CA1047403A - Methode de fabrication d'un dispositif monobloc temporisateur de la liberation du produit pharmaceutique qu'il renferme - Google Patents

Methode de fabrication d'un dispositif monobloc temporisateur de la liberation du produit pharmaceutique qu'il renferme

Info

Publication number
CA1047403A
CA1047403A CA228,740A CA228740A CA1047403A CA 1047403 A CA1047403 A CA 1047403A CA 228740 A CA228740 A CA 228740A CA 1047403 A CA1047403 A CA 1047403A
Authority
CA
Canada
Prior art keywords
active agent
polymer matrix
agent
layer
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA228,740A
Other languages
English (en)
Inventor
Richard W. Baker
Alan S. Michaels
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of CA1047403A publication Critical patent/CA1047403A/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
CA228,740A 1974-06-07 1975-06-06 Methode de fabrication d'un dispositif monobloc temporisateur de la liberation du produit pharmaceutique qu'il renferme Expired CA1047403A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US477297A US3923939A (en) 1974-06-07 1974-06-07 Process for improving release kinetics of a monolithic drug delivery device

Publications (1)

Publication Number Publication Date
CA1047403A true CA1047403A (fr) 1979-01-30

Family

ID=23895337

Family Applications (1)

Application Number Title Priority Date Filing Date
CA228,740A Expired CA1047403A (fr) 1974-06-07 1975-06-06 Methode de fabrication d'un dispositif monobloc temporisateur de la liberation du produit pharmaceutique qu'il renferme

Country Status (10)

Country Link
US (1) US3923939A (fr)
JP (1) JPS6043327B2 (fr)
CA (1) CA1047403A (fr)
CH (1) CH611160A5 (fr)
DE (1) DE2525061C2 (fr)
FR (1) FR2273515A1 (fr)
GB (1) GB1477545A (fr)
IT (1) IT1036192B (fr)
MX (1) MX3007E (fr)
SE (1) SE405803B (fr)

