BRPI0506486A - derivados de piridìnio e quinolìnio - Google Patents
derivados de piridìnio e quinolìnioInfo
- Publication number
- BRPI0506486A BRPI0506486A BRPI0506486-4A BRPI0506486A BRPI0506486A BR PI0506486 A BRPI0506486 A BR PI0506486A BR PI0506486 A BRPI0506486 A BR PI0506486A BR PI0506486 A BRPI0506486 A BR PI0506486A
- Authority
- BR
- Brazil
- Prior art keywords
- pyridinium
- blocking
- diseases
- compounds
- parasitic
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 title 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 2
- 230000000903 blocking effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000002745 Choline Kinase Human genes 0.000 abstract 1
- 108010018888 Choline kinase Proteins 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 abstract 1
- 229950004354 phosphorylcholine Drugs 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200400072A ES2237332B1 (es) | 2004-01-14 | 2004-01-14 | Derivados de piridinio y quinolinio. |
| PCT/ES2005/070002 WO2005068429A1 (es) | 2004-01-14 | 2005-01-11 | Derivados de piridinio y quinolinio |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0506486A true BRPI0506486A (pt) | 2007-02-13 |
Family
ID=34778265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0506486-4A BRPI0506486A (pt) | 2004-01-14 | 2005-01-11 | derivados de piridìnio e quinolìnio |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7781458B2 (https=) |
| EP (2) | EP2085386A3 (https=) |
| JP (2) | JP5047627B2 (https=) |
| KR (1) | KR101157206B1 (https=) |
| CN (1) | CN1910153B (https=) |
| AT (1) | ATE461918T1 (https=) |
| BR (1) | BRPI0506486A (https=) |
| CA (1) | CA2553328C (https=) |
| DE (1) | DE602005020112D1 (https=) |
| DK (1) | DK1710236T3 (https=) |
| ES (2) | ES2237332B1 (https=) |
| MX (1) | MXPA06007940A (https=) |
| PL (1) | PL1710236T3 (https=) |
| PT (1) | PT1710236E (https=) |
| WO (1) | WO2005068429A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8586613B2 (en) * | 2004-01-14 | 2013-11-19 | Universidad De Granada | Pyridinium and quinolinium derivatives |
| RU2509809C2 (ru) | 2008-07-04 | 2014-03-20 | Транслэшионал Кэнсэр Драгз Фарма, С.Л. | Способы лечения и диагностики рака |
| US20100068302A1 (en) * | 2008-09-17 | 2010-03-18 | Traslational Cancer Drugs Pharma, S.L. | Methods and compositions for the treatment of cancer |
| US20110212994A1 (en) * | 2009-06-26 | 2011-09-01 | Brian Clem | Small Molecule Choline Kinase Inhibitors, Screening Assays, and Methods for Safe and Effective Treatment of Neoplastic Disorders |
| WO2012041493A1 (en) * | 2010-09-28 | 2012-04-05 | Julius-Maximilians-Universität Würzburg | Aminoquinolinium salts, methods of their production and their use as active agents for biotechnological and medical applications against binary toxins |
| EP2468259A1 (en) * | 2010-12-23 | 2012-06-27 | Traslational Cancer Drugs Pharma, S.L. | Pharmaceutical compositions of pyridinium and quinolinium derivatives |
| JP2014527397A (ja) | 2011-06-20 | 2014-10-16 | トラスラショナル、キャンサー、ドラッグス、ファーマ、ソシエダッド、リミターダＴｒａｓｌａｔｉｏｎａｌ Ｃａｎｃｅｒ Ｄｒｕｇｓ Ｐｈａｒｍａ， Ｓ．Ｌ． | 癌患者の化学療法に対する臨床応答を予測する方法 |
| WO2013043960A1 (en) * | 2011-09-22 | 2013-03-28 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of choline kinase |
| ES2472367B1 (es) * | 2012-12-28 | 2015-06-02 | Universidad De Granada | Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica |
| WO2015028662A1 (en) | 2013-08-30 | 2015-03-05 | Consejo Superior De Investigaciones Cientificas (Csic) | Compositions and methods for characterization and amelioration of rheumatoid arthritis |
| ES2482290B1 (es) * | 2014-06-05 | 2015-05-19 | Universidad De Granada | Inhibidores polares simétricos de colina cinasa con actividad antitumoral |
| US10683292B2 (en) | 2016-07-25 | 2020-06-16 | Nerviano Medical Sciences S.R.L. | Purine and 3-deazapurine analogues as choline kinase inhibitors |
| JP7178401B2 (ja) | 2017-07-11 | 2022-11-25 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | コリンキナーゼ阻害剤としてのピラゾロキナゾリン誘導体 |
| WO2025196502A1 (en) * | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1533952A (en) * | 1976-02-25 | 1978-11-29 | Sterling Drug Inc | Anti-microbial bis-pyridinium compounds |
| US4206215A (en) * | 1976-02-25 | 1980-06-03 | Sterling Drug Inc. | Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes |
| FR2498187A1 (fr) * | 1981-01-16 | 1982-07-23 | Rhone Poulenc Sante | Procede de preparation d'amino-4 chloro-7 quinoleines |
| GT198900005A (es) * | 1988-01-29 | 1990-07-17 | Quinolinas y cinolinas substituidas. | |
| ES2117950B1 (es) | 1996-08-02 | 1999-09-16 | Univ Granada | Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular. |
-
2004
- 2004-01-14 ES ES200400072A patent/ES2237332B1/es not_active Expired - Fee Related
-
2005
- 2005-01-11 EP EP09157208A patent/EP2085386A3/en not_active Withdrawn
- 2005-01-11 BR BRPI0506486-4A patent/BRPI0506486A/pt not_active IP Right Cessation
- 2005-01-11 WO PCT/ES2005/070002 patent/WO2005068429A1/es not_active Ceased
- 2005-01-11 CA CA2553328A patent/CA2553328C/en not_active Expired - Fee Related
- 2005-01-11 MX MXPA06007940A patent/MXPA06007940A/es active IP Right Grant
- 2005-01-11 PL PL05708100T patent/PL1710236T3/pl unknown
- 2005-01-11 CN CN2005800024289A patent/CN1910153B/zh not_active Expired - Fee Related
- 2005-01-11 KR KR1020067016298A patent/KR101157206B1/ko not_active Expired - Fee Related
- 2005-01-11 ES ES05708100T patent/ES2343418T3/es not_active Expired - Lifetime
- 2005-01-11 EP EP05708100A patent/EP1710236B1/en not_active Expired - Lifetime
- 2005-01-11 JP JP2006548321A patent/JP5047627B2/ja not_active Expired - Fee Related
- 2005-01-11 US US10/597,095 patent/US7781458B2/en not_active Expired - Fee Related
- 2005-01-11 DK DK05708100.2T patent/DK1710236T3/da active
- 2005-01-11 DE DE602005020112T patent/DE602005020112D1/de not_active Expired - Lifetime
- 2005-01-11 AT AT05708100T patent/ATE461918T1/de active
- 2005-01-11 PT PT05708100T patent/PT1710236E/pt unknown
-
2012
- 2012-03-19 JP JP2012062569A patent/JP5619805B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5619805B2 (ja) | 2014-11-05 |
| EP2085386A3 (en) | 2009-10-28 |
| EP2085386A2 (en) | 2009-08-05 |
| CN1910153A (zh) | 2007-02-07 |
| ATE461918T1 (de) | 2010-04-15 |
| JP2007517837A (ja) | 2007-07-05 |
| US20070185170A1 (en) | 2007-08-09 |
| ES2237332A1 (es) | 2005-07-16 |
| JP2012149077A (ja) | 2012-08-09 |
| EP1710236B1 (en) | 2010-03-24 |
| EP1710236A1 (en) | 2006-10-11 |
| PT1710236E (pt) | 2010-06-18 |
| MXPA06007940A (es) | 2007-01-23 |
| DE602005020112D1 (de) | 2010-05-06 |
| WO2005068429A1 (es) | 2005-07-28 |
| JP5047627B2 (ja) | 2012-10-10 |
| CA2553328A1 (en) | 2005-07-28 |
| KR101157206B1 (ko) | 2012-07-06 |
| ES2343418T3 (es) | 2010-07-30 |
| DK1710236T3 (da) | 2010-07-12 |
| HK1100441A1 (en) | 2007-09-21 |
| PL1710236T3 (pl) | 2010-08-31 |
| US7781458B2 (en) | 2010-08-24 |
| CA2553328C (en) | 2012-05-15 |
| CN1910153B (zh) | 2010-05-26 |
| ES2237332B1 (es) | 2006-11-01 |
| KR20060110364A (ko) | 2006-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |