JP2009502810A5 - - Google Patents

Info

Publication number

JP2009502810A5

JP2009502810A5 JP2008523045A JP2008523045A JP2009502810A5 JP 2009502810 A5 JP2009502810 A5 JP 2009502810A5 JP 2008523045 A JP2008523045 A JP 2008523045A JP 2008523045 A JP2008523045 A JP 2008523045A JP 2009502810 A5 JP2009502810 A5 JP 2009502810A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acids

infection

pharmaceutical composition

Prior art date

2006-07-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001184 polypeptide Polymers 0.000 claims 10
• 102000004196 processed proteins & peptides Human genes 0.000 claims 10
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 208000015181 infectious disease Diseases 0.000 claims 9
• 150000001413 amino acids Chemical class 0.000 claims 7
• 230000000813 microbial effect Effects 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 241001465754 Metazoa Species 0.000 claims 3
• 208000027096 gram-negative bacterial infections Diseases 0.000 claims 3
• 241000588724 Escherichia coli Species 0.000 claims 2
• 206010040047 Sepsis Diseases 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 101000653189 Homo sapiens Tissue factor pathway inhibitor Proteins 0.000 claims 1
• 230000004154 complement system Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 244000005700 microbiome Species 0.000 claims 1