BRPI1007350B8 - compostos espiro heterocíclicos bicíclicos - Google Patents
compostos espiro heterocíclicos bicíclicosInfo
- Publication number
- BRPI1007350B8 BRPI1007350B8 BRPI1007350A BRPI1007350A BRPI1007350B8 BR PI1007350 B8 BRPI1007350 B8 BR PI1007350B8 BR PI1007350 A BRPI1007350 A BR PI1007350A BR PI1007350 A BRPI1007350 A BR PI1007350A BR PI1007350 B8 BRPI1007350 B8 BR PI1007350B8
- Authority
- BR
- Brazil
- Prior art keywords
- bicyclic heterocyclic
- spiro compounds
- heterocyclic spiro
- compounds
- diabetes
- Prior art date
Links
- -1 bicyclic heterocyclic spiro compounds Chemical class 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14714309P | 2009-01-26 | 2009-01-26 | |
| US61/147,143 | 2009-01-26 | ||
| PCT/IL2010/000064 WO2010084499A2 (en) | 2009-01-26 | 2010-01-26 | Bicyclic heterocyclic spiro compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1007350A2 BRPI1007350A2 (pt) | 2018-03-06 |
| BRPI1007350B1 BRPI1007350B1 (pt) | 2020-11-17 |
| BRPI1007350B8 true BRPI1007350B8 (pt) | 2021-05-25 |
Family
ID=42291285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1007350A BRPI1007350B8 (pt) | 2009-01-26 | 2010-01-26 | compostos espiro heterocíclicos bicíclicos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8673931B2 (enExample) |
| EP (1) | EP2389383B1 (enExample) |
| JP (2) | JP5874878B2 (enExample) |
| KR (2) | KR101675174B1 (enExample) |
| CN (1) | CN102361876B (enExample) |
| AU (1) | AU2010207486B2 (enExample) |
| BR (1) | BRPI1007350B8 (enExample) |
| CA (1) | CA2750777C (enExample) |
| NZ (1) | NZ594768A (enExample) |
| RU (1) | RU2506266C2 (enExample) |
| WO (1) | WO2010084499A2 (enExample) |
| ZA (1) | ZA201106221B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010084499A2 (en) * | 2009-01-26 | 2010-07-29 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
| JP5909070B2 (ja) * | 2010-10-28 | 2016-04-26 | 国立大学法人 東京大学 | Ｇｓ共役受容体に対する医薬品候補化合物をスクリーニングする方法 |
| EP2882428B1 (en) * | 2012-07-13 | 2019-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
| WO2014113893A1 (en) * | 2013-01-28 | 2014-07-31 | University Of Manitoba | Use of galantamine and related compounds for treatment of inflammatory bowel diseases |
| GB201504675D0 (en) * | 2015-03-19 | 2015-05-06 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| RU2604878C1 (ru) * | 2015-11-17 | 2016-12-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | 7-АМИНО-2,2',4-ТРИОКСО-5'-ФЕНИЛ-1,1',2,2',3,4-ГЕКСАГИДРОСПИРО{ПИРАНО[2,3-d]ПИРИМИДИН-5,3'-ПИРРОЛ}-6-КАРБОНИТРИЛЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| EP3768261A1 (en) | 2018-03-22 | 2021-01-27 | NSC THERAPEUTICS GmbH | Compounds and methods for use in the treatment of microglia-mediated disorders |
| AR120169A1 (es) * | 2019-10-09 | 2022-02-02 | Novartis Ag | Derivados de 2-azaespiro[3.4]octano como agonistas de m4 |
| PE20221453A1 (es) | 2019-10-09 | 2022-09-21 | Novartis Ag | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 |
| JP7654271B2 (ja) * | 2020-05-12 | 2025-04-01 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Ｎｍｄａ受容体の活性を調節する化合物、その医薬組成物及び使用 |
| JP2025525799A (ja) * | 2022-07-29 | 2025-08-07 | アナベックス ライフ サイエンス コーポレイション | 変性疾患によって引き起こされる認知低下の予防のための組成物及び方法 |
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| JP2010155827A (ja) * | 2008-12-04 | 2010-07-15 | Takeda Chem Ind Ltd | スピロ環化合物 |
| WO2010084499A2 (en) * | 2009-01-26 | 2010-07-29 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
-
2010
- 2010-01-26 WO PCT/IL2010/000064 patent/WO2010084499A2/en not_active Ceased
- 2010-01-26 BR BRPI1007350A patent/BRPI1007350B8/pt active IP Right Grant
- 2010-01-26 AU AU2010207486A patent/AU2010207486B2/en active Active
- 2010-01-26 CA CA2750777A patent/CA2750777C/en active Active
- 2010-01-26 JP JP2011547054A patent/JP5874878B2/ja active Active
- 2010-01-26 CN CN201080013672.6A patent/CN102361876B/zh active Active
- 2010-01-26 US US13/146,209 patent/US8673931B2/en active Active
- 2010-01-26 KR KR1020117019687A patent/KR101675174B1/ko active Active
- 2010-01-26 RU RU2011134290/04A patent/RU2506266C2/ru active
- 2010-01-26 NZ NZ594768A patent/NZ594768A/xx unknown
- 2010-01-26 EP EP10708648.0A patent/EP2389383B1/en active Active
- 2010-01-26 KR KR1020157026733A patent/KR20150116466A/ko not_active Ceased
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2506266C2 (ru) | 2014-02-10 |
| KR101675174B1 (ko) | 2016-11-10 |
| WO2010084499A9 (en) | 2010-12-09 |
| JP2012515763A (ja) | 2012-07-12 |
| AU2010207486B2 (en) | 2013-03-07 |
| NZ594768A (en) | 2013-02-22 |
| WO2010084499A3 (en) | 2010-10-21 |
| BRPI1007350B1 (pt) | 2020-11-17 |
| KR20110127160A (ko) | 2011-11-24 |
| WO2010084499A2 (en) | 2010-07-29 |
| JP5874878B2 (ja) | 2016-03-02 |
| AU2010207486A1 (en) | 2011-09-15 |
| RU2011134290A (ru) | 2013-03-10 |
| EP2389383B1 (en) | 2019-04-24 |
| CN102361876A (zh) | 2012-02-22 |
| CA2750777C (en) | 2018-04-03 |
| BRPI1007350A2 (pt) | 2018-03-06 |
| US8673931B2 (en) | 2014-03-18 |
| JP2015172098A (ja) | 2015-10-01 |
| CN102361876B (zh) | 2015-02-04 |
| US20110281903A1 (en) | 2011-11-17 |
| ZA201106221B (en) | 2013-04-24 |
| KR20150116466A (ko) | 2015-10-15 |
| EP2389383A2 (en) | 2011-11-30 |
| CA2750777A1 (en) | 2010-07-29 |
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