WO2005046561A3 - Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix - Google Patents

Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix Download PDF

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Publication number
WO2005046561A3
WO2005046561A3 PCT/EP2004/010300 EP2004010300W WO2005046561A3 WO 2005046561 A3 WO2005046561 A3 WO 2005046561A3 EP 2004010300 W EP2004010300 W EP 2004010300W WO 2005046561 A3 WO2005046561 A3 WO 2005046561A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
optionally
matrix
dosage form
modulatory
Prior art date
Application number
PCT/EP2004/010300
Other languages
English (en)
French (fr)
Other versions
WO2005046561A2 (de
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
Roehm Gmbh
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh, Rosario Lizio, Hans-Ulrich Petereit, Manfred Assmus, Hema Ravishankar filed Critical Roehm Gmbh
Priority to EP04765214A priority Critical patent/EP1682094A2/de
Priority to JP2006538672A priority patent/JP2007510677A/ja
Priority to US10/573,019 priority patent/US20070042045A1/en
Priority to CA002544487A priority patent/CA2544487A1/en
Priority to BRPI0416492-0A priority patent/BRPI0416492A/pt
Publication of WO2005046561A2 publication Critical patent/WO2005046561A2/de
Publication of WO2005046561A3 publication Critical patent/WO2005046561A3/de
Priority to IL175562A priority patent/IL175562A0/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Die Erfindung betrifft eine mehrschichtige Arzneiform für die kontrollierte Wirkstofffreisetzung, enthaltend im wesentlichen a) optional einen neutralen Kern (Nonpareilles), b) eine innere Kontrollschicht, enthaltend eine modulatorisch wirkende Substanz, die in eine die Abgabe der modulatorischen Substanz beeinflussende Matrix eingebettet ist, die pharmazeutisch verwendbare - Polymere, Wachse, Harze und/oder Proteine sowie gegebenenfalls einen Wirkstoff enthält, c) eine Wirkstoffschicht, enthaltend einen pharmazeutischen Wirkstoff und gegebenenfalls eine modulatorisch wirkende Substanz, d) eine äussere Kontrollschicht, enthaltend zu mindestens 60 Gew.-% ein oder eine Mischung aus mehreren (Meth)acrylatcopolymeren, aus 98 bis 85 C1,- bis C4-Alkylestern der (Meth)acrylsäure und 2 bis 15 Gew.-% Methacrylatmonomeren mit einer quaternären Ammoniumgruppe im Alkylrest, und gegebenenfalls bis zu 40 Gew.-% weitere pharmazeutisch verwendbare Polymere, wobei die Schichten zusätzlich und in an sich bekannter Weise pharmazeutisch übliche Hilfsstoffe enthalten können.
PCT/EP2004/010300 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix WO2005046561A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP04765214A EP1682094A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix
JP2006538672A JP2007510677A (ja) 2003-11-13 2004-09-15 調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形
US10/573,019 US20070042045A1 (en) 2003-11-13 2004-09-15 Multilayer dosage form comprising a matrix that influences release of a modulatory substance
CA002544487A CA2544487A1 (en) 2003-11-13 2004-09-15 Multilayer pharmaceutical form with a matrix which influences the delivery of a modulatory substance
BRPI0416492-0A BRPI0416492A (pt) 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória
IL175562A IL175562A0 (en) 2003-11-13 2006-05-11 Multilayer dosage form comprising a matrix that influences release of a modulatory substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
DE10353196.3 2003-11-13

Publications (2)

Publication Number Publication Date
WO2005046561A2 WO2005046561A2 (de) 2005-05-26
WO2005046561A3 true WO2005046561A3 (de) 2006-03-16

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/010300 WO2005046561A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix

Country Status (10)

Country Link
US (1) US20070042045A1 (de)
EP (1) EP1682094A2 (de)
JP (1) JP2007510677A (de)
KR (1) KR20060113728A (de)
CN (1) CN1863516A (de)
BR (1) BRPI0416492A (de)
CA (1) CA2544487A1 (de)
DE (1) DE10353196A1 (de)
IL (1) IL175562A0 (de)
WO (1) WO2005046561A2 (de)

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EP2422772A3 (de) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestriermitteluntereinheit und zugehörige Zusammensetzungen und Verfahren
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
KR20070119658A (ko) * 2005-03-29 2007-12-20 에보니크 룀 게엠베하 활성 성분 방출에 대한 조절 효과를 가지는 물질을포함하는 펠렛을 포함하는 다중 미립자 제약 형태
WO2006102964A2 (en) * 2005-03-29 2006-10-05 Evonik Röhm Gmbh Multiparticulate pharmaceutical form comprising pellets with a substance having a modular effect in relation to active ingredient release
KR101320016B1 (ko) * 2005-12-14 2013-10-29 주식회사 대웅 안정화된 코엔자임ｑ10, 종합 비타민 및 미네랄 성분을함유하는 복합제제
DE102006006532B4 (de) 2006-02-10 2007-11-08 Biogenerics Pharma Gmbh Pharmazeutische Zubereitung
ITMI20061024A1 (it) * 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
KR101486228B1 (ko) 2006-06-19 2015-01-26 알파마 파머슈티컬스 엘엘씨 약제학적 조성물
DE102006035549A1 (de) * 2006-07-27 2008-01-31 Evonik Röhm Gmbh Arzneiform mit mindestens zweischichtiger Trennschicht
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CA2711473C (en) 2008-01-10 2016-01-26 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced active substance release in the colon
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US20100159009A1 (en) * 2008-12-24 2010-06-24 Zhongshui Yu Controlled-release formulations
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WO2010096732A1 (en) * 2009-02-20 2010-08-26 University Of Medicine And Dentistry Of New Jersey Combination therapy to improve drug efficiency
KR101317592B1 (ko) 2009-10-28 2013-10-15 씨제이제일제당 (주) 프레가발린, 폴리에틸렌옥사이드 및 폴리비닐알코올-폴리에틸렌글리콜 그라프트 공중합체를 함유하는 위체류형 서방성 제제
KR101137467B1 (ko) * 2009-11-02 2012-04-20 안국약품 주식회사 테오브로민 함유 서방성 정제
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Also Published As

Publication number Publication date
JP2007510677A (ja) 2007-04-26
IL175562A0 (en) 2008-04-13
WO2005046561A2 (de) 2005-05-26
KR20060113728A (ko) 2006-11-02
CA2544487A1 (en) 2005-05-26
DE10353196A1 (de) 2005-06-16
EP1682094A2 (de) 2006-07-26
CN1863516A (zh) 2006-11-15
BRPI0416492A (pt) 2007-03-13
US20070042045A1 (en) 2007-02-22

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