BRPI0916333A2 - piridinas substituídas por piperazin-1-il-trifluorometila como antagonistas do receptor de dopamina 2 de rápida dissociação - Google Patents
piridinas substituídas por piperazin-1-il-trifluorometila como antagonistas do receptor de dopamina 2 de rápida dissociaçãoInfo
- Publication number
- BRPI0916333A2 BRPI0916333A2 BRPI0916333A BRPI0916333A BRPI0916333A2 BR PI0916333 A2 BRPI0916333 A2 BR PI0916333A2 BR PI0916333 A BRPI0916333 A BR PI0916333A BR PI0916333 A BRPI0916333 A BR PI0916333A BR PI0916333 A2 BRPI0916333 A2 BR PI0916333A2
- Authority
- BR
- Brazil
- Prior art keywords
- piperazin
- trifluoromethyl
- receptor antagonists
- substituted pyridines
- dissociating dopamine
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 229960003638 dopamine Drugs 0.000 title 1
- -1 piperazin-1-yl-trifluoromethyl-substituted pyridines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08161576 | 2008-07-31 | ||
PCT/EP2009/059788 WO2010012758A1 (en) | 2008-07-31 | 2009-07-29 | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0916333A2 true BRPI0916333A2 (pt) | 2016-02-16 |
Family
ID=39817023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0916333A BRPI0916333A2 (pt) | 2008-07-31 | 2009-07-29 | piridinas substituídas por piperazin-1-il-trifluorometila como antagonistas do receptor de dopamina 2 de rápida dissociação |
Country Status (17)
Country | Link |
---|---|
US (1) | US8895562B2 (pt) |
EP (1) | EP2307374B1 (pt) |
JP (1) | JP5457450B2 (pt) |
KR (1) | KR101609218B1 (pt) |
CN (1) | CN102171189B (pt) |
AU (1) | AU2009275887B2 (pt) |
BR (1) | BRPI0916333A2 (pt) |
CA (1) | CA2730774C (pt) |
DK (1) | DK2307374T3 (pt) |
EA (1) | EA019048B1 (pt) |
ES (1) | ES2622161T3 (pt) |
HK (1) | HK1159083A1 (pt) |
HR (1) | HRP20170570T1 (pt) |
HU (1) | HUE033768T2 (pt) |
LT (1) | LT2307374T (pt) |
SI (1) | SI2307374T1 (pt) |
WO (1) | WO2010012758A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
MX2009011415A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. |
RU2480462C2 (ru) * | 2007-04-23 | 2013-04-27 | Янссен Фармацевтика Н.В. | Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2 |
JP5431306B2 (ja) | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのチア(ジア)ゾール |
RU2502734C2 (ru) | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
JP5457450B2 (ja) | 2008-07-31 | 2014-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 迅速解離性ドーパミン2受容体拮抗薬としてのピペラジン−1−イル−トリフルオロメチル−置換−ピリジン |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933823A (en) * | 1971-03-29 | 1976-01-20 | E. R. Squibb & Sons, Inc. | Isoxazolopyridine ketone derivatives |
DE2341965C3 (de) * | 1973-08-20 | 1979-01-25 | C.H. Boehringer Sohn, 6507 Ingelheim | 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen |
US4197304A (en) * | 1975-09-23 | 1980-04-08 | Janssen Pharmaceutica N.V. | N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides |
NO147672C (no) | 1975-09-23 | 1983-05-25 | Janssen Pharmaceutica Nv | Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider |
EG12406A (en) * | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
DE3218482A1 (de) * | 1982-05-15 | 1983-11-17 | Bayer Ag, 5090 Leverkusen | Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
ES8802151A1 (es) | 1985-07-31 | 1988-04-01 | Janssen Pharmaceutica Nv | Un procedimiento para la preparacion de nuevos piridazinaminas. |
MX173362B (es) | 1987-03-02 | 1994-02-23 | Pfizer | Compuestos de piperazinil heterociclicos y procedimiento para su preparacion |
PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
GB9216298D0 (en) | 1991-08-15 | 1992-09-16 | Ici Plc | Piperidine derivatives |
CN1046507C (zh) | 1993-12-28 | 1999-11-17 | 法玛西雅厄普约翰美国公司 | 用于治疗中枢神经系统和心血管疾病的杂环化合物 |
DE4425145A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung von Thiazol- und Thiadiazolverbindungen |
TW406075B (en) * | 1994-12-13 | 2000-09-21 | Upjohn Co | Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds |
US5560931A (en) * | 1995-02-14 | 1996-10-01 | Nawosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5753679A (en) | 1995-05-10 | 1998-05-19 | Hoffmann-La Roche Inc. | Benzyl-piperidine derivatives |
MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
BR9811557A (pt) | 1997-08-15 | 2000-08-22 | Pfizer Prod Inc | Derivados do 2-)4-aril ou heteroaril-piperazin-1-ilmetil)-1h-indol |
KR100261139B1 (ko) | 1998-01-16 | 2000-08-01 | 황준수 | 신규한 알릴티오피리다진 유도체 및 그의 제조방법 |
AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
IL157254A0 (en) | 2001-02-23 | 2004-02-19 | Merck & Co Inc | N-substituted nonaryl-heterocyclic nmda/mr2b antagonists |
KR100938369B1 (ko) | 2001-10-09 | 2010-01-22 | 교린 세이야꾸 가부시키 가이샤 | 신규 4-(2-푸로일)아미노피페리딘, 그의 합성 중간체,그의 제조방법 및 의약으로서의 그의 용도 |
GB0127832D0 (en) | 2001-11-20 | 2002-01-09 | Jagotec Ag | Method for the preparation of pharmaceutical nanosuspensions |
AU2002360561A1 (en) | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
EP1467981A1 (en) | 2002-01-25 | 2004-10-20 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
EP1474401A2 (en) | 2002-02-05 | 2004-11-10 | Novo Nordisk A/S | Novel aryl- and heteroarylpiperazines |
EP1476428B1 (en) | 2002-02-22 | 2010-11-17 | Pharmacia & Upjohn Company LLC | Pyridyl sulfone derivatives as 5-ht6 receptor ligands |
SE0201544D0 (sv) * | 2002-05-17 | 2002-05-17 | Biovitrum Ab | Novel compounds and thier use |
US7754774B2 (en) * | 2002-09-26 | 2010-07-13 | Mandom Corporation | Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides |
ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
CA2524589A1 (en) | 2003-05-07 | 2004-11-18 | Ifac Gmbh & Co. Kg | Compositions for the targetted release of fragrances and aromas |
MXPA05012007A (es) | 2003-05-08 | 2006-05-31 | Kyorin Seiyaku Kk | Compuesto de 4- (2-furoil) aminopiperidina util como agente terapeutico para el prurito. |
WO2005005779A2 (en) | 2003-07-14 | 2005-01-20 | Genesis Mining Technologies (Pty) Ltd | Dual retention cutting arrangement |
AU2004259263B2 (en) | 2003-07-29 | 2010-12-16 | High Point Pharmaceuticals, Llc | Pyridazinyl- piperazines and their use as histamine H3 receptor ligands |
ES2568769T3 (es) * | 2003-07-30 | 2016-05-04 | Xenon Pharmaceuticals Inc. | Derivados de piperazina y su uso como agentes terapéuticos |
EP1653969A4 (en) | 2003-08-07 | 2006-12-20 | Japan Tobacco Inc | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES |
WO2005046581A2 (en) | 2003-10-24 | 2005-05-26 | Cheng Tao M D | P18 in stem cell manipulations |
US20050209232A1 (en) | 2004-02-10 | 2005-09-22 | Kent Barbay | Pyridazinone ureas as antagonists of alpha4 integrins |
EP1730120A1 (en) | 2004-03-23 | 2006-12-13 | F.Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
MXPA06012510A (es) | 2004-04-28 | 2006-12-15 | Pfizer | Derivados de 3-heterociclil-4-fenil-triazol como inhibidores del receptor de vasopresina via. |
JP2008501031A (ja) | 2004-05-28 | 2008-01-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251867B1 (es) | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
WO2006055187A1 (en) | 2004-10-29 | 2006-05-26 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
CA2602654A1 (en) * | 2005-04-05 | 2006-10-12 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Method for shielding functional sites or epitopes on proteins |
WO2007001975A1 (en) | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
WO2008019967A2 (en) | 2006-08-15 | 2008-02-21 | F. Hoffmann-La Roche Ag | Phenyl, pyridine and quinoline derivatives |
US8058243B2 (en) * | 2006-10-13 | 2011-11-15 | Hsc Research And Development Limited Partnership | Method for treating a brain cancer with ifenprodil |
JO2642B1 (en) * | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
TW200829566A (en) | 2006-12-08 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
MX2009011415A (es) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Derivados de 4-alcoxipiridazina como antagonistas del receptor de dopamina 2 de rapida disociacion. |
JP5431306B2 (ja) * | 2007-04-23 | 2014-03-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 高速解離性ドパミン2受容体アンタゴニストとしてのチア(ジア)ゾール |
RU2480462C2 (ru) * | 2007-04-23 | 2013-04-27 | Янссен Фармацевтика Н.В. | Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2 |
TW200930367A (en) * | 2007-09-20 | 2009-07-16 | Glaxo Group Ltd | Compounds which have activity at M1 receptor and their uses in medicine |
AU2009256574A1 (en) * | 2008-06-13 | 2009-12-17 | Novartis Ag | 2,4'-bipyridinyl compounds as protein kinase D inhibitors useful for the treatment of IA heart failure and cancer |
RU2502734C2 (ru) * | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
JP5457450B2 (ja) | 2008-07-31 | 2014-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 迅速解離性ドーパミン2受容体拮抗薬としてのピペラジン−1−イル−トリフルオロメチル−置換−ピリジン |
-
2009
- 2009-07-29 JP JP2011520499A patent/JP5457450B2/ja active Active
- 2009-07-29 EP EP09802514.1A patent/EP2307374B1/en active Active
- 2009-07-29 BR BRPI0916333A patent/BRPI0916333A2/pt not_active Application Discontinuation
- 2009-07-29 HU HUE09802514A patent/HUE033768T2/en unknown
- 2009-07-29 DK DK09802514.1T patent/DK2307374T3/en active
- 2009-07-29 WO PCT/EP2009/059788 patent/WO2010012758A1/en active Application Filing
- 2009-07-29 EA EA201170256A patent/EA019048B1/ru not_active IP Right Cessation
- 2009-07-29 ES ES09802514.1T patent/ES2622161T3/es active Active
- 2009-07-29 SI SI200931644A patent/SI2307374T1/sl unknown
- 2009-07-29 KR KR1020117004503A patent/KR101609218B1/ko active IP Right Grant
- 2009-07-29 CA CA2730774A patent/CA2730774C/en active Active
- 2009-07-29 AU AU2009275887A patent/AU2009275887B2/en not_active Ceased
- 2009-07-29 US US13/056,287 patent/US8895562B2/en active Active
- 2009-07-29 CN CN2009801395994A patent/CN102171189B/zh active Active
