CA1012535A - Process for the manufacture of benzodiazepine derivatives - Google Patents

Process for the manufacture of benzodiazepine derivatives

Info

Publication number
CA1012535A
CA1012535A CA179,143A CA179143A CA1012535A CA 1012535 A CA1012535 A CA 1012535A CA 179143 A CA179143 A CA 179143A CA 1012535 A CA1012535 A CA 1012535A
Authority
CA
Canada
Prior art keywords
manufacture
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA179,143A
Other languages
English (en)
Other versions
CA179143S (en
Inventor
George O. Chase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1012535A publication Critical patent/CA1012535A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA179,143A 1972-08-21 1973-08-20 Process for the manufacture of benzodiazepine derivatives Expired CA1012535A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US35981473A 1973-05-14 1973-05-14

Publications (1)

Publication Number Publication Date
CA1012535A true CA1012535A (en) 1977-06-21

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
CA179,143A Expired CA1012535A (en) 1972-08-21 1973-08-20 Process for the manufacture of benzodiazepine derivatives

Country Status (24)

Country Link
JP (1) JPS5911589B2 (cs)
AR (1) AR198108A1 (cs)
AT (1) AT341527B (cs)
AU (1) AU472777B2 (cs)
CA (1) CA1012535A (cs)
CH (1) CH578544A5 (cs)
DD (1) DD107040A5 (cs)
DE (1) DE2340159A1 (cs)
DK (1) DK155326C (cs)
ES (1) ES418014A1 (cs)
FI (1) FI57939C (cs)
FR (1) FR2197003B1 (cs)
GB (1) GB1392681A (cs)
HU (1) HU170153B (cs)
IE (1) IE38091B1 (cs)
IL (1) IL42947A (cs)
LU (1) LU68269A1 (cs)
NL (1) NL179582C (cs)
NO (1) NO139481C (cs)
PH (1) PH13640A (cs)
PL (1) PL99162B1 (cs)
SE (1) SE408302B (cs)
SU (1) SU550980A3 (cs)
YU (1) YU219873A (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
RU2120441C1 (ru) * 1996-10-18 1998-10-20 Олег Иванович Лукашов Способ получения 7-бром-1,3-дигидро-5-/2-хлорфенил/-2н-1,4-бензидиазепин-2-она, промежуточное соединение 5-бром-2-/2-хлорацетамидо/-2'-хлорбензофенон
RU2150467C1 (ru) * 1998-01-06 2000-06-10 Петрунин Александр Иванович Способ получения 1,3-дигидро-7-нитро-5-фенил-2h-1,4-бензодиазепин-2-она (нитразепама) (варианты)
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342B (zh) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
CH537393A (de) * 1969-10-16 1973-05-31 Hoffmann La Roche Verfahren zur Herstellung von 1,4-Benzodiazepin-derivaten
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Also Published As

Publication number Publication date
AT341527B (de) 1978-02-10
DK155326C (da) 1989-08-14
FR2197003B1 (cs) 1978-01-13
IE38091L (en) 1974-02-21
PL99162B1 (pl) 1978-06-30
HU170153B (cs) 1977-04-28
IL42947A (en) 1977-01-31
FR2197003A1 (cs) 1974-03-22
DE2340159A1 (de) 1974-03-07
FI57939C (fi) 1980-11-10
CH578544A5 (cs) 1976-08-13
DK155326B (da) 1989-03-28
ATA720773A (de) 1977-06-15
AU472777B2 (en) 1976-06-03
ES418014A1 (es) 1976-03-16
NL179582B (nl) 1986-05-01
DE2340159C2 (cs) 1989-01-19
DD107040A5 (cs) 1974-07-12
AU5918073A (en) 1975-02-13
AR198108A1 (es) 1974-05-31
SE408302B (sv) 1979-06-05
NL179582C (nl) 1986-10-01
IE38091B1 (en) 1977-12-21
JPS4956992A (cs) 1974-06-03
NO139481B (no) 1978-12-11
PH13640A (en) 1980-08-18
SU550980A3 (ru) 1977-03-15
FI57939B (fi) 1980-07-31
NO139481C (no) 1979-03-21
GB1392681A (en) 1975-04-30
YU219873A (en) 1982-06-30
NL7311507A (cs) 1974-02-25
IL42947A0 (en) 1973-11-28
JPS5911589B2 (ja) 1984-03-16
LU68269A1 (cs) 1975-05-21

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