431B2 (en) * 1984-12-17 1988-11-24 Chugai Seiyaku Kabushiki Kaisha Method for production of stable nicorandil preparation
WO2010000673A1 (en) * 2008-07-01 2010-01-07 Politechnika Lódzka N'-nitroxyalkylnicotinamides for the treatment of cardiovascular diseases

Also Published As

Publication number Publication date
SE7703868L (sv) 1977-10-03
AR217423A1 (es) 1980-03-31
ATA235077A (de) 1980-06-15
DK128277A (da) 1977-10-03
DE2714713B2 (de) 1980-02-21
NL930042I1 (nl) 1993-08-02
NL930042I2 (nl) 1993-09-16
ES468462A1 (es) 1979-10-01
DE2714713A1 (de) 1977-10-20
ES457421A1 (es) 1978-11-16
FI66598B (fi) 1984-07-31
FI66598C (fi) 1984-11-12
AU2353277A (en) 1978-09-28
SE436029B (sv) 1984-11-05
NL7703624A (nl) 1977-10-04
DE2714713C3 (de) 1980-10-16
FR2346334B1 (de) 1980-02-01
NL176674B (nl) 1984-12-17
CH633535A5 (en) 1982-12-15
DK145608C (da) 1983-07-11
AR220907A1 (es) 1980-12-15
FI771024A (de) 1977-10-03
MX5534E (es) 1983-09-27
NL176674C (nl) 1985-05-17
FR2346334A1 (fr) 1977-10-28
AT360532B (de) 1981-01-12
AU509591B2 (en) 1980-05-15
DK145608B (da) 1982-12-27

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Legal Events

Date Code Title Description
MKEX Expiry