BRPI0416534A - composições multiparticuladas com estabilidade melhorada - Google Patents

composições multiparticuladas com estabilidade melhorada

Info

Publication number
BRPI0416534A
BRPI0416534A BRPI0416534-9A BRPI0416534A BRPI0416534A BR PI0416534 A BRPI0416534 A BR PI0416534A BR PI0416534 A BRPI0416534 A BR PI0416534A BR PI0416534 A BRPI0416534 A BR PI0416534A
Authority
BR
Brazil
Prior art keywords
stability
improved stability
multiparticulate compositions
multiparticulate
compositions
Prior art date
Application number
BRPI0416534-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Marshall David Crew
Dwayne Thomas Friesen
Roderick Jack Ray
Leah Elisabeth Appel
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0416534A publication Critical patent/BRPI0416534A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0416534-9A 2003-12-04 2004-11-22 composições multiparticuladas com estabilidade melhorada BRPI0416534A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52724503P 2003-12-04 2003-12-04
PCT/IB2004/003807 WO2005053651A1 (en) 2003-12-04 2004-11-22 Multiparticulate compositions with improved stability

Publications (1)

Publication Number Publication Date
BRPI0416534A true BRPI0416534A (pt) 2007-01-09

Family

ID=34652485

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416534-9A BRPI0416534A (pt) 2003-12-04 2004-11-22 composições multiparticuladas com estabilidade melhorada

Country Status (6)

Country Link
US (1) US7736672B2 (ja)
EP (1) EP1691786A1 (ja)
JP (1) JP2007513139A (ja)
BR (1) BRPI0416534A (ja)
CA (1) CA2547597A1 (ja)
WO (1) WO2005053651A1 (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064762A2 (en) 2003-01-21 2004-08-05 S.S.C.I. Inc. Novel cocrystallization
US20070287194A1 (en) 2004-03-12 2007-12-13 S.S.C.I., Inc Screening For Solid Forms By Ultrasound Crystallization And Cocrystallization Using Ultrasound
SI1765292T1 (en) 2004-06-12 2018-04-30 Collegium Pharmaceutical, Inc. Formulations of medicines to discourage abuse
US9265731B2 (en) 2005-01-28 2016-02-23 Bend Research, Inc. Drying of drug-containing particles
WO2007075793A2 (en) * 2005-12-21 2007-07-05 S.S.C.I., Inc. Sonication methods for screening and preparing solid forms
PT2043610E (pt) * 2006-07-21 2015-10-22 Bend Res Inc Secagem de partículas contendo fármacos
EP2091519B1 (en) * 2006-11-30 2015-06-24 Bend Research, Inc Multiparticulates of spray-coated drug and polymer on a meltable core
US11116728B2 (en) 2006-11-30 2021-09-14 Bend Research, Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
WO2011039686A1 (en) 2009-09-30 2011-04-07 Pfizer Inc. Latrepirdine oral sustained release dosage forms
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP2366378A1 (en) 2010-03-01 2011-09-21 Dexcel Pharma Technologies Ltd. Sustained-release donepezil formulations
DK2661254T3 (da) 2011-01-05 2017-11-06 Hospira Inc Sprøjtetørring af vancomycin
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
JP6041823B2 (ja) 2013-03-16 2016-12-14 ファイザー・インク トファシチニブの経口持続放出剤形
EP3154529B1 (en) 2014-06-10 2020-07-08 Capsugel Belgium NV Orally disintegrating tablet containing solid lipid particles and methods for their preparation and use
ES2602497T3 (es) 2014-08-14 2017-02-21 Capsugel Belgium Nv Aparato y proceso para verter materiales particulados
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
MX2018007248A (es) 2018-06-14 2019-12-16 Centro De Investigacion En Quim Aplicada Método de obtención de partículas porosas mediante un proceso híbrido de pulverización por secado-enfriamiento.
WO2021014360A1 (en) 2019-07-23 2021-01-28 Pfizer Inc. Oral modified release dosage forms
KR20220101150A (ko) 2019-11-14 2022-07-19 화이자 인코포레이티드 1-(((2s,3s,4s)-3-에틸-4-플루오로-5-옥소피롤리딘-2-일)메톡시)-7-메톡시이소퀴놀린-6-카복사마이드 조합물 및 경구 투여 형태
CN114831950B (zh) * 2022-04-29 2023-05-05 广州新济药业科技有限公司 硝酸甘油包覆物、硝酸甘油舌下片及其制备方法

