CA1073458A - Pyrimidone derivatives - Google Patents

Pyrimidone derivatives

Info

Publication number
CA1073458A
CA1073458A CA267,385A CA267385A CA1073458A CA 1073458 A CA1073458 A CA 1073458A CA 267385 A CA267385 A CA 267385A CA 1073458 A CA1073458 A CA 1073458A
Authority
CA
Canada
Prior art keywords
pyrimidone
methyl
pyridylmethyl
pyridyl
ethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA267,385A
Other languages
English (en)
French (fr)
Inventor
Thomas H. Brown
Charon R. Ganellin
Graham J. Durant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Application granted granted Critical
Publication of CA1073458A publication Critical patent/CA1073458A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA267,385A 1975-12-29 1976-12-08 Pyrimidone derivatives Expired CA1073458A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5300175 1975-12-29

Publications (1)

Publication Number Publication Date
CA1073458A true CA1073458A (en) 1980-03-11

Family

ID=10466233

Family Applications (1)

Application Number Title Priority Date Filing Date
CA267,385A Expired CA1073458A (en) 1975-12-29 1976-12-08 Pyrimidone derivatives

Country Status (37)

Country Link
JP (1) JPS5283388A (hu)
AR (1) AR222290A1 (hu)
AT (1) AT360024B (hu)
AU (1) AU508123B2 (hu)
BE (1) BE849810A (hu)
BG (1) BG29722A3 (hu)
CA (1) CA1073458A (hu)
CH (1) CH631981A5 (hu)
CS (1) CS203995B2 (hu)
DD (1) DD128588A5 (hu)
DE (1) DE2658267A1 (hu)
DK (1) DK587076A (hu)
EG (1) EG12439A (hu)
ES (1) ES454656A1 (hu)
FI (1) FI62668C (hu)
FR (1) FR2336935A1 (hu)
GR (1) GR62441B (hu)
HU (1) HU175171B (hu)
IE (1) IE45082B1 (hu)
IL (1) IL51040A (hu)
IT (2) IT1124740B (hu)
LU (1) LU76481A1 (hu)
MW (1) MW5076A1 (hu)
MX (1) MX5119E (hu)
NL (1) NL7614538A (hu)
NO (1) NO146396C (hu)
NZ (1) NZ182759A (hu)
OA (1) OA05526A (hu)
PH (1) PH14723A (hu)
PL (1) PL104376B1 (hu)
PT (1) PT65949B (hu)
RO (1) RO72475A (hu)
SE (1) SE431544B (hu)
SU (1) SU791235A3 (hu)
YU (1) YU311676A (hu)
ZA (1) ZA767198B (hu)
ZM (1) ZM14376A1 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
IN151188B (hu) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
ZA792607B (en) * 1978-05-30 1980-07-30 Smith Kline French Lab Nitro compounds
PT69886A (en) * 1978-07-15 1979-08-01 Smith Kline French Lab Process for preparing isoureas and isothioureas
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
US4255428A (en) 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
EP0017680B1 (en) * 1979-04-11 1982-04-21 Smith Kline & French Laboratories Limited Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
IN146736B (hu) * 1975-10-02 1979-08-25 Smith Kline French Lab

Also Published As

Publication number Publication date
BG29722A3 (en) 1981-01-15
FI62668B (fi) 1982-10-29
NO146396C (no) 1982-09-22
JPS6129355B2 (hu) 1986-07-05
IE45082B1 (en) 1982-06-16
OA05526A (fr) 1981-04-30
RO72475A (ro) 1982-10-26
HU175171B (hu) 1980-05-28
IL51040A (en) 1980-12-31
JPS5283388A (en) 1977-07-12
ATA960876A (de) 1980-05-15
CH631981A5 (en) 1982-09-15
NO764370L (hu) 1977-06-30
FR2336935B1 (hu) 1980-03-21
EG12439A (en) 1979-09-30
AT360024B (de) 1980-12-10
PL104376B1 (pl) 1979-08-31
ZA767198B (en) 1977-11-30
PH14723A (en) 1981-11-13
IE45082L (en) 1977-06-29
SE7614620L (sv) 1977-06-30
YU311676A (en) 1983-01-21
ES454656A1 (es) 1977-11-16
FR2336935A1 (fr) 1977-07-29
LU76481A1 (hu) 1977-06-15
CS203995B2 (en) 1981-03-31
MW5076A1 (en) 1978-02-08
IL51040A0 (en) 1977-02-28
PT65949A (pt) 1977-01-01
AR222290A1 (es) 1981-05-15
NZ182759A (en) 1978-06-02
FI62668C (fi) 1983-02-10
SU791235A3 (ru) 1980-12-23
AU2097676A (en) 1978-07-06
DD128588A5 (de) 1977-11-30
AU508123B2 (en) 1980-03-13
NL7614538A (nl) 1977-07-01
NO146396B (no) 1982-06-14
BE849810A (fr) 1977-06-23
DE2658267A1 (de) 1977-07-07
ZM14376A1 (en) 1977-08-22
GR62441B (en) 1979-04-12
IT1124740B (it) 1986-05-14
IT7919107A0 (it) 1979-01-05
SE431544B (sv) 1984-02-13
MX5119E (es) 1983-03-24
DK587076A (da) 1977-06-30
FI763664A (hu) 1977-06-30
PT65949B (pt) 1978-06-15

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Legal Events

Date Code Title Description
MKEX Expiry