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US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
DE3218150C2 (de) * 1982-05-14 1986-09-25 Akzo Gmbh, 5600 Wuppertal Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung
JPS5931701A (ja) * 1982-08-16 1984-02-20 Nitto Electric Ind Co Ltd 液状活性物質含有膜及びその製造方法
US4557925A (en) * 1982-07-08 1985-12-10 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
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US4624848A (en) * 1984-05-10 1986-11-25 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4629620A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
US4629619A (en) * 1984-09-05 1986-12-16 Ab Ferrosan Membrane-coated sustained-release tablets and method
EP0203186B1 (fr) * 1984-12-03 1992-03-04 BAXTER INTERNATIONAL INC. (a Delaware corporation) Appareil de distribution de medicaments permettant de prevenir la toxicite systemique et la toxicite locale
US4874366A (en) * 1984-12-03 1989-10-17 Baxter Internatiional Inc. Housing enabling passive mixing of a beneficial agent with a diluent
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
US4898733A (en) * 1985-11-04 1990-02-06 International Minerals & Chemical Corp. Layered, compression molded device for the sustained release of a beneficial agent
ES2028074T3 (es) * 1986-06-13 1992-07-01 Alza Corporation Activacion por humedad de un sistema de suministro transdermico de farmacos.
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4761289A (en) * 1986-10-10 1988-08-02 International Minerals & Chemical Corp. Sustained release implant and method for preparing same
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
DE3743945A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung
US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US5165944A (en) * 1989-04-19 1992-11-24 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5198251A (en) * 1989-04-19 1993-03-30 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US4978537A (en) * 1989-04-19 1990-12-18 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5229148A (en) * 1989-04-19 1993-07-20 Wm. Wrigley Jr. Company Method of combining active ingredients with polyvinyl acetates
US5154939A (en) * 1989-04-19 1992-10-13 Wm. Wrigley Jr. Company Use of salt to improve extrusion encapsulation of chewing gum ingredients
US5108762A (en) * 1989-04-19 1992-04-28 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI904598A0 (fi) * 1989-10-10 1990-09-18 Wrigley W M Jun Co Gradvis aemnesfrigoerande strukturer som framstaellts med fiberspinningsteknik.
JPH03287525A (ja) * 1990-04-03 1991-12-18 Toichi Chikuma 貼付鎮痛具
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
JPH0421521U (fr) * 1990-06-14 1992-02-24
US5128155A (en) * 1990-12-20 1992-07-07 Wm. Wrigley Jr. Company Flavor releasing structures for chewing gum
US5271736A (en) * 1991-05-13 1993-12-21 Applied Medical Research Collagen disruptive morphology for implants
WO1993013758A1 (fr) * 1992-01-13 1993-07-22 Pfizer Inc. Preparation de comprimes a efficacite amelioree
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5962011A (en) * 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5633000A (en) * 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
US5819742A (en) * 1996-11-06 1998-10-13 Family Health International Vaginal device for preventing conception or the transmission of sexually transmitted diseases, or both
US6331311B1 (en) 1996-12-20 2001-12-18 Alza Corporation Injectable depot gel composition and method of preparing the composition
US6039968A (en) * 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US6110500A (en) * 1998-03-25 2000-08-29 Temple University Coated tablet with long term parabolic and zero-order release kinetics
US20050175959A1 (en) * 2000-03-14 2005-08-11 Coll Partners Ltd. System for the controlled delivery of an active material to a dental site
IL135061A0 (en) * 2000-03-14 2001-05-20 Ahron Jodaikin Strategic targeted fluoridation and chemical treatment of teeth
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
EP1322235B2 (fr) * 2000-09-29 2010-08-11 Cordis Corporation Dispositifs medicaux enrobes
DE60232987D1 (de) * 2001-11-14 2009-08-27 Durect Corp Injizierbare depotzusammensetzungen
AU2002359407B2 (en) 2001-11-14 2008-02-28 Durect Corporation Catheter injectable depot compositions and uses thereof
EP1509182A4 (fr) * 2002-05-31 2009-12-30 Titan Pharmaceuticals Inc Dispositif polymere implantable permettant la liberation prolongee de buprenorphine
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
WO2004011054A2 (fr) 2002-07-31 2004-02-05 Alza Corporation Compositions de depot polymere multimode injectables et leurs utilisations
ES2319400T3 (es) 2002-07-31 2009-05-07 Durect Corporation Composiciones deposito inyectables y empleo de las mismas.
DK1610791T3 (da) 2003-03-31 2011-05-09 Titan Pharmaceuticals Inc Implanterbar polymer anordning for vedvarende frigivelse af dopamin-agonist
US7850453B2 (en) * 2007-08-08 2010-12-14 Coll Partners Ltd. Reshapable device for fixation at a dental site
USRE48948E1 (en) * 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
AU2010215745A1 (en) * 2009-02-23 2011-09-01 Qlt Inc. Lacrimal implants and related methods
BR112012010026B8 (pt) * 2009-10-30 2021-02-02 Aton Pharma Inc método de formação de um dispositivo de liberação ocular e dispositivo de liberação ocular
US9138308B2 (en) 2010-02-03 2015-09-22 Apollo Endosurgery, Inc. Mucosal tissue adhesion via textured surface
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
EP2569021B1 (fr) * 2010-05-11 2017-01-04 Allergan, Inc. Compositions d'agents porogènes, leurs procédés de fabrication et utilisations
US9668844B2 (en) 2013-11-06 2017-06-06 Colldent Y.A Ltd Device for fixation at a dental site
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
WO2021146215A1 (fr) 2020-01-13 2021-07-22 Durect Corporation Systèmes d'administration de médicament à libération prolongée avec impuretés réduites et procédés associés

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US3402240A (en) * 1957-06-25 1968-09-17 Pfizer & Co C Medicinal tablet and process of making same
US3639583A (en) * 1968-06-28 1972-02-01 Goodrich Co B F Biocidal elastomeric compositions
US3700380A (en) * 1970-10-01 1972-10-24 Tecna Corp Surface or lining compatible with blood or other tissue
GB1412983A (en) * 1971-11-30 1975-11-05 Debell & Richardson Method of producing porous plastic materials
FR2183546B1 (fr) * 1972-05-10 1975-06-20 Servier Lab
JPS49118827A (fr) * 1973-03-27 1974-11-13
JPS506709A (fr) * 1973-05-18 1975-01-23

Also Published As

Publication number Publication date
GB1477545A (en) 1977-06-22
DE2525061C2 (de) 1985-08-22
JPS5112920A (fr) 1976-01-31
DE2525061A1 (de) 1976-01-02
FR2273515B1 (fr) 1980-02-15
FR2273515A1 (fr) 1976-01-02
CH611160A5 (fr) 1979-05-31
US3923939A (en) 1975-12-02
IT1036192B (it) 1979-10-30
MX3007E (es) 1980-01-28
SE405803B (sv) 1979-01-08
SE7506099L (sv) 1975-12-08
JPS6043327B2 (ja) 1985-09-27

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