CA1047403A - Process for making a monolithic drug delivery device - Google Patents
Process for making a monolithic drug delivery deviceInfo
- Publication number
- CA1047403A CA1047403A CA228,740A CA228740A CA1047403A CA 1047403 A CA1047403 A CA 1047403A CA 228740 A CA228740 A CA 228740A CA 1047403 A CA1047403 A CA 1047403A
- Authority
- CA
- Canada
- Prior art keywords
- active agent
- polymer matrix
- agent
- layer
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000012377 drug delivery Methods 0.000 title description 6
- 239000013543 active substance Substances 0.000 claims abstract description 49
- 239000011159 matrix material Substances 0.000 claims abstract description 36
- 229920000642 polymer Polymers 0.000 claims abstract description 36
- 229940079593 drug Drugs 0.000 claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 26
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 21
- 238000005406 washing Methods 0.000 claims abstract description 14
- 239000006185 dispersion Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000005977 Ethylene Substances 0.000 claims abstract description 6
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- 238000012384 transportation and delivery Methods 0.000 claims abstract description 5
- 230000003204 osmotic effect Effects 0.000 claims description 23
- 230000009172 bursting Effects 0.000 claims description 17
- 238000009792 diffusion process Methods 0.000 claims description 17
- 239000007787 solid Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 10
- 238000005213 imbibition Methods 0.000 claims description 2
- 208000034423 Delivery Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 8
- 229940117958 vinyl acetate Drugs 0.000 abstract 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 18
- 239000010410 layer Substances 0.000 description 16
- 239000000186 progesterone Substances 0.000 description 9
- 229960003387 progesterone Drugs 0.000 description 9
- 230000007423 decrease Effects 0.000 description 6
- YKFROQCFVXOUPW-UHFFFAOYSA-N 4-(methylthio) aniline Chemical compound CSC1=CC=C(N)C=C1 YKFROQCFVXOUPW-UHFFFAOYSA-N 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 229960001963 pilocarpine nitrate Drugs 0.000 description 5
- 238000011068 loading method Methods 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229940023490 ophthalmic product Drugs 0.000 description 3
- 239000002344 surface layer Substances 0.000 description 3
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 3
- 229920003345 Elvax® Polymers 0.000 description 2
- 239000003732 agents acting on the eye Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- -1 sex sterilants Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 239000000150 Sympathomimetic Substances 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003619 algicide Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 229940125688 antiparkinson agent Drugs 0.000 description 1
- 239000000939 antiparkinson agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940125716 antipyretic agent Drugs 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 210000003717 douglas' pouch Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001076 estrogenic effect Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000004009 herbicide Substances 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 239000005554 hypnotics and sedatives Substances 0.000 description 1
- 229940005535 hypnotics and sedatives Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 239000003375 plant hormone Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001072 progestational effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000003128 rodenticide Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000807 solvent casting Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US477297A US3923939A (en) | 1974-06-07 | 1974-06-07 | Process for improving release kinetics of a monolithic drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1047403A true CA1047403A (en) | 1979-01-30 |
Family
ID=23895337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA228,740A Expired CA1047403A (en) | 1974-06-07 | 1975-06-06 | Process for making a monolithic drug delivery device |
Country Status (10)
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177256A (en) * | 1973-04-25 | 1979-12-04 | Alza Corporation | Osmotic bursting drug delivery device |
| US4145408A (en) * | 1976-08-16 | 1979-03-20 | The Procter & Gamble Company | Controlled release article |
| HU174057B (hu) * | 1976-09-17 | 1979-10-28 | Richter Gedeon Vegyeszet | Sostav dlja pokrytij obespechivajuhhij uregulirovannuju otdachy aktivnogo vehhestva biologicheski aktivnykh preparatov i sposob poluchenija takikh preparatov s uregulirovannoj otdachej aktivnogo vehhestva |
| US4190642A (en) * | 1978-04-17 | 1980-02-26 | Alza Corporation | Ocular therapeutic system for dispensing a medication formulation |
