BRPI0818273A2 - Sequências sinalizadoras e chaperonas coexpressas para aprimoramento de produção de proteína em uma célula hospedeira. - Google Patents
Sequências sinalizadoras e chaperonas coexpressas para aprimoramento de produção de proteína em uma célula hospedeira.Info
- Publication number
- BRPI0818273A2 BRPI0818273A2 BRPI0818273-6A2A BRPI0818273A BRPI0818273A2 BR PI0818273 A2 BRPI0818273 A2 BR PI0818273A2 BR PI0818273 A BRPI0818273 A BR PI0818273A BR PI0818273 A2 BRPI0818273 A2 BR PI0818273A2
- Authority
- BR
- Brazil
- Prior art keywords
- chaperonas
- coexpress
- improvement
- host cell
- protein production
- Prior art date
Links
- 230000011664 signaling Effects 0.000 title 1
- 230000014616 translation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
- C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
- C12N9/0061—Laccase (1.10.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
- C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
- C12Y110/03002—Laccase (1.10.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98443007P | 2007-11-01 | 2007-11-01 | |
| PCT/US2008/081721 WO2009058956A1 (en) | 2007-11-01 | 2008-10-30 | Signal sequences and co-expressed chaperones for improving protein production in a host cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0818273A2 true BRPI0818273A2 (pt) | 2014-10-14 |
Family
ID=40304979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0818273-6A2A BRPI0818273A2 (pt) | 2007-11-01 | 2008-10-30 | Sequências sinalizadoras e chaperonas coexpressas para aprimoramento de produção de proteína em uma célula hospedeira. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090221030A1 (enExample) |
| EP (1) | EP2203556A1 (enExample) |
| JP (3) | JP5252746B2 (enExample) |
| CN (1) | CN101842479A (enExample) |
| AU (1) | AU2008318644B2 (enExample) |
| BR (1) | BRPI0818273A2 (enExample) |
| CA (1) | CA2704548A1 (enExample) |
| CO (1) | CO6210760A2 (enExample) |
| MX (1) | MX2010004325A (enExample) |
| WO (1) | WO2009058956A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010075402A1 (en) | 2008-12-24 | 2010-07-01 | Danisco Us Inc. | Laccases and methods of use thereof at low temperature |
| PT2403809E (pt) | 2009-03-03 | 2015-10-13 | Danisco Us Inc | Método de descoloração oxidativa de corantes com perácido gerado por acção enzimática |
| FI20095615A0 (fi) * | 2009-06-02 | 2009-06-02 | Oulun Yliopisto | Menetelmä luonnollisesti laskostuneiden proteiinien tuottamiseksi prokaryootti-isännässä |
| CN103189564A (zh) | 2010-10-18 | 2013-07-03 | 丹尼斯科美国公司 | 使用漆酶体系对染色织物进行局部颜色修改 |
| EP2694647A1 (en) | 2011-04-06 | 2014-02-12 | Danisco US Inc. | Laccase variants having increased expression and/or activity |
| JP2012235767A (ja) * | 2011-04-27 | 2012-12-06 | Toyota Motor Corp | 変異トリコデルマ属微生物及びこれを用いたタンパク質の製造方法 |
| US9567596B2 (en) | 2012-01-05 | 2017-02-14 | Glykos Finland Oy | Protease deficient filamentous fungal cells and methods of use thereof |
| EP2808388B1 (en) * | 2012-01-23 | 2019-03-13 | AGC Inc. | Expression vector and method for producing protein |
| WO2013174927A1 (en) | 2012-05-23 | 2013-11-28 | Novartis International Pharmaceutical Limited | Production of fucosylated glycoproteins |
| US9993534B2 (en) * | 2013-03-12 | 2018-06-12 | Wisconsin Alumni Research Foundation | Method of treating fungal infection |
| JP2016523552A (ja) | 2013-07-10 | 2016-08-12 | ノバルティス アーゲー | 多重プロテアーゼ欠損糸状菌細胞及びその使用方法 |
| CN104694560A (zh) * | 2013-12-04 | 2015-06-10 | 中国科学院天津工业生物技术研究所 | 一种源于里氏木霉的二硫键异构酶基因Trpdi2及其用途 |
| SG10201809152QA (en) | 2014-04-17 | 2018-11-29 | Boehringer Ingelheim Rcv Gmbh | Recombinant host cell for expressing proteins of interest |
| KR102373954B1 (ko) | 2014-04-17 | 2022-03-14 | 베링거 인겔하임 에르체파우 게엠베하 운트 코 카게 | 보조 단백질을 과발현하도록 조작된 재조합 숙주세포 |
| AU2015293949B2 (en) | 2014-07-21 | 2019-07-25 | Teknologian Tutkimuskeskus Vtt Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
| JP2017525359A (ja) * | 2014-08-15 | 2017-09-07 | ダニスコ・ユーエス・インク | タンパク質の産生改善のための組成物及び方法 |
| US10526609B2 (en) * | 2016-08-01 | 2020-01-07 | Aduro Biotech, Inc. | Protein expression enhancer sequences and use thereof |
| WO2020002494A1 (en) * | 2018-06-27 | 2020-01-02 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Means and methods for increased protein expression by use of transcription factors |
| KR102138272B1 (ko) * | 2018-09-19 | 2020-07-28 | 주식회사 바이오앱 | BiP 단편을 포함하는 재조합 벡터 및 상기 벡터를 이용한 재조합 단백질의 제조 방법 |
| WO2021112540A1 (ko) * | 2019-12-02 | 2021-06-10 | 주식회사 엘지화학 | Cho 세포 유래 단백질 분비 인자 및 이를 포함하는 발현 벡터 |
| CN112501141A (zh) * | 2020-10-22 | 2021-03-16 | 重庆中元汇吉生物技术有限公司 | 一种增加人甲状腺过氧化物酶产量的试剂和表达方法 |
| CN112175977B (zh) * | 2020-10-30 | 2022-04-15 | 华中农业大学 | 一种米曲霉角蛋白酶基因及其表达载体与应用 |
| CN112391402B (zh) * | 2020-11-17 | 2023-03-28 | 华中科技大学 | 一种提高解脂耶氏酵母中目的蛋白表达水平的方法 |
| CN112409464B (zh) * | 2020-11-23 | 2022-04-22 | 江南大学 | 提高枯草芽孢杆菌重组蛋白胞外生产水平的信号肽突变体及应用 |
| EP4399295A1 (en) * | 2021-09-09 | 2024-07-17 | International N&H Denmark ApS | Over expression of foldases and chaperones improves protein production |
| CN113736817B (zh) * | 2021-10-08 | 2023-02-03 | 枣庄市杰诺生物酶有限公司 | 一种毕赤酵母中提高碱性脂肪酶分泌效率及酶活的方法 |
| CN117903294B (zh) * | 2024-03-19 | 2024-06-14 | 北京国科星联科技有限公司 | 一种发酵生产乳铁蛋白的马克斯克鲁维酵母及其构建方法与应用 |
| CN117903295B (zh) * | 2024-03-19 | 2024-05-31 | 北京国科星联科技有限公司 | 一种用于分泌表达乳铁蛋白的马克斯克鲁维酵母及其构建方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2097180C (en) * | 1990-12-10 | 2007-08-14 | Timothy Fowler | Saccharification of cellulose by cloning and amplification of the .beta.-glucosidase gene of trichoderma reesei |
| EP0663010B1 (en) * | 1992-10-02 | 2000-08-09 | Research Corporation Technologies, Inc. | Methods for increasing secretion of overexpressed proteins |
| US5861271A (en) * | 1993-12-17 | 1999-01-19 | Fowler; Timothy | Cellulase enzymes and systems for their expressions |
| US6008029A (en) * | 1995-08-25 | 1999-12-28 | Novo Nordisk Biotech Inc. | Purified coprinus laccases and nucleic acids encoding the same |
| CN1151264C (zh) * | 1997-04-07 | 2004-05-26 | 尤尼利弗公司 | 农杆菌介导的霉菌特别是属于曲霉菌属的霉菌的转化 |
| EP1032655B1 (en) * | 1997-11-21 | 2005-06-29 | Novozymes A/S | Protease variants and compositions |
| US6268328B1 (en) * | 1998-12-18 | 2001-07-31 | Genencor International, Inc. | Variant EGIII-like cellulase compositions |
| EP1266018B1 (en) * | 2000-03-24 | 2008-05-07 | Genencor International, Inc. | Production of secreted proteins by recombinant eukaryotic cells |
| US6358733B1 (en) * | 2000-05-19 | 2002-03-19 | Apolife, Inc. | Expression of heterologous multi-domain proteins in yeast |
| JP2002065282A (ja) * | 2000-09-04 | 2002-03-05 | Iwate Prefecture | シイタケラッカーゼ遺伝子 |
| KR20120099303A (ko) * | 2003-11-06 | 2012-09-07 | 다니스코 유에스 인크. | 프로테아제 저해자 및 그 변이체의 사상균 내에서의 발현 |
| DK1680507T3 (da) * | 2003-11-06 | 2011-10-10 | Danisco Us Inc | Bakterieekspression af proteaseinhibitorer og varianter deraf |
| MXPA06013600A (es) * | 2004-05-27 | 2007-03-15 | Genencor Int | Alfa amilasas acidoestables con actividad hidrolizante de almidon granular y composiciones enzimaticas. |
| MX2007007862A (es) * | 2004-12-30 | 2007-08-17 | Genencor Int | Proteasas fungales acidas. |
| BRPI0721285A2 (pt) * | 2006-12-18 | 2014-03-25 | Danisco Us Inc Genencor Div | Mediadores de lacase e métodos de uso |
| EP2129685B1 (en) * | 2007-03-21 | 2013-11-20 | Danisco US Inc. | Over expression of foldases and chaperones improves protein production |
-
2008
- 2008-10-30 US US12/261,306 patent/US20090221030A1/en not_active Abandoned
- 2008-10-30 CA CA2704548A patent/CA2704548A1/en not_active Abandoned
- 2008-10-30 AU AU2008318644A patent/AU2008318644B2/en not_active Ceased
- 2008-10-30 JP JP2010532232A patent/JP5252746B2/ja not_active Expired - Fee Related
- 2008-10-30 EP EP08844940A patent/EP2203556A1/en not_active Withdrawn
- 2008-10-30 WO PCT/US2008/081721 patent/WO2009058956A1/en not_active Ceased
- 2008-10-30 BR BRPI0818273-6A2A patent/BRPI0818273A2/pt not_active IP Right Cessation
- 2008-10-30 CN CN200880114429A patent/CN101842479A/zh active Pending
- 2008-10-30 MX MX2010004325A patent/MX2010004325A/es active IP Right Grant
-
2010
- 2010-04-23 CO CO10048157A patent/CO6210760A2/es not_active Application Discontinuation
-
2013
- 2013-01-22 JP JP2013009289A patent/JP2013121354A/ja active Pending
-
2014
- 2014-09-30 JP JP2014200112A patent/JP2015027308A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011502483A (ja) | 2011-01-27 |
| US20090221030A1 (en) | 2009-09-03 |
| JP5252746B2 (ja) | 2013-07-31 |
| AU2008318644A1 (en) | 2009-05-07 |
| CN101842479A (zh) | 2010-09-22 |
| JP2015027308A (ja) | 2015-02-12 |
| EP2203556A1 (en) | 2010-07-07 |
| CA2704548A1 (en) | 2009-05-07 |
| WO2009058956A1 (en) | 2009-05-07 |
| JP2013121354A (ja) | 2013-06-20 |
| MX2010004325A (es) | 2010-05-20 |
| CO6210760A2 (es) | 2010-10-20 |
| AU2008318644B2 (en) | 2013-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |