BRPI9611271A2 - inibidores de atividade de enzima rotamase - Google Patents
inibidores de atividade de enzima rotamaseInfo
- Publication number
- BRPI9611271A2 BRPI9611271A2 BRPI9611271-9A BRPI9611271A BRPI9611271A2 BR PI9611271 A2 BRPI9611271 A2 BR PI9611271A2 BR PI9611271 A BRPI9611271 A BR PI9611271A BR PI9611271 A2 BRPI9611271 A2 BR PI9611271A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme activity
- inhibitors
- activity inhibitors
- rotamase enzyme
- rotamase
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 101710103508 FK506-binding protein Proteins 0.000 title 1
- 101710104425 FK506-binding protein 2 Proteins 0.000 title 1
- 101710104423 FK506-binding protein 3 Proteins 0.000 title 1
- 101710104333 FK506-binding protein 4 Proteins 0.000 title 1
- 101710104342 FK506-binding protein 5 Proteins 0.000 title 1
- 101710149710 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710121306 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710180800 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA Proteins 0.000 title 1
- 101710104030 Long-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 title 1
- 101710116692 Peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710111764 Peptidyl-prolyl cis-trans isomerase FKBP10 Proteins 0.000 title 1
- 101710111749 Peptidyl-prolyl cis-trans isomerase FKBP11 Proteins 0.000 title 1
- 101710111747 Peptidyl-prolyl cis-trans isomerase FKBP12 Proteins 0.000 title 1
- 101710111757 Peptidyl-prolyl cis-trans isomerase FKBP14 Proteins 0.000 title 1
- 101710111682 Peptidyl-prolyl cis-trans isomerase FKBP1A Proteins 0.000 title 1
- 101710111689 Peptidyl-prolyl cis-trans isomerase FKBP1B Proteins 0.000 title 1
- 101710147154 Peptidyl-prolyl cis-trans isomerase FKBP2 Proteins 0.000 title 1
- 101710147149 Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 title 1
- 101710147152 Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 title 1
- 101710147150 Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 title 1
- 101710147138 Peptidyl-prolyl cis-trans isomerase FKBP7 Proteins 0.000 title 1
- 101710147137 Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 title 1
- 101710147136 Peptidyl-prolyl cis-trans isomerase FKBP9 Proteins 0.000 title 1
- 102100038809 Peptidyl-prolyl cis-trans isomerase FKBP9 Human genes 0.000 title 1
- 101710174853 Peptidyl-prolyl cis-trans isomerase Mip Proteins 0.000 title 1
- 101710200991 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme Proteins 0.000 title 1
- 101710092145 Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 title 1
- 101710092146 Peptidyl-prolyl cis-trans isomerase-like 2 Proteins 0.000 title 1
- 101710092148 Peptidyl-prolyl cis-trans isomerase-like 3 Proteins 0.000 title 1
- 101710092149 Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 title 1
- 101710113444 Probable parvulin-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710090737 Probable peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710133309 Putative peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 101710124237 Short-type peptidyl-prolyl cis-trans isomerase Proteins 0.000 title 1
- 102000000521 Immunophilins Human genes 0.000 abstract 2
- 108010016648 Immunophilins Proteins 0.000 abstract 2
- 102000004195 Isomerases Human genes 0.000 abstract 1
- 108090000769 Isomerases Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007514 neuronal growth Effects 0.000 abstract 1
- 230000009689 neuronal regeneration Effects 0.000 abstract 1
- 230000000508 neurotrophic effect Effects 0.000 abstract 1
- -1 pipecolic acid derivative compounds Chemical class 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Abstract
inibioores de atividade de enzima rotamase esta invenção se refere ao processo de uso de compostos de derivado de ácido pipecólico neurotrófico especialmente formulados, tendo uma afinidade para imunofilins tipo fkbp como inibidores da atividade de enzima associado com proteinas imunofilins, e particularmente inibidores de peptidil-propil isomerase ou atividade de enzima, para estimular ou promover crescimento ou regeneração neuronal.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/551,026 | 1995-10-31 | ||
