BRPI0714648B8 - preparação de 3-[(1r,2r)-3-(dimetilamino)-1etil-2-metilpropil] fenol - Google Patents

preparação de 3-[(1r,2r)-3-(dimetilamino)-1etil-2-metilpropil] fenol

Info

Publication number
BRPI0714648B8
BRPI0714648B8 BRPI0714648A BRPI0714648A BRPI0714648B8 BR PI0714648 B8 BRPI0714648 B8 BR PI0714648B8 BR PI0714648 A BRPI0714648 A BR PI0714648A BR PI0714648 A BRPI0714648 A BR PI0714648A BR PI0714648 B8 BRPI0714648 B8 BR PI0714648B8
Authority
BR
Brazil
Prior art keywords
methylpropyl
dimethylamino
preparation
phenol
1ethyl
Prior art date
Application number
BRPI0714648A
Other languages
English (en)
Inventor
Wolfgang Hell
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BRPI0714648A2 publication Critical patent/BRPI0714648A2/pt
Publication of BRPI0714648B1 publication Critical patent/BRPI0714648B1/pt
Publication of BRPI0714648B8 publication Critical patent/BRPI0714648B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

preparação de 3-[(1r,2r)-3-(dimetilamino)-1-etil-2-metilpropil] fenol. a presente invenção se relaciona com um processo melhorado para preparação de monohidrocloruro de 3-[(1r, 2r)-3-(dimetilamino1-etil-2-metilpropil] fenol.
BRPI0714648A 2006-07-24 2007-07-23 preparação de 3-[(1r,2r)-3-(dimetilamino)-1etil-2-metilpropil] fenol BRPI0714648B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06015317.8 2006-07-24
EP06015317 2006-07-24
PCT/EP2007/006514 WO2008012046A1 (en) 2006-07-24 2007-07-23 Preparation of 3-[(1r,2r)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol

Publications (3)

Publication Number Publication Date
BRPI0714648A2 BRPI0714648A2 (pt) 2013-05-07
BRPI0714648B1 BRPI0714648B1 (pt) 2021-02-02
BRPI0714648B8 true BRPI0714648B8 (pt) 2021-05-25

Family

ID=37492362

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714648A BRPI0714648B8 (pt) 2006-07-24 2007-07-23 preparação de 3-[(1r,2r)-3-(dimetilamino)-1etil-2-metilpropil] fenol

Country Status (24)

Country Link
US (1) US8263809B2 (pt)
EP (1) EP2049464B1 (pt)
JP (1) JP5357756B2 (pt)
KR (1) KR101433685B1 (pt)
CN (1) CN101495446B (pt)
AT (1) ATE515491T1 (pt)
AU (1) AU2007278463B2 (pt)
BR (1) BRPI0714648B8 (pt)
CA (1) CA2658648C (pt)
CY (1) CY1111829T1 (pt)
DK (1) DK2049464T3 (pt)
ES (1) ES2366390T3 (pt)
HK (1) HK1130247A1 (pt)
HR (1) HRP20110572T1 (pt)
IL (1) IL196626A (pt)
MX (1) MX2008016380A (pt)
NO (1) NO341683B1 (pt)
NZ (1) NZ573906A (pt)
PL (1) PL2049464T3 (pt)
RU (1) RU2463290C2 (pt)
SI (1) SI2049464T1 (pt)
TW (1) TWI401237B (pt)
WO (1) WO2008012046A1 (pt)
ZA (1) ZA200901279B (pt)

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AU2009305563C1 (en) 2008-10-17 2015-09-03 Signature Therapeutics, Inc. Pharmaceutical compositions with attenuated release of phenolic opioids
CN102002065B (zh) * 2009-09-02 2014-09-10 上海特化医药科技有限公司 他喷他多的制备方法及其中间体
US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
IT1397189B1 (it) * 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
WO2011080756A1 (en) * 2009-12-29 2011-07-07 Ind-Swift Laboratories Limited Process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives
WO2011107876A2 (en) 2010-03-05 2011-09-09 Actavis Group Ptc Ehf Improved resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol
CA2793948A1 (en) 2010-04-05 2011-10-20 Actavis Group Ptc Ehf Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof
US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
DK2560486T3 (en) 2010-04-21 2019-02-04 Signature Therapeutics Inc COMPOSITIONS COMPREHENSIVE ENZYM-TENDABLE AMPHETAMINE PRODRUGS AND ITS INHIBITORS
US9238020B2 (en) 2010-04-21 2016-01-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug
ITMI20100924A1 (it) * 2010-05-21 2011-11-22 Fidia Farmaceutici Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol
CN104725246B (zh) * 2010-06-15 2017-05-03 格吕伦塔尔有限公司 用于制备取代的3‑(1‑氨基‑2‑甲基戊烷‑3‑基)苯基化合物的方法
IT1401109B1 (it) * 2010-07-02 2013-07-12 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
PT3656765T (pt) * 2010-07-23 2021-05-25 Gruenenthal Gmbh Sais ou cocristais de 3-(3-dimetilamino-1-etil-2- metilpropil)fenol
WO2012023147A1 (en) 2010-08-16 2012-02-23 Indoco Remedies Limited Process for the preparation of tapentadol
WO2012038974A1 (en) * 2010-09-20 2012-03-29 Ind-Swift Laboratories Limited Process for preparing l-phenyl-3-dimethylaminopropane derivative
WO2012089181A1 (en) * 2010-12-30 2012-07-05 Zentiva, K.S. O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same
CA2814763C (en) 2011-01-11 2019-05-28 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
EP2545028A4 (en) * 2011-01-27 2013-07-03 Symed Labs Ltd STEREOSPECIFIC SYNTHESIS OF (-) (2S, 3S) -1-DIMETHYLAMINO-3- (3-METHOXYPHENYL) -2-METHYLPENTAN-3-OLE
CN102617501A (zh) 2011-01-31 2012-08-01 中国科学院上海药物研究所 取代正戊酰胺类化合物、其制备方法及用途
PT3287123T (pt) * 2011-03-04 2020-05-22 Gruenenthal Gmbh Formulação farmacêutica aquosa de tapentadol para administração oral
JP6148182B2 (ja) 2011-03-09 2017-06-14 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. 複素環式リンカーを有する活性薬剤プロドラッグ
WO2012146978A2 (en) 2011-04-28 2012-11-01 Actavis Group Ptc Ehf A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof
WO2013105109A1 (en) 2011-11-09 2013-07-18 Indoco Remedies Limited Process for the preparation of tapentadol
US20130150622A1 (en) 2011-12-12 2013-06-13 Boehringer Ingelheim International Gmbh Stereoselective synthesis of tapentadol and its salts
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
CN103159633B (zh) * 2012-07-06 2015-08-12 江苏恩华药业股份有限公司 他喷他多的制备方法及用于制备他喷他多的化合物
CN102924303B (zh) * 2012-10-31 2013-11-20 合肥市新星医药化工有限公司 盐酸他喷他多晶型c及其制备方法和应用
WO2014141296A2 (en) * 2013-03-09 2014-09-18 Ind-Swift Laboratories Limited Process for the preparation of tapentadol via novel intermediate
RU2016120002A (ru) * 2013-11-01 2017-12-04 Сан Фарма Адвансед Ресёрч Компани Новое промежуточное соединение тапентадола
CN103553940A (zh) * 2013-11-07 2014-02-05 南京艾德凯腾生物医药有限责任公司 一种新晶型盐酸他喷他多的制备方法
IN2013MU03670A (pt) 2013-11-21 2015-07-31 Unimark Remedies Ltd
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CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
US9556108B2 (en) 2014-07-10 2017-01-31 Mallinckrodt Llc Process for preparing substituted phenylalkanes
AU2016292797B2 (en) 2015-07-10 2018-05-31 SpecGx LLC A two-step process for preparing 3-substituted phenylalkylamines
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EP4116288A1 (en) 2021-07-08 2023-01-11 KRKA, d.d., Novo mesto Racemization of (s) and/or (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one and its mixtures

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JP4202327B2 (ja) * 1996-04-09 2008-12-24 ヤマサ醤油株式会社 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
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Also Published As

Publication number Publication date
MX2008016380A (es) 2009-01-30
TW200815317A (en) 2008-04-01
RU2463290C2 (ru) 2012-10-10
IL196626A0 (en) 2009-11-18
EP2049464A1 (en) 2009-04-22
AU2007278463B2 (en) 2011-11-24
AU2007278463A1 (en) 2008-01-31
NO20090691L (no) 2009-02-23
CY1111829T1 (el) 2015-10-07
CN101495446B (zh) 2012-12-05
CA2658648C (en) 2014-02-25
ES2366390T3 (es) 2011-10-19
DK2049464T3 (da) 2011-08-15
CA2658648A1 (en) 2008-01-31
HK1130247A1 (pt) 2009-12-24
WO2008012046A1 (en) 2008-01-31
EP2049464B1 (en) 2011-07-06
IL196626A (en) 2013-07-31
NZ573906A (en) 2011-04-29
TWI401237B (zh) 2013-07-11
BRPI0714648A2 (pt) 2013-05-07
ATE515491T1 (de) 2011-07-15
KR101433685B1 (ko) 2014-08-25
CN101495446A (zh) 2009-07-29
BRPI0714648B1 (pt) 2021-02-02
SI2049464T1 (sl) 2011-10-28
HRP20110572T1 (hr) 2011-09-30
KR20090035003A (ko) 2009-04-08
NO341683B1 (no) 2017-12-18
ZA200901279B (en) 2010-02-24
US8263809B2 (en) 2012-09-11
JP2009544637A (ja) 2009-12-17
RU2009106169A (ru) 2010-08-27
PL2049464T3 (pl) 2011-11-30
US20090326271A1 (en) 2009-12-31
JP5357756B2 (ja) 2013-12-04

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NO20171811A1 (no) Fremgangsmåte for fremstilling av (1R,2R)-3-(3-dimetylamino-1-etyl-2-metyl-propyl)-fenol
EA200970147A1 (ru) Получение (2r,3r)-3-(3-метоксифенил)-n,n,2-триметилпентанамина

Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/07/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF