BRPI0920577A2 - polipeptídeos transdutível para modificação do metabolismo mitocondrial - Google Patents

polipeptídeos transdutível para modificação do metabolismo mitocondrial

Info

Publication number
BRPI0920577A2
BRPI0920577A2 BRPI0920577A BRPI0920577A BRPI0920577A2 BR PI0920577 A2 BRPI0920577 A2 BR PI0920577A2 BR PI0920577 A BRPI0920577 A BR PI0920577A BR PI0920577 A BRPI0920577 A BR PI0920577A BR PI0920577 A2 BRPI0920577 A2 BR PI0920577A2
Authority
BR
Brazil
Prior art keywords
modification
mitochondrial metabolism
transducible polypeptides
transducible
polypeptides
Prior art date
Application number
BRPI0920577A
Other languages
English (en)
Portuguese (pt)
Inventor
Shararyar Khan
Original Assignee
Gencia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gencia Corp filed Critical Gencia Corp
Publication of BRPI0920577A2 publication Critical patent/BRPI0920577A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0920577A 2008-10-16 2009-10-14 polipeptídeos transdutível para modificação do metabolismo mitocondrial BRPI0920577A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/253,138 US20090123468A1 (en) 2003-10-24 2008-10-16 Transducible polypeptides for modifying metabolism
PCT/US2009/060652 WO2010045335A1 (en) 2008-10-16 2009-10-14 Transducible polypeptides for modifying mitochondrial metabolism

Publications (1)

Publication Number Publication Date
BRPI0920577A2 true BRPI0920577A2 (pt) 2015-12-29

Family

ID=41360255

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0920577A BRPI0920577A2 (pt) 2008-10-16 2009-10-14 polipeptídeos transdutível para modificação do metabolismo mitocondrial

Country Status (11)

Country Link
US (2) US20090123468A1 (OSRAM)
EP (1) EP2352752A1 (OSRAM)
JP (1) JP2012505902A (OSRAM)
KR (1) KR20110080159A (OSRAM)
CN (1) CN102245631A (OSRAM)
AU (1) AU2009303382B2 (OSRAM)
BR (1) BRPI0920577A2 (OSRAM)
CA (1) CA2740801A1 (OSRAM)
MX (1) MX2011004002A (OSRAM)
RU (1) RU2529950C2 (OSRAM)
WO (1) WO2010045335A1 (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8039587B2 (en) * 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8507277B2 (en) * 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8062891B2 (en) * 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
JP5794541B2 (ja) 2010-04-21 2015-10-14 国立大学法人北海道大学 核内移行性を有する脂質膜構造体
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
MX359070B (es) 2010-12-01 2018-09-13 Alderbio Holdings Llc Composiciones anti-ngf y uso de las mismas.
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
WO2013103972A1 (en) 2012-01-06 2013-07-11 Gencia Corporation Treatment of frailty syndrome and symptoms thereof
CN105647938B (zh) * 2012-01-20 2019-04-02 中国农业科学院上海兽医研究所 一种重组载体及其在制备或筛选抗流感药物中的应用
WO2013181633A1 (en) * 2012-05-31 2013-12-05 Volio, Inc. Providing a converstional video experience
WO2013188874A1 (en) 2012-06-15 2013-12-19 Gencia Corporation Methods of mitigating side effects of radiation exposure and chemotherapy
US20150283233A1 (en) * 2012-06-15 2015-10-08 Gencia Corporation Compositions and Methods for Enhancing Immune Responses
CA2906697A1 (en) * 2013-03-15 2014-09-18 Gencia Corporation Compositions and methods for treating conditions that affect epidermis
US9580758B2 (en) 2013-11-12 2017-02-28 Luc Montagnier System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
SI3149025T1 (sl) * 2014-05-21 2019-09-30 Entrada Therapeutics, Inc. V celico prodirajoči peptidi in postopki njihove izdelave in uporabe
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
EP2992892A1 (en) * 2014-09-05 2016-03-09 Universität zu Köln Fusion protein for use in the treatment of mitochondrial diseases
IT201700041980A1 (it) 2017-04-14 2018-10-14 Medical Microinstruments Spa Assieme robotico per microchirurgia
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
US11793884B2 (en) 2018-01-29 2023-10-24 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
CA3092062A1 (en) 2018-02-22 2019-08-29 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
CN108486124B (zh) * 2018-03-26 2020-08-04 浙江大学 嘉兴黑猪tfam基因特征序列及肉质性能鉴定方法
CN108676806B (zh) * 2018-03-26 2020-08-04 浙江大学 嘉兴黑猪tfb2m基因特征序列及肉质性能鉴定方法
CN113801857B (zh) * 2021-11-16 2022-02-15 中国科学院华南植物园 一种酶活提高的NADH脱氢酶突变体SlNOX及其应用

Family Cites Families (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4622302A (en) 1984-08-09 1986-11-11 American National Red Cross Process for inducing membrane fusion under an electric field
US4752473A (en) 1984-10-12 1988-06-21 The Regents Of The University Of California Expression of glycosylated human influenza hemagglutinin proteins
US4873089A (en) 1985-07-12 1989-10-10 Cornell Research Foundation Inc., Cornell University Proteoliposomes as drug carriers
