BRPI0418254A - ésteres de beta-hidróxi heteroaromáticos, opticamente ativos, processos para sua preparação a partir de beta-cetoésteres e processos para a preparação desses beta-cetoésteres - Google Patents

ésteres de beta-hidróxi heteroaromáticos, opticamente ativos, processos para sua preparação a partir de beta-cetoésteres e processos para a preparação desses beta-cetoésteres

Info

Publication number
BRPI0418254A
BRPI0418254A BRPI0418254-5A BRPI0418254A BRPI0418254A BR PI0418254 A BRPI0418254 A BR PI0418254A BR PI0418254 A BRPI0418254 A BR PI0418254A BR PI0418254 A BRPI0418254 A BR PI0418254A
Authority
BR
Brazil
Prior art keywords
beta
processes
heteroaromatic
preparation
optically active
Prior art date
Application number
BRPI0418254-5A
Other languages
English (en)
Inventor
Johannes Platzek
Ludwig Zorn
Bernd Buchmann
Werner Skuballa
Orlin Petrov
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0418254A publication Critical patent/BRPI0418254A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"éSTERES DE BETA-HIDRóXI HETEROAROMáTICOS, OPTICAMENTE ATIVOS, PROCESSOS PARA SUA PREPARAçãO A PARTIR DE BETA-CETOéSTERES E PROCESSOS PARA A PREPARAçãO DESSES BETA-CETOéSTERES". A presente invenção refere-se a ésteres de <225>-hidróxi heteroaromáticos opticamente ativos de fórmula (I) úteis na síntese de derivados de epotilona, os beta-cetoésteres de fórmula (IV) empregados para produzir estes intermediários por meio de uma hidrogenação assimétrica com um catalisador de metal quiral ou redução microbiológica ou enzimática, assim como a processos para sua produção (I), em que: A é um resíduo heteroaromático bicíclico de fórmula (A), Heteroaromático em que 'heteroaromático' representa um anel heteroaromático de 5 ou 6 membros tendo até 2 heteroátomos selecionados de oxigênio, nitrogênio ou enxofre, que é opcionalmente substituído com um ou dois substituintes selecionados de alquila, hidroxialquila opcionalmente protegida, halo-alquila, halogênio ou CN, e R é uma cadeia linear ou cadeia de alquila ramificada, opcionalmente saturada, que opcionalmente contém 1 a 3 átomos de oxigênio; fenila; ciclohexila; ou resíduo de benzila (IV).
BRPI0418254-5A 2003-12-31 2004-12-21 ésteres de beta-hidróxi heteroaromáticos, opticamente ativos, processos para sua preparação a partir de beta-cetoésteres e processos para a preparação desses beta-cetoésteres BRPI0418254A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361794A DE10361794B3 (de) 2003-12-31 2003-12-31 Optisch aktive heteroaromatische ß-Hydroxy-Ester und Verfahren zu deren Herstellung sowie deren Verwendung als Zwischenprodukte bei der Epothilon-Totalsynthese
PCT/EP2004/014753 WO2005064006A1 (en) 2003-12-31 2004-12-21 OPTICALLY ACTIVE, HETEROAROMATIC β-HYDROXY ESTERS, PROCESSES FOR THEIR PREPARATION FROM β-KETO ESTERS AND PROCESSES FOR THE PREPARATION OF THESE β-KETO ESTERS

Publications (1)

Publication Number Publication Date
BRPI0418254A true BRPI0418254A (pt) 2007-04-17

Family

ID=34716267

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418254-5A BRPI0418254A (pt) 2003-12-31 2004-12-21 ésteres de beta-hidróxi heteroaromáticos, opticamente ativos, processos para sua preparação a partir de beta-cetoésteres e processos para a preparação desses beta-cetoésteres

Country Status (17)

Country Link
EP (1) EP2113031A1 (pt)
JP (1) JP2007516999A (pt)
KR (1) KR20070029641A (pt)
CN (1) CN100510098C (pt)
AU (1) AU2004309076A1 (pt)
BR (1) BRPI0418254A (pt)
CA (1) CA2546981A1 (pt)
CR (1) CR8492A (pt)
DE (1) DE10361794B3 (pt)
EC (1) ECSP066740A (pt)
HK (1) HK1097000A1 (pt)
IL (1) IL175908A0 (pt)
MX (1) MXPA06007564A (pt)
NO (1) NO20063477L (pt)
RU (1) RU2006127553A (pt)
WO (1) WO2005064006A1 (pt)
ZA (1) ZA200606293B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104328152A (zh) * 2014-10-13 2015-02-04 青岛科技大学 一种产朊酵母催化生产亚环己基烯醇的方法
CN108118004B (zh) * 2017-12-15 2021-06-25 北京工商大学 一株喜仙人掌毕赤酵母在水果采后病害防治中的应用
CN116159601B (zh) * 2019-03-15 2024-07-23 博瑞生物医药（苏州）股份有限公司 艾日布林中间体及其制备方法
CN110283733B (zh) * 2019-06-20 2020-10-27 浙江工业大学 土星轮头酵母zjph1807及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012884A1 (en) * 1995-10-04 1997-04-10 Fmc Corporation Herbicidal 6-heterocyclic indazole derivatives
US5942644A (en) * 1997-05-27 1999-08-24 Biocatalytics, Inc. Precursors for the production of chiral vicinal aminoalcohols
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
AR023792A1 (es) * 1999-04-30 2002-09-04 Bayer Schering Pharma Ag Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos
JP2001213874A (ja) * 1999-07-22 2001-08-07 Mercian Corp イソクマリン誘導体の製造およびそのための中間体
DE10041470A1 (de) * 2000-08-18 2002-02-28 Schering Ag 12,13-Cyclopropyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
WO2003029195A1 (fr) * 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediaires pour l'elaboration d'un derive de l'epothilone, et leur procede de production
JP4432315B2 (ja) * 2002-03-19 2010-03-17 三菱化学株式会社 光学活性３−ヒドロキシ−３−（２’−チエニル）プロピオン酸エステル誘導体の製造方法

Also Published As

Publication number Publication date
CN1902322A (zh) 2007-01-24
CA2546981A1 (en) 2005-07-14
CN100510098C (zh) 2009-07-08
CR8492A (es) 2007-03-08
IL175908A0 (en) 2006-10-05
MXPA06007564A (es) 2006-12-14
EP2113031A1 (en) 2009-11-04
ECSP066740A (es) 2006-10-31
ZA200606293B (en) 2009-08-26
NO20063477L (no) 2006-08-23
JP2007516999A (ja) 2007-06-28
WO2005064006A1 (en) 2005-07-14
KR20070029641A (ko) 2007-03-14
DE10361794B3 (de) 2005-10-06
AU2004309076A1 (en) 2005-07-14
RU2006127553A (ru) 2008-02-10
HK1097000A1 (en) 2007-06-15

Similar Documents

Publication Publication Date Title
ECSP088773A (es) Derivados de amida y su aplicación para el tratamiento de enfermedades relacionadas con proteína-g
BRPI0708685B8 (pt) composto de 4-oxoquinolina, seu uso e método para produção dos mesmos
TW200745069A (en) Novel 1,4-benzothiazepine 1,1-dioxide derivative with improved properties, process for its preparation, medicaments comprising this compound and its use
TW200745070A (en) Novel 1,4-benzothiazepine 1,1-dioxide derivative with improved properties, process for its preparation, medicaments comprising this compound and their use
BRPI0510940A (pt) 1-aza-biciclo-3.1.1-nonanos
MA29464B1 (fr) Methode de preparation d&#39;acides 1,6-dihydro-6-oxo-4-pyrimidinecarboxyliques eventuellement 2-substitues
ATE517869T1 (de) Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
CY1111327T1 (el) Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος
BR0317005A (pt) Processo para a preparação de compostos ativos opticamente puros
ATE438617T1 (de) Substituierte cyclohexyl-1,4-diamin-derivate
EA200900797A1 (ru) Способ синтеза производных 3-аминотетрагидрофуран-3-карбоновой кислоты и их применение в качестве лекарственных средств
BR112012017845A2 (pt) novo processo para produção de derivados de benzofenona
AR053351A1 (es) Procedimiento para la produccion de compuesto tiazol
BRPI0606976A2 (pt) processo para preparação de intermediários
BRPI0409013A (pt) processos para preparação de um produto de reação, de uma composição farmacêutica, de uma composição agroquìmica, de uma composição de limpeza, de uma composição de tinta e de um refrigerador ou lubrificante
BRPI0418254A (pt) ésteres de beta-hidróxi heteroaromáticos, opticamente ativos, processos para sua preparação a partir de beta-cetoésteres e processos para a preparação desses beta-cetoésteres
EA200900008A1 (ru) Новые хиральные промежуточные продукты, способ их получения и их применение в производстве толтеродина, фезотеродина или их активных метаболитов
TW200624418A (en) Method for producing hydroxybenzoate compound
DE602005010369D1 (de) 2-thiaquinolizidines als Glycosidase- und Glycosyltransferase-Inhibitoren
MA30354B1 (fr) Procede de preparation de derives heterocycliques
BR112014007460A2 (pt) processos enanciosseletivos para pirrolidinas 3-aril-3-trifluorometil-substituídas inseticidas
BR112015024815A2 (pt) processo para a preparação de um composto
BRPI0719205B1 (pt) pleuromutilinas, seus intermediários, seu sal de adição de ácido e seu processo para preparação, e composição farmacêutica
BRPI0409012A (pt) processos para preparação de um produto reacional, de uma composição farmacêutica, de uma composição agroquìmica, de uma composição de limpeza, de uma composição de tinta e de um refrigerante ou lubrificante
BRPI0407480A (pt) Cristal de intermediário sintético de carbapenem

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.