MX2009010556A - Formas de dosificacion modificada de tacrolimus. - Google Patents

Formas de dosificacion modificada de tacrolimus.

Info

Publication number
MX2009010556A
MX2009010556A MX2009010556A MX2009010556A MX2009010556A MX 2009010556 A MX2009010556 A MX 2009010556A MX 2009010556 A MX2009010556 A MX 2009010556A MX 2009010556 A MX2009010556 A MX 2009010556A MX 2009010556 A MX2009010556 A MX 2009010556A
Authority
MX
Mexico
Prior art keywords
tacrolimus
amount
hours
released
dosage forms
Prior art date
Application number
MX2009010556A
Other languages
English (en)
Inventor
Amarjit Singh
Rajesh Jain
Sarabjit Singh
Shivanand Puthli
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39642954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009010556(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of MX2009010556A publication Critical patent/MX2009010556A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

La presente invención provee una forma de dosificación de liberación modificada de tacrolimus que libera dos o más cantidades de tacrolimus tras la administración oral, en donde la primera cantidad de tacrolimus es liberada de la unidad de dosificación de liberación inmediata sustancialmente inmediatamente dentro de 0 a 2 horas, seguida de un intervalo de tiempo que varia de aproximadamente 1 a 10 horas durante el cual sustancialmente ninguna cantidad de tacrolimus es liberada de la forma de dosificación, después de lo cual una segunda cantidad de tacrolimus es liberada, en donde dicha segunda cantidad es liberada de la unidad de dosificación de liberación retardada inmediatamente, por ejemplo, dentro de 0 a 2 horas, o durante un período que varía de aproximadamente 2 a 12 horas de su liberación inicial de la unidad de dosificación de liberación retardada; la forma de dosificación puede comprender además una cantidad adicional de tacrolimus para proveer pulso adicional de tacrolimus; las formas de dosificación de tacrolimus exhiben biodisponibilidad mejorada y flujo o fluctuación reducido sobre la composición existente de tacrolimus; se describe también un método para preparar las formas de dosificación.
MX2009010556A 2007-03-29 2008-03-25 Formas de dosificacion modificada de tacrolimus. MX2009010556A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN583MU2007 2007-03-29
PCT/IN2008/000179 WO2009022354A2 (en) 2007-03-29 2008-03-25 Modified dosage forms of tacrolimus

Publications (1)

Publication Number Publication Date
MX2009010556A true MX2009010556A (es) 2009-10-22

Family

ID=39642954

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010556A MX2009010556A (es) 2007-03-29 2008-03-25 Formas de dosificacion modificada de tacrolimus.

Country Status (15)

Country Link
US (1) US20100086592A1 (es)
EP (1) EP1974722A3 (es)
JP (1) JP2010522742A (es)
KR (1) KR20100014629A (es)
CN (1) CN101652141A (es)
AU (1) AU2008288105A1 (es)
BR (1) BRPI0809563A2 (es)
CA (1) CA2680680A1 (es)
CL (1) CL2008000914A1 (es)
EA (1) EA200970897A1 (es)
IL (1) IL201008A0 (es)
MX (1) MX2009010556A (es)
NZ (1) NZ579811A (es)
UA (1) UA93148C2 (es)
WO (1) WO2009022354A2 (es)

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Publication number Priority date Publication date Assignee Title
PL2167033T4 (pl) 2007-05-30 2018-08-31 Veloxis Pharmaceuticals A/S Podawana raz dziennie doustna postać dawkowania zawierająca takrolimus
BRPI0915411A2 (pt) * 2008-06-26 2015-11-03 Mcneil Ppc Inc partículas revestidas contendo agentes farmaceuticamente ativos
KR101174183B1 (ko) 2008-11-28 2012-08-16 주식회사 삼양바이오팜 생체이용률이 향상된 타크로리무스 제제 및 상기 제제의 제조방법
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
KR101873075B1 (ko) * 2010-08-18 2018-06-29 에보니크 룀 게엠베하 하나 이상의 알긴산 염을 포함하는 위 내성 제약 또는 건강기능식품 제제
KR101243938B1 (ko) 2010-10-19 2013-03-19 이희엽 타크롤리무스를 유효성분으로 함유하는 서방형 펠렛
CA2835277A1 (en) 2011-05-10 2012-11-15 Theravida, Inc. Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder
DE102011053068A1 (de) * 2011-08-29 2013-02-28 Hennig Arzneimittel Gmbh & Co. Kg Darreichungsform mit stabilisierten Wirkstoffpartikeln
KR20130028824A (ko) * 2011-09-09 2013-03-20 주식회사 삼양바이오팜 타크로리무스를 포함하는 고체 분산체 및 이의 제조방법
JP6150896B2 (ja) 2012-08-27 2017-06-21 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ Ｒｏｅｈｍ ＧｍｂＨ エタノールの影響に対して耐性を有する胃液抵抗性の医薬組成物又は栄養補助組成物
WO2016025533A2 (en) * 2014-08-11 2016-02-18 Whitehead Institute For Biomedical Research Compositions and methods for treating synucleinopathies
CN104473907A (zh) * 2014-12-25 2015-04-01 北京华禧联合科技发展有限公司 一种他克莫司的口服缓释制剂
JP2018507209A (ja) 2015-02-20 2018-03-15 サイテック インダストリーズ インコーポレイテッド ジアルキルスルホスクシナート組成物、製造方法、および使用方法
BR112018014661A2 (pt) 2016-01-20 2018-12-11 Theravida Inc composição e composição para uso
MX2021000127A (es) 2018-06-29 2021-03-29 Incyte Corp Formulaciones de un inhibidor de axl/mer.
CA3063417C (en) * 2018-12-04 2023-01-03 Leon-Nanodrugs Gmbh Nanoparticles comprising tacrolimus
GR1009790B (el) * 2019-03-20 2020-08-03 Φαρματεν Α.Β.Ε.Ε. Σκευασμα παρατεταμενης αποδεσμευσης που περιλαμβανει τακρολιμους
US10752642B1 (en) 2019-04-30 2020-08-25 George Mason University Macrocyclic lactones
CN112569187B (zh) * 2019-09-27 2022-04-12 武汉科福新药有限责任公司 一种他克莫司纳米眼用乳及其制备方法
US11666560B2 (en) 2020-09-24 2023-06-06 George Mason University Anti-fibrotic agent

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100505464B1 (ko) * 1998-03-26 2005-08-04 후지사와 야꾸힝 고교 가부시키가이샤 서방성 제제
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
PL1663217T3 (pl) * 2003-08-29 2010-12-31 Lifecycle Pharma As Stałe dyspersje zawierające takrolimus
PT1663217E (pt) 2003-08-29 2010-10-18 Lifecycle Pharma As Dispersão sólida que compreende tacromílus
DE10353196A1 (de) * 2003-11-13 2005-06-16 Röhm GmbH & Co. KG Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
US7470435B2 (en) * 2003-11-17 2008-12-30 Andrx Pharmaceuticals, Llc Extended release venlafaxine formulation
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EA013741B1 (ru) * 2004-12-15 2010-06-30 Элан Фарма Интернэшнл Лтд. Дисперсии наночастиц такролимуса с повышенными растворимостью в воде и биодоступностью, способы их приготовления и применения

Also Published As

Publication number Publication date
EA200970897A1 (ru) 2010-04-30
UA93148C2 (ru) 2011-01-10
KR20100014629A (ko) 2010-02-10
CA2680680A1 (en) 2009-02-19
NZ579811A (en) 2012-02-24
AU2008288105A1 (en) 2009-02-19
EP1974722A3 (en) 2009-03-04
CN101652141A (zh) 2010-02-17
JP2010522742A (ja) 2010-07-08
WO2009022354A3 (en) 2009-04-09
CL2008000914A1 (es) 2008-07-18
EP1974722A2 (en) 2008-10-01
US20100086592A1 (en) 2010-04-08
BRPI0809563A2 (pt) 2014-09-16
IL201008A0 (en) 2010-05-17
WO2009022354A2 (en) 2009-02-19

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Legal Events

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