BRPI9914031B8 - partículas micronizadas de sulfometato de sódio colistina, composição, forma de dosagem farmacêutica e cápsula compreendendo as mesmas e processo para a preparação da referida composição. - Google Patents
partículas micronizadas de sulfometato de sódio colistina, composição, forma de dosagem farmacêutica e cápsula compreendendo as mesmas e processo para a preparação da referida composição.Info
- Publication number
- BRPI9914031B8 BRPI9914031B8 BRPI9914031A BRPI9914031A BRPI9914031B8 BR PI9914031 B8 BRPI9914031 B8 BR PI9914031B8 BR PI9914031 A BRPI9914031 A BR PI9914031A BR PI9914031 A BRPI9914031 A BR PI9914031A BR PI9914031 B8 BRPI9914031 B8 BR PI9914031B8
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- sulfometate
- capsule
- particles
- preparation
- Prior art date
Links
- 108010078777 Colistin Proteins 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 2
- 229960003346 colistin Drugs 0.000 title abstract 2
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 title abstract 2
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 title abstract 2
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052708 sodium Inorganic materials 0.000 title abstract 2
- 239000011734 sodium Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 2
- 239000002775 capsule Substances 0.000 title 1
- 239000002552 dosage form Substances 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
patente de invenção: <b>"composições farmacêuticas micronizadas"<d>. são descritas composições farmacêuticas compreendendo sulfometato de sódio colistina micronizado. a substância farmacêutica micronizada pode ser usada em conjunto com um veículo, tal como lactose. as composições farmacêuticas podem ser embaladas em recipientes, tais como, cápsulas de gelatina, e administradas por inalação do pó.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9820746.7A GB9820746D0 (en) | 1998-09-23 | 1998-09-23 | Micronised pharmaceutical compositions |
| PCT/GB1999/003172 WO2000016745A2 (en) | 1998-09-23 | 1999-09-22 | Micronised pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI9914031B8 true BRPI9914031B8 (pt) | 2019-02-26 |
Family
ID=10839350
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9914031A BRPI9914031B8 (pt) | 1998-09-23 | 1999-09-22 | partículas micronizadas de sulfometato de sódio colistina, composição, forma de dosagem farmacêutica e cápsula compreendendo as mesmas e processo para a preparação da referida composição. |
| BRPI9914031-4A BR9914031B1 (pt) | 1998-09-23 | 1999-09-22 | partìculas micronizadas de sulfonetato de sódio colistina, composição, forma de dosagem farmacêutica e cápsula compreendendo as mesmas e processo para a preparação da referida composição. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9914031-4A BR9914031B1 (pt) | 1998-09-23 | 1999-09-22 | partìculas micronizadas de sulfonetato de sódio colistina, composição, forma de dosagem farmacêutica e cápsula compreendendo as mesmas e processo para a preparação da referida composição. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1115380B2 (pt) |
| JP (1) | JP5165168B2 (pt) |
| CN (1) | CN1148168C (pt) |
| AT (1) | ATE267585T1 (pt) |
| AU (1) | AU752266B2 (pt) |
| BR (2) | BRPI9914031B8 (pt) |
| CA (1) | CA2341366C (pt) |
| CZ (1) | CZ298603B6 (pt) |
| DE (1) | DE69917658T3 (pt) |
| DK (1) | DK1115380T4 (pt) |
| EA (1) | EA003193B1 (pt) |
| ES (1) | ES2222733T5 (pt) |
| GB (1) | GB9820746D0 (pt) |
| HU (1) | HU228888B1 (pt) |
| IL (1) | IL141913A0 (pt) |
| MX (1) | MXPA01003103A (pt) |
| NZ (1) | NZ509881A (pt) |
| PL (1) | PL197871B1 (pt) |
| PT (1) | PT1115380E (pt) |
| WO (1) | WO2000016745A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1129705A1 (en) * | 2000-02-17 | 2001-09-05 | Rijksuniversiteit te Groningen | Powder formulation for inhalation |
| WO2005053647A1 (en) * | 2003-12-03 | 2005-06-16 | Microdrug Ag | Medical product containing tiotropium |
| SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
| WO2012061902A1 (en) * | 2010-11-12 | 2012-05-18 | Monash University | Micronised spray-dried particles comprising polymyxin |
| US10441536B2 (en) * | 2013-03-13 | 2019-10-15 | Actavis Group Ptc Ehf | Micronized colistimethane sodium pharmaceutical compositions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579846A (en) * | 1984-10-11 | 1986-04-01 | Pfizer Inc. | Antiinflammatory compositions and methods |
| IT1228459B (it) † | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| GB8911259D0 (en) † | 1989-05-17 | 1989-07-05 | Fisons Plc | Inhalation medicament |
| US5916596A (en) † | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| US5875776A (en) † | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| EP0920324B1 (en) * | 1996-11-15 | 2001-06-27 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
-
1998
- 1998-09-23 GB GBGB9820746.7A patent/GB9820746D0/en not_active Ceased
-
1999
- 1999-09-22 NZ NZ509881A patent/NZ509881A/xx not_active IP Right Cessation
- 1999-09-22 EP EP99949133A patent/EP1115380B2/en not_active Expired - Lifetime
- 1999-09-22 CZ CZ20011050A patent/CZ298603B6/cs not_active IP Right Cessation
- 1999-09-22 CN CNB998113360A patent/CN1148168C/zh not_active Expired - Lifetime
- 1999-09-22 PL PL346774A patent/PL197871B1/pl unknown
- 1999-09-22 CA CA002341366A patent/CA2341366C/en not_active Expired - Lifetime
- 1999-09-22 MX MXPA01003103A patent/MXPA01003103A/es active IP Right Grant
- 1999-09-22 AU AU62122/99A patent/AU752266B2/en not_active Expired
- 1999-09-22 EA EA200100253A patent/EA003193B1/ru not_active IP Right Cessation
- 1999-09-22 ES ES99949133T patent/ES2222733T5/es not_active Expired - Lifetime
- 1999-09-22 DE DE69917658T patent/DE69917658T3/de not_active Expired - Lifetime
- 1999-09-22 HU HU0104928A patent/HU228888B1/hu active Protection Beyond IP Right Term
- 1999-09-22 JP JP2000573706A patent/JP5165168B2/ja not_active Expired - Lifetime
- 1999-09-22 DK DK99949133T patent/DK1115380T4/da active
- 1999-09-22 BR BRPI9914031A patent/BRPI9914031B8/pt unknown
- 1999-09-22 WO PCT/GB1999/003172 patent/WO2000016745A2/en active IP Right Grant
- 1999-09-22 PT PT99949133T patent/PT1115380E/pt unknown
- 1999-09-22 BR BRPI9914031-4A patent/BR9914031B1/pt not_active IP Right Cessation
- 1999-09-22 AT AT99949133T patent/ATE267585T1/de not_active IP Right Cessation
- 1999-09-22 IL IL14191399A patent/IL141913A0/xx not_active IP Right Cessation
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