BRPI0506939A - derivados de indolilmaleimida como inibidores de pkc - Google Patents

derivados de indolilmaleimida como inibidores de pkc

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Publication number
BRPI0506939A
BRPI0506939A BRPI0506939-4A BRPI0506939A BRPI0506939A BR PI0506939 A BRPI0506939 A BR PI0506939A BR PI0506939 A BRPI0506939 A BR PI0506939A BR PI0506939 A BRPI0506939 A BR PI0506939A
Authority
BR
Brazil
Prior art keywords
pkc inhibitors
indolylmaleimide derivatives
pkc
indolylmaleimide
derivatives
Prior art date
Application number
BRPI0506939-4A
Other languages
English (en)
Inventor
Maurice Van Eis
Juergen Wagner
Peter Von Matt
Jean-Pierre Evenou
Walter Schuler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0401089A external-priority patent/GB0401089D0/en
Priority claimed from GB0401090A external-priority patent/GB0401090D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0506939A publication Critical patent/BRPI0506939A/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)

Abstract

DERIVADOS DE INDOLILMALEIMIDA COMO INIBIDORES DE PKC. A presente invenção refere-se a inibidores de PKC os quais são capazes de seletivamente inibir, por exemplo, a e opcionalmente <sym>, isoforma de PKC, e seu uso em particular em transplantação.
BRPI0506939-4A 2004-01-19 2005-01-19 derivados de indolilmaleimida como inibidores de pkc BRPI0506939A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0401089A GB0401089D0 (en) 2004-01-19 2004-01-19 Organic compounds
GB0401090A GB0401090D0 (en) 2004-01-19 2004-01-19 Organic compounds
PCT/EP2005/000502 WO2005068455A1 (en) 2004-01-19 2005-01-19 Indolylmaleimde derivatives as pkc inhibitors

Publications (1)

Publication Number Publication Date
BRPI0506939A true BRPI0506939A (pt) 2007-06-12

Family

ID=34796827

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0506939-4A BRPI0506939A (pt) 2004-01-19 2005-01-19 derivados de indolilmaleimida como inibidores de pkc
BRPI0506958-0A BRPI0506958A (pt) 2004-01-19 2005-01-19 derivados de indolilmaleimida

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0506958-0A BRPI0506958A (pt) 2004-01-19 2005-01-19 derivados de indolilmaleimida

Country Status (15)

Country Link
US (2) US7691861B2 (pt)
EP (3) EP1709030B1 (pt)
JP (2) JP2007518730A (pt)
CN (1) CN101933926A (pt)
AT (1) ATE391127T1 (pt)
AU (3) AU2005205183B2 (pt)
BR (2) BRPI0506939A (pt)
CA (2) CA2552740A1 (pt)
DE (1) DE602005005787T2 (pt)
ES (2) ES2402298T3 (pt)
MX (1) MXPA06008158A (pt)
PL (1) PL1709030T3 (pt)
PT (1) PT1709030E (pt)
RU (2) RU2373201C2 (pt)
WO (2) WO2005068455A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1904482B1 (en) 2005-07-11 2011-01-19 Novartis AG Indolylmaleimide derivatives
DK2056851T3 (da) * 2005-12-09 2013-10-14 Philadelphia College Of Osteopathic Medicine Organkonservering og/eller -perfusion
US20070148628A1 (en) * 2005-12-09 2007-06-28 Philadelphia College Of Osteopathic Medicine Organ preservation and/or perfusion
MX2009005945A (es) * 2006-12-07 2009-06-17 Novartis Ag Uso de inhibidores de pkc en transplantes.
CN102838610B (zh) * 2012-08-28 2014-09-10 吕叶叶 双吲哚二氧杂双环辛二酮
MA42043A (fr) 2015-05-07 2018-03-14 Agenus Inc Anticorps anti-ox40 et procédés d'utilisation de ceux-ci
CN108348492B (zh) 2015-07-31 2021-09-28 约翰霍普金斯大学 使用谷氨酰胺类似物的用于癌症和免疫疗法的方法
US10842763B2 (en) 2015-07-31 2020-11-24 The Johns Hopkins University Methods for cancer and immunotherapy using prodrugs of glutamine analogs
MX2018001300A (es) 2015-07-31 2019-03-14 Univ Johns Hopkins Profarmacos de analogos de glutamina.
CN116063542A (zh) 2015-12-02 2023-05-05 阿吉纳斯公司 抗体和其使用方法
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
JP2020506233A (ja) 2017-02-01 2020-02-27 ザ・ジョンズ・ホプキンス・ユニバーシティー グルタミン類似体のプロドラッグ
CN110551103B (zh) 2018-05-30 2022-08-23 北京大学深圳研究生院 一种jak3选择性抑制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US36736A (en) * 1862-10-21 Improvement in curry-combs
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
USRE36736E (en) 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
PE20020544A1 (es) 2000-11-07 2002-07-30 Novartis Ag Derivados de indolilmaleimida
US6645970B2 (en) * 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
BE1014306A6 (fr) 2001-07-19 2003-08-05 Project 21C Dispositif de stationnement d'un cycle avec antivol.
TW200918046A (en) * 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
EP1513520B1 (en) * 2002-06-05 2008-09-24 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors

Also Published As

Publication number Publication date
EP1709030B1 (en) 2008-04-02
RU2006129891A (ru) 2008-02-27
JP2007518731A (ja) 2007-07-12
EP2270001A1 (en) 2011-01-05
AU2005205182B2 (en) 2009-07-16
JP4914223B2 (ja) 2012-04-11
US20080242675A1 (en) 2008-10-02
EP1745037A1 (en) 2007-01-24
DE602005005787D1 (de) 2008-05-15
WO2005068454A1 (en) 2005-07-28
ATE391127T1 (de) 2008-04-15
ES2303218T3 (es) 2008-08-01
CA2552738A1 (en) 2005-07-28
MXPA06008158A (es) 2007-01-30
RU2373201C2 (ru) 2009-11-20
WO2005068455A1 (en) 2005-07-28
AU2005205183B2 (en) 2009-08-06
EP1709030A1 (en) 2006-10-11
CN101933926A (zh) 2011-01-05
AU2009227818A1 (en) 2009-11-05
US20080234494A1 (en) 2008-09-25
RU2372348C2 (ru) 2009-11-10
EP1745037B1 (en) 2013-01-02
BRPI0506958A (pt) 2007-07-24
AU2005205182A1 (en) 2005-07-28
ES2402298T3 (es) 2013-04-30
PT1709030E (pt) 2008-07-01
CA2552740A1 (en) 2005-07-28
PL1709030T3 (pl) 2008-09-30
JP2007518730A (ja) 2007-07-12
DE602005005787T2 (de) 2009-04-30
US7648989B2 (en) 2010-01-19
RU2006129890A (ru) 2008-02-27
AU2005205183A1 (en) 2005-07-28
US7691861B2 (en) 2010-04-06

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.