WO2007076013A3 - Homocysteine immunoassay - Google Patents

Homocysteine immunoassay Download PDF

Info

Publication number
WO2007076013A3
WO2007076013A3 PCT/US2006/049024 US2006049024W WO2007076013A3 WO 2007076013 A3 WO2007076013 A3 WO 2007076013A3 US 2006049024 W US2006049024 W US 2006049024W WO 2007076013 A3 WO2007076013 A3 WO 2007076013A3
Authority
WO
WIPO (PCT)
Prior art keywords
homocysteine
immunoreaction
influence
inhibiting substances
immunoassay
Prior art date
Application number
PCT/US2006/049024
Other languages
French (fr)
Other versions
WO2007076013A2 (en
Inventor
Toru Yoshimura
Original Assignee
Abbott Lab
Toru Yoshimura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Toru Yoshimura filed Critical Abbott Lab
Priority to CA002634899A priority Critical patent/CA2634899A1/en
Priority to EP06848972A priority patent/EP1977253A2/en
Priority to US11/646,697 priority patent/US20070259376A1/en
Publication of WO2007076013A2 publication Critical patent/WO2007076013A2/en
Publication of WO2007076013A3 publication Critical patent/WO2007076013A3/en
Priority to US12/575,131 priority patent/US20100022029A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine

Abstract

In homocysteine immunoassays, it is known that the measured values are dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily and efficiently suppressed or eliminated, and also provides a kit used for such a method. The influence of the immunoreaction inhibiting substances is suppressed or eliminated when the homocysteine contained in biological samples is reacted with an antibody in the presence of extrinsic polyanion.
PCT/US2006/049024 2005-12-22 2006-12-21 Homocysteine immunoassay WO2007076013A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002634899A CA2634899A1 (en) 2005-12-22 2006-12-21 Homocysteine immunoassay
EP06848972A EP1977253A2 (en) 2005-12-22 2006-12-21 Homocysteine immunoassay
US11/646,697 US20070259376A1 (en) 2005-12-22 2006-12-28 Homocysteine immunoassay
US12/575,131 US20100022029A1 (en) 2005-12-22 2009-10-07 Homocysteine immunoassay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-369198 2005-12-22
JP2005369198A JP2007170992A (en) 2005-12-22 2005-12-22 Method for immunological measurement of homocysteines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/646,697 Continuation-In-Part US20070259376A1 (en) 2005-12-22 2006-12-28 Homocysteine immunoassay

Publications (2)

Publication Number Publication Date
WO2007076013A2 WO2007076013A2 (en) 2007-07-05
WO2007076013A3 true WO2007076013A3 (en) 2007-09-13

Family

ID=38164471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/049024 WO2007076013A2 (en) 2005-12-22 2006-12-21 Homocysteine immunoassay

Country Status (4)

Country Link
EP (1) EP1977253A2 (en)
JP (1) JP2007170992A (en)
CA (1) CA2634899A1 (en)
WO (1) WO2007076013A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010127827A (en) * 2008-11-28 2010-06-10 Abbott Japan Co Ltd Nonspecific interaction inhibitor, and its application to diagnostic measuring system
DE102010002546B4 (en) 2009-03-05 2018-05-09 Denso Corporation Signal processing circuit of a rotation detector and rotation angle detector
JP4947128B2 (en) 2009-11-25 2012-06-06 株式会社デンソー Rotation detection device signal processing circuit
JP5919914B2 (en) * 2012-03-15 2016-05-18 東ソー株式会社 Pretreatment reagent for homocysteine measurement
WO2017179611A1 (en) 2016-04-13 2017-10-19 株式会社Ｌｓｉメディエンス Immunoassay employing sulfated polysaccharide
WO2018138264A2 (en) 2017-01-27 2018-08-02 Roche Diagnostics Gmbh Methods for modulating signal intensity in interaction assays
CN113030470B (en) * 2021-02-24 2022-03-18 江西英大生物技术有限公司 Creatine kinase isoenzyme determination kit

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478729A (en) * 1994-04-28 1995-12-26 Syntex (U.S.A.) Inc. Immunoassay for homocysteine
WO2000040973A1 (en) * 1999-01-05 2000-07-13 Axis-Shield Asa Assay for homocysteine
WO2002028407A1 (en) * 2000-09-29 2002-04-11 University Of Connecticut Health Center Methods of recovering heat shock proteins and complexes thereof
US20030124616A1 (en) * 2001-06-21 2003-07-03 Jacobsen Donald W. Homocysteinylated transthyretin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726322B2 (en) * 1992-01-22 2011-12-07 Axis-Shield ASA Homocysteine assay

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478729A (en) * 1994-04-28 1995-12-26 Syntex (U.S.A.) Inc. Immunoassay for homocysteine
WO2000040973A1 (en) * 1999-01-05 2000-07-13 Axis-Shield Asa Assay for homocysteine
WO2002028407A1 (en) * 2000-09-29 2002-04-11 University Of Connecticut Health Center Methods of recovering heat shock proteins and complexes thereof
US20030124616A1 (en) * 2001-06-21 2003-07-03 Jacobsen Donald W. Homocysteinylated transthyretin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DUCROS V ET AL: "Methods for homocysteine analysis and biological relevance of the results", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 781, no. 1-2, 5 December 2002 (2002-12-05), pages 207 - 226, XP004394155, ISSN: 1570-0232 *

Also Published As

Publication number Publication date
EP1977253A2 (en) 2008-10-08
JP2007170992A (en) 2007-07-05
WO2007076013A2 (en) 2007-07-05
CA2634899A1 (en) 2007-07-05

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