BRPI0519000A2 - variantes de il-7 com imunogenicidade reduzida - Google Patents
variantes de il-7 com imunogenicidade reduzidaInfo
- Publication number
- BRPI0519000A2 BRPI0519000A2 BRPI0519000-2A BRPI0519000A BRPI0519000A2 BR PI0519000 A2 BRPI0519000 A2 BR PI0519000A2 BR PI0519000 A BRPI0519000 A BR PI0519000A BR PI0519000 A2 BRPI0519000 A2 BR PI0519000A2
- Authority
- BR
- Brazil
- Prior art keywords
- variants
- reduced immunogenicity
- polypeptides
- modified
- alterations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
VARIANTES DE IL-7 COM IMUNOGENICIDADE REDUZIDA. A presente invenção refere-se em geral a moléculas de IL-7 modificadas para reduzir sua imunogenicidade. Essas moléculas incluem também proteínas de fusão compreendendo as ditas moléculas de IL-7 modificadas e moléculas de imunoglobulina ou porções das mesmas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63447004P | 2004-12-09 | 2004-12-09 | |
PCT/EP2005/013145 WO2006061219A2 (en) | 2004-12-09 | 2005-12-08 | Il-7 variants with reduced immunogenicity |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0519000A2 true BRPI0519000A2 (pt) | 2008-12-23 |
Family
ID=36578271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0519000-2A BRPI0519000A2 (pt) | 2004-12-09 | 2005-12-08 | variantes de il-7 com imunogenicidade reduzida |
Country Status (14)
Country | Link |
---|---|
US (1) | US7589179B2 (pt) |
EP (1) | EP1819728B1 (pt) |
JP (1) | JP4937132B2 (pt) |
KR (1) | KR20070085886A (pt) |
CN (1) | CN101072793B (pt) |
AT (1) | ATE465176T1 (pt) |
AU (1) | AU2005313492B2 (pt) |
BR (1) | BRPI0519000A2 (pt) |
CA (1) | CA2591297C (pt) |
DE (1) | DE602005020837D1 (pt) |
ES (1) | ES2342964T3 (pt) |
RU (1) | RU2437893C2 (pt) |
WO (1) | WO2006061219A2 (pt) |
ZA (1) | ZA200705559B (pt) |
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ATE400030T1 (de) | 2001-02-19 | 2008-07-15 | Merck Patent Gmbh | Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität |
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CA2440221C (en) | 2001-03-07 | 2013-02-05 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Expression technology for proteins containing a hybrid isotype antibody moiety |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
DE10119338A1 (de) | 2001-04-20 | 2002-10-24 | Clariant Gmbh | Verwendung von Copolymerisaten auf Basis von Acrylamidoalkylsulfonsäuren als Verdicker in Zubereitungen enthaltend organische Lösemittel |
DE60239454D1 (de) | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
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EP1699821B1 (en) | 2003-12-31 | 2012-06-20 | Merck Patent GmbH | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
AU2005206277B2 (en) | 2004-01-22 | 2011-06-23 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
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KR20070085886A (ko) | 2004-12-09 | 2007-08-27 | 메르크 파텐트 게엠베하 | 감소된 면역원성의 il-7 변이체 |
-
2005
- 2005-12-08 KR KR1020077012885A patent/KR20070085886A/ko not_active Application Discontinuation
- 2005-12-08 CN CN2005800422055A patent/CN101072793B/zh not_active Expired - Fee Related
- 2005-12-08 DE DE602005020837T patent/DE602005020837D1/de active Active
- 2005-12-08 ES ES05850240T patent/ES2342964T3/es active Active
- 2005-12-08 AT AT05850240T patent/ATE465176T1/de not_active IP Right Cessation
- 2005-12-08 RU RU2007125381/10A patent/RU2437893C2/ru not_active IP Right Cessation
- 2005-12-08 US US11/297,166 patent/US7589179B2/en not_active Expired - Fee Related
- 2005-12-08 WO PCT/EP2005/013145 patent/WO2006061219A2/en active Application Filing
- 2005-12-08 CA CA2591297A patent/CA2591297C/en not_active Expired - Fee Related
- 2005-12-08 BR BRPI0519000-2A patent/BRPI0519000A2/pt not_active IP Right Cessation
- 2005-12-08 AU AU2005313492A patent/AU2005313492B2/en not_active Ceased
- 2005-12-08 EP EP05850240A patent/EP1819728B1/en not_active Not-in-force
- 2005-12-08 JP JP2007544816A patent/JP4937132B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-06 ZA ZA200705559A patent/ZA200705559B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES2342964T3 (es) | 2010-07-20 |
JP4937132B2 (ja) | 2012-05-23 |
CN101072793A (zh) | 2007-11-14 |
ATE465176T1 (de) | 2010-05-15 |
WO2006061219A2 (en) | 2006-06-15 |
CN101072793B (zh) | 2012-06-20 |
CA2591297A1 (en) | 2006-06-15 |
WO2006061219A3 (en) | 2007-01-11 |
JP2008522600A (ja) | 2008-07-03 |
AU2005313492B2 (en) | 2011-12-15 |
EP1819728B1 (en) | 2010-04-21 |
DE602005020837D1 (de) | 2010-06-02 |
RU2437893C2 (ru) | 2011-12-27 |
US20060141581A1 (en) | 2006-06-29 |
ZA200705559B (en) | 2008-10-29 |
US7589179B2 (en) | 2009-09-15 |
RU2007125381A (ru) | 2009-01-20 |
CA2591297C (en) | 2015-01-13 |
KR20070085886A (ko) | 2007-08-27 |
EP1819728A2 (en) | 2007-08-22 |
AU2005313492A1 (en) | 2006-06-15 |
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