JP2009502810A - 補体系と相互作用する抗微生物剤 - Google Patents

補体系と相互作用する抗微生物剤 Download PDF

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Publication number
JP2009502810A
JP2009502810A JP2008523045A JP2008523045A JP2009502810A JP 2009502810 A JP2009502810 A JP 2009502810A JP 2008523045 A JP2008523045 A JP 2008523045A JP 2008523045 A JP2008523045 A JP 2008523045A JP 2009502810 A JP2009502810 A JP 2009502810A
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JP
Japan
Prior art keywords
tfpi
polypeptide
seq
peptide
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008523045A
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English (en)
Japanese (ja)
Other versions
JP2009502810A5 (enExample
Inventor
サビーヌ・シャーム
スティーブン・ハーディ
Original Assignee
ノバルティス アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2009502810A publication Critical patent/JP2009502810A/ja
Publication of JP2009502810A5 publication Critical patent/JP2009502810A5/ja
Pending legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114Kunitz type inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2008523045A 2005-07-22 2006-07-24 補体系と相互作用する抗微生物剤 Pending JP2009502810A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70204905P 2005-07-22 2005-07-22
US72251205P 2005-09-29 2005-09-29
PCT/US2006/028804 WO2007014199A2 (en) 2005-07-22 2006-07-24 Tfpi fragments as anti-microbial agents

Publications (2)

Publication Number Publication Date
JP2009502810A true JP2009502810A (ja) 2009-01-29
JP2009502810A5 JP2009502810A5 (enExample) 2009-04-30

Family

ID=37683904

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008523045A Pending JP2009502810A (ja) 2005-07-22 2006-07-24 補体系と相互作用する抗微生物剤

Country Status (9)

Country Link
US (1) US20090176701A1 (enExample)
EP (1) EP1913025A2 (enExample)
JP (1) JP2009502810A (enExample)
KR (1) KR20080040676A (enExample)
AU (1) AU2006272653A1 (enExample)
BR (1) BRPI0613676A2 (enExample)
CA (1) CA2615777A1 (enExample)
RU (1) RU2008106460A (enExample)
WO (1) WO2007014199A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129164A1 (en) * 2008-04-15 2009-10-22 Novartis Ag Pharmaceutical combinations of tfpi-fragments and an antibiotic
GB0916578D0 (en) * 2009-09-22 2009-10-28 Malmsten Nils M Polypeptides and uses thereof
WO2023142096A1 (en) * 2022-01-30 2023-08-03 Westlake University Composition and method for preventing and/or treating clostridioides difficile infections caused by clade 2 strains

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005515214A (ja) * 2001-10-15 2005-05-26 カイロン コーポレイション 組織因子経路インヒビター(tfpi)の低量投与による敗血症の処置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005515214A (ja) * 2001-10-15 2005-05-26 カイロン コーポレイション 組織因子経路インヒビター(tfpi)の低量投与による敗血症の処置

Also Published As

Publication number Publication date
EP1913025A2 (en) 2008-04-23
WO2007014199A3 (en) 2007-05-24
KR20080040676A (ko) 2008-05-08
BRPI0613676A2 (pt) 2011-01-25
CA2615777A1 (en) 2007-02-01
RU2008106460A (ru) 2009-08-27
WO2007014199A2 (en) 2007-02-01
US20090176701A1 (en) 2009-07-09
AU2006272653A1 (en) 2007-02-01

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