CA1083568A - Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor - Google Patents

Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor

Info

Publication number
CA1083568A
CA1083568A CA276,055A CA276055A CA1083568A CA 1083568 A CA1083568 A CA 1083568A CA 276055 A CA276055 A CA 276055A CA 1083568 A CA1083568 A CA 1083568A
Authority
CA
Canada
Prior art keywords
kanamycin
group
formula
compound
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA276,055A
Other languages
English (en)
French (fr)
Inventor
William A. Million
Rhona M. Plews
Kenneth Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Application granted granted Critical
Publication of CA1083568A publication Critical patent/CA1083568A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA276,055A 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor Expired CA1083568A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB15421/76A GB1530201A (en) 1976-04-14 1976-04-14 Process for the preparation of aminoglycoside antibiotics and intermediates therefor
GB15421/76 1976-04-14

Publications (1)

Publication Number Publication Date
CA1083568A true CA1083568A (en) 1980-08-12

Family

ID=10058845

Family Applications (1)

Application Number Title Priority Date Filing Date
CA276,055A Expired CA1083568A (en) 1976-04-14 1977-04-13 Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor

Country Status (28)

Country Link
JP (2) JPS52139044A (de)
AR (1) AR219074A1 (de)
AT (1) AT356267B (de)
AU (1) AU497416B2 (de)
BE (1) BE853564A (de)
BG (2) BG28072A4 (de)
CA (1) CA1083568A (de)
CH (1) CH622528A5 (de)
CS (1) CS202570B2 (de)
DD (2) DD135496A5 (de)
DE (1) DE2716533C3 (de)
DK (1) DK164277A (de)
EG (1) EG12909A (de)
ES (1) ES457793A1 (de)
FI (1) FI771144A (de)
FR (1) FR2348223A1 (de)
GB (1) GB1530201A (de)
GR (1) GR68936B (de)
IE (1) IE45030B1 (de)
IL (1) IL51775A (de)
LU (1) LU77108A1 (de)
NL (1) NL7703567A (de)
NZ (1) NZ183733A (de)
PH (1) PH14029A (de)
PL (2) PL112867B1 (de)
PT (1) PT66422B (de)
RO (2) RO79969A (de)
ZA (1) ZA771944B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2924659A1 (de) * 1979-06-19 1981-01-22 Bayer Ag Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel
JPH0414628Y2 (de) * 1984-12-13 1992-04-02
JPS61191642U (de) * 1985-05-20 1986-11-28
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
CN101481397B (zh) * 2009-01-23 2012-10-31 北京大学 一种新的卡那霉素a衍生物及其制备方法和用途
CN103260625B (zh) 2010-11-08 2016-01-06 阿尔比里奥公司 用于治疗肝脏疾病的ibat抑制剂
WO2015199146A1 (ja) 2014-06-25 2015-12-30 味の素株式会社 固形製剤及びその安定化方法
KR102560954B1 (ko) 2014-06-25 2023-07-31 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (de) 2014-10-24 2016-04-27 Ferring BV Kristalline Form von elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof

Also Published As

Publication number Publication date
BG27759A3 (en) 1979-12-12
NZ183733A (en) 1979-12-11
LU77108A1 (de) 1979-01-18
FR2348223A1 (fr) 1977-11-10
ATA261477A (de) 1979-09-15
CS202570B2 (en) 1981-01-30
DD135496A5 (de) 1979-05-09
JPS52139044A (en) 1977-11-19
DE2716533B2 (de) 1981-04-30
RO79969B (ro) 1983-01-30
DK164277A (da) 1977-10-15
ZA771944B (en) 1978-03-29
PL197372A1 (pl) 1979-06-18
AR219074A1 (es) 1980-07-31
FI771144A (de) 1977-10-15
DD130661A5 (de) 1978-04-19
PH14029A (en) 1980-12-12
JPS535141A (en) 1978-01-18
EG12909A (en) 1979-12-31
NL7703567A (nl) 1977-10-18
GR68936B (de) 1982-03-29
DE2716533C3 (de) 1982-05-13
PL112867B1 (en) 1980-11-29
CH622528A5 (en) 1981-04-15
PT66422A (en) 1977-05-01
PT66422B (en) 1978-09-18
AT356267B (de) 1980-04-25
IE45030L (en) 1977-10-14
IE45030B1 (en) 1982-06-02
JPS5549587B2 (de) 1980-12-12
IL51775A0 (en) 1977-05-31
IL51775A (en) 1980-07-31
RO79969A (ro) 1983-02-01
AU2372177A (en) 1978-10-05
DE2716533A1 (de) 1977-11-03
BE853564A (fr) 1977-10-13
JPS5421326B2 (de) 1979-07-30
GB1530201A (en) 1978-10-25
BG28072A4 (en) 1980-02-25
AU497416B2 (en) 1978-12-14
ES457793A1 (es) 1978-08-01
RO74431A (ro) 1981-08-30

Similar Documents

Publication Publication Date Title
CA1083568A (en) Process for the preparation of aminoglycoside antibiotics and novel intermediates therefor
US4347354A (en) Preparation of 1-N-[ω-amino-α-hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products obtained therefrom
US4136254A (en) Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4117221A (en) Aminoacyl derivatives of aminoglycoside antibiotics
US4065615A (en) Deoxyaminoglycoside antibiotic derivatives
PL103737B1 (pl) Sposob wytwarzania 1-n-aminoglikozydow
US4178437A (en) 1-N-Kanamycin derivatives
US4060682A (en) Process for the synthetic production of 3-deoxy derivative of an aminoglycosidic antibiotic
US4051315A (en) 6"-Deoxykanamycin B and 6"-deoxytobramycin
CA1044229A (en) Antibiotic derivatives of xk-62-2 and method of production thereof
Pelyvás et al. Synthesis of N-trifluoroacetyl-l-acosamine, N-trifluoroacetyl-l-daunosamine, and their 1-thio analogs
US4353893A (en) Ka-6606 Aminoglycosides antibiotics and compositions thereof
US4160082A (en) Intermediates for aminoglycoside antibiotics
US4252972A (en) Fortimicin B-1,2:4,5-bis-carbamates
US4290972A (en) Process for the production of 4-aminobutyric acid or its derivatives
US4093797A (en) Novel aminocyclitols and process for production thereof
US4132846A (en) 1-N-(α-Hydroxy-β-aminopropionyl) XK-62-2 and method of production thereof
CA1046057A (en) 1-N-(.alpha.-HYDROXY-.beta.-AMINOPROPIONYL) XK-62-2 AND METHOD OF PRODUCTION THEREOF
AT356273B (de) Verfahren zur herstellung von neuen geschuetzten kanamycinverbindungen
CA1081693A (en) Kanamycin c derivatives
KR890002557B1 (ko) 아미노글리코사이드 계 항생물질 유도체의 제조방법
Matsuda et al. Polydeoxyaminohexopyranosylnucleosides. Synthesis of 1-(2, 3, 4-Trideoxy-3-nitro-β-D-erythro-and threo-hexopyranosyl)-uracils from Uridine
Tadanier et al. 4-N-(2-aminoethanesulfonyl) fortimicin B and 4-N-(p-aminobenzenesulfonyl) fortimicin B
JPS631955B2 (de)
KR820000144B1 (ko) 아미노글리코사이드 유도체의 제조방법

Legal Events

Date Code Title Description
MKEX Expiry