EP0257362A1 (de) 1986-08-27 1988-03-02 Siemens Aktiengesellschaft Addierer
US4803072A (en) 1986-09-10 1989-02-07 Smithkline Beckman Corporation Immunomodulation
US5149782A (en) 1988-08-19 1992-09-22 Tanox Biosystems, Inc. Molecular conjugates containing cell membrane-blending agents
US6306625B1 (en) 1988-12-30 2001-10-23 Smithkline Beecham Biologicals, Sa Method for obtaining expression of mixed polypeptide particles in yeast
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
CA2040896C (en) 1990-04-20 2002-01-29 Edwin F. Ullman Double receptor polynucleotide assay method
US5709879A (en) 1990-06-29 1998-01-20 Chiron Corporation Vaccine compositions containing liposomes
US5985318A (en) 1990-08-24 1999-11-16 Burroughs Wellcome Co. Fusogenic liposomes that are free of active neuraminidase
EP0474247B1 (en) 1990-09-07 1998-12-16 Nec Corporation Shift amount floating-point calculating circuit with a small amount of hardware and rapidly operable
US5756041A (en) 1991-07-11 1998-05-26 Arruda; William C. Method and apparatus for processing blown tube films
NZ244306A (en) 1991-09-30 1995-07-26 Boehringer Ingelheim Int Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
US5981273A (en) 1991-09-30 1999-11-09 Boehringer Ingelheim Int'l. Gmbh Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells
US5780444A (en) 1991-12-13 1998-07-14 Trustees Of Princeton University Compositions and methods for cell transformation
US5422277A (en) 1992-03-27 1995-06-06 Ortho Diagnostic Systems Inc. Cell fixative composition and method of staining cells without destroying the cell surface
US6113946A (en) 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
US6080791A (en) 1992-07-24 2000-06-27 Seres Laboratories, Inc. Method of treating a viral condition by inhibiting membrane fusion
US6337070B1 (en) 1993-04-29 2002-01-08 Takara Shuzo Co., Ltd. Polypeptides for use in generating anti-human influenza virus antibodies
EP0670905B1 (en) 1992-09-22 2003-07-23 Biofocus Discovery Limited Recombinant viruses displaying a nonviral polypeptide on their external surface
US5552155A (en) 1992-12-04 1996-09-03 The Liposome Company, Inc. Fusogenic lipsomes and methods for making and using same
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5789156A (en) 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5912411A (en) 1993-06-14 1999-06-15 University Of Heidelberg Mice transgenic for a tetracycline-inducible transcriptional activator
US6004941A (en) 1993-06-14 1999-12-21 Basf Aktiengesellschaft Methods for regulating gene expression
US5866755A (en) 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
US5859310A (en) 1993-06-14 1999-01-12 Basf Aktiengesellschaft Mice transgenic for a tetracycline-controlled transcriptional activator
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5589362A (en) 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
WO1994029442A2 (en) 1993-06-14 1994-12-22 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US20030022315A1 (en) 1993-06-14 2003-01-30 Basf Aktiengesellschaft And Knoll Aktiengesellschaft Tetracycline-inducible transcriptional inhibitor fusion proteins
US5888981A (en) 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
US5654168A (en) 1994-07-01 1997-08-05 Basf Aktiengesellschaft Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
GB9317380D0 (en) 1993-08-20 1993-10-06 Therexsys Ltd Transfection process
DE4335025A1 (de) 1993-10-14 1995-04-20 Boehringer Ingelheim Int Endosomolytisch wirksame Partikel
AU2589095A (en) 1994-05-16 1995-12-05 Washington University Cell membrane fusion composition and method
US5728399A (en) 1994-06-29 1998-03-17 University Of Conn. Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
US5837533A (en) 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5799515A (en) 1995-02-17 1998-09-01 Floyd; Herbert R. Auto column pivot lock
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US5733540A (en) 1995-03-08 1998-03-31 Lee; Peter Poon-Hang Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria
US5723319A (en) 1995-06-05 1998-03-03 Avid Therapeutics, Inc. Cultured cell line that inducibly expresses the hepatitis B virus genome, and uses thereof for screening antiviral substances
US5851796A (en) 1995-06-07 1998-12-22 Yale University Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
US6017734A (en) * 1995-07-07 2000-01-25 The Texas A & M University System Unique nucleotide and amino acid sequence and uses thereof
GB9515356D0 (en) 1995-07-26 1995-09-20 Medical Res Council Improvements in or relating to delivery of nucleic acid
WO1997007226A1 (en) 1995-08-17 1997-02-27 Introgene B.V. Poly(organo)phosphazenes for use in synthetic transfection systems
