BRPI0416501A - forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas - Google Patents
forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativasInfo
- Publication number
- BRPI0416501A BRPI0416501A BRPI0416501-2A BRPI0416501A BRPI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A BR PI0416501 A BRPI0416501 A BR PI0416501A
- Authority
- BR
- Brazil
- Prior art keywords
- substance
- release
- sub
- optionally
- active substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"FORMA DE DOSAGEM FARMACêUTICA COM MúLTIPLAS CAMADAS CONTENDO UMA SUBSTáNCIA QUE AGE DE UMA FORMA MODULATóRIA, NO QUE DIZ RESPEITO à LIBERAçãO DAS SUBSTáNCIAS ATIVAS". A presente invenção refere-se a uma forma de dosagem farmacêutica com múltiplas camadas para a liberação controlada de substâncias ativas, contendo: a) uma camada nuclear, compreendendo uma substância que age de uma forma modulatória em consideração à liberação de substâncias ativas, opcionalmente um núcleo neutro e/ou uma substância ativa; b) uma camada de controle interna que influencia a liberação da substância que age de uma forma modulatória e da substância ativa opcionalmente contida da camada nuclear, contendo polímeros, ceras, resinas e/ou proteínas farmaceuticamente usáveis; c) uma camada de substância ativa contendo uma substância farmaceuticamente ativa e, opcionalmente, uma substância que age de uma forma modulatória; d) uma camada de controle externa contendo um copolímero de (met)acrilato ou uma mistura consistindo em uma variedade de copolímeros de (met)acrilato compreendidos de 98 a 85 ésteres de alquila C~ 1-C~ 4~ do ácido (met)acrílico e 2 a 15% em peso de monómeros de metacrilato com um grupo de amónio quaternário no radical alquila e opcionalmente contendo polímeros farmaceuticamente usáveis que são insolúveis em água, por meio do qual as camadas podem conter, em adição e de uma forma conhecida, adjuvantes farmaceuticamente convencionais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10353186A DE10353186A1 (de) | 2003-11-13 | 2003-11-13 | Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz |
PCT/EP2004/010297 WO2005046649A2 (de) | 2003-11-13 | 2004-09-15 | Mehrschichtige arzneiform, enthaltend eine in bezug auf die wirkstoffreigabe modularisch wirkende substanz |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0416501A true BRPI0416501A (pt) | 2007-01-09 |
Family
ID=34585088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0416501-2A BRPI0416501A (pt) | 2003-11-13 | 2004-09-15 | forma de dosagem farmacêutica com múltiplas camadas contendo uma substáncia que age de uma forma modulatória, no que diz respeito á liberação das substáncias ativas |
Country Status (15)
Country | Link |
---|---|
US (1) | US20060269605A1 (pt) |
EP (1) | EP1684729B1 (pt) |
JP (1) | JP2007510676A (pt) |
KR (1) | KR20060121182A (pt) |
CN (1) | CN1863515A (pt) |
AT (1) | ATE395046T1 (pt) |
BR (1) | BRPI0416501A (pt) |
CA (1) | CA2544497A1 (pt) |
DE (2) | DE10353186A1 (pt) |
ES (1) | ES2307044T3 (pt) |
IL (1) | IL175561A0 (pt) |
MX (1) | MX2007010611A (pt) |
PL (1) | PL1684729T3 (pt) |
SI (1) | SI1684729T1 (pt) |
WO (1) | WO2005046649A2 (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0108379A (pt) | 2000-02-08 | 2002-11-05 | Euro Celtique Sa | Composições de liberação controlada contendo agonista e antagonista opióide, método para a preparação de uma formulação em dosagem de analgésico opióide de liberação controlada com potência analgésica aumentada e sistema de administração através da derme para um analgésico opióide |
SI1551372T1 (en) | 2002-09-20 | 2018-08-31 | Alpharma Pharmaceuticals Llc | SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES |
DE10250543A1 (de) * | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
DE102004036437A1 (de) | 2004-07-27 | 2006-03-23 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
DE102004059792A1 (de) * | 2004-12-10 | 2006-06-14 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
AU2005325930B2 (en) * | 2005-01-27 | 2012-01-19 | Alembic Limited | Extended release formulation of Levetiracetam |
DE102005007059A1 (de) | 2005-02-15 | 2006-08-24 | Röhm GmbH & Co. KG | Teilneutralisiertes anionisches (Meth)acrylat-Copolymer |
CN101111230B (zh) * | 2005-03-29 | 2010-05-19 | 赢创罗姆有限责任公司 | 包含对活性成分具有调节释放作用的小丸的多颗粒药用形式 |
KR20070119658A (ko) * | 2005-03-29 | 2007-12-20 | 에보니크 룀 게엠베하 | 활성 성분 방출에 대한 조절 효과를 가지는 물질을포함하는 펠렛을 포함하는 다중 미립자 제약 형태 |
KR101413613B1 (ko) * | 2006-01-27 | 2014-07-10 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 선택성 세로토닌 5-ht3 차단제와 유기산을 포함하는 약물 전달 시스템 |
JP2009526096A (ja) * | 2006-02-07 | 2009-07-16 | エフ エム シー コーポレーション | 徐放性被覆をつくるためのコーティング方法 |
WO2007092717A1 (en) * | 2006-02-07 | 2007-08-16 | Fmc Corporation | Latex or pseudolatex compositions coatings and coating processes |
KR20080099334A (ko) * | 2006-02-24 | 2008-11-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 메토프로롤 숙시네이트 서방정 및 이의 제조 방법 |
DK2526932T3 (en) | 2006-06-19 | 2017-07-17 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
DE102006035549A1 (de) * | 2006-07-27 | 2008-01-31 | Evonik Röhm Gmbh | Arzneiform mit mindestens zweischichtiger Trennschicht |
WO2008070072A2 (en) * | 2006-12-01 | 2008-06-12 | Mutual Pharmaceutical Company, Inc. | Carvedilol forms, compositions, and methods of preparation thereof |
US20090028935A1 (en) * | 2006-12-01 | 2009-01-29 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
JP5228359B2 (ja) * | 2007-04-12 | 2013-07-03 | ニプロ株式会社 | 主薬粒子及びその製造方法ならびに口腔内崩壊錠 |
US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
WO2009086942A1 (en) * | 2008-01-10 | 2009-07-16 | Evonik Röhm Gmbh | Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release |
SI2230932T1 (sl) * | 2008-01-10 | 2017-07-31 | Evonik Roehm Gmbh | Oplaščeni farmacevtski ali nutracevtski pripravek s povečanim sproščanjem aktivne učinkovine v črevesu |
MX2010007579A (es) * | 2008-01-10 | 2010-08-03 | Evonik Roehm Gmbh | Preparacion nutriceutica o farmaceutica revestida con una liberacion de sustancia activa de impulsion mejorada. |
TWI519322B (zh) * | 2008-04-15 | 2016-02-01 | 愛戴爾製藥股份有限公司 | 包含弱鹼性藥物及控制釋放劑型之組合物 |
PL2358360T3 (pl) * | 2008-11-18 | 2017-02-28 | Ucb Biopharma Sprl | Preparaty o przedłużonym uwalnianiu zawierające pochodną 2-okso-1-pirolidyny |
WO2011025673A1 (en) * | 2009-08-26 | 2011-03-03 | Aptapharma, Inc. | Multilayer minitablets |
WO2011025969A1 (en) * | 2009-08-27 | 2011-03-03 | The U.S.A., As Represented By The Secretary, Dept. Of Health And Human Services | Compounds that treat malaria and prevent malaria transmission |
ES2508490T3 (es) * | 2010-05-04 | 2014-10-16 | Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi | Formulación de trimetazidina con diferentes perfiles de liberación |
US8980318B2 (en) | 2010-06-24 | 2015-03-17 | Merz Pharma Gmbh & Co. Kgaa | Neramexane multiple unit dosage form |
KR20130124551A (ko) | 2011-02-02 | 2013-11-14 | 알파마 파머슈티컬스 엘엘씨 | 오피오이드 효능제 및 격리된 길항제를 포함하는 제약 조성물 |
WO2012137610A1 (ja) * | 2011-04-08 | 2012-10-11 | 国立大学法人山梨大学 | 医薬製剤 |
BR112014004370A2 (pt) * | 2011-08-26 | 2017-03-21 | Wockhardt Ltd | métodos para tratar distúrbios cardiovasculares |
KR20140065862A (ko) * | 2012-11-22 | 2014-05-30 | 에스케이케미칼주식회사 | 발포성 속붕해성 이매티닙 제제 |
