BRPI1007945B8 - formulação farmacêutica de liberação controlada de nitazoxamida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral - Google Patents

formulação farmacêutica de liberação controlada de nitazoxamida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral

Info

Publication number
BRPI1007945B8
BRPI1007945B8 BRPI1007945A BRPI1007945A BRPI1007945B8 BR PI1007945 B8 BRPI1007945 B8 BR PI1007945B8 BR PI1007945 A BRPI1007945 A BR PI1007945A BR PI1007945 A BRPI1007945 A BR PI1007945A BR PI1007945 B8 BRPI1007945 B8 BR PI1007945B8
Authority
BR
Brazil
Prior art keywords
controlled release
nitazoxanide
nitazoxamide
tizoxanide
combination
Prior art date
Application number
BRPI1007945A
Other languages
English (en)
Inventor
Rossignol Jean-François
Ayers Marc
Original Assignee
Romark Laboratories Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Romark Laboratories Lc filed Critical Romark Laboratories Lc
Publication of BRPI1007945A2 publication Critical patent/BRPI1007945A2/pt
Publication of BRPI1007945B1 publication Critical patent/BRPI1007945B1/pt
Publication of BRPI1007945B8 publication Critical patent/BRPI1007945B8/pt
Publication of BRPI1007945C1 publication Critical patent/BRPI1007945C1/pt
Publication of BRPI1007945C8 publication Critical patent/BRPI1007945C8/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/2853Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

composição farmacêutica,com´primido, e, usos de nitazoxanida ou de um seu análogo. são fornecidos formulações de dosagem sólidas de nitazoxanida ou um análogo de nitazoxanida que compreendem uma porção de liberação controlada e uma porção de liberação imediata. a composição farmacêutica está tipicamente na forma de uma dosagem oral sólida de bicamada compreendendo (a) uma primeira camada compreendendo uma primeira quantidade de nitazoxanida ou de seu análogo em uma formulação de liberação controlada, e (b) uma segunda quantidade de nitazoxanida ou de seu análogo em uma formulação de liberação imediata. também é fornecido método de uso das formulações no tratamento de hepatite c.
BRPI1007945A 2009-02-13 2010-02-12 formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral BRPI1007945C8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20228509P 2009-02-13 2009-02-13
US61/202285 2009-02-13
PCT/US2010/024000 WO2010093854A1 (en) 2009-02-13 2010-02-12 Controlled release pharmaceutical formulations of nitazoxanide

Publications (5)

Publication Number Publication Date
BRPI1007945A2 BRPI1007945A2 (pt) 2015-09-01
BRPI1007945B1 BRPI1007945B1 (pt) 2020-08-04
BRPI1007945B8 true BRPI1007945B8 (pt) 2020-08-18
BRPI1007945C1 BRPI1007945C1 (pt) 2020-09-01
BRPI1007945C8 BRPI1007945C8 (pt) 2021-05-25

Family

ID=42560126

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1007945A BRPI1007945C8 (pt) 2009-02-13 2010-02-12 formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral

Country Status (23)

Country Link
US (5) US8524278B2 (pt)
EP (1) EP2395840B1 (pt)
JP (3) JP5726766B2 (pt)
KR (1) KR101697800B1 (pt)
CN (2) CN102395276A (pt)
AU (3) AU2010213678B2 (pt)
BR (1) BRPI1007945C8 (pt)
CA (1) CA2752233C (pt)
CO (1) CO6501159A2 (pt)
CY (1) CY1123162T1 (pt)
DK (1) DK2395840T3 (pt)
EA (1) EA029018B1 (pt)
ES (1) ES2797493T3 (pt)
HR (1) HRP20201055T1 (pt)
HU (1) HUE049501T2 (pt)
IL (1) IL214624A0 (pt)
LT (1) LT2395840T (pt)
MX (1) MX348282B (pt)
PL (1) PL2395840T3 (pt)
PT (1) PT2395840T (pt)
SI (1) SI2395840T1 (pt)
UA (1) UA107564C2 (pt)
WO (1) WO2010093854A1 (pt)

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Also Published As

Publication number Publication date
UA107564C2 (uk) 2015-01-26
US20180085353A1 (en) 2018-03-29
SI2395840T1 (sl) 2020-08-31
JP2015143258A (ja) 2015-08-06
EA201190127A1 (ru) 2012-03-30
AU2016200971A1 (en) 2016-03-03
JP2012518002A (ja) 2012-08-09
US9351937B2 (en) 2016-05-31
BRPI1007945A2 (pt) 2015-09-01
EP2395840A1 (en) 2011-12-21
CO6501159A2 (es) 2012-08-15
EA029018B1 (ru) 2018-01-31
EP2395840A4 (en) 2013-12-25
AU2010213678B2 (en) 2015-11-26
US20160243087A1 (en) 2016-08-25
ES2797493T3 (es) 2020-12-02
BRPI1007945C8 (pt) 2021-05-25
BRPI1007945B1 (pt) 2020-08-04
HRP20201055T1 (hr) 2020-10-30
PL2395840T3 (pl) 2020-09-07
JP6491174B2 (ja) 2019-03-27
JP6117845B2 (ja) 2017-04-19
MX348282B (es) 2017-06-05
AU2017203148B2 (en) 2018-08-09
KR101697800B1 (ko) 2017-01-18
US20140065215A1 (en) 2014-03-06
CY1123162T1 (el) 2021-10-29
AU2010213678A1 (en) 2011-09-01
EP2395840B1 (en) 2020-04-15
JP2017061561A (ja) 2017-03-30
CA2752233C (en) 2017-01-03
CN107260695A (zh) 2017-10-20
WO2010093854A1 (en) 2010-08-19
PT2395840T (pt) 2020-07-06
BRPI1007945C1 (pt) 2020-09-01
US10383855B2 (en) 2019-08-20
AU2017203148A1 (en) 2017-06-01
US8524278B2 (en) 2013-09-03
CA2752233A1 (en) 2010-08-19
MX2011008530A (es) 2011-10-14
LT2395840T (lt) 2020-07-10
US20190321338A1 (en) 2019-10-24
AU2016200971B2 (en) 2017-02-23
KR20120008024A (ko) 2012-01-25
US9827227B2 (en) 2017-11-28
HUE049501T2 (hu) 2020-09-28
US20100209505A1 (en) 2010-08-19
US11426388B2 (en) 2022-08-30
DK2395840T3 (da) 2020-06-08
JP5726766B2 (ja) 2015-06-03
IL214624A0 (en) 2011-09-27
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