BRPI0821266A2 - Derivados de arilamida triazol-substituída e seu uso como anatagonistas de receptores purinérgicos p2x3 e/ou p2x2/3 - Google Patents
Derivados de arilamida triazol-substituída e seu uso como anatagonistas de receptores purinérgicos p2x3 e/ou p2x2/3Info
- Publication number
- BRPI0821266A2 BRPI0821266A2 BRPI0821266-0A BRPI0821266A BRPI0821266A2 BR PI0821266 A2 BRPI0821266 A2 BR PI0821266A2 BR PI0821266 A BRPI0821266 A BR PI0821266A BR PI0821266 A2 BRPI0821266 A2 BR PI0821266A2
- Authority
- BR
- Brazil
- Prior art keywords
- triazol
- purinergic receptor
- arylamide derivatives
- substituted arylamide
- receptor anatagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122018070508A BR122018070508B8 (pt) | 2007-12-17 | 2008-12-08 | derivados de arilamida triazol-substituída e seu uso |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US789007P | 2007-12-17 | 2007-12-17 | |
PCT/EP2008/066987 WO2009077366A1 (en) | 2007-12-17 | 2008-12-08 | Triazole-substituted arylamide derivatives and their use as p2x3 and /or p2x2/3 purinergic receptor antagonists |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0821266A2 true BRPI0821266A2 (pt) | 2015-06-16 |
BRPI0821266B1 BRPI0821266B1 (pt) | 2019-01-29 |
BRPI0821266B8 BRPI0821266B8 (pt) | 2023-02-07 |
Family
ID=40383852
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122018070508A BR122018070508B8 (pt) | 2007-12-17 | 2008-12-08 | derivados de arilamida triazol-substituída e seu uso |
BRPI0821266A BRPI0821266B8 (pt) | 2007-12-17 | 2008-12-08 | Derivados de arilamida triazol-substituída e seu uso e composição farmacêutica |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122018070508A BR122018070508B8 (pt) | 2007-12-17 | 2008-12-08 | derivados de arilamida triazol-substituída e seu uso |
Country Status (12)
Country | Link |
---|---|
US (3) | US7989637B2 (pt) |
EP (2) | EP2225213B1 (pt) |
JP (2) | JP5318883B2 (pt) |
KR (2) | KR101284510B1 (pt) |
CN (1) | CN101903359B (pt) |
AU (1) | AU2008337660B2 (pt) |
BR (2) | BR122018070508B8 (pt) |
CA (1) | CA2707422C (pt) |
ES (2) | ES2542245T3 (pt) |
IL (1) | IL205608A (pt) |
MX (1) | MX2010006230A (pt) |
WO (1) | WO2009077366A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101903362B (zh) * | 2007-12-17 | 2013-07-17 | 霍夫曼-拉罗奇有限公司 | 四唑取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途 |
KR101284510B1 (ko) * | 2007-12-17 | 2013-07-23 | 에프. 호프만-라 로슈 아게 | 트리아졸 치환된 아릴아미드 유도체 및 p2x3 및/또는 p2x2/3 퓨린성 수용체 길항제로서의 용도 |
CN104058999A (zh) | 2008-02-29 | 2014-09-24 | 伊沃泰克股份公司 | 酰胺化合物、组合物及其应用 |
EP2346825A2 (en) | 2008-09-18 | 2011-07-27 | Evotec AG | Modulators of p2x3 receptor activity |
JP5465782B2 (ja) * | 2009-06-22 | 2014-04-09 | エフ.ホフマン−ラ ロシュ アーゲー | 新規オキサゾロン及びピロリジノン置換アリールアミド |
JP5476467B2 (ja) | 2009-06-22 | 2014-04-23 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なビフェニルピリジンアミドおよびフェニルピリジンアミド |
US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
UY36422A (es) | 2014-12-09 | 2016-06-30 | Evotec Ag | Benzamidas sustituidas con 1,3-tiazol-2-ilo |
CN107207449B (zh) | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
WO2017060202A1 (en) * | 2015-10-06 | 2017-04-13 | F. Hoffmann-La Roche Ag | Triazole derivatives |
EP3411365B1 (en) | 2016-02-02 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
AR108222A1 (es) * | 2016-05-05 | 2018-08-01 | Elanco Tiergesundheit Ag | Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol |
JP6936257B2 (ja) | 2016-05-27 | 2021-09-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Eaat3阻害剤としてのピラゾール化合物 |
CN109563049B (zh) | 2016-10-14 | 2022-11-29 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的咪唑化合物 |
CN112888680A (zh) * | 2018-10-19 | 2021-06-01 | 先正达参股股份有限公司 | 杀有害生物活性的唑-酰胺化合物 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL109570A0 (en) | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
US6277873B1 (en) | 1999-03-25 | 2001-08-21 | Dingwei Tim Yu | Oxadiazole antifungal agents |
CA2380866A1 (en) | 1999-06-30 | 2001-01-11 | Synaptic Pharmaceutical Corporation | Selective npy (y5) antagonists |
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EP1294735A2 (en) | 2000-05-26 | 2003-03-26 | Novirio Pharmaceuticals Limited | Methods and compositions for treating flaviviruses and pestiviruses |
WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
DE10055713A1 (de) | 2000-11-10 | 2002-05-23 | Dingwei Tim Yu | Neue Klasse von Antifungimitteln |
RS50236B (sr) | 2001-01-22 | 2009-07-15 | Merck & Co.Inc., | Nukleozidni derivati kao inhibitori rnk-zavisne rnk virusne polimeraze |
AP2004003049A0 (en) | 2001-11-08 | 2004-06-30 | Elan Pharm Inc | N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives. |
WO2003063791A2 (en) | 2002-01-30 | 2003-08-07 | Entremed, Inc. | Non-steroidal analogs of 2-methoxyestradiol |
WO2003105770A2 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
RS114004A (en) | 2002-06-28 | 2007-02-05 | Idenix (Cayman) Limited, | Modified 2' and 3'-nucleoside produgs for treating flaviridae infections |
JP2005533852A (ja) | 2002-07-18 | 2005-11-10 | セレテック エルエルシー | Edg−1受容体に関連した症状の治療方法 |
CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′-支链核苷和黄病毒突变 |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
WO2004084890A1 (en) | 2003-03-26 | 2004-10-07 | Crc For Asthma Limited | Therapeutic and prophylactic compositions and uses therefor |
US20070060584A1 (en) | 2003-04-18 | 2007-03-15 | Chakravarty Prasun K | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
CA2525437C (en) | 2003-05-12 | 2009-04-28 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
DK1658302T3 (da) | 2003-07-25 | 2010-11-22 | Idenix Pharmaceuticals Inc | Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C |
WO2007020194A1 (en) * | 2005-08-15 | 2007-02-22 | F. Hoffmann-La Roche Ag | Piperidine and piperazine derivatives as p2x3 antagonists |
CN103159692B (zh) * | 2006-06-29 | 2015-03-18 | 弗·哈夫曼-拉罗切有限公司 | 四唑取代的芳基酰胺类 |
EP2091927B1 (en) | 2006-11-09 | 2011-07-20 | F. Hoffmann-La Roche AG | Thiazole and oxazole-substituted arylamides |
AU2008319308B2 (en) * | 2007-10-31 | 2013-01-31 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
KR101284510B1 (ko) * | 2007-12-17 | 2013-07-23 | 에프. 호프만-라 로슈 아게 | 트리아졸 치환된 아릴아미드 유도체 및 p2x3 및/또는 p2x2/3 퓨린성 수용체 길항제로서의 용도 |
-
2008
- 2008-12-08 KR KR1020107013245A patent/KR101284510B1/ko active IP Right Grant
- 2008-12-08 BR BR122018070508A patent/BR122018070508B8/pt active IP Right Grant
- 2008-12-08 CN CN2008801209500A patent/CN101903359B/zh active Active
- 2008-12-08 WO PCT/EP2008/066987 patent/WO2009077366A1/en active Application Filing
- 2008-12-08 BR BRPI0821266A patent/BRPI0821266B8/pt active IP Right Grant
- 2008-12-08 EP EP20080861017 patent/EP2225213B1/en active Active
- 2008-12-08 AU AU2008337660A patent/AU2008337660B2/en not_active Ceased
- 2008-12-08 ES ES12195604.9T patent/ES2542245T3/es active Active
- 2008-12-08 MX MX2010006230A patent/MX2010006230A/es active IP Right Grant
- 2008-12-08 ES ES08861017.5T patent/ES2541662T3/es active Active
- 2008-12-08 KR KR1020137005619A patent/KR101405746B1/ko active IP Right Grant
- 2008-12-08 EP EP20120195604 patent/EP2607356B1/en active Active
- 2008-12-08 JP JP2010538559A patent/JP5318883B2/ja active Active
- 2008-12-08 CA CA2707422A patent/CA2707422C/en active Active
- 2008-12-17 US US12/317,017 patent/US7989637B2/en active Active - Reinstated
-
2010
- 2010-05-06 IL IL205608A patent/IL205608A/en not_active IP Right Cessation
-
2011
- 2011-06-16 US US13/162,378 patent/US8440708B2/en active Active
-
2013
- 2013-04-18 US US13/865,781 patent/US20150065521A1/en not_active Abandoned
- 2013-07-10 JP JP2013144402A patent/JP5697722B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0821266A2 (pt) | Derivados de arilamida triazol-substituída e seu uso como anatagonistas de receptores purinérgicos p2x3 e/ou p2x2/3 | |
BRPI0815043A2 (pt) | mcp-1 mutantes antagonistas de glicosaminoglicanos e métodos para o seu uso | |
BR112012024870A2 (pt) | derivados de 4-aminopirimidina e seus antagonistas do receptor a2a de adenosina | |
BRPI0814963A2 (pt) | Pró-fármacos de dipeptóides e seu uso | |
BRPI0810523A2 (pt) | Derivado heterocíclico de 5 membros e uso do mesmo para propósitos médicos. | |
BRPI0814267A2 (pt) | Agentes citotóxicos compreendendo novos derivados de tomaicmicina e o seu uso terapêutico. | |
BRPI0820838A2 (pt) | Derivados de arilamida substituidos por tetrazol e seu uso como antagonistas do receptor purinérgico p2x3 e/ou p2x2/3 | |
BRPI0716936A2 (pt) | derivados de adenosina como antigonistas de receptor de a2a | |
BRPI1010621A2 (pt) | derivado de imidazoquinolinonas, sua composição farmacêutica e seu uso | |
ATE481409T1 (de) | Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor | |
BRPI0820819A2 (pt) | Formulação de anticorpos | |
BRPI0813244A2 (pt) | Compostos e seus usos 708 | |
BRPI0815190A2 (pt) | Composto derivado de piridina, composição farmacêutica que o compreende e uso do mesmo | |
BRPI0817685A2 (pt) | Polissacarídeos com funcionalidade azetidínio e seus usos | |
BRPI0807667A2 (pt) | Composição emulsificada de óleo-em-água | |
BRPI0819410A2 (pt) | "dispositivo com múltiplas camadas para detecção de analitos" | |
BRPI0720866A2 (pt) | Derivados de oxindol substituídos e seu uso como ligandos de receptor de vasopressina | |
DK1973886T3 (da) | Prokineticin-1-receptor-antagonister | |
CR10725A (es) | Compuestos de pirazolina y su uso y composiones farmaceuticas | |
BRPI0818690A2 (pt) | Derivados de quinazolinediona, sua preparação e seus usos terapêuticos. | |
BRPI0816372A2 (pt) | Ácidos 6-fenilnicotínicos substituídos e seu uso | |
BRPI0617511A2 (pt) | Conjugado de peptídeo-imunoglobulina | |
BRPI0808798A2 (pt) | Fenoxifenilamidinas 3,5-dissubstituídas e seu uso como fungicidas | |
BRPI0815040A2 (pt) | Polímeros emulsificantes e seu uso | |
BRPI0821244A2 (pt) | Proteína de cereal hipoalergênica e seus usos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/01/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/12/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: REFERENTE A RPI 2629 DE 25/05/2021, QUANTO AO ITEM (54) TITULO. |