BRPI0519354B8 - método para detecção de um anticorpo terapêutico e uso de um anticorpo - Google Patents
método para detecção de um anticorpo terapêutico e uso de um anticorpoInfo
- Publication number
- BRPI0519354B8 BRPI0519354B8 BRPI0519354A BRPI0519354A BRPI0519354B8 BR PI0519354 B8 BRPI0519354 B8 BR PI0519354B8 BR PI0519354 A BRPI0519354 A BR PI0519354A BR PI0519354 A BRPI0519354 A BR PI0519354A BR PI0519354 B8 BRPI0519354 B8 BR PI0519354B8
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- therapeutic
- sample
- therapeutic antibody
- detecting
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
Abstract
método para detecção de um anticorpo terapêutico e uso de um anticorpo. a presente invenção refere-se ao campo dos anticorpos terapêuticos. refere-se especialmente ao estudo dos anticorpos terapêuticos em um animal experimental. a presente invenção descreve um método para a detecção de um anticorpo terapêutico em uma amostra obtida a partir de um animal experimental compreendendo as etapas de (a) provendo a amostra a ser analisada, (b) incubando a referida amostra com um anticorpo que se liga a um anticorpo terapêutico e não se liga a imunoglobulina do referido animal experimental, (c) opcionalmente incubando a referida amostra com um reagente apropriado para a detecção seletiva do anticorpo terapêutico total, ativo ou ligado ao antígeno, e (d) correlacionando o complexo formado em (b) ou (c) com a concentração do referido anticorpo terapêutico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04030545 | 2004-12-23 | ||
| PCT/EP2005/013849 WO2006066912A2 (en) | 2004-12-23 | 2005-12-22 | Detection of a therapeutic antibody in an experimental animal |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0519354A2 BRPI0519354A2 (pt) | 2009-01-20 |
| BRPI0519354B1 BRPI0519354B1 (pt) | 2020-06-09 |
| BRPI0519354B8 true BRPI0519354B8 (pt) | 2021-07-27 |
Family
ID=34927934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519354A BRPI0519354B8 (pt) | 2004-12-23 | 2005-12-22 | método para detecção de um anticorpo terapêutico e uso de um anticorpo |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7955806B2 (pt) |
| EP (2) | EP2237041A1 (pt) |
| JP (2) | JP4664377B2 (pt) |
| KR (1) | KR100950635B1 (pt) |
| CN (1) | CN101088014B (pt) |
| AT (1) | ATE503187T1 (pt) |
| AU (2) | AU2005318407B2 (pt) |
| BR (1) | BRPI0519354B8 (pt) |
| CA (1) | CA2589054C (pt) |
| DE (1) | DE602005027127D1 (pt) |
| ES (1) | ES2360369T5 (pt) |
| MX (1) | MX2007006895A (pt) |
| RU (1) | RU2393483C2 (pt) |
| SG (1) | SG164389A1 (pt) |
| WO (1) | WO2006066912A2 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2221619A1 (en) * | 2006-09-12 | 2010-08-25 | F. Hoffmann-La Roche AG | Anti-drug antibody assay |
| CN101506659B (zh) * | 2006-09-12 | 2012-12-12 | 弗·哈夫曼-拉罗切有限公司 | 抗药物抗体测定法 |
| WO2010042031A1 (en) * | 2008-10-07 | 2010-04-15 | Gyros Patent Ab | Semi-sequential assay for detection of an analyte in a sample |
| EP2356148A2 (en) * | 2008-11-10 | 2011-08-17 | Novartis AG | Antibodies to modified human igf-1/e peptides |
| BR112012005668A2 (pt) * | 2009-10-19 | 2020-10-13 | F. Hoffmann La Roche Ag | '' linhagem celular, anticorpo, uso de um anticorpo, kit, método de detecção de um anticorpo terapêutico, método de determinação imunológica de um anticorpo terapêutico, composição de anticorpo, uso de uma composição de anticorpo'' |
| JP5766286B2 (ja) | 2010-08-17 | 2015-08-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ヒトＩｇＧ１抗体 |
| RU2638812C2 (ru) | 2012-03-08 | 2017-12-15 | Ф. Хоффманн-Ля Рош Аг | Мультиплексный иммунохроматографический способ определения циркулирующих иммунокомплексов |
| EP2885639B1 (en) | 2012-08-17 | 2019-04-10 | MorphoSys AG | Complex-specific antibodies and antibody fragments and their use |
| JP6561043B2 (ja) * | 2013-03-20 | 2019-08-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | マウス血清中のラット抗体の特異的検出 |
| JP6985572B2 (ja) | 2015-11-09 | 2021-12-22 | 国立大学法人京都工芸繊維大学 | 単鎖抗体のスクリーニング方法及び単鎖抗体 |