- 2009-07-29 LT LTEP09802514.1T patent/LT2307374T/lt unknown
-
2011
- 2011-12-09 HK HK11113345.2A patent/HK1159083A1/xx not_active IP Right Cessation
-
2017
- 2017-04-10 HR HRP20170570TT patent/HRP20170570T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20170570T1 (hr) | 2017-06-16 |
EA019048B1 (ru) | 2013-12-30 |
KR20110041548A (ko) | 2011-04-21 |
HUE033768T2 (en) | 2017-12-28 |
AU2009275887A1 (en) | 2010-02-04 |
DK2307374T3 (en) | 2017-05-01 |
US8895562B2 (en) | 2014-11-25 |
SI2307374T1 (sl) | 2017-05-31 |
CN102171189B (zh) | 2013-11-20 |
EA201170256A1 (ru) | 2011-08-30 |
US20110130408A1 (en) | 2011-06-02 |
CA2730774A1 (en) | 2010-02-04 |
KR101609218B1 (ko) | 2016-04-05 |
JP5457450B2 (ja) | 2014-04-02 |
AU2009275887B2 (en) | 2013-06-20 |
EP2307374B1 (en) | 2017-01-25 |
CA2730774C (en) | 2016-09-13 |
LT2307374T (lt) | 2017-04-25 |
ES2622161T3 (es) | 2017-07-05 |
HK1159083A1 (en) | 2012-07-27 |
CN102171189A (zh) | 2011-08-31 |
EP2307374A1 (en) | 2011-04-13 |
JP2011529471A (ja) | 2011-12-08 |
WO2010012758A1 (en) | 2010-02-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0821141A2 (pt) | Derivados de heteroarila como antagonistas do receptor de orexina | |
ZA201100866B (en) | Tripyridyl carboxamide orexin receptor antagonists | |
BRPI0910592A2 (pt) | antagonistas de receptor 2 de somatostatina | |
ZA201103156B (en) | Isonicotinamide orexin receptor antagonists | |
BRPI0909157A2 (pt) | compostos heterocíclicos como antagonistas de receptores de adenosina | |
BRPI0817245A2 (pt) | Derivados e quinolina como antagonistas receptores de 5ht5a | |
BRPI0910118A2 (pt) | antagonistas de receptores do glucagon | |
IL212545A0 (en) | Toll-like receptor 3 antagonists | |
IL209264A0 (en) | Heteroaromatic monoamides as orexinin receptor antagonists | |
BRPI0717937A2 (pt) | Compostos de pirazona como antagonistas do receptor mineralocorticóide | |
BRPI0916333A2 (pt) | piridinas substituídas por piperazin-1-il-trifluorometila como antagonistas do receptor de dopamina 2 de rápida dissociação | |
BRPI0814767A2 (pt) | Derivados de monoamida como antagonistas do receptor de orexina | |
DK2121630T3 (da) | Hurtigt dissocierende dopamin-2-receptor-antagonister | |
EP2365749A4 (en) | QUINOLONE ANTAGONISTS OF THE NEUROPEPTIDE S RECEPTOR | |
ZA201108724B (en) | Toll-like receptor 3 antagonists | |
SMT201300020B (it) | Derivati di isochinolinone come antagonisti dei recettori nk3 | |
BR112012003976A2 (pt) | antagonistas de receptor glyt1 carbocíclico | |
IL213982A0 (en) | Piperidine derivatives as nk3 receptor antagonists | |
EP2365748A4 (en) | IMIDAZOISOINDOLA ANTAGONISTS OF NEUROPEPTIDE S RECEPTORS | |
BRPI0914779A2 (pt) | derivados de pirrolidina como antagonistas de receptor de nk2 | |
BRPI0914797A2 (pt) | derivados de éter de pirrolidina como antagonistas do receptor de nk3 | |
BRPI0921788A2 (pt) | derivados de 3-(benzilamino)-pirrolidina e sua aplicação como antagonistas de receptores de nk-3 | |
HK1169992A1 (en) | Pyrrolidine derivatives as nk - 3 receptor antagonists nk-3 | |
IL210927A0 (en) | 6-substituted benzoxazines as 5-ht-5a receptor antagonists | |
DK2257534T3 (da) | 3-aminoalkyl-1,4-diazepan-2-on-melanocortin-5-receptorantagonister |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |