BRPI0416744A - sistemas de expressão de proteìna aperfeiçoados - Google Patents
sistemas de expressão de proteìna aperfeiçoadosInfo
- Publication number
- BRPI0416744A BRPI0416744A BRPI0416744-9A BRPI0416744A BRPI0416744A BR PI0416744 A BRPI0416744 A BR PI0416744A BR PI0416744 A BRPI0416744 A BR PI0416744A BR PI0416744 A BRPI0416744 A BR PI0416744A
- Authority
- BR
- Brazil
- Prior art keywords
- expression systems
- protein expression
- improved
- improved protein
- present
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/78—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
- C12Y305/05001—Nitrilase (3.5.5.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52342003P | 2003-11-19 | 2003-11-19 | |
| US53714704P | 2004-01-16 | 2004-01-16 | |
| PCT/US2004/038884 WO2005052151A1 (en) | 2003-11-19 | 2004-11-19 | Improved protein expression systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416744A true BRPI0416744A (pt) | 2007-01-16 |
Family
ID=34636466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416744-9A BRPI0416744A (pt) | 2003-11-19 | 2004-11-19 | sistemas de expressão de proteìna aperfeiçoados |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20050186666A1 (enExample) |
| EP (1) | EP1692282B1 (enExample) |
| JP (2) | JP5087741B2 (enExample) |
| KR (1) | KR101237651B1 (enExample) |
| CN (1) | CN1906294B (enExample) |
| AU (1) | AU2004293810B2 (enExample) |
| BR (1) | BRPI0416744A (enExample) |
| CA (1) | CA2545610C (enExample) |
| MX (1) | MXPA06005634A (enExample) |
| WO (1) | WO2005052151A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| US20050186666A1 (en) | 2003-11-19 | 2005-08-25 | Dow Global Technologies Inc. | Protein expression systems |
| US8603824B2 (en) | 2004-07-26 | 2013-12-10 | Pfenex, Inc. | Process for improved protein expression by strain engineering |
| AU2006298674B2 (en) * | 2005-10-06 | 2012-05-31 | Advanced Accelerator Applications Sa | Novel selection system |
| WO2007055789A2 (en) * | 2005-10-31 | 2007-05-18 | Neose Technologies, Inc. | Expression of soluble therapeutic proteins |
| GB0602173D0 (en) | 2006-02-03 | 2006-03-15 | Avecia Ltd | Expression system |
| WO2007120932A2 (en) | 2006-04-19 | 2007-10-25 | Neose Technologies, Inc. | Expression of o-glycosylated therapeutic proteins in prokaryotic microorganisms |
| MX2008015213A (es) * | 2006-05-30 | 2008-12-09 | Dow Global Technologies Inc | Metodo de optimizacion de codon. |
| KR100824541B1 (ko) * | 2007-02-26 | 2008-04-24 | 고려대학교 산학협력단 | 항산화 효소의 과발현을 통해 환경오염물질 분해능이향상된 균주 |
| MX2009011523A (es) | 2007-04-27 | 2009-11-09 | Dow Global Technologies Inc | Metodo para clasificar rapidamente huespedes microbianos para identificar ciertas cepas con rendimiento y/o calidad mejorados en la expresion de proteinas heterologas. |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| US20100267067A1 (en) * | 2007-11-29 | 2010-10-21 | Novozymes A/S | Synthase Inhibitor Screening Method |
| EP2227553A4 (en) * | 2007-11-30 | 2011-01-19 | Scarab Genomics Llc | LAC-EXPRESSION SYSTEM |
| WO2010008764A1 (en) * | 2008-06-23 | 2010-01-21 | Dow Global Technologies Inc. | Pseudomonas fluorescens strains for production of extracellular recombinant protein |
| JP2010017131A (ja) * | 2008-07-10 | 2010-01-28 | Mitsui Eng & Shipbuild Co Ltd | モーレラ属細菌及びプライマー |
| US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8153391B2 (en) | 2008-08-29 | 2012-04-10 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8357503B2 (en) | 2008-08-29 | 2013-01-22 | Bunge Oils, Inc. | Hydrolases, nucleic acids encoding them and methods for making and using them |
| US8623652B2 (en) * | 2009-04-06 | 2014-01-07 | Lucigen Corporation | Host-vector system for cloning and expressing genes |
| EP2430164B1 (en) * | 2009-05-11 | 2017-07-19 | Pfenex, Inc. | Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein |
| UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
| UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
| WO2011109556A2 (en) | 2010-03-04 | 2011-09-09 | Pfenex Inc. | Method for producing soluble recombinant interferon protein without denaturing |
| BR112012024898A2 (pt) | 2010-03-30 | 2015-10-06 | Pfenex Inc | expressão de nível elevado de proteínas recombinantes de toxinas |
| NZ603033A (en) | 2010-04-01 | 2014-06-27 | Pfenex Inc | Methods for g-csf production in a pseudomonas host cell |
| EP4242320A3 (en) | 2010-07-12 | 2023-11-29 | Inbiose N.V. | Metabolically engineered organisms for the production of added value bio-products |
| EP3366697B1 (en) | 2010-08-10 | 2020-12-30 | Sachdev Sidhu | Specific active site inhibitors of enzymes or substrate binding partners and methods of producing same |
| PL222067B1 (pl) * | 2011-08-11 | 2016-06-30 | Inst Biotechnologii I Antybiotyków | Kaseta ekspresyjna, zastosowanie kasety ekspresyjnej, wektor ekspresyjny, komórka prokariotycznego gospodarza zawierająca wektor ekspresyjny, szczep bakteryjny oraz sposób wytwarzania polipeptydu |
| BR112014024220A2 (pt) | 2012-03-30 | 2017-07-25 | Verenium Corp | genes que codificam celulase |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| WO2014047625A1 (en) | 2012-09-24 | 2014-03-27 | Montana State University | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
| JP6448909B2 (ja) * | 2013-03-01 | 2019-01-09 | 学校法人関西学院 | 目的遺伝子を欠損した酢酸菌の製造方法及びその利用 |
| GB201308828D0 (en) | 2013-03-12 | 2013-07-03 | Verenium Corp | Phytase |
| GB201308853D0 (en) | 2013-03-12 | 2013-07-03 | Verenium Corp | Genes encoding xylanase |
| GB201308843D0 (en) | 2013-03-14 | 2013-07-03 | Verenium Corp | Phytase formulation |
| JP2016525354A (ja) | 2013-07-25 | 2016-08-25 | ビーエーエスエフ エンザイムズ エルエルシー | フィターゼ |
| AU2015271666B2 (en) | 2014-06-06 | 2021-07-08 | The Hospital For Sick Children | Soluble bacterial and fungal proteins and methods and uses thereof in inhibiting and dispersing biofilm |
| CN104004760B (zh) * | 2014-06-12 | 2017-11-28 | 华东理工大学 | 一种用于在米曲霉细胞分泌表达外源蛋白的表达设备及其米曲霉基因工程菌 |
| CA3130696A1 (en) | 2014-06-27 | 2015-12-30 | National Research Council Of Canada | Cannabichromenic acid synthase from cannabis sativa |
| WO2016004024A1 (en) | 2014-07-02 | 2016-01-07 | Sutro Biopharma, Inc. | High growth capacity auxotrophic escherichia coli and methods of use |
| CN107532190B (zh) | 2014-12-01 | 2021-07-09 | 菲尼克斯公司 | 用于肽生产的融合伴侣 |
| WO2016127137A1 (en) | 2015-02-05 | 2016-08-11 | Haeberle Adam | Compositions and methods for treating granulomatosis with polyangiitis |
| KR20170068304A (ko) * | 2015-12-09 | 2017-06-19 | 삼성전자주식회사 | 대장균 및 코마가타에이박터 속 세포에서 복제가능한 벡터, 그를 포함한 세포, 및 그를 이용하는 방법 |
| WO2019063614A1 (en) | 2017-09-26 | 2019-04-04 | Bunge Global Innovation, Llc. | ENZYMATIC REMOVAL OF CHLOROPHYLLIC SUBSTRATES FROM TRIACYLGLYCEROL OILS |
| JP7358347B2 (ja) | 2017-10-27 | 2023-10-10 | フェネックス インク． | 組み換えＥ．ｃｏｌｉアスパラギナーゼの製造のための方法 |
| EP3700915B1 (en) | 2017-10-27 | 2025-06-18 | Pelican Technology Holdings, Inc. | Bacterial leader sequences for periplasmic protein expression |
| SG11202002943PA (en) | 2017-10-27 | 2020-05-28 | Pfenex Inc | Method for production of recombinant erwinia asparaginase |
| CN108504677B (zh) * | 2018-03-06 | 2020-05-12 | 上海晶诺生物科技有限公司 | 一个用于构建谷氨酸基因家族缺失结核分枝杆菌的重组tm4噬菌体文库及其应用 |
| US11098265B2 (en) | 2019-03-27 | 2021-08-24 | Bunge Global Innovation, Llc | Silica adsorbent treatment for removal of chlorophyll derivatives from triacylglycerol-based oils |
| EP3976799A4 (en) * | 2019-05-31 | 2023-07-12 | The Trustees Of Columbia University In The City Of New York | MULTIPLICATION OF AN AUXOTROPHIC CELL LINE FOR THE PRODUCTION OF RECOMBINANT PROTEINS AND METHODS THEREOF |
| TW202122582A (zh) * | 2019-08-26 | 2021-06-16 | 美商航海家醫療公司 | 病毒蛋白之控制表現 |
| CN111041029B (zh) * | 2019-12-23 | 2022-05-10 | 中国科学院天津工业生物技术研究所 | 一种强启动子及其在产维生素b12菌株中的应用 |
| CN113025601B (zh) * | 2019-12-25 | 2024-06-21 | 上海奥博生物医药股份有限公司 | 腈水解酶启动子优化表达及应用 |
| US11746352B2 (en) | 2019-12-30 | 2023-09-05 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| US12098372B2 (en) | 2019-12-30 | 2024-09-24 | Eligo Bioscience | Microbiome modulation of a host by delivery of DNA payloads with minimized spread |
| CN112080451A (zh) * | 2020-07-13 | 2020-12-15 | 宁波大学 | 一种嗜酸乳杆菌的食品级基因表达体系及其制备方法和应用 |
| WO2022144382A1 (en) | 2020-12-30 | 2022-07-07 | Eligo Bioscience | Chimeric receptor binding proteins resistant to proteolytic degradation |
| US20220313798A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
| US11697802B2 (en) | 2021-05-12 | 2023-07-11 | Eligo Bioscience | Production bacterial cells and use thereof in production methods |
| WO2024211833A2 (en) | 2023-04-05 | 2024-10-10 | Primrose Bio, Inc. | Methods and compositions for nucleic acid synthesis |
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| US20050186666A1 (en) * | 2003-11-19 | 2005-08-25 | Dow Global Technologies Inc. | Protein expression systems |
-
2004
- 2004-11-19 US US10/994,138 patent/US20050186666A1/en not_active Abandoned
- 2004-11-19 MX MXPA06005634A patent/MXPA06005634A/es active IP Right Grant
- 2004-11-19 AU AU2004293810A patent/AU2004293810B2/en not_active Expired
- 2004-11-19 EP EP04811581A patent/EP1692282B1/en not_active Expired - Lifetime
- 2004-11-19 BR BRPI0416744-9A patent/BRPI0416744A/pt not_active IP Right Cessation
- 2004-11-19 CN CN2004800407027A patent/CN1906294B/zh not_active Expired - Lifetime
- 2004-11-19 KR KR1020067009838A patent/KR101237651B1/ko not_active Expired - Lifetime
- 2004-11-19 WO PCT/US2004/038884 patent/WO2005052151A1/en not_active Ceased
- 2004-11-19 CA CA2545610A patent/CA2545610C/en not_active Expired - Lifetime
- 2004-11-19 JP JP2006541422A patent/JP5087741B2/ja not_active Expired - Lifetime
-
2009
- 2009-07-30 US US12/512,930 patent/US8288127B2/en active Active
-
2011
- 2011-12-16 JP JP2011275338A patent/JP2012100669A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1906294B (zh) | 2013-09-11 |
| US20090325230A1 (en) | 2009-12-31 |
| CN1906294A (zh) | 2007-01-31 |
| JP2007511238A (ja) | 2007-05-10 |
| MXPA06005634A (es) | 2006-08-23 |
| WO2005052151A1 (en) | 2005-06-09 |
| EP1692282A4 (en) | 2008-04-02 |
| AU2004293810A1 (en) | 2005-06-09 |
| KR20060132587A (ko) | 2006-12-21 |
| CA2545610A1 (en) | 2005-06-09 |
| CA2545610C (en) | 2014-03-25 |
| KR101237651B1 (ko) | 2013-02-27 |
| JP5087741B2 (ja) | 2012-12-05 |
| EP1692282A1 (en) | 2006-08-23 |
| JP2012100669A (ja) | 2012-05-31 |
| AU2004293810B2 (en) | 2010-07-01 |
| US20050186666A1 (en) | 2005-08-25 |
| US8288127B2 (en) | 2012-10-16 |
| EP1692282B1 (en) | 2012-08-08 |
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