DE69634697T2 (de) 1995-10-25 2006-05-04 Octoplus B.V. Kationische polyacrylate und poly(alkyl)acrylate oder die entsprechende acrylamide zur verwendung in synthetischen transfektions-systemen
US5804445A (en) * 1996-01-11 1998-09-08 Board Of Regents, The University Of Texas System High affinity mutants of nuclear factor-interleukin 6 and methods of use therefor
RU2201961C2 (ru) 1996-01-29 2003-04-10 Кие-Хиунг ПАЙК Способ получения белка с использованием трансляционной системы митохондрий
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
RU2066552C1 (ru) 1996-02-12 1996-09-20 Товарищество с ограниченной ответственностью "Био Прогресс" Композиция для фотодинамического повреждения клеток-мишеней и способ фотодинамического повреждения клеток-мишеней
DE19605279A1 (de) 1996-02-13 1997-08-14 Hoechst Ag Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung
US5770414A (en) 1996-02-20 1998-06-23 The Regents Of The University Of California Regulatable retrovirus system for genetic modification of cells
CA2253561A1 (en) 1996-05-08 1997-11-13 Nika Health Products Limited Cationic virosomes as transfer system for genetic material
US6004808A (en) 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
US5948681A (en) 1996-08-14 1999-09-07 Children's Hospital Of Philadelphia Non-viral vehicles for use in gene transfer
US6025192A (en) 1996-09-20 2000-02-15 Cold Spring Harbor Laboratory Modified retroviral vectors
US6255071B1 (en) 1996-09-20 2001-07-03 Cold Spring Harbor Laboratory Mammalian viral vectors and their uses
US5854016A (en) 1996-09-27 1998-12-29 Icos Corporation Creba Isoform
AU725257B2 (en) 1996-10-15 2000-10-12 Transave, Inc. N-acyl phosphatidylethanolamine-mediated liposomal drug delivery
US20020155095A1 (en) * 1996-10-18 2002-10-24 Tattanahalli L. Nagabhushan Methods and compositions for delivery and expression of interferon-a nucleic acids
GB9623051D0 (en) 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
FR2759382A1 (fr) 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
DE19716732C2 (de) 1997-03-07 1999-03-25 Max Delbrueck Centrum Spezifische Magnetosomen, Verfahren zu ihrer Herstellung und ihre Verwendung
US5831020A (en) * 1997-03-25 1998-11-03 The Research Foundation Of State University Of New York Protein-mediated nuclear import of DNA
US6368821B1 (en) 1997-04-14 2002-04-09 Stratagene Process for infecting eukaryotic cells with a bacterial virus
US6099847A (en) 1997-05-15 2000-08-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric Gag pseudovirions
GB9711115D0 (en) 1997-05-29 1997-07-23 Inst Of Child Health Integrin-targeting vectors having enhanced transfection activity
US6127159A (en) * 1997-06-06 2000-10-03 The Board Of Trustees Of The Leland Stanford Junior University Mitofusin genes and their uses
US7811803B2 (en) 1997-06-19 2010-10-12 University Of Medicine And Dentistry Of New Jersey Methods and compositions for rapid purification of proteasomes and methods of use of components thereof
CA2295322C (en) 1997-06-19 2009-05-26 University Of Medicine And Dentistry Of New Jersey Methods and compositions for rapid purification of proteasomes and methods of use of components thereof
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
US6087166A (en) 1997-07-03 2000-07-11 Basf Aktiengesellschaft Transcriptional activators with graded transactivation potential
FR2766195A1 (fr) 1997-07-21 1999-01-22 Transgene Sa Polymeres cationiques, complexes associant lesdits polymeres cationiques et des substances therapeutiquement actives comprenant au moins une charges negative, notamment des acides nucleiques, et leur utilisation en therapie genique
US6207648B1 (en) 1997-07-24 2001-03-27 Trustees Of Boston University Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
US6054312A (en) 1997-08-29 2000-04-25 Selective Genetics, Inc. Receptor-mediated gene delivery using bacteriophage vectors
AU9399498A (en) 1997-09-18 1999-04-05 Trustees Of The University Of Pennsylvania, The Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery
GB9720148D0 (en) * 1997-09-22 1997-11-26 Innes John Centre Innov Ltd Gene silencing materials and methods
US6734171B1 (en) 1997-10-10 2004-05-11 Inex Pharmaceuticals Corp. Methods for encapsulating nucleic acids in lipid bilayers
US6136536A (en) 1997-10-29 2000-10-24 Genetics Institute, Inc. Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US5968773A (en) 1997-11-14 1999-10-19 Heddle; John A. System and method for regulation of gene expression
IT1297090B1 (it) 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
EP1037911A4 (en) * 1997-12-10 2003-07-23 Univ Washington ANTI-PATHOGEN SYSTEM AND METHOD FOR USE THEREOF
ZA9811377B (en) 1997-12-12 1999-08-27 Expression Genetics Inc Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake.
US6410057B1 (en) 1997-12-12 2002-06-25 Samyang Corporation Biodegradable mixed polymeric micelles for drug delivery
WO1999029303A1 (en) 1997-12-12 1999-06-17 Samyang Corporation Biodegradable mixed polymeric micelles for gene delivery
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6372720B1 (en) 1998-02-05 2002-04-16 Kenneth J. Longmuir Liposome fusion and delivery vehicle
WO1999042091A2 (en) 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
US6737506B1 (en) 1998-02-25 2004-05-18 Paul Anziano Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms
CZ121599A3 (cs) 1998-04-09 1999-10-13 Aventis Pharma Deutschland Gmbh Jednořetězcová molekula vázající několik antigenů, způsob její přípravy a léčivo obsahující tuto molekulu
US6986902B1 (en) 1998-04-28 2006-01-17 Inex Pharmaceuticals Corporation Polyanionic polymers which enhance fusogenicity
ATE491780T1 (de) 1998-06-10 2011-01-15 Univ South Florida Elektrofusions-kammer
US6143564A (en) 1998-07-07 2000-11-07 University Of Hawaii Use of the polar body chromosomes for the production of embryos and normal offspring
US6759236B1 (en) 1998-08-18 2004-07-06 Research Development Foundation Methods to enhance and confine expression of genes
US20040071736A1 (en) 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
AU5779499A (en) 1998-08-28 2000-03-21 Pioneer Hi-Bred International, Inc. Organelle targeting sequences
WO2000023568A2 (en) 1998-10-06 2000-04-27 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for decreasing mitochondrial overproduction of reactive oxygen species in cells
US6759574B1 (en) * 1998-11-05 2004-07-06 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Plants having enhanced gall resistance and methods and compositions for producing same
US20050037335A1 (en) 1998-11-07 2005-02-17 Wolfgang Hillen Method for identifying novel transcriptional regulatory proteins
DE19856052A1 (de) 1998-12-04 2000-06-08 Deutsches Krebsforsch Konjugat zur Anreicherung in neuronalen Zellen
CA2354195C (en) 1998-12-22 2012-07-17 Dow Agrosciences Llc Methods and genetic compositions to limit outcrossing and undesired gene flow in crop plants
US6903077B1 (en) * 1999-01-04 2005-06-07 University Of Vermont And State Agricultural College Methods and products for delivering nucleic acids
DE19900743A1 (de) 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
US6323391B1 (en) 1999-01-25 2001-11-27 Trustees Of The University Of Pennsylvania Methods and transgenic mouse model for identifying and modulating factors leading to motor neuron degeneration
AU775001B2 (en) 1999-03-31 2004-07-15 Invitrogen Corporation Delivery of functional protein sequences by translocating polypeptides
US6849272B1 (en) 1999-04-21 2005-02-01 Massachusetts Institute Of Technology Endosomolytic agents and cell delivery systems
ATE368122T1 (de) 1999-04-29 2007-08-15 Cell Genesys Inc Verfahren und mittel für die herstellung von sicheren rekombinanten lentiviralen vektoren mit hohem titer
US7582301B1 (en) 1999-05-17 2009-09-01 Conjuchem Biotechnologies, Inc. Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides
JP4106402B2 (ja) 1999-05-21 2008-06-25 フジコピアン株式会社 熱転写画像形成方法およびそれに用いる熱転写材の組み合わせ
US7319086B1 (en) 1999-05-28 2008-01-15 University Of Sydney Method of prophylaxis and treatment and agents useful for same
DE60043889D1 (en) 1999-06-07 2010-04-08 Tet Systems Holding Gmbh & Co Tet repressor basierte transkriptionale regulatorische proteine
CA2272788A1 (en) 1999-06-11 2000-12-11 Garching Innovation Gmbh Means and methods for transformation of plant mitochondria
US6770632B1 (en) 1999-07-16 2004-08-03 The General Hospital Corporation Folypolyglutamyl synthetase gene transfer to enhance antifolate
US6632800B1 (en) 1999-08-17 2003-10-14 Mayo Foundation For Medical Education And Research System for monitoring the expression of transgenes
US6586411B1 (en) 2000-08-16 2003-07-01 Mayo Foundation For Medical Education And Research System for monitoring the location of transgenes
US6780639B1 (en) 1999-08-24 2004-08-24 Universite Libre De Bruxelles Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization
EP2267009B1 (en) 1999-08-25 2014-10-29 Allergan, Inc. Activatable recombinant neurotoxins
US20030104622A1 (en) 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
WO2001017511A1 (en) 1999-09-03 2001-03-15 Chugai Seiyaku Kabushiki Kaisha Method of intracellular sustained-release of drug and preparations
US6633933B1 (en) 1999-09-30 2003-10-14 Oak Technology, Inc. Controller for ATAPI mode operation and ATAPI driven universal serial bus mode operation and methods for making the same
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
US20040072739A1 (en) * 1999-11-10 2004-04-15 Anderson Christen M. Compositions and methods for regulating endogenous inhibitor of ATP synthase, including treatment for diabetes
US6867036B1 (en) 1999-11-23 2005-03-15 Mayo Foundation For Medical Education And Research Gene expression by positive feedback activation of a cell type-specific promoter
US7060291B1 (en) 1999-11-24 2006-06-13 Transave, Inc. Modular targeted liposomal delivery system
DE10003241A1 (de) 2000-01-26 2001-08-02 Werner Lubitz Verschließen von Bakterienghosts
US6872406B2 (en) 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
KR20030000029A (ko) 2000-02-21 2003-01-03 후지사와 야꾸힝 고교 가부시키가이샤 매트릭스 메탈로프로테이나제 저해제로서 티아제피닐하이드록삼산 유도체
DE60140676D1 (de) * 2000-03-30 2010-01-14 Massachusetts Inst Technology Mediatoren von rns-interferenz, die rns-sequenzspezifisch sind
ATE353361T1 (de) * 2000-04-28 2007-02-15 Sangamo Biosciences Inc Gezielten modifikation der chromatinstruktur
US20020151028A1 (en) 2000-05-18 2002-10-17 Cornell Research Foundation, Inc. Structure-based drug design for Ulp1 protease substrates
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6544780B1 (en) 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
AU2001268683A1 (en) 2000-06-22 2002-01-02 Mount Sinai School Of Medicine Modification of mdm2 activity
GB0027328D0 (en) * 2000-06-23 2000-12-27 Aventis Pharma Inc Bioengineered vehicles for targeted nucleic acid delivery
CA2416664A1 (en) * 2000-07-21 2002-01-31 Syngenta Participations Ag Zinc finger domain recognition code and uses thereof
US6696038B1 (en) 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
WO2002038759A2 (en) * 2000-11-10 2002-05-16 Mitotech Ab Method for inducing apoptiosis
GB0027905D0 (en) 2000-11-15 2000-12-27 Glaxo Group Ltd New protein
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
US6771623B2 (en) 2000-12-01 2004-08-03 Telefonaktiebolaget Lm Ericsson (Publ) Method for ensuring reliable mobile IP service
EP1427837B1 (de) 2001-01-10 2011-10-26 Lonza Cologne GmbH Modulare transfektionssysteme auf der basis von nukleoproteinfilamenten
US6897196B1 (en) 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
GB0106315D0 (en) 2001-03-14 2001-05-02 Ich Productions Ltd Transfection complexes
JP2002368577A (ja) 2001-04-06 2002-12-20 Murata Mfg Co Ltd 二重モードフィルタ
WO2002090495A2 (en) 2001-05-04 2002-11-14 Cornell Research Foundation, Inc. Rapidly cleavable sumo fusion protein expression system for difficult to express proteins
EP1390399B1 (en) 2001-05-31 2005-05-11 Conjuchem, Inc. Long lasting fusion peptide inhibitors for hiv infection
US7314971B2 (en) * 2001-07-12 2008-01-01 Basf Plant Science Gmbh Nuclear fertility restorer genes and methods of use in plants
KR100495138B1 (ko) 2001-07-31 2005-06-14 학교법인 한림대학교 식물세포 투과 도메인-화물분자 복합체
DE10143205A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Verfahren zur Proteinproduktion in Pflanzen
EP1434878A4 (en) 2001-09-17 2007-03-14 Yeda Res & Dev FOR HIGHLY EFFICIENT ADMINISTRATION OF POLYNUCLEOTIDES IN DNA-CONTAINING ORGANIC SKINNY NUCLEIC ACID CONSTRUCTS AND METHOD OF UTILIZING THEM
CN1612753A (zh) 2001-11-14 2005-05-04 诺瓦瓦克斯有限公司 分枝杆菌疫苗
US7750134B2 (en) 2001-11-20 2010-07-06 Sanford-Burnham Medical Research Institute Nucleic acids encoding microbial SUMO protease homologs
US7018819B2 (en) 2001-11-30 2006-03-28 Cellectricon Ab Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof
EP1463836B1 (en) 2001-12-13 2009-09-16 University Of Virginia Patent Foundation Vector mediated organelle transfection
US20030186281A1 (en) 2001-12-21 2003-10-02 Wolfgang Hillen Modified tetracycline repressor protein compositions and methods of use
US7220576B2 (en) 2002-01-07 2007-05-22 Lifesensors, Inc. Methods and compositions for protein expression and purification
DE60318014T2 (de) 2002-01-07 2008-11-27 Lifesensors, Inc. Verfahren und zusammensetzungen für die proteinexpression und reinigung
AU2003210422A1 (en) 2002-03-09 2003-09-22 Artemis Pharmaceuticals Gmbh Recombinase fusion protein with enhanced cellular uptake
US7919075B1 (en) 2002-03-20 2011-04-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
EP1495045B1 (en) * 2002-03-29 2009-09-02 Creagene, Inc. Cytoplasmic transduction peptides and uses thereof
US20070015271A1 (en) * 2002-04-04 2007-01-18 Rosen Craig A Human secreted proteins
US20040101874A1 (en) * 2002-04-12 2004-05-27 Mitokor Inc. Targets for therapeutic intervention identified in the mitochondrial proteome
WO2003087162A2 (en) 2002-04-18 2003-10-23 Mtm Laboratories Ag Neopeptides and methods useful for detection and treatment of cancer
WO2003089457A2 (en) * 2002-04-22 2003-10-30 The Board Of Trustees Of The Leland Stanford Junior University Peptide inhibitors of protein kinase c ϝ for pain management
US7402427B2 (en) 2002-04-30 2008-07-22 Dnavec Research Inc. Vectors with modified protease-dependent tropism
US6835810B2 (en) * 2002-05-13 2004-12-28 Geneshuttle Biopharma, Inc. Fusion protein for use as vector
US7056529B2 (en) 2002-05-14 2006-06-06 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
US7273620B1 (en) 2002-05-20 2007-09-25 University Of British Columbia Triggered release of liposomal drugs following mixing of cationic and anionic liposomes
DK1531666T3 (da) 2002-05-29 2014-01-13 Regeneron Pharma Inducerbart eukaryot-ekspressionssystem
US7553667B2 (en) 2002-06-06 2009-06-30 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Regulation of gene expression using chromatin remodelling factors
US7105347B2 (en) 2002-07-30 2006-09-12 Corning Incorporated Method and device for protein delivery into cells
US7371922B2 (en) 2002-07-31 2008-05-13 The Board Of Trustees Of The University Of Illinois Nuclear transfer with porcine embryonic stem cells
US6850133B2 (en) 2002-08-14 2005-02-01 Intel Corporation Electrode configuration in a MEMS switch
DE10238046A1 (de) 2002-08-20 2004-03-04 Giesing, Michael, Prof. Dr.med. Verfahren zum Untersuchen von Körperflüssigkeiten auf Krebszellen, dessen Verwendung, entsprechende Analysekits und Verwendung bestimmter Wirkstoffe zur Behandlung von Krebs
US7666668B2 (en) 2002-08-28 2010-02-23 Tet Systems Holding Gmbh & Co. Kg Chromosomal loci for the stringent control of gene activities via transcription activation systems
US7042608B2 (en) 2002-09-18 2006-05-09 Pentax Corporation Scanning optical system
US7376128B2 (en) 2002-10-25 2008-05-20 Utstarcom (China) Co., Ltd. Method and system for voice handling via dynamic home agents in a network employing all-IP architecture
WO2004083902A2 (en) 2002-10-25 2004-09-30 Georgia Tech Research Corporation Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
KR100472938B1 (ko) 2002-10-31 2005-03-11 학교법인 한림대학교 세포침투 효율을 향상시킨 수송도메인-목표단백질-수송도메인 융합단백질 및 그 용도
CN100488491C (zh) 2002-11-21 2009-05-20 派维翁生物技术有限公司 高效融合小泡,其制备方法和含有该小泡的药物组合物
US7579515B2 (en) 2002-12-24 2009-08-25 North Carolina State University Increasing gamete production with a gene switch
EP1579221A2 (de) 2003-01-03 2005-09-28 Alcedo Biotech GmbH Verwendungen von hmgb, hmgn, hmga proteinen
JP2006517790A (ja) * 2003-01-09 2006-08-03 インヴィトロジェン コーポレーション ポリペプチド−核酸複合体の細胞の送達および活性化
WO2004067710A2 (en) 2003-01-21 2004-08-12 Salk Institute For Biological Studies Compositions and methods for tissue specific targeting of lentivirus vectors
