BRPI0708942A2 - composto promotor de apoptose, uso e mÉtodo de produÇço do mesmo e composiÇço farmacÊutica - Google Patents
composto promotor de apoptose, uso e mÉtodo de produÇço do mesmo e composiÇço farmacÊutica Download PDFInfo
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- BRPI0708942A2 BRPI0708942A2 BRPI0708942-2A BRPI0708942A BRPI0708942A2 BR PI0708942 A2 BRPI0708942 A2 BR PI0708942A2 BR PI0708942 A BRPI0708942 A BR PI0708942A BR PI0708942 A2 BRPI0708942 A2 BR PI0708942A2
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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Applications Claiming Priority (5)
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| US78461206P | 2006-03-21 | 2006-03-21 | |
| US60/784,612 | 2006-05-21 | ||
| US85497506P | 2006-10-27 | 2006-10-27 | |
| US60/854,975 | 2006-10-27 | ||
| PCT/US2007/064569 WO2007136921A2 (en) | 2006-03-21 | 2007-03-21 | Small molecule apoptosis promoters |
Publications (1)
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| BRPI0708942A2 true BRPI0708942A2 (pt) | 2011-06-14 |
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| Country | Link |
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| EP (1) | EP1996184A4 (enExample) |
| JP (1) | JP2009530424A (enExample) |
| AU (1) | AU2007254033A1 (enExample) |
| BR (1) | BRPI0708942A2 (enExample) |
| CA (1) | CA2646186A1 (enExample) |
| MX (1) | MX2008012053A (enExample) |
| WO (1) | WO2007136921A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1773766B1 (en) * | 2004-07-15 | 2014-04-02 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
| ATE477254T1 (de) | 2004-12-20 | 2010-08-15 | Genentech Inc | Pyrrolidine als inhibitoren von iap |
| BRPI0607988A2 (pt) | 2005-02-25 | 2009-10-27 | Tetralogic Pharmaceuticals | composto, composição farmacêutica, e método para induzir apoptose em uma célula |
| US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
| JP2009512719A (ja) | 2005-10-25 | 2009-03-26 | アエゲラ セラピューティクス インコーポレイテッド | Iapbirドメイン結合化合物 |
| CN101374829A (zh) | 2005-12-19 | 2009-02-25 | 健泰科生物技术公司 | Iap的抑制剂 |
| TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
| CA2646186A1 (en) * | 2006-03-21 | 2007-11-29 | Joyant Pharmaceuticals, Inc. | Small molecule apoptosis promoters |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| WO2008014238A2 (en) * | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| US20100144650A1 (en) * | 2006-07-24 | 2010-06-10 | Tetralogic Pharmaceuticals Corporation | Dimeric iap inhibitors |
| WO2008014252A2 (en) | 2006-07-24 | 2008-01-31 | Tetralogic Pharmaceuticals Corporation | Iap inhibitors |
| AR063943A1 (es) | 2006-07-24 | 2009-03-04 | Tetralogic Pharmaceuticals Cor | Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer. |
| CN101687787A (zh) | 2007-04-30 | 2010-03-31 | 健泰科生物技术公司 | Iap的抑制剂 |
| JP2010528587A (ja) * | 2007-05-07 | 2010-08-26 | テトラロジック ファーマシューティカルズ コーポレーション | アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてTNFα遺伝子の発現を用いる方法 |
| NZ590550A (en) | 2008-08-02 | 2013-05-31 | Genentech Inc | Inhibitors of Apoptosis (IAP) for treating cancer |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| TW201109335A (en) | 2009-08-04 | 2011-03-16 | Takeda Pharmaceutical | Heterocyclic compounds |
| WO2011059763A2 (en) | 2009-10-28 | 2011-05-19 | Joyant Pharmaceuticals, Inc. | Dimeric smac mimetics |
| ES2513291T3 (es) | 2009-10-29 | 2014-10-24 | Janssen Pharmaceutica Nv | Derivados alquinilo útiles como inhibidores de la DPP-1 |
| EP2534170B1 (en) | 2010-02-12 | 2017-04-19 | Pharmascience Inc. | Iap bir domain binding compounds |
| UY33236A (es) | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| JP5906253B2 (ja) * | 2010-12-16 | 2016-04-20 | アッヴィ・インコーポレイテッド | 抗ウイルス性化合物 |
| WO2013058825A1 (en) * | 2011-04-07 | 2013-04-25 | Cornell University | Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same |
| WO2014025759A1 (en) * | 2012-08-09 | 2014-02-13 | Bristol-Myers Squibb Company | Iap antagonists |
| PL405505A1 (pl) * | 2013-09-30 | 2015-04-13 | Warszawski Uniwersytet Medyczny | Zastosowanie pochodnej kwasu diaminodikarboksylowego jako inhibitora aktywności biologicznej IL-15 I IL-2 |
| RU2685505C1 (ru) * | 2018-11-29 | 2019-04-19 | Михаил Владимирович Овчинников | Гетероциклические амиды тирозина, обладающие анальгетическим, противовоспалительным и противоотечным действием |
| US20220220152A1 (en) * | 2019-04-05 | 2022-07-14 | Hepagene Therapeutics (HK) Limited | Bivalent antagonists of inhibitors of apoptosis proteins |
| WO2021148396A1 (en) | 2020-01-20 | 2021-07-29 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| WO2022198196A1 (en) | 2021-03-15 | 2022-09-22 | Maze Therapeutics, Inc. | Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1495124A2 (en) | 2002-04-17 | 2005-01-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Smac-peptides as therapeutics against cancer and autoimmune diseases |
| CA2582734C (en) * | 2004-03-01 | 2011-05-03 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
| EP1773766B1 (en) * | 2004-07-15 | 2014-04-02 | Tetralogic Pharmaceuticals Corporation | Iap binding compounds |
| JP2009512719A (ja) * | 2005-10-25 | 2009-03-26 | アエゲラ セラピューティクス インコーポレイテッド | Iapbirドメイン結合化合物 |
| TWI543988B (zh) * | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
| CA2646186A1 (en) * | 2006-03-21 | 2007-11-29 | Joyant Pharmaceuticals, Inc. | Small molecule apoptosis promoters |
-
2007
- 2007-03-21 CA CA002646186A patent/CA2646186A1/en not_active Abandoned
- 2007-03-21 JP JP2009509903A patent/JP2009530424A/ja not_active Withdrawn
- 2007-03-21 WO PCT/US2007/064569 patent/WO2007136921A2/en not_active Ceased
- 2007-03-21 AU AU2007254033A patent/AU2007254033A1/en not_active Abandoned
- 2007-03-21 EP EP07759058A patent/EP1996184A4/en not_active Withdrawn
- 2007-03-21 US US11/726,602 patent/US7807699B2/en not_active Expired - Fee Related
- 2007-03-21 BR BRPI0708942-2A patent/BRPI0708942A2/pt not_active IP Right Cessation
- 2007-03-21 MX MX2008012053A patent/MX2008012053A/es unknown
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2010
- 2010-10-04 US US12/897,760 patent/US8222291B2/en not_active Expired - Fee Related
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2012
- 2012-06-28 US US13/536,974 patent/US8586542B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2646186A1 (en) | 2007-11-29 |
| MX2008012053A (es) | 2008-12-17 |
| WO2007136921A3 (en) | 2008-03-20 |
| WO2007136921A8 (en) | 2008-10-23 |
| US7807699B2 (en) | 2010-10-05 |
| EP1996184A2 (en) | 2008-12-03 |
| WO2007136921A2 (en) | 2007-11-29 |
| US8586542B2 (en) | 2013-11-19 |
| EP1996184A4 (en) | 2010-09-22 |
| US20080051389A1 (en) | 2008-02-28 |
| JP2009530424A (ja) | 2009-08-27 |
| AU2007254033A1 (en) | 2007-11-29 |
| US20130281385A1 (en) | 2013-10-24 |
| US20120082640A1 (en) | 2012-04-05 |
| US8222291B2 (en) | 2012-07-17 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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