CA1079641A - Pharmaceutical composition containing ergot alkaloids - Google Patents

Pharmaceutical composition containing ergot alkaloids

Info

Publication number
CA1079641A
CA1079641A CA263,423A CA263423A CA1079641A CA 1079641 A CA1079641 A CA 1079641A CA 263423 A CA263423 A CA 263423A CA 1079641 A CA1079641 A CA 1079641A
Authority
CA
Canada
Prior art keywords
composition according
polymer
dispersion
solid solution
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA263,423A
Other languages
English (en)
French (fr)
Inventor
Lothar Ehrhardt
Volker Hartmann
Ludwig Patt
Karl-Heinz Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1079641A publication Critical patent/CA1079641A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA263,423A 1975-10-17 1976-10-14 Pharmaceutical composition containing ergot alkaloids Expired CA1079641A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2546577A DE2546577B2 (de) 1975-10-17 1975-10-17 Feste Stoffe aus Polyvinylpyrrolidon und Ergotalkaloiden

Publications (1)

Publication Number Publication Date
CA1079641A true CA1079641A (en) 1980-06-17

Family

ID=5959411

Family Applications (1)

Application Number Title Priority Date Filing Date
CA263,423A Expired CA1079641A (en) 1975-10-17 1976-10-14 Pharmaceutical composition containing ergot alkaloids

Country Status (28)

Country Link
JP (1) JPS5854122B2 (ja)
AT (1) AT362510B (ja)
AU (1) AU508628B2 (ja)
BE (1) BE847368A (ja)
CA (1) CA1079641A (ja)
CH (1) CH643737A5 (ja)
CS (1) CS199647B2 (ja)
DE (1) DE2546577B2 (ja)
DK (1) DK146194C (ja)
ES (1) ES452420A1 (ja)
FI (1) FI762875A (ja)
FR (1) FR2327764A1 (ja)
GB (1) GB1560406A (ja)
GR (1) GR61268B (ja)
HK (1) HK3183A (ja)
HU (1) HU172533B (ja)
IE (1) IE43778B1 (ja)
IL (1) IL50686A (ja)
MY (1) MY8400063A (ja)
NL (1) NL184558C (ja)
NO (1) NO144468C (ja)
NZ (1) NZ182341A (ja)
PH (1) PH14513A (ja)
PT (1) PT65719B (ja)
SE (1) SE430379B (ja)
SG (1) SG63082G (ja)
SU (1) SU1165223A3 (ja)
ZA (1) ZA766166B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1572226A (en) * 1977-11-03 1980-07-30 Hoechst Uk Ltd Pharmaceutical preparations in solid unit dosage form
DK154607C (da) * 1978-12-21 1989-06-05 Sandoz Ag Fremgangsmaade til fremstilling af en laegemiddelform til oral administration af ergotalkaloider
US4411882A (en) 1978-12-21 1983-10-25 Sandoz Ltd. Galenical compositions
FR2454804B1 (fr) * 1979-04-26 1986-11-21 Sanofi Sa Medicament a base de dihydroergotoxine et son procede de preparation
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
US4898729A (en) * 1983-12-09 1990-02-06 Euroceltique, S.A. Treatment of hypertension, compounds and compositions for antihypertension and diuresis
NL194389C (nl) * 1984-06-14 2002-03-04 Novartis Ag Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager.
ATE72111T1 (de) * 1987-01-14 1992-02-15 Ciba Geigy Ag Therapeutisches system fuer schwerloesliche wirkstoffe.
FR2610827B1 (fr) * 1987-02-18 1991-09-13 Pf Medicament Comprime de dihydroergotamine (d.h.e.) du type a matrice hydrophile et son procede de fabrication
US5064656A (en) * 1989-11-14 1991-11-12 Dr. Gergely & Co. Uncoated pharmaceutical reaction tablet
DE4401646A1 (de) * 1994-01-21 1995-07-27 Krewel Werke Gmbh Optimal freisetzende Kava-Extrakte
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
MY126580A (en) * 1997-12-22 2006-10-31 Merck Sharp & Dohme Molecular dispersion composition with enchanced bioavailabity
US6632455B2 (en) 1997-12-22 2003-10-14 Schering Corporation Molecular dispersion composition with enhanced bioavailability
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
ES2236017T3 (es) * 1999-12-03 2005-07-16 Polichem S.A. Procedimientos para la prepaaraciones farmaceuticas de liberacion sostenida de alcaloides del ergot que tienen biodfisponibilidad mejorada y composiciones de los mismos.
US7771746B2 (en) 1999-12-03 2010-08-10 Polichem Sa Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof
US7135436B2 (en) 2003-05-05 2006-11-14 J.F. Daley International, Ltd. Solid algicide, preparation and usage in recirculating water
US20060141038A1 (en) * 2003-06-27 2006-06-29 Bioprogress S. P. A. Composite product obtainable by cogrinding of a active principle with a copolymer n-vinyl-2 pyrrolidone/vinyl-acetate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1175430A (en) * 1966-04-07 1969-12-23 Sandoz Ltd Pharmaceutical Compositions containing Ergot Alkaloids

Also Published As

Publication number Publication date
DE2546577A1 (de) 1977-04-21
AT362510B (de) 1981-05-25
SE7611189L (sv) 1977-04-18
NL184558C (nl) 1989-09-01
FR2327764B1 (ja) 1979-03-02
AU508628B2 (en) 1980-03-27
SG63082G (en) 1983-09-09
ATA767976A (de) 1980-10-15
HK3183A (en) 1983-01-20
PT65719A (fr) 1976-11-01
SE430379B (sv) 1983-11-14
NO144468C (no) 1981-09-09
SU1165223A3 (ru) 1985-06-30
AU1875476A (en) 1978-04-20
PT65719B (fr) 1978-06-12
IL50686A (en) 1979-05-31
JPS5854122B2 (ja) 1983-12-02
NZ182341A (en) 1978-09-20
NL7611295A (nl) 1977-04-19
FR2327764A1 (fr) 1977-05-13
GR61268B (en) 1978-10-17
CS199647B2 (en) 1980-07-31
NL184558B (nl) 1989-04-03
PH14513A (en) 1981-08-24
MY8400063A (en) 1984-12-31
HU172533B (hu) 1978-09-28
DK146194B (da) 1983-07-25
ES452420A1 (es) 1978-04-16
NO144468B (no) 1981-06-01
DE2546577B2 (de) 1981-04-02
DK454176A (da) 1977-04-18
IL50686A0 (en) 1976-12-31
CH643737A5 (en) 1984-06-29
GB1560406A (en) 1980-02-06
ZA766166B (en) 1978-05-30
DK146194C (da) 1984-01-02
IE43778B1 (en) 1981-05-20
JPS5251014A (en) 1977-04-23
NO763446L (ja) 1977-04-19
FI762875A (ja) 1977-04-18
BE847368A (fr) 1977-04-15
IE43778L (en) 1977-04-17

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Legal Events

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