US7402409B2 (en) 2003-01-23 2008-07-22 Epitomics, Inc. Cell fusion method
US6878374B2 (en) 2003-02-25 2005-04-12 Nitto Denko Corporation Biodegradable polyacetals
US7560264B2 (en) 2003-03-14 2009-07-14 Brookhaven Science Associates, Llc High density growth of T7 expression strains with auto-induction option
US8399217B2 (en) 2003-03-14 2013-03-19 Brookhaven Science Associates, Llc High density growth of T7 expression strains with auto-induction option
EP1623015A4 (en) 2003-05-15 2007-10-10 Univ Oklahoma State HA1 OF THE EQUINE-2 INFLUENZAVIRUS EXPRESSIVE DNA VACCINE
GB0313132D0 (en) 2003-06-06 2003-07-09 Ich Productions Ltd Peptide ligands
WO2005003766A2 (en) 2003-06-13 2005-01-13 Whitehead Institute For Biomedical Research Methods of regulating metabolism and mitochondrial function
AU2004316996A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
EP1644496A4 (en) * 2003-06-25 2006-10-04 Gencia Corp MODIFIED VECTORS FOR ORGANIC TRANSFECTION
CA2530530A1 (en) 2003-06-26 2005-01-13 Lifesensors, Inc. Methods and compositions for enhanced protein expression and purification
WO2005003315A2 (en) * 2003-07-01 2005-01-13 Allele Biotechnology & Pharmaceuticals, Inc. Compositions and methods for peptide-assisted transfection
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
US7048925B2 (en) 2003-08-28 2006-05-23 Nitto Denko Corporation Acid-sensitive polyacetals and methods
JP2005108515A (ja) 2003-09-29 2005-04-21 Sanyo Electric Co Ltd 非水電解質電池
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
WO2005042560A2 (en) * 2003-10-24 2005-05-12 Wake Forest University Health Sciences Non-viral delivery of compounds to mitochondria
US8062891B2 (en) * 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8133733B2 (en) * 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8507277B2 (en) * 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US20090123468A1 (en) * 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8039587B2 (en) * 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
CA2554735A1 (en) 2004-01-30 2005-08-11 Peplin Biolipids Pty Ltd Therapeutic and carrier molecules
NZ549776A (en) 2004-03-17 2009-07-31 Crucell Holland Bv Assay for the separation and quantification of hemagglutinin antigens
RU2262945C1 (ru) * 2004-04-29 2005-10-27 Закрытое акционерное общество "Научно-производственное предприятие "Тринита" Способ снижения массы тела в эксперименте на животных
JP4485523B2 (ja) 2004-05-11 2010-06-23 医療法人社団珠光会 腫瘍ワクチンなどへの養子免疫細胞
CA2570959C (en) 2004-06-21 2014-09-30 Progenra Inc. Diagnostic and screening methods and kits associated with proteolytic activity
EP1634955B1 (en) 2004-09-14 2007-11-14 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Conditional gene vectors regulated in cis
DE602005025676D1 (de) 2004-10-18 2011-02-10 Nitto Denko Corp Intrazelluläre peptidabgabe
US7829104B2 (en) 2004-12-01 2010-11-09 Aeras Global Tb Vaccine Foundation Electroporation of Mycobacterium and overexpression of antigens in mycobacteria
FR2878846B1 (fr) 2004-12-07 2007-02-23 Enscr Composes analogues de lipides membranaires d'archaebacteries et compositions liposomiales integrant de tel composes
US7964571B2 (en) 2004-12-09 2011-06-21 Egen, Inc. Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
EP1836214A4 (en) 2004-12-30 2009-01-21 Lifesensors Inc COMPOSITIONS, METHODS, AND KITS FOR IMPROVING PROTEIN EXPRESSION, SOLUBILITY, AND ISOLATION
US7741431B2 (en) 2005-02-01 2010-06-22 The United States Of America As Represented By The Secretary Of The Army Liposomes containing novel targeting and/or fusogenic peptides, preparations containing them and therapeutic use thereof
CA2598884A1 (en) 2005-02-24 2006-10-05 University Of Massachusetts Influenza nucleic acids, polypeptides, and uses thereof
ES2327269T3 (es) 2005-03-15 2009-10-27 4Sc Ag N-sulfonilpirroles y su utilizacion como inhibidores de la histona desacetilasa.