US08/551,026 US20020013344A1 (en) | 1995-10-31 | 1995-10-31 | Rotamas enzyme activity inhibitors |
US08/645,149 | 1996-05-13 | ||
US08/645,149 US5801197A (en) | 1995-10-31 | 1996-05-13 | Rotamase enzyme activity inhibitors |
PCT/US1996/013624 WO1997016190A1 (en) | 1995-10-31 | 1996-08-26 | Rotamase enzyme activity inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI9611271A2 true BRPI9611271A2 (pt) | 2019-04-30 |
Family
ID=27069634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9611271-9A BRPI9611271A2 (pt) | 1995-10-31 | 1996-08-26 | inibidores de atividade de enzima rotamase |
Country Status (17)
Country | Link |
---|---|
US (1) | US5801197A (pt) |
EP (1) | EP0859614A4 (pt) |
JP (1) | JPH11514643A (pt) |
KR (1) | KR19990067257A (pt) |
BG (1) | BG62596B1 (pt) |
BR (1) | BRPI9611271A2 (pt) |
CA (1) | CA2236328A1 (pt) |
CZ (1) | CZ125198A3 (pt) |
EA (1) | EA001481B1 (pt) |
EE (1) | EE9800125A (pt) |
HU (1) | HUP9901752A3 (pt) |
LV (1) | LV12102B (pt) |
NO (1) | NO981903L (pt) |
NZ (1) | NZ316361A (pt) |
PL (1) | PL326420A1 (pt) |
SK (1) | SK55998A3 (pt) |
WO (1) | WO1997016190A1 (pt) |
Families Citing this family (60)
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AT500193B1 (de) * | 1995-06-07 | 2007-11-15 | Guilford Pharm Inc | Neurotrophe verbindung und verfahren zu ihrer herstellung |
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US6509477B1 (en) | 1998-11-12 | 2003-01-21 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6291510B1 (en) | 1995-06-07 | 2001-09-18 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
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US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
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CA2334204A1 (en) * | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | Heterocyclic ester and amide hair growth compositions and uses |
KR20010071920A (ko) | 1998-07-17 | 2001-07-31 | 개리 이. 프라이드만 | 뉴우런 성장 및 연장을 자극하는 화합물, 조성물 및 방법 |
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-
1996
- 1996-05-13 US US08/645,149 patent/US5801197A/en not_active Expired - Lifetime
- 1996-08-26 SK SK559-98A patent/SK55998A3/sk unknown
- 1996-08-26 EA EA199800329A patent/EA001481B1/ru not_active IP Right Cessation
- 1996-08-26 NZ NZ316361A patent/NZ316361A/xx unknown
- 1996-08-26 EP EP96929014A patent/EP0859614A4/en not_active Withdrawn
- 1996-08-26 PL PL96326420A patent/PL326420A1/xx unknown
- 1996-08-26 KR KR1019980703218A patent/KR19990067257A/ko not_active Application Discontinuation
- 1996-08-26 HU HU9901752A patent/HUP9901752A3/hu unknown
- 1996-08-26 WO PCT/US1996/013624 patent/WO1997016190A1/en not_active Application Discontinuation
- 1996-08-26 BR BRPI9611271-9A patent/BRPI9611271A2/pt unknown
- 1996-08-26 CZ CZ981251A patent/CZ125198A3/cs unknown
- 1996-08-26 CA CA002236328A patent/CA2236328A1/en not_active Abandoned
- 1996-08-26 EE EE9800125A patent/EE9800125A/xx unknown
- 1996-08-26 JP JP9517308A patent/JPH11514643A/ja active Pending
-
1998
- 1998-04-27 NO NO981903A patent/NO981903L/no not_active Application Discontinuation
- 1998-04-28 BG BG102410A patent/BG62596B1/bg unknown
- 1998-06-25 LV LVP-98-85A patent/LV12102B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ316361A (en) | 1999-08-30 |
EA001481B1 (ru) | 2001-04-23 |
LV12102B (en) | 1998-10-20 |
US5801197A (en) | 1998-09-01 |
LV12102A (lv) | 1998-08-20 |
HUP9901752A3 (en) | 2001-04-28 |
CZ125198A3 (cs) | 1998-12-16 |
JPH11514643A (ja) | 1999-12-14 |
EP0859614A1 (en) | 1998-08-26 |
SK55998A3 (en) | 1999-02-11 |
EA199800329A1 (ru) | 1998-12-24 |
BG62596B1 (bg) | 2000-03-31 |
EE9800125A (et) | 1998-10-15 |
WO1997016190A1 (en) | 1997-05-09 |
BG102410A (en) | 1998-12-30 |
AU713302B2 (en) | 1999-11-25 |
MX9803356A (es) | 1998-09-30 |
AU6857396A (en) | 1997-05-22 |
NO981903D0 (no) | 1998-04-27 |
EP0859614A4 (en) | 2000-04-26 |
CA2236328A1 (en) | 1997-05-09 |
HUP9901752A2 (hu) | 1999-10-28 |
KR19990067257A (ko) | 1999-08-16 |
PL326420A1 (en) | 1998-09-14 |
NO981903L (no) | 1998-06-30 |
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