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26851A (en) * 1860-01-17 Improvement
US25342A (en) * 1859-09-06 Justus k
US6650A (en) * 1849-08-14 Edmund blunt
US3590A (en) * 1844-05-17 Rule or measure
US165563A (en) * 1875-07-13 Improvement in snow-plows
US190365A (en) * 1877-05-01 Improvement in running-gear for vehicles
US228357A (en) * 1880-06-01 Walter m
US2955956A (en) 1957-05-15 1960-10-11 Morton Salt Co Process and apparatus for coating granules
US4092089A (en) 1974-04-06 1978-05-30 Bayer Aktiengesellschaft Apparatus for the preparation of melt-sprayed spherical phenacetin granules
US4086346A (en) 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
US4053264A (en) 1976-01-30 1977-10-11 United Technologies Corporation Apparatus for making metal powder
US4293570A (en) 1979-04-02 1981-10-06 Chimicasa Gmbh Process for the preparation of sweetener containing product
FR2471186A1 (fr) 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation
US4340582A (en) 1981-01-15 1982-07-20 Abbott Laboratories Erythromycin base tablets
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
DK150008C (da) 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4675140A (en) 1984-05-18 1987-06-23 Washington University Technology Associates Method for coating particles or liquid droplets
US4874611A (en) 1985-06-20 1989-10-17 The Dow Chemical Company Microencapsulated ant bait
US5019302A (en) 1986-03-12 1991-05-28 Washington University Technology Associates, Inc. Method for granulation
US5100592A (en) 1986-03-12 1992-03-31 Washington University Technology Associated, Inc. Method and apparatus for granulation and granulated product
US5236734A (en) 1987-04-20 1993-08-17 Fuisz Technologies Ltd. Method of preparing a proteinaceous food product containing a melt spun oleaginous matrix
US5387431A (en) 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
US5456932A (en) 1987-04-20 1995-10-10 Fuisz Technologies Ltd. Method of converting a feedstock to a shearform product and product thereof
RO107257B1 (ro) 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
US5064650A (en) 1988-04-19 1991-11-12 Southwest Research Institute Controlled-release salt sensitive capsule for oral use and adhesive system
US4931285A (en) 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5160743A (en) 1988-04-28 1992-11-03 Alza Corporation Annealed composition for pharmaceutically acceptable drug
US5024842A (en) 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5047244A (en) 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
US5084287A (en) 1990-03-15 1992-01-28 Warner-Lambert Company Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat
US5213810A (en) 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
EP0452862B1 (en) 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Spherical seed cores, spherical granules and process for production thereof
US5183690A (en) 1990-06-25 1993-02-02 The United States Of America, As Represented By The Secretary Of Agriculture Starch encapsulation of biologically active agents by a continuous process
GB9014646D0 (en) 1990-07-02 1990-08-22 Courtaulds Coatings Holdings Coating compositions
US5194262A (en) 1990-10-22 1993-03-16 Revlon Consumer Products Corporation Encapsulated antiperspirant salts and deodorant/antiperspirants
US5196199A (en) 1990-12-14 1993-03-23 Fuisz Technologies Ltd. Hydrophilic form of perfluoro compounds and method of manufacture
US5292657A (en) 1990-12-31 1994-03-08 Pioneer Hi-Bred International, Inc. Process for preparing rotary disc fatty acid microspheres of microorganisms
US5143662A (en) 1991-02-12 1992-09-01 United States Surgical Corporation Process for preparing particles of bioabsorbable polymer
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5405617A (en) 1991-11-07 1995-04-11 Mcneil-Ppc, Inc. Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals
GB9201857D0 (en) 1992-01-29 1992-03-18 Smithkline Beecham Plc Novel compound
JP3265680B2 (ja) 1992-03-12 2002-03-11 大正製薬株式会社 経口製剤用組成物
DE4214272A1 (de) 1992-05-04 1993-11-11 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von Mikrokugeln
CA2095776C (en) 1992-05-12 2007-07-10 Richard C. Fuisz Rapidly dispersable compositions containing polydextrose
DK0641195T3 (da) 1992-05-22 1996-08-05 Goedecke Ag Fremgangsmåde til fremstilling af lægemiddelblandinger med forsinket virkning
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
TW271400B (ja) 1992-07-30 1996-03-01 Pfizer
US5348758A (en) 1992-10-20 1994-09-20 Fuisz Technologies Ltd. Controlled melting point matrix formed with admixtures of a shearform matrix material and an oleaginous material
US5380473A (en) 1992-10-23 1995-01-10 Fuisz Technologies Ltd. Process for making shearform matrix
GB9224855D0 (en) 1992-11-27 1993-01-13 Smithkline Beecham Plc Pharmaceutical compositions
US5569467A (en) 1993-05-15 1996-10-29 Societe De Conseils De Recherches Et D'applications (S.C.R.A.S.) Process for the preparation of microballs and microballs thus obtained
US5690959A (en) 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
US5851553A (en) 1993-09-10 1998-12-22 Fuisz Technologies, Ltd. Process and apparatus for making rapidly dissolving dosage units and product therefrom
US5597416A (en) 1993-10-07 1997-01-28 Fuisz Technologies Ltd. Method of making crystalline sugar and products resulting therefrom
US5935600A (en) 1993-09-10 1999-08-10 Fuisz Technologies Ltd. Process for forming chewable quickly dispersing comestible unit and product therefrom
US5433951A (en) 1993-10-13 1995-07-18 Bristol-Myers Squibb Company Sustained release formulation containing captopril and method
AT401871B (de) 1994-01-28 1996-12-27 Gebro Broschek Gmbh Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
CA2185803C (en) 1994-03-18 2006-07-11 Edward M. Rudnic Emulsified drug delivery systems
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
DK0758244T4 (da) 1994-05-06 2008-06-16 Pfizer Doseringsformer af azithromycin med styret frigivelse
DE19509807A1 (de) 1995-03-21 1996-09-26 Basf Ag Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen
US5567439A (en) 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5533416A (en) * 1994-06-16 1996-07-09 Mtd Products Inc. Transmission shift key
US5582855A (en) 1994-07-01 1996-12-10 Fuisz Technologies Ltd. Flash flow formed solloid delivery systems
US5556652A (en) 1994-08-05 1996-09-17 Fuisz Technologies Ltd. Comestibles containing stabilized highly odorous flavor component delivery systems
US5601761A (en) 1994-09-26 1997-02-11 The Dow Chemical Company Encapsulated active materials and method for preparing same
US6083430A (en) 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
US5965164A (en) 1994-10-28 1999-10-12 Fuisz Technologies Ltd. Recipient-dosage delivery system
US5683720A (en) 1994-10-28 1997-11-04 Fuisz Technologies Ltd. Liquiflash particles and method of making same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
FR2732621B1 (fr) 1995-04-10 1997-06-06 Rhone Poulenc Chimie Perles d'un produit presentant le phenomene de surfusion et leur procede d'obtention
EP0826376B1 (en) 1995-05-02 2007-01-24 Taisho Pharmaceutical Co. Ltd Composition for oral administration
US5883103A (en) 1995-06-07 1999-03-16 Shire Laboratories Inc. Oral acyclovir delivery
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US5855915A (en) 1995-06-30 1999-01-05 Baylor University Tablets or biologically acceptable implants for long-term antiinflammatory drug release
EP0784933A3 (en) 1995-10-16 1997-11-26 Leaf, Inc. Extended release of additives in comestible products
US5919489A (en) 1995-11-01 1999-07-06 Abbott Laboratories Process for aqueous granulation of clarithromycin
DE19543633C2 (de) 1995-11-23 2000-08-17 Cognis Deutschland Gmbh Kosmetische und/oder pharmazeutische Zubereitungen
US5705190A (en) 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs
DE19629753A1 (de) 1996-07-23 1998-01-29 Basf Ag Verfahren zur Herstellung von festen Arzneiformen
US6139872A (en) 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
TW474824B (en) 1996-09-13 2002-02-01 Basf Ag The production of solid pharmaceutical forms
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US5948407A (en) 1997-03-19 1999-09-07 Shire Laboratories Inc. Oral induction of tolerance to parenterally administered non-autologous polypeptides
EP2036544B1 (en) * 1997-03-20 2016-12-28 Merck Sharp & Dohme Corp. Dosage form of powder agglomerates
US6551616B1 (en) 1997-04-11 2003-04-22 Abbott Laboratories Extended release formulations of erythromycin derivatives
CA2284988A1 (en) * 1997-04-11 1998-10-22 Fujisawa Pharmaceutical Co., Ltd. Medicinal composition
US6010718A (en) 1997-04-11 2000-01-04 Abbott Laboratories Extended release formulations of erythromycin derivatives
DE19729487A1 (de) 1997-07-10 1999-01-14 Dresden Arzneimittel Verfahren zur Herstellung von Wirkstoff-Zubereitungen mit kontrollierter Freisetzung aus einer Matrix
SI9700186B (sl) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
US5851555A (en) 1997-08-15 1998-12-22 Fuisz Technologies Ltd. Controlled release dosage forms containing water soluble drugs
US5840334A (en) 1997-08-20 1998-11-24 Fuisz Technologies Ltd. Self-binding shearform compositions
US5869098A (en) 1997-08-20 1999-02-09 Fuisz Technologies Ltd. Fast-dissolving comestible units formed under high-speed/high-pressure conditions
US5980941A (en) 1997-08-20 1999-11-09 Fuisz Technologies Ltd. Self-binding shearform compositions
JP2002522354A (ja) 1997-09-19 2002-07-23 シャイア ラボラトリーズ,インコーポレイテッド 固溶体ビードレット
IE970731A1 (en) 1997-10-07 2000-10-04 Fuisz Internat Ltd Product and method for the treatment of hyperlipidemia
US6013280A (en) 1997-10-07 2000-01-11 Fuisz Technologies Ltd. Immediate release dosage forms containing microspheres
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US5891845A (en) 1997-11-21 1999-04-06 Fuisz Technologies Ltd. Drug delivery systems utilizing liquid crystal structures
PT925789E (pt) 1997-12-02 2004-10-29 Pfizer Prod Inc Es oculares utilizacao de azitromicina no tratamento topico de infecco
JP4546643B2 (ja) 1997-12-08 2010-09-15 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 酸不安定な活性化合物を含有する新規の坐剤形
EP0943341A1 (en) 1998-02-18 1999-09-22 Oscar Gold Procedure to prepare granulated compositions that contain erythromycin macrolides and procedure to prepare pharmaceutical compositions that contain said macrolides
US6270804B1 (en) 1998-04-03 2001-08-07 Biovail Technologies Ltd. Sachet formulations
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
FR2779651B1 (fr) 1998-06-16 2001-04-20 Gattefosse Ets Sa Procede pour la fabrication de comprimes a liberation prolongee de principe(s) actif(s) presentant une cinetique de dissolution d'ordre zero
US6117452A (en) 1998-08-12 2000-09-12 Fuisz Technologies Ltd. Fatty ester combinations
US6086920A (en) 1998-08-12 2000-07-11 Fuisz Technologies Ltd. Disintegratable microspheres
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
US6165512A (en) 1998-10-30 2000-12-26 Fuisz Technologies Ltd. Dosage forms containing taste masked active agents
IL143376A0 (en) 1998-11-30 2002-04-21 Teva Pharma Ethanolate of azithromycin, process for the manufacture, and pharmaceutical compositions thereof
AR022695A1 (es) * 1999-01-28 2002-09-04 Schering Corp PORTADOR SoLIDO PARTICULADO Y MÉTODO PARA PROVEER CONTROL DE LA PARTICULADA PARA LA DISTRIBUCIoN DE TAMANO DE PARTíCULAS Y DE CONTENIDO AMORFO CONVERTIBLE DURANTE SU PREPARACION
IN187487B (ja) 1999-02-25 2002-05-04 M S Alembic Chemical Works Com
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6500459B1 (en) 1999-07-21 2002-12-31 Harinderpal Chhabra Controlled onset and sustained release dosage forms and the preparation thereof
IL141438A0 (en) 2000-02-23 2002-03-10 Pfizer Prod Inc Method of increasing the bioavailability and tissue penetration of azithromycin
GB0012260D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
US6660762B2 (en) * 2001-05-14 2003-12-09 George P. Sakalosky Methods and compositions to treat lung diseases
CZ2004232A3 (cs) 2001-08-21 2005-10-12 Pfizer Products Inc. Jednorázová dávka azithromycinu
AU2002348884A1 (en) 2001-12-21 2003-07-09 Pfizer Products Inc. Directly compressible formulations of azithromycin
JP2005515212A (ja) * 2001-12-21 2005-05-26 ファイザー・プロダクツ・インク アジスロマイシンの湿式造粒法
KR100676025B1 (ko) 2002-02-01 2007-01-29 화이자 프로덕츠 인코포레이티드 아지쓰로마이신의 건조 과립화 제제
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
US20050152845A1 (en) * 2002-02-04 2005-07-14 Keith Biggadike Amorphous fluticasone 2-furoate, pharmaceutical compositions thereof and its conversion to the crystalline unsolvated form
US20040121003A1 (en) 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US7572773B2 (en) 2003-07-24 2009-08-11 Pliva Hrvatska D.O.O. Single dose fast dissolving azithromycin

Also Published As

Publication number Publication date
JP2007513139A (ja) 2007-05-24
WO2005053651A1 (en) 2005-06-16
US20050186285A1 (en) 2005-08-25
EP1691786A1 (en) 2006-08-23
US7736672B2 (en) 2010-06-15
CA2547597A1 (en) 2005-06-16

Similar Documents

Publication Publication Date Title
BRPI0416534A (pt) composições multiparticuladas com estabilidade melhorada
NL300933I2 (nl) Letermovir
BRPI0508758A (pt) processo para a preparação de cloridrato de oxicodona tendo menos que 25 ppm de 14 - hidroxicodeinona
GT200100183A (es) Derivados de quinolina y quinazolina.
DK1881967T3 (da) Substituerede benzo (D) isoaxol-3-yl-amin-forbindelser som analgetika
BRPI0407074A (pt) Método para produção de uma preparação revestida, preparação revestida, e, método para melhorar a dissolução do cloridreto de pioglitazona de uma preparação revestida com cloridreto de pioglitazona
SE0201544D0 (sv) Novel compounds and thier use
BRPI0408681A (pt) compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos
NO20054787L (no) Indenderivater som farmasotiske midler
IS8505A (is) (S)-2-N-própýlamínó-5-hýdroxýetralín sem D3-gerandefni
BRPI0517091A (pt) composto, e, método para tratar uma doença ou condição alterando-se uma resposta mediada por um receptor de opióide
ECSP056071A (es) Nueva difenilazetidinona con características fisiológicas mejoradas, correspondiente método de producción, medicamentos que contienen dicho compuesto y su uso
BR0208741A (pt) Derivados de piperidina
BRPI0412999A (pt) 2-aminotetralina substituìda para tratamento de depressão
BRPI0409454A (pt) compostos, processo para a sua manufatura, composições farmacêuticas que compreendem os mesmos, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com o receptor de glucagon e sua utilização
PT1414816E (pt) Polimorfo estavel da flibanserina, processo tecnico para a sua preparacao e sua utilizacao na preparacao de medicamentos
BRPI0407097A (pt) Antagonista do casr
ZA200409379B (en) Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof
BR0211739A (pt) Novas formas polimórficas cristalinas de cloridrato de lercanidipina e processo para preparação das mesmas
BRPI0409436A (pt) compostos de 4-fenil-piperidina e a sua utilização como moduladores de receptores de opióides
BRPI0417360A (pt) método para a preparação de multiparticulados farmacêuticos
BRPI0407913A (pt) antagonistas receptores de ccr-3
IS7910A (is) Samsett lyf
BRPI0416188A (pt) formulações de medicamentos que contêm aromatizante, com propriedades farmacêuticas aperfeiçoadas
GT200400134A (es) Sistemas emulsionantes que contienen derivados de azetidina

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.