| US4156604A (en) * | 1978-09-15 | 1979-05-29 | Minnesota Mining And Manufacturing Company | Controlled delivery of corrosion inhibitors for silver recovery cartridges |
| US4333850A (en) * | 1979-06-15 | 1982-06-08 | Borg-Warner Corporation | Filled polymer composition for automatic addition of a corrosion inhibitor to a coolant system |
| US4304765A (en) * | 1980-10-14 | 1981-12-08 | Alza Corporation | Ocular insert housing steroid in two different therapeutic forms |
| US4432964A (en) * | 1981-08-24 | 1984-02-21 | Alza Corporation | Topical composition containing steroid in two forms released independently from polymeric carrier |
| DE3218150C2 (de) * | 1982-05-14 | 1986-09-25 | Akzo Gmbh, 5600 Wuppertal | Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung |
| JPS5931701A (ja) * | 1982-08-16 | 1984-02-20 | Nitto Electric Ind Co Ltd | 液状活性物質含有膜及びその製造方法 |
| US4557925A (en) * | 1982-07-08 | 1985-12-10 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
| US4478818A (en) * | 1982-12-27 | 1984-10-23 | Alza Corporation | Ocular preparation housing steroid in two different therapeutic forms |
| US4564364A (en) * | 1983-05-26 | 1986-01-14 | Alza Corporation | Active agent dispenser |
| GB8331546D0 (en) * | 1983-11-25 | 1984-01-04 | Exxon Research Engineering Co | Polymeric compositions |
| US4624848A (en) * | 1984-05-10 | 1986-11-25 | Ciba-Geigy Corporation | Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use |
| US4725439A (en) * | 1984-06-29 | 1988-02-16 | Alza Corporation | Transdermal drug delivery device |
| US4704282A (en) * | 1984-06-29 | 1987-11-03 | Alza Corporation | Transdermal therapeutic system having improved delivery characteristics |
| US4629620A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
| US4629619A (en) * | 1984-09-05 | 1986-12-16 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
| AU592546B2 (en) * | 1984-12-03 | 1990-01-18 | Baxter International Inc. | Drug delivery apparatus preventing local and systemic toxicity |
| US4874366A (en) * | 1984-12-03 | 1989-10-17 | Baxter Internatiional Inc. | Housing enabling passive mixing of a beneficial agent with a diluent |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
| US4898733A (en) * | 1985-11-04 | 1990-02-06 | International Minerals & Chemical Corp. | Layered, compression molded device for the sustained release of a beneficial agent |
| ATE71287T1 (de) * | 1986-06-13 | 1992-01-15 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
| US5344656A (en) * | 1986-09-12 | 1994-09-06 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4908027A (en) * | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
| US5071656A (en) * | 1987-03-05 | 1991-12-10 | Alza Corporation | Delayed onset transdermal delivery device |
| DE3743945A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung |
| US4917895A (en) * | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
| US4837027A (en) * | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
| US5198251A (en) * | 1989-04-19 | 1993-03-30 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
| US5229148A (en) * | 1989-04-19 | 1993-07-20 | Wm. Wrigley Jr. Company | Method of combining active ingredients with polyvinyl acetates |
| US5108762A (en) * | 1989-04-19 | 1992-04-28 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
| US4978537A (en) * | 1989-04-19 | 1990-12-18 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
| US5154939A (en) * | 1989-04-19 | 1992-10-13 | Wm. Wrigley Jr. Company | Use of salt to improve extrusion encapsulation of chewing gum ingredients |
| US5165944A (en) * | 1989-04-19 | 1992-11-24 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
| US5091186A (en) * | 1989-08-15 | 1992-02-25 | Cygnus Therapeutic Systems | Biphasic transdermal drug delivery device |
| US5124157A (en) | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| FI904598A7 (fi) * | 1989-10-10 | 1991-04-11 | Wrigley W M Jun Co | Kuidunkehruutekniikalla valmistetut ainetta vähitellen vapauttavat rakenteet |
| JPH03287525A (ja) * | 1990-04-03 | 1991-12-18 | Toichi Chikuma | 貼付鎮痛具 |
| US5508038A (en) * | 1990-04-16 | 1996-04-16 | Alza Corporation | Polyisobutylene adhesives for transdermal devices |
| JPH0421521U (enrdf_load_stackoverflow) * | 1990-06-14 | 1992-02-24 | ||
| US5128155A (en) * | 1990-12-20 | 1992-07-07 | Wm. Wrigley Jr. Company | Flavor releasing structures for chewing gum |
| US5271736A (en) * | 1991-05-13 | 1993-12-21 | Applied Medical Research | Collagen disruptive morphology for implants |
| ES2096103T3 (es) * | 1992-01-13 | 1997-03-01 | Pfizer | Preparacion de comprimidos de resistencia incrementada. |
| US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5962011A (en) * | 1993-12-06 | 1999-10-05 | Schering-Plough Healthcare Products, Inc. | Device for delivery of dermatological ingredients |
| US5633000A (en) * | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
| US5819742A (en) * | 1996-11-06 | 1998-10-13 | Family Health International | Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both |
| DE69705746T2 (de) * | 1996-12-20 | 2001-10-31 | Alza Corp., Palo Alto | Injizierbare depotgelzubereitung und herstellungsverfahren |
| US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
| US6110500A (en) * | 1998-03-25 | 2000-08-29 | Temple University | Coated tablet with long term parabolic and zero-order release kinetics |
| IL135061A0 (en) * | 2000-03-14 | 2001-05-20 | Ahron Jodaikin | Strategic targeted fluoridation and chemical treatment of teeth |
| US20050175959A1 (en) * | 2000-03-14 | 2005-08-11 | Coll Partners Ltd. | System for the controlled delivery of an active material to a dental site |
| US20030211974A1 (en) * | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
| JP5100951B2 (ja) * | 2000-09-29 | 2012-12-19 | コーディス・コーポレイション | 被覆医用器具 |
| IL162001A0 (en) | 2001-11-14 | 2005-11-20 | Alza Corp | Catheter injectable depot compositions and uses thereof |
| MXPA04004664A (es) * | 2001-11-14 | 2004-09-10 | Alza Corp | Composiciones de deposito inyectables. |
| MXPA04011875A (es) * | 2002-05-31 | 2005-03-31 | Titan Pharmaceuticals Inc | Dispositivo polimerico implantable para liberacion sostenida de buprenorfina. |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US8501215B2 (en) | 2002-07-31 | 2013-08-06 | Guohua Chen | Injectable multimodal polymer depot compositions and uses thereof |
| CN1668276A (zh) | 2002-07-31 | 2005-09-14 | 阿尔萨公司 | 可注射的储库组合物及其用途 |
| DK1610791T3 (da) | 2003-03-31 | 2011-05-09 | Titan Pharmaceuticals Inc | Implanterbar polymer anordning for vedvarende frigivelse af dopamin-agonist |
| US7850453B2 (en) * | 2007-08-08 | 2010-12-14 | Coll Partners Ltd. | Reshapable device for fixation at a dental site |
| USRE48948E1 (en) * | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| CA2977078C (en) * | 2009-02-23 | 2021-07-20 | Mati Therapeutics, Inc. | Lacrimal implants and related methods |
| BR112012010026B8 (pt) * | 2009-10-30 | 2021-02-02 | Aton Pharma Inc | método de formação de um dispositivo de liberação ocular e dispositivo de liberação ocular |
| US9138308B2 (en) | 2010-02-03 | 2015-09-22 | Apollo Endosurgery, Inc. | Mucosal tissue adhesion via textured surface |
| US9205577B2 (en) * | 2010-02-05 | 2015-12-08 | Allergan, Inc. | Porogen compositions, methods of making and uses |
| PL2569021T3 (pl) * | 2010-05-11 | 2017-07-31 | Allergan, Inc. | Kompozycje, sposoby wytwarzania i zastosowania czynnika porotwórczego |
| US9668844B2 (en) | 2013-11-06 | 2017-06-06 | Colldent Y.A Ltd | Device for fixation at a dental site |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| BR112022013784A2 (pt) | 2020-01-13 | 2022-10-11 | Durect Corp | Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3402240A (en) * | 1957-06-25 | 1968-09-17 | Pfizer & Co C | Medicinal tablet and process of making same |
| US3639583A (en) * | 1968-06-28 | 1972-02-01 | Goodrich Co B F | Biocidal elastomeric compositions |
| US3700380A (en) * | 1970-10-01 | 1972-10-24 | Tecna Corp | Surface or lining compatible with blood or other tissue |
| GB1412983A (en) * | 1971-11-30 | 1975-11-05 | Debell & Richardson | Method of producing porous plastic materials |
| FR2183546B1 (enrdf_load_stackoverflow) * | 1972-05-10 | 1975-06-20 | Servier Lab | |
| JPS49118827A (enrdf_load_stackoverflow) * | 1973-03-27 | 1974-11-13 | ||
| JPS506709A (enrdf_load_stackoverflow) * | 1973-05-18 | 1975-01-23 |
-
1974
- 1974-06-07 US US477297A patent/US3923939A/en not_active Expired - Lifetime
-
1975
- 1975-05-20 GB GB2165075A patent/GB1477545A/en not_active Expired
- 1975-05-28 SE SE7506099A patent/SE405803B/xx not_active IP Right Cessation
- 1975-06-03 CH CH714475A patent/CH611160A5/xx not_active IP Right Cessation
- 1975-06-05 DE DE2525061A patent/DE2525061C2/de not_active Expired
- 1975-06-06 IT IT68466/75A patent/IT1036192B/it active
- 1975-06-06 CA CA228,740A patent/CA1047403A/en not_active Expired
- 1975-06-06 MX MX001433U patent/MX3007E/es unknown
- 1975-06-06 JP JP50068485A patent/JPS6043327B2/ja not_active Expired
- 1975-06-06 FR FR7517693A patent/FR2273515A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE405803B (sv) | 1979-01-08 |
| DE2525061A1 (de) | 1976-01-02 |
| JPS6043327B2 (ja) | 1985-09-27 |
| MX3007E (es) | 1980-01-28 |
| US3923939A (en) | 1975-12-02 |
| DE2525061C2 (de) | 1985-08-22 |
| JPS5112920A (enrdf_load_stackoverflow) | 1976-01-31 |
| SE7506099L (sv) | 1975-12-08 |
| FR2273515A1 (fr) | 1976-01-02 |
| IT1036192B (it) | 1979-10-30 |
| CH611160A5 (enrdf_load_stackoverflow) | 1979-05-31 |
| FR2273515B1 (enrdf_load_stackoverflow) | 1980-02-15 |
| GB1477545A (en) | 1977-06-22 |
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