KR101451327B1 (ko) | 2013-01-08 | 2014-11-03 | 안국약품 주식회사 | 보센탄의 제어방출성 다층 정제 및 그 제조방법 |
KR102241487B1 (ko) | 2013-02-20 | 2021-04-16 | 주식회사 종근당 | 제어방출 펠릿으로 된 약제학적 조성물 |
CN103637999B (zh) * | 2013-12-12 | 2014-12-03 | 南通联亚药业有限公司 | 一种多层固体药物剂型 |
WO2016044704A1 (en) | 2014-09-19 | 2016-03-24 | The Procter & Gamble Company | Pulsed release phenylephrine dosage forms |
TWI525110B (zh) | 2014-12-24 | 2016-03-11 | 財團法人工業技術研究院 | 聚合物、及包含其之醫藥組合物 |
US10278930B2 (en) | 2017-03-16 | 2019-05-07 | The Procter & Gamble Company | Method for relieving sinus congestion |
DK3648743T3 (da) * | 2017-07-07 | 2022-10-03 | Dsm Ip Assets Bv | Pressede tabletter, der omfatter nitrooxyforbindelser |
EP3459528B1 (en) | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Preparation of solid dosage forms comprising antibodies by solution/suspension layering |
CN114159400A (zh) * | 2021-11-22 | 2022-03-11 | 山东省药学科学院 | 法匹拉韦包芯片 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3426230B2 (ja) * | 1991-05-20 | 2003-07-14 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | 複数層の制御放出処方剤 |
US5260068A (en) * | 1992-05-04 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Multiparticulate pulsatile drug delivery system |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
DE19845358A1 (de) * | 1998-10-02 | 2000-04-06 | Roehm Gmbh | Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe |
US20010055613A1 (en) * | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
DE19956486A1 (de) * | 1999-11-24 | 2001-06-21 | Lohmann Therapie Syst Lts | Mehrschichtige Zubereitung zur gesteuerten, pulsartigen Abgabe von Wirkstoffen |
DE10149674A1 (de) * | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
DE10250543A1 (de) * | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
-
2003
- 2003-11-13 DE DE10353186A patent/DE10353186A1/de not_active Withdrawn
-
2004
- 2004-09-15 ES ES04765211T patent/ES2307044T3/es active Active
- 2004-09-15 CA CA002544497A patent/CA2544497A1/en not_active Abandoned
- 2004-09-15 BR BRPI0416501-2A patent/BRPI0416501A/pt not_active IP Right Cessation
- 2004-09-15 SI SI200430816T patent/SI1684729T1/sl unknown
- 2004-09-15 EP EP04765211A patent/EP1684729B1/de not_active Not-in-force
- 2004-09-15 MX MX2007010611A patent/MX2007010611A/es unknown
- 2004-09-15 PL PL04765211T patent/PL1684729T3/pl unknown
- 2004-09-15 DE DE502004007172T patent/DE502004007172D1/de not_active Expired - Fee Related
- 2004-09-15 AT AT04765211T patent/ATE395046T1/de not_active IP Right Cessation
- 2004-09-15 JP JP2006538671A patent/JP2007510676A/ja active Pending
- 2004-09-15 CN CNA2004800290437A patent/CN1863515A/zh active Pending
- 2004-09-15 US US10/572,963 patent/US20060269605A1/en not_active Abandoned
- 2004-09-15 KR KR1020067011599A patent/KR20060121182A/ko not_active Application Discontinuation
- 2004-09-15 WO PCT/EP2004/010297 patent/WO2005046649A2/de active IP Right Grant
-
2006
- 2006-05-11 IL IL175561A patent/IL175561A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
SI1684729T1 (sl) | 2008-10-31 |
DE10353186A1 (de) | 2005-06-16 |
JP2007510676A (ja) | 2007-04-26 |
ES2307044T3 (es) | 2008-11-16 |
ATE395046T1 (de) | 2008-05-15 |
EP1684729A2 (de) | 2006-08-02 |
US20060269605A1 (en) | 2006-11-30 |
CN1863515A (zh) | 2006-11-15 |
CA2544497A1 (en) | 2005-05-26 |
KR20060121182A (ko) | 2006-11-28 |
IL175561A0 (en) | 2006-09-05 |
DE502004007172D1 (de) | 2008-06-26 |
MX2007010611A (es) | 2009-02-19 |
WO2005046649A3 (de) | 2005-10-27 |
EP1684729B1 (de) | 2008-05-14 |
WO2005046649A2 (de) | 2005-05-26 |
PL1684729T3 (pl) | 2008-10-31 |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S) |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |