CA1085417A - Disubstituted phenol ethers of 3-amino-2- hydroxypropane, processes for their preparation and their use as medicaments - Google Patents

Disubstituted phenol ethers of 3-amino-2- hydroxypropane, processes for their preparation and their use as medicaments

Info

Publication number
CA1085417A
CA1085417A CA263,964A CA263964A CA1085417A CA 1085417 A CA1085417 A CA 1085417A CA 263964 A CA263964 A CA 263964A CA 1085417 A CA1085417 A CA 1085417A
Authority
CA
Canada
Prior art keywords
hydroxy
phenoxy
process according
reaction
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA263,964A
Other languages
English (en)
French (fr)
Inventor
Rudolf Hiltmann
Arend Heise
Stanislav Kazda
Friedrich Hoffmeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA1085417A publication Critical patent/CA1085417A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/36—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
CA263,964A 1975-10-23 1976-10-22 Disubstituted phenol ethers of 3-amino-2- hydroxypropane, processes for their preparation and their use as medicaments Expired CA1085417A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP2547524.5 1975-10-23
DE19752547524 DE2547524A1 (de) 1975-10-23 1975-10-23 Disubstituierte phenolaether des 3-amino-2-hydroxypropans, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
CA1085417A true CA1085417A (en) 1980-09-09

Family

ID=5959934

Family Applications (1)

Application Number Title Priority Date Filing Date
CA263,964A Expired CA1085417A (en) 1975-10-23 1976-10-22 Disubstituted phenol ethers of 3-amino-2- hydroxypropane, processes for their preparation and their use as medicaments

Country Status (29)

Country Link
US (1) US4110472A (en, 2012)
JP (1) JPS5935387B2 (en, 2012)
AT (2) AT344682B (en, 2012)
AU (1) AU502167B2 (en, 2012)
BE (1) BE847541A (en, 2012)
BG (2) BG27732A3 (en, 2012)
CA (1) CA1085417A (en, 2012)
CH (2) CH623562A5 (en, 2012)
CS (2) CS191322B2 (en, 2012)
DD (1) DD128555A5 (en, 2012)
DE (1) DE2547524A1 (en, 2012)
DK (1) DK480376A (en, 2012)
ES (1) ES452616A1 (en, 2012)
FI (1) FI67075C (en, 2012)
FR (1) FR2328458A1 (en, 2012)
GB (1) GB1497500A (en, 2012)
GR (1) GR61598B (en, 2012)
HU (1) HU174097B (en, 2012)
IE (1) IE43745B1 (en, 2012)
IL (1) IL50732A (en, 2012)
LU (1) LU76057A1 (en, 2012)
NL (1) NL7611683A (en, 2012)
NO (1) NO143844C (en, 2012)
PL (2) PL110002B1 (en, 2012)
PT (1) PT65737B (en, 2012)
RO (1) RO76883A (en, 2012)
SE (1) SE432926B (en, 2012)
SU (2) SU639443A3 (en, 2012)
ZA (1) ZA766303B (en, 2012)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1223395B (it) * 1987-12-01 1990-09-19 Simes Composti ad attivita' cardiovascolare
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
MX2009011360A (es) 2007-04-20 2010-02-12 Acucela Inc Compuestos derivados de estirenilo para tratar enfermedades y trastornos oftalmicos.
FR3030514A1 (fr) * 2014-12-18 2016-06-24 Centre De Coop Int En Rech Agronomique Pour Le Dev (Cirad) Dimeres polyaromatiques
EP3144289A1 (en) * 2015-09-16 2017-03-22 Evonik Technochemie GmbH [(2-ethoxy-5-trans-1-propen-1-yl)-phenoxyl]-terminated compounds
RU2766146C2 (ru) * 2016-10-05 2022-02-08 Юниверсити Оф Питтсбург - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Низкомолекулярные активаторы амфк

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758583A (en) * 1971-01-21 1973-09-11 Syntex Corp 2-(2-hydroxy-3-aminopropyl-1-yloxy)-1,6-dilfuoro-and-1,6-methano-{8 10{9 annulenes and the salts thereof

Also Published As

Publication number Publication date
CH623562A5 (en, 2012) 1981-06-15
BE847541A (fr) 1977-04-22
RO76883A (ro) 1981-08-30
FI763010A7 (en, 2012) 1977-04-24
AU502167B2 (en) 1979-07-12
NL7611683A (nl) 1977-04-26
BG31796A3 (bg) 1982-03-15
IL50732A0 (en) 1976-12-31
FR2328458B1 (en, 2012) 1979-03-02
PL193206A1 (pl) 1979-03-12
DD128555A5 (de) 1977-11-23
SE432926B (sv) 1984-04-30
AT344682B (de) 1978-08-10
SE7611686L (sv) 1977-04-24
ZA766303B (en) 1977-09-28
NO763442L (en, 2012) 1977-04-26
CS191344B2 (en) 1979-06-29
CS191322B2 (en) 1979-06-29
ATA606377A (de) 1978-02-15
IL50732A (en) 1979-12-30
LU76057A1 (en, 2012) 1977-05-31
GR61598B (en) 1978-12-02
DE2547524A1 (de) 1977-04-28
DK480376A (da) 1977-04-24
BG27732A3 (bg) 1979-12-12
NO143844C (no) 1981-04-22
FI67075C (fi) 1985-01-10
PT65737A (en) 1976-11-01
US4110472A (en) 1978-08-29
AU1879776A (en) 1978-04-27
IE43745L (en) 1977-04-23
JPS5935387B2 (ja) 1984-08-28
ES452616A1 (es) 1978-01-16
HU174097B (hu) 1979-11-28
FI67075B (fi) 1984-09-28
ATA784476A (de) 1977-12-15
IE43745B1 (en) 1981-05-20
NO143844B (no) 1981-01-12
GB1497500A (en) 1978-01-12
SU639443A3 (ru) 1978-12-25
JPS5251352A (en) 1977-04-25
PL110002B1 (en) 1980-06-30
FR2328458A1 (fr) 1977-05-20
SU664559A3 (ru) 1979-05-25
CH630058A5 (de) 1982-05-28
AT345792B (de) 1978-10-10
PL110007B1 (en) 1980-06-30
PT65737B (en) 1978-04-20

Similar Documents

Publication Publication Date Title
EP0210849B1 (en) 2-hydroxy-3-phenoxypropyl amines
US4234595A (en) 3-Indolyl-tertiary butylaminopropanols
NO151411B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-aryloksy-2-hydroksy-3-alkylenaminopropan-derivater
PL90695B1 (en, 2012)
DK152288B (da) Analogifremgangsmaade til fremstilling af 3-(1,4-benzodioxan-2-yl-methoxy)-2-propanolaminer eller syreadditionssalte deraf
CA1085417A (en) Disubstituted phenol ethers of 3-amino-2- hydroxypropane, processes for their preparation and their use as medicaments
NL8800683A (nl) Farmacologisch actieve gesubstitueerde benzamiden.
US4460605A (en) 2-[2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy]-β-phenylpropiophenone, its physiologically acceptable acid addition salts, and pharmaceutical compositions
EP0467325A2 (en) Carbostyril derivatives
US4363808A (en) N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4608391A (en) Catecholamine derivatives, a process for their preparation and pharmaceutical compositions thereof
US4181738A (en) Catecholamine derivatives, a process for their preparation and pharmaceutical compositions thereof
JPH072812A (ja) チアジアジノン
EP0007710A1 (en) Bicyclo(3.1.0)hexyl-substituted carbonylaminophenoxy compounds, their preparation, and compositions containing them for use in treating mammals
AU653444B2 (en) Thiadiazinone
US4526893A (en) Isocarbostyril derivatives
HU198052B (en) Process for producing purine derivatives substituted by side chain containing piperazinyl ring and pharmaceutical compositions comprising such compounds
CA1236116A (en) Process for the production of s(-)-3-/3-acetyl-4- (3-tert.butylamino-2-hydroxy-propoxy)-phenyl/-1,1- diethylurea and its salts
IE47604B1 (en) Subsituted pyrrolidines, process for their preparation,their use and medicaments containing them
US4340595A (en) Aminopropanol derivatives of 6-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one and pharmaceutical formulations containing the said compounds
NZ202817A (en) Morpholine carboximide or urea derivatives and pharmaceutical compositions
RU2075477C1 (ru) 1-//2-(динизший алкиламино)алкил/амино/-4-замещенные тиоксантен-9-оны и фармацевтическая композиция, обладающая противоопухолевой активностью
CA1126296A (en) R-n-(2-phenyl-2-hydroxyethyl)-3-phenylpropyl amines, formulations and method of treatment
US4252824A (en) Amino-ethanol derivatives
JPH02258749A (ja) ポリヒドロキシベンジルオキシプロパノールアミン

Legal Events

Date Code Title Description
MKEX Expiry