CA1065874A - 3-substituted indoles and precursors therefor - Google Patents

3-substituted indoles and precursors therefor

Info

Publication number
CA1065874A
CA1065874A CA242,669A CA242669A CA1065874A CA 1065874 A CA1065874 A CA 1065874A CA 242669 A CA242669 A CA 242669A CA 1065874 A CA1065874 A CA 1065874A
Authority
CA
Canada
Prior art keywords
indole
acid addition
methyl
therapeutically active
active acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA242,669A
Other languages
English (en)
French (fr)
Inventor
Michael Zelesko
David Mccomsey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Application granted granted Critical
Publication of CA1065874A publication Critical patent/CA1065874A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA242,669A 1974-12-30 1975-12-29 3-substituted indoles and precursors therefor Expired CA1065874A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53761274A 1974-12-30 1974-12-30
US63179875A 1975-11-13 1975-11-13

Publications (1)

Publication Number Publication Date
CA1065874A true CA1065874A (en) 1979-11-06

Family

ID=27065555

Family Applications (1)

Application Number Title Priority Date Filing Date
CA242,669A Expired CA1065874A (en) 1974-12-30 1975-12-29 3-substituted indoles and precursors therefor

Country Status (27)

Country Link
JP (1) JPS51131872A (xx)
AR (1) AR219052A1 (xx)
AT (1) AT356648B (xx)
AU (1) AU505215B2 (xx)
CA (1) CA1065874A (xx)
CH (1) CH622516A5 (xx)
DD (1) DD125781A5 (xx)
DE (1) DE2559211A1 (xx)
DK (1) DK580175A (xx)
ES (1) ES443935A1 (xx)
FI (1) FI64590C (xx)
FR (2) FR2296413A1 (xx)
GB (1) GB1527510A (xx)
HU (2) HU174948B (xx)
IE (1) IE42390B1 (xx)
IL (1) IL48756A (xx)
IN (1) IN142735B (xx)
IT (1) IT1052654B (xx)
NL (1) NL7515100A (xx)
NO (1) NO145383C (xx)
NZ (1) NZ179580A (xx)
PH (1) PH12328A (xx)
PL (1) PL99353B1 (xx)
RO (1) RO69196A (xx)
SE (1) SE422210B (xx)
SU (1) SU667132A3 (xx)
YU (1) YU332275A (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
US4558048A (en) * 1984-04-06 1985-12-10 Pfizer Inc. Method of treating diarrhoea using indole compounds
EP1216988A4 (en) * 1999-09-28 2005-04-20 Nihon Nohyaku Co Ltd THIOALKYLAMINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
UA79504C2 (en) * 2002-11-07 2007-06-25 Organon Nv Indols for treating diseases associated with androgen receptors
KR20050072812A (ko) 2002-11-07 2005-07-12 악조 노벨 엔.브이. 안드로겐-수용체와 관련된 질병의 치료에 효과적인 인돌
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
WO2007020653A1 (en) * 2005-08-12 2007-02-22 Suven Life Sciences Limited Thioether derivatives as functional 5-ht6 ligands

Also Published As

Publication number Publication date
IT1052654B (it) 1981-07-20
HU174948B (hu) 1980-04-28
DK580175A (da) 1976-07-01
IE42390B1 (en) 1980-07-30
FR2315921B1 (xx) 1979-09-28
FR2315921A1 (fr) 1977-01-28
YU332275A (en) 1983-02-28
IL48756A (en) 1979-03-12
JPS51131872A (en) 1976-11-16
IL48756A0 (en) 1976-02-29
FI753669A (xx) 1976-07-01
DD125781A5 (xx) 1977-05-18
AU8791675A (en) 1977-07-07
AR219052A1 (es) 1980-07-31
GB1527510A (en) 1978-10-04
AU505215B2 (en) 1979-11-15
NZ179580A (en) 1978-04-03
SE7514458L (sv) 1976-07-01
IE42390L (en) 1976-06-30
ATA986075A (de) 1979-10-15
FR2296413A1 (fr) 1976-07-30
DE2559211A1 (de) 1976-07-08
NO145383B (no) 1981-11-30
FI64590B (fi) 1983-08-31
HU174949B (hu) 1980-04-28
PL99353B1 (pl) 1978-07-31
NL7515100A (nl) 1976-07-02
SU667132A3 (ru) 1979-06-05
PH12328A (en) 1979-01-16
FI64590C (fi) 1983-12-12
NO754313L (xx) 1976-07-01
CH622516A5 (en) 1981-04-15
AT356648B (de) 1980-05-12
FR2296413B1 (xx) 1980-06-27
NO145383C (no) 1982-03-10
ES443935A1 (es) 1977-08-16
SE422210B (sv) 1982-02-22
RO69196A (ro) 1980-08-15
IN142735B (xx) 1977-08-20

Similar Documents

Publication Publication Date Title
US4059583A (en) Substituted indoles
CA1190224A (en) Derivatives of 1,2-diamino-cyclobutene-3,4-dione as potent histamine h.sub.2-antagonists
US3472870A (en) Sulfonamidotryptamines
US3666767A (en) 2-amino-1-(2-imidazolin-2-yl)-2-imidazolines
DK165833B (da) Analogifremgangsmaade til fremstilling af diazabicyclo-(3,3,1)-nonaner
CA1065874A (en) 3-substituted indoles and precursors therefor
CA1262908A (en) Pyrrolobenzimidazoles, process for the preparation thereof and pharmaceutical compositions containing them
CA1207763A (en) Chemical process for preparing subtituted 3,4- diamino-1,2,5-thiadiazoles having histamine h.sub.2-receptor antagonist activity
US4891375A (en) Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
IE44792B1 (en) Heterocyclic derivatives of guanidine
US3314963A (en) Azabenzocycloalkane-n-carboxamidines
EP0279598A2 (en) Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
US3725410A (en) 3-aminomethyl-3-quinuclidinols
US3450694A (en) Substituted benzoxazepines and benzothiazepines
US4006232A (en) Therapeutic method of treating cardiac arrhythmias utilizing 3-substituted diphenylhydantoins
SE410460B (sv) Forfarande for framstellning av imidazoforeningar
US3546227A (en) 2,3-dihydro-1h-benz(d,e)isoquinoline carboxamidines
US5053409A (en) Aminobenzenesulfonic acid derivatives
US4025508A (en) 6-(Trifluoromethyl)-benzothiadiazines
US3184460A (en) 1-(alkoxyphenylalkyl)-2-imidazolinones, -2-imidazolidinones and -2-pyrimidinones
US4503051A (en) Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
US4000304A (en) Diuretic antiturombogenic and antiarrhythmic processes using N-substituted indole dimers and pyrrolobenzodia-zepine rearrangement products thereof
US4539316A (en) Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US3528991A (en) 1h- and 2h-benzotriazolyl-lower-alkyl-amidoximes,-amidines,and -guanidines
KR790001525B1 (ko) 치환된 인돌유도체의 제법