JP2008535486A (ja) 2005-03-15 2008-09-04 アラーガン、インコーポレイテッド クロストリジウム毒素標的細胞に対する改変された標的能力を有する修飾クロストリジウム毒素
US7881468B2 (en) 2005-04-08 2011-02-01 Telefonaktiebolaget L M Ericsson (Publ) Secret authentication key setup in mobile IPv6
US8114581B2 (en) 2005-09-15 2012-02-14 The Regents Of The University Of California Methods and compositions for detecting neoplastic cells
US8383364B2 (en) 2005-11-17 2013-02-26 Tet Systems Gmbh & Co. Kg Inducible expression systems
ES2325644B1 (es) 2005-12-30 2010-06-28 Universidad Del Pais Vasco (Upv/Ehu) Hexapeptidos no proteolizables inhibidores de la glicoproteina 41 del virus del sida.
JP2009532017A (ja) 2006-02-10 2009-09-10 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア ＰＴＤ／ＣＰＰＳへのｄｓＲＮＡ結合ドメイン融合体によるｓｉＲＮＡの導入可能な送達
US7807363B2 (en) 2006-02-28 2010-10-05 Alcon Research, Ltd. Superoxide dismutase-2 expression for glaucoma diagnosis
US7795380B2 (en) 2006-06-02 2010-09-14 University Of Iowa Research Foundation Compositions and methods for nucleic acid delivery
US7993656B2 (en) 2006-07-11 2011-08-09 Allergan, Inc. Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells
CA2670014A1 (en) 2006-11-22 2008-11-20 Emory University Production of anti-microbial peptides
US7989185B2 (en) 2006-11-29 2011-08-02 The Board Of Trustees Of The Leland Stanford Junior University Rapid, informative diagnostic assay for influenza viruses including H5N1
JPWO2008072781A1 (ja) 2006-12-12 2010-04-02 国立大学法人九州大学 哺乳動物における記憶障害の抑制又は治療方法
TWI328040B (en) 2007-05-04 2010-08-01 Stresspro Biomedicine Inc Expression system of recombinant proteins with enhanced yield and immunogenecity
US7973019B1 (en) 2007-10-03 2011-07-05 Alcon Research, Ltd. Transferrin/transferrin receptor-mediated siRNA delivery
TW200932274A (en) 2007-12-18 2009-08-01 Alcon Res Ltd Interfering RNA delivery system and uses thereof
EP2100961A1 (en) 2008-03-04 2009-09-16 Icon Genetics GmbH Method of protease production in plants
US8103278B2 (en) 2008-04-01 2012-01-24 Mediatek Inc. Method and system for managing idle mode of a mobile node with multiple interfaces
US20090280531A1 (en) 2008-05-06 2009-11-12 Academia Sinica Preparation of Soluble Capsid Proteins of Picornaviruses Using SUMO Fusion Technology
TW200951219A (en) 2008-05-06 2009-12-16 Academia Sinica An improved SUMO fusion protein system for effective production of native proteins
CN101307316B (zh) 2008-07-22 2011-03-16 北京中农颖泰生物技术有限公司 抗菌肽cad在枯草杆菌中的分泌表达及重组枯草杆菌表达系统
US8440449B2 (en) 2008-09-30 2013-05-14 The United States Of America, As Represented By The Secretary Of Agriculture Transformed Saccharomyces cerevisiae engineered for xylose utilization
AU2009299987A1 (en) 2008-10-01 2010-04-08 Tet Systems Gmbh & Co. Kg Tetracycline inducible transcription control sequence
US8007786B2 (en) 2009-10-20 2011-08-30 Asi Agenzia Spaziale Italiana Radioprotective SOD soluble isoform and uses thereof
EP2510107A4 (en) 2009-12-07 2013-08-07 Synaptic Res Llc METHOD FOR IDENTIFYING INHIBITORS OF PROTEASE ACTIVITY AND ASSAYING THE PRESENCE OF PROTEASE ACTIVITY
JP5331756B2 (ja) 2010-06-29 2013-10-30 ダンロップスポーツ株式会社 ゴルフボール

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