BRPI0813634A2 - controle óptico de enchimento de cápsulas farmacêuticas em máquinas de enchimento de cápsulas. - Google Patents
controle óptico de enchimento de cápsulas farmacêuticas em máquinas de enchimento de cápsulas.Info
- Publication number
- BRPI0813634A2 BRPI0813634A2 BRPI0813634-3A BRPI0813634A BRPI0813634A2 BR PI0813634 A2 BRPI0813634 A2 BR PI0813634A2 BR PI0813634 A BRPI0813634 A BR PI0813634A BR PI0813634 A2 BRPI0813634 A2 BR PI0813634A2
- Authority
- BR
- Brazil
- Prior art keywords
- filling
- capsule
- capsule filling
- contour
- optical control
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title abstract 8
- 230000003287 optical effect Effects 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000000945 filler Substances 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000004590 computer program Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000005429 filling process Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
- G01N21/9508—Capsules; Tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
- B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
- B07C5/3425—Sorting according to other particular properties according to optical properties, e.g. colour of granular material, e.g. ore particles, grain
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F17/00—Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0004—Industrial image inspection
- G06T7/0006—Industrial image inspection using a design-rule based approach
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0096—Investigating consistence of powders, dustability, dustiness
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1497—Particle shape
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/069—Supply of sources
- G01N2201/0694—Microprocessor controlled supply
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/124—Sensitivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
- G01N2201/12746—Calibration values determination
- G01N2201/12753—Calibration values determination and storage
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10024—Color image
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Theoretical Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Quality & Reliability (AREA)
- Fluid Mechanics (AREA)
- Signal Processing (AREA)
- Dispersion Chemistry (AREA)
- Mathematical Physics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Basic Packing Technique (AREA)
Abstract
controle óptico de enchimento de cápsulas farmacêuticas em máquinas de enchimento de cápsulas a presente invenção refere-se a um processo para o monitoramento de enchimento de uma cápsula com um medicamento, a um processo de enchimento correspondente, aos dispositivos correspondentes, bem como, a um programa de computador para o monitoramento do processo e do dispositivo. no caso do processo de monitoramento, depois que, pelo menos, uma parte das cápsulas foi enchida com uma massa de enchimento especificada de contorno fechado predeterminado do medicamento, em uma primeira etapa, pelo menos, a massa de enchimento que se encontra na parte da cápsula após o enchimento é registrada usando imagem digital, em uma segunda etapa, do registro usando imagem digital, é determinado o contorno da massa de enchimento que se encontra na parte da cápsula e, em uma terceira etapa, o contorno é analisado, a fim de proceder a uma avaliação do enchimento na comparação com o contorno predeterminado. de acordo com a invenção está previsto compensar, por meio de regulagem do sistema óptico, influências externas sobre as propriedades da imagem.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112146 | 2007-07-10 | ||
| EP07112146.1 | 2007-07-10 | ||
| PCT/EP2008/058734 WO2009007333A1 (de) | 2007-07-10 | 2008-07-07 | Optische befuellungskontrolle von pharmazeutischen kapseln auf kapselfuellmaschinen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0813634A2 true BRPI0813634A2 (pt) | 2019-04-30 |
| BRPI0813634B1 BRPI0813634B1 (pt) | 2019-12-03 |
Family
ID=38814263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0813634-3 BRPI0813634B1 (pt) | 2007-07-10 | 2008-07-07 | processo para o monitoramento de enchimento de uma cápsula com um medicamento, processo para o enchimento mecânico contínuo de cápsulas com um medicamento e dispositivo para a realização dos processos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8584715B2 (pt) |
| EP (1) | EP2179272B1 (pt) |
| JP (1) | JP5138773B2 (pt) |
| KR (1) | KR101456873B1 (pt) |
| CN (1) | CN101688844B (pt) |
| AR (1) | AR067484A1 (pt) |
| AT (1) | ATE503179T1 (pt) |
| AU (1) | AU2008274263C1 (pt) |
| BR (1) | BRPI0813634B1 (pt) |
| CA (1) | CA2693620C (pt) |
| CL (1) | CL2008002023A1 (pt) |
| DE (1) | DE502008002959D1 (pt) |
| IL (1) | IL202981A (pt) |
| NZ (1) | NZ609807A (pt) |
| RU (1) | RU2475727C2 (pt) |
| TW (1) | TWI475217B (pt) |
| WO (1) | WO2009007333A1 (pt) |
| ZA (1) | ZA200908133B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8335343B2 (en) * | 2009-07-29 | 2012-12-18 | Mercury Scientific Inc | Method for characterizing powder in a rotating cylindrical container by image analysis |
| KR20140022805A (ko) * | 2011-02-03 | 2014-02-25 | 스위스로그 이탈리아 에스.피.에이. | 패키지된 약제 검사 시스템 및 방법 |
| KR101899269B1 (ko) * | 2011-04-28 | 2018-10-29 | 가부시키가이샤 유야마 세이사쿠쇼 | 약제 감사 장치 및 약제 분포 장치 |
| ITBO20130178A1 (it) * | 2013-04-19 | 2014-10-20 | Mg 2 Srl | Macchina rotativa continua per il riempimento di capsule con prodotti farmaceutici |
| JP6395739B2 (ja) * | 2015-03-10 | 2018-09-26 | 富士フイルム株式会社 | 測定方法及び測定装置 |
| US10187593B2 (en) | 2016-09-27 | 2019-01-22 | Rxsafe Llc | Verification system for a pharmacy packaging system |
| US11595595B2 (en) | 2016-09-27 | 2023-02-28 | Rxsafe Llc | Verification system for a pharmacy packaging system |
| CN116863598A (zh) | 2017-10-13 | 2023-10-10 | 快而安有限责任公司 | 用于自动包装机的通用供给机构 |
| CN111182698B (zh) * | 2019-10-09 | 2022-06-03 | 安徽宏实光机电高科有限公司 | 一种自动调整物料照明亮度的控制方法及控制系统 |
| CN111209950B (zh) * | 2020-01-02 | 2023-10-10 | 格朗思(天津)视觉科技有限公司 | 基于x光成像和深度学习的胶囊识别与检测方法及系统 |
| JP7313310B2 (ja) * | 2020-03-31 | 2023-07-24 | 日本碍子株式会社 | セラミックス製の柱状ハニカム構造体の検査方法及び検査装置 |
| CN112957339B (zh) * | 2021-02-09 | 2022-11-25 | 桂林华信制药有限公司 | 缬沙坦胶囊的制备工艺 |
| CN114088624B (zh) * | 2021-11-09 | 2022-08-26 | 北京中检葆泰生物技术有限公司 | 用于谷物颗粒表面规则度检测设备 |
| CN117022817B (zh) * | 2023-10-08 | 2023-12-01 | 南京比逊弥特智能科技有限公司 | 具有残片检测功能的矩阵式智能模组数粒系统及方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE789263A (fr) * | 1971-09-27 | 1973-03-26 | Lilly Co Eli | Systeme et procede electroniques de controle de capsules |
| US3969227A (en) * | 1974-11-01 | 1976-07-13 | Smithkline Corporation | Photoelectric inspection of transparent or translucent medicinal capsules |
| IT1201613B (it) * | 1986-12-23 | 1989-02-02 | Ima Spa | Dispositivo per il rilevamento e della presenza di prodotti in corrispondenti sedi e di irregolarita'nel profilo di base di tali prodotti gia'collocati nelle relative sedi |
| JPH04350543A (ja) * | 1991-05-28 | 1992-12-04 | Fuji Electric Co Ltd | カプセル外観検査装置 |
| CH692841A5 (de) * | 1993-12-14 | 2002-11-29 | Buehler Ag | Sortiervorrichtung. |
| RU2142860C1 (ru) * | 1997-09-25 | 1999-12-20 | Открытое акционерное общество "Союзстекломаш" | Контрольно-сортировочный автомат |
| US6207946B1 (en) * | 1998-09-03 | 2001-03-27 | Semiconductor Technologies & Instruments, Inc. | Adaptive lighting system and method for machine vision apparatus |
| US20020081732A1 (en) * | 2000-10-18 | 2002-06-27 | Bowlin Gary L. | Electroprocessing in drug delivery and cell encapsulation |
| DE10017126C1 (de) * | 2000-04-06 | 2001-06-13 | Krones Ag | Verfahren und Vorrichtung zum optischen Überprüfen transparenter Behälter |
| JP2001330412A (ja) | 2000-05-24 | 2001-11-30 | Mitsubishi Electric Corp | 視程計測装置 |
| JP2002107309A (ja) | 2000-09-28 | 2002-04-10 | Toshiba Corp | 欠陥検査装置及び欠陥検査方法 |
| JP2003240545A (ja) | 2002-02-14 | 2003-08-27 | Fuji Photo Film Co Ltd | 測距装置，露出量決定装置および画像合成装置 |
| ITBO20020433A1 (it) * | 2002-07-04 | 2004-01-05 | Ima Spa | Metodo per il controllo optoelettronico di articoli farmaceutici |
| JP2004350963A (ja) * | 2003-05-29 | 2004-12-16 | Olympus Corp | カプセル型医療装置 |
| JP4350543B2 (ja) | 2004-02-05 | 2009-10-21 | キヤノン株式会社 | 画像処理装置、画像処理装置における処理方法、プログラム |
| US20050256314A1 (en) * | 2004-05-04 | 2005-11-17 | Soojin Kim | Process employing controlled crystallization in forming crystals of a pharmaceutical |
| ITBO20040310A1 (it) * | 2004-05-18 | 2004-08-18 | Ima Spa | Macchina opercolatrice e relativo metodo per la produzione di capsule in gelatina dura. |
| CN2757122Y (zh) * | 2004-12-24 | 2006-02-08 | 王韬 | 利用白光测量能见度和大气消光系数的仪器 |
| DE102005049958A1 (de) * | 2005-10-19 | 2007-04-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Optische semiquantitative 100%-Befüllungskontrolle von pharmazeutischen Kapseln auf Kapselfüllmaschinen |
-
2008
- 2008-07-07 BR BRPI0813634-3 patent/BRPI0813634B1/pt not_active IP Right Cessation
- 2008-07-07 JP JP2010515481A patent/JP5138773B2/ja active Active
- 2008-07-07 CN CN2008800242766A patent/CN101688844B/zh active Active
- 2008-07-07 CA CA2693620A patent/CA2693620C/en active Active
- 2008-07-07 RU RU2010104046/28A patent/RU2475727C2/ru active
- 2008-07-07 AU AU2008274263A patent/AU2008274263C1/en not_active Ceased
- 2008-07-07 EP EP08774809A patent/EP2179272B1/de active Active
- 2008-07-07 AT AT08774809T patent/ATE503179T1/de active
- 2008-07-07 US US12/668,350 patent/US8584715B2/en active Active
- 2008-07-07 DE DE502008002959T patent/DE502008002959D1/de active Active
- 2008-07-07 NZ NZ609807A patent/NZ609807A/en not_active IP Right Cessation
- 2008-07-07 WO PCT/EP2008/058734 patent/WO2009007333A1/de active Application Filing
- 2008-07-07 KR KR1020107002957A patent/KR101456873B1/ko active IP Right Grant
- 2008-07-08 AR ARP080102950A patent/AR067484A1/es active IP Right Grant
- 2008-07-09 TW TW097125811A patent/TWI475217B/zh not_active IP Right Cessation
- 2008-07-10 CL CL2008002023A patent/CL2008002023A1/es unknown
-
2009
- 2009-11-18 ZA ZA200908133A patent/ZA200908133B/xx unknown
- 2009-12-27 IL IL202981A patent/IL202981A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008002023A1 (es) | 2009-09-11 |
| CA2693620C (en) | 2017-10-17 |
| US20100192523A1 (en) | 2010-08-05 |
| ZA200908133B (en) | 2010-07-28 |
| AU2008274263B2 (en) | 2013-12-05 |
| AU2008274263A1 (en) | 2009-01-15 |
| JP5138773B2 (ja) | 2013-02-06 |
| RU2475727C2 (ru) | 2013-02-20 |
| WO2009007333A1 (de) | 2009-01-15 |
| EP2179272B1 (de) | 2011-03-23 |
| ATE503179T1 (de) | 2011-04-15 |
| KR20100046003A (ko) | 2010-05-04 |
| IL202981A (en) | 2013-05-30 |
| TWI475217B (zh) | 2015-03-01 |
| AU2008274263C1 (en) | 2014-01-16 |
| BRPI0813634B1 (pt) | 2019-12-03 |
| CN101688844B (zh) | 2013-02-27 |
| RU2010104046A (ru) | 2011-09-10 |
| JP2010533009A (ja) | 2010-10-21 |
| CA2693620A1 (en) | 2009-01-15 |
| AR067484A1 (es) | 2009-10-14 |
| TW200912290A (en) | 2009-03-16 |
| NZ609807A (en) | 2014-07-25 |
| DE502008002959D1 (de) | 2011-05-05 |
| EP2179272A1 (de) | 2010-04-28 |
| CN101688844A (zh) | 2010-03-31 |
| US8584715B2 (en) | 2013-11-19 |
| KR101456873B1 (ko) | 2014-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
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