BRPI0613676A2

BRPI0613676A2 - polipeptìdeo, seu uso e composição farmacêutica compreendendo o mesmo

polipeptìdeo, seu uso e composição farmacêutica compreendendo o mesmo Download PDF

Info

Publication number: BRPI0613676A2
Authority: BR; Brazil
Prior art keywords: tfpi; polypeptide; lys; seq; amino acids
Prior art date: 2005-07-22

Application number

BRPI0613676-1A

Other languages

English (en)

Portuguese (pt)

Inventor

Sabine Schirm

Stephen Hardy

Original Assignee

Novartis Ag

Priority date

2005-07-22

Filing date

2006-07-24

Publication date

2011-01-25

2006-07-24 Application filed by Novartis Ag filed Critical Novartis Ag

2011-01-25 Publication of BRPI0613676A2 publication Critical patent/BRPI0613676A2/pt

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 227
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 155
229920001184 polypeptide Polymers 0.000 title claims abstract description 129
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 14
150000001413 amino acids Chemical class 0.000 claims abstract description 82
239000012634 fragment Substances 0.000 claims abstract description 46
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208000015181 infectious disease Diseases 0.000 claims abstract description 22
239000003814 drug Substances 0.000 claims abstract description 13
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125000003275 alpha amino acid group Chemical group 0.000 claims description 35
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FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
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SJNZALDHDUYDBU-IHRRRGAJSA-N Lys-Arg-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(O)=O SJNZALDHDUYDBU-IHRRRGAJSA-N 0.000 description 8
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239000004472 Lysine Substances 0.000 description 4
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