| CN107703310B (zh) * | 2017-10-11 | 2019-08-30 | 潍坊医学院附属医院 | 一种针对老鼠免疫抗体的实验操作系统 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2095818B (en) | 1981-03-27 | 1985-10-02 | Exxon Research Engineering Co | Staged adsorption/resorption heat pump |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4870003A (en) * | 1987-06-15 | 1989-09-26 | Coulter Corporation | Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans |
| US4816067A (en) * | 1988-06-20 | 1989-03-28 | Gte Products Corporation | Process for producing fine spherical particles |
| JP4124480B2 (ja) * | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| WO1998004281A1 (en) * | 1996-07-26 | 1998-02-05 | Smithkline Beecham Corpration | Improved method of treating immune cell mediated systemic diseases |
| US6525174B1 (en) * | 1997-06-06 | 2003-02-25 | Human Genome Sciences, Inc. | Precerebellin-like protein |
| US6413783B1 (en) * | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| JP2000304750A (ja) * | 1999-04-16 | 2000-11-02 | Fuji Photo Film Co Ltd | 発光標識イムノアッセイ及びその分析要素 |
| IT1315254B1 (it) * | 1999-11-05 | 2003-02-03 | Diesse Diagnostica Senese Spa | Metodo per la determinazione qualitativa e quantitativa di anticorpiumani di classe igc. |
| AUPR617901A0 (en) * | 2001-07-06 | 2001-08-02 | Pacmab Pty Ltd | Method for treating multiple myeloma |
| EP2131198B1 (en) * | 2001-09-20 | 2013-03-27 | Board of Regents, The University of Texas System | Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays |
| JP4636225B2 (ja) | 2002-11-30 | 2011-02-23 | 司甫 横山 | 検査試薬キット |
-
2005
- 2005-12-22 BR BRPI0519354A patent/BRPI0519354B8/pt active IP Right Grant
- 2005-12-22 DE DE602005027127T patent/DE602005027127D1/de active Active
- 2005-12-22 US US11/792,910 patent/US7955806B2/en active Active
- 2005-12-22 AU AU2005318407A patent/AU2005318407B2/en active Active
- 2005-12-22 MX MX2007006895A patent/MX2007006895A/es active IP Right Grant
- 2005-12-22 RU RU2007128103/15A patent/RU2393483C2/ru active
- 2005-12-22 KR KR1020077014471A patent/KR100950635B1/ko active IP Right Grant
- 2005-12-22 ES ES05824356T patent/ES2360369T5/es active Active
- 2005-12-22 SG SG201005471-6A patent/SG164389A1/en unknown
- 2005-12-22 EP EP10155679A patent/EP2237041A1/en not_active Withdrawn
- 2005-12-22 CA CA2589054A patent/CA2589054C/en active Active
- 2005-12-22 CN CN2005800444980A patent/CN101088014B/zh active Active
- 2005-12-22 AT AT05824356T patent/ATE503187T1/de active
- 2005-12-22 EP EP05824356.9A patent/EP1853921B2/en active Active
- 2005-12-22 JP JP2007547356A patent/JP4664377B2/ja active Active
- 2005-12-22 WO PCT/EP2005/013849 patent/WO2006066912A2/en active Application Filing
-
2010
- 2010-01-27 AU AU2010200299A patent/AU2010200299A1/en not_active Abandoned
- 2010-09-28 JP JP2010216636A patent/JP2011039072A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2360369T3 (es) | 2011-06-03 |
| WO2006066912A2 (en) | 2006-06-29 |
| DE602005027127D1 (de) | 2011-05-05 |
| JP2011039072A (ja) | 2011-02-24 |
| CA2589054A1 (en) | 2006-06-29 |
| EP1853921B1 (en) | 2011-03-23 |
| ES2360369T5 (es) | 2021-12-13 |
| EP1853921B2 (en) | 2021-07-21 |
| BRPI0519354B1 (pt) | 2020-06-09 |
| RU2393483C2 (ru) | 2010-06-27 |
| KR20070086642A (ko) | 2007-08-27 |
| CN101088014B (zh) | 2012-10-03 |
| US7955806B2 (en) | 2011-06-07 |
| WO2006066912A3 (en) | 2006-08-10 |
| ATE503187T1 (de) | 2011-04-15 |
| US20080102474A1 (en) | 2008-05-01 |
| AU2005318407B2 (en) | 2009-11-05 |
| EP2237041A1 (en) | 2010-10-06 |
| SG164389A1 (en) | 2010-09-29 |
| BRPI0519354A2 (pt) | 2009-01-20 |
| KR100950635B1 (ko) | 2010-04-01 |
| EP1853921A2 (en) | 2007-11-14 |
| RU2007128103A (ru) | 2009-01-27 |
| AU2010200299A1 (en) | 2010-02-18 |
| AU2005318407A1 (en) | 2006-06-29 |
| MX2007006895A (es) | 2007-06-26 |
| CN101088014A (zh) | 2007-12-12 |
| JP2008525766A (ja) | 2008-07-17 |
| CA2589054C (en) | 2010-11-02 |
| WO2006066912A9 (en) | 2007-02-22 |
| JP4664377B2 (ja) | 2011-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: REF. A RPI NO 2150 DE 20/03/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO. |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/06/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/12/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |