BRPI0416501A - forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas - Google Patents

forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas

Info

Publication number
BRPI0416501A
BRPI0416501A BRPI0416501-2A BRPI0416501A BRPI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A
Authority
BR
Brazil
Prior art keywords
substance
release
sub
optionally
active substances
Prior art date
Application number
BRPI0416501-2A
Other languages
English (en)
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh filed Critical Roehm Gmbh
Publication of BRPI0416501A publication Critical patent/BRPI0416501A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"FORMA DE DOSAGEM FARMACêUTICA COM MúLTIPLAS CAMADAS CONTENDO UMA SUBSTáNCIA QUE AGE DE UMA FORMA MODULATóRIA, NO QUE DIZ RESPEITO à LIBERAçãO DAS SUBSTáNCIAS ATIVAS". A presente invenção refere-se a uma forma de dosagem farmacêutica com múltiplas camadas para a liberação controlada de substâncias ativas, contendo: a) uma camada nuclear, compreendendo uma substância que age de uma forma modulatória em consideração à liberação de substâncias ativas, opcionalmente um núcleo neutro e/ou uma substância ativa; b) uma camada de controle interna que influencia a liberação da substância que age de uma forma modulatória e da substância ativa opcionalmente contida da camada nuclear, contendo polímeros, ceras, resinas e/ou proteínas farmaceuticamente usáveis; c) uma camada de substância ativa contendo uma substância farmaceuticamente ativa e, opcionalmente, uma substância que age de uma forma modulatória; d) uma camada de controle externa contendo um copolímero de (met)acrilato ou uma mistura consistindo em uma variedade de copolímeros de (met)acrilato compreendidos de 98 a 85 ésteres de alquila C~ 1-C~ 4~ do ácido (met)acrílico e 2 a 15% em peso de monómeros de metacrilato com um grupo de amónio quaternário no radical alquila e opcionalmente contendo polímeros farmaceuticamente usáveis que são insolúveis em água, por meio do qual as camadas podem conter, em adição e de uma forma conhecida, adjuvantes farmaceuticamente convencionais.
BRPI0416501-2A 2003-11-13 2004-09-15 forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas BRPI0416501A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353186A DE10353186A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz
PCT/EP2004/010297 WO2005046649A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz

Publications (1)

Publication Number Publication Date
BRPI0416501A true BRPI0416501A (pt) 2007-01-09

Family

ID=34585088

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416501-2A BRPI0416501A (pt) 2003-11-13 2004-09-15 forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas

Country Status (15)

Country Link
US (1) US20060269605A1 (pt)
EP (1) EP1684729B1 (pt)
JP (1) JP2007510676A (pt)
KR (1) KR20060121182A (pt)
CN (1) CN1863515A (pt)
AT (1) ATE395046T1 (pt)
BR (1) BRPI0416501A (pt)
CA (1) CA2544497A1 (pt)
DE (2) DE10353186A1 (pt)
ES (1) ES2307044T3 (pt)
IL (1) IL175561A0 (pt)
MX (1) MX2007010611A (pt)
PL (1) PL1684729T3 (pt)
SI (1) SI1684729T1 (pt)
WO (1) WO2005046649A2 (pt)

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US7829148B2 (en) * 2006-02-07 2010-11-09 Fmc Corporation Coating process to produce controlled release coatings
JP5649784B2 (ja) * 2006-02-07 2015-01-07 エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ 組成物、基材を組成物でコーティングする方法、被覆基材、製品、フィルム、ペレット、タブレット及びカプセル
US20070202172A1 (en) * 2006-02-24 2007-08-30 Tomer Gold Metoprolol succinate E.R. tablets and methods for their preparation
KR101486228B1 (ko) 2006-06-19 2015-01-26 알파마 파머슈티컬스 엘엘씨 약제학적 조성물
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JP5228359B2 (ja) * 2007-04-12 2013-07-03 ニプロ株式会社 主薬粒子及びその製造方法ならびに口腔内崩壊錠
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TWI519322B (zh) * 2008-04-15 2016-02-01 愛戴爾製藥股份有限公司 包含弱鹼性藥物及控制釋放劑型之組合物
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Also Published As

Publication number Publication date
US20060269605A1 (en) 2006-11-30
CN1863515A (zh) 2006-11-15
PL1684729T3 (pl) 2008-10-31
JP2007510676A (ja) 2007-04-26
DE502004007172D1 (de) 2008-06-26
IL175561A0 (en) 2006-09-05
EP1684729B1 (de) 2008-05-14
ATE395046T1 (de) 2008-05-15
DE10353186A1 (de) 2005-06-16
KR20060121182A (ko) 2006-11-28
SI1684729T1 (sl) 2008-10-31
WO2005046649A3 (de) 2005-10-27
CA2544497A1 (en) 2005-05-26
MX2007010611A (es) 2009-02-19
WO2005046649A2 (de) 2005-05-26
ES2307044T3 (es) 2008-11-16
EP1684729A2 (de) 2006-08-02

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.