TW200730200A - Method for the preparation of a wet granulated drug product - Google Patents

Method for the preparation of a wet granulated drug product

Info

Publication number
TW200730200A
TW200730200A TW095122891A TW95122891A TW200730200A TW 200730200 A TW200730200 A TW 200730200A TW 095122891 A TW095122891 A TW 095122891A TW 95122891 A TW95122891 A TW 95122891A TW 200730200 A TW200730200 A TW 200730200A
Authority
TW
Taiwan
Prior art keywords
preparation
drug product
wet granulated
granulated drug
angiotensin
Prior art date
Application number
TW095122891A
Other languages
Chinese (zh)
Other versions
TWI407978B (en
Inventor
Takeshi Hamaura
Mitsuru Kanno
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of TW200730200A publication Critical patent/TW200730200A/en
Application granted granted Critical
Publication of TWI407978B publication Critical patent/TWI407978B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a method for the preparation of a solid dosage form comprising an angiotensin II receptor antagonist and a calcium channel blocker, said method comprising a step of preparing by wet granulation a composition comprising said angiotensin II receptor antagonist and said calcium channel blocker. The solid dosage form obtainable by the method of the present invention demonstrates improved dissolution properties.
TW095122891A 2005-06-27 2006-06-26 Method for the preparation of a wet granulated drug product TWI407978B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005187212 2005-06-27

Publications (2)

Publication Number Publication Date
TW200730200A true TW200730200A (en) 2007-08-16
TWI407978B TWI407978B (en) 2013-09-11

Family

ID=37114405

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095122891A TWI407978B (en) 2005-06-27 2006-06-26 Method for the preparation of a wet granulated drug product

Country Status (3)

Country Link
JP (1) JP5063370B2 (en)
TW (1) TWI407978B (en)
WO (1) WO2007001065A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103127110A (en) * 2013-03-18 2013-06-05 吉林省博大伟业制药有限公司 Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100237530A1 (en) * 2006-06-27 2010-09-23 Daiichi Sankyo Company, Limited Compressed preparation
TWI399223B (en) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd Solid dosage form of olmesartan medoxomil and amlodipine
TWI488658B (en) * 2006-12-26 2015-06-21 Daiichi Sankyo Co Ltd Method for improvement of elution
TWI414310B (en) * 2006-12-26 2013-11-11 Daiichi Sankyo Co Ltd Elution-improved pharmaceutical preparation
TWI402083B (en) * 2006-12-26 2013-07-21 Daiichi Sankyo Co Ltd Solid dosage form and stabilization method thereof
CN101416966B (en) * 2007-10-22 2010-11-10 鲁南制药集团股份有限公司 Medical composition capable of treating hypertension
WO2009113420A1 (en) * 2008-03-13 2009-09-17 第一三共株式会社 Improvement of dissolvability of preparation containing olmesartan medoxomil
JP5296456B2 (en) * 2008-08-26 2013-09-25 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
NZ594738A (en) 2009-01-23 2013-11-29 Hanmi Science Co Ltd Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
PE20120315A1 (en) * 2009-04-30 2012-04-07 Takeda Pharmaceutical A PHARMACEUTICAL COMPOSITION INCLUDING CANDESARTAN, CANDESARTAN CILEXETIL, OR AZILSARTAN, COMBINED WITH AMLODIPINE
CN101596195B (en) * 2009-05-15 2011-09-28 迪沙药业集团有限公司 Oral medicine composite for reducing blood pressure
US9173848B2 (en) * 2009-06-30 2015-11-03 Sanofi Solid pharmaceutical fixed dose compositions comprising irbesartan and amlodipine, their preparation and their therapeutic application
JP5421945B2 (en) * 2010-03-10 2014-02-19 大日本住友製薬株式会社 Pharmaceutical composition containing irbesartan and amlodipine or a salt thereof
EP2425859A1 (en) * 2010-08-08 2012-03-07 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Olmesartan formulations
KR101778050B1 (en) * 2012-10-12 2017-09-13 이에이 파마 가부시키가이샤 Method for producing pharmaceutical preparation containing calcium antagonist/angiotensin ii receptor antagonist
MX2013001277A (en) * 2013-01-31 2014-07-30 Miguel Ángel García Pérez Pharmaceutical composition comprising an angiotensin ii-receptor antagonist and a calcium channel blocker for the treatment of arterial hypertension.
JP5714652B2 (en) * 2013-06-13 2015-05-07 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
CN104434823A (en) * 2013-09-17 2015-03-25 许昌恒生制药有限公司 Manidipine hydrochloride tablets and preparation method thereof
EP2883539A1 (en) 2013-12-12 2015-06-17 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of olmesartan and amlodipine
JP5978335B2 (en) * 2015-03-11 2016-08-24 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
JP6445923B2 (en) * 2015-04-22 2018-12-26 ダイト株式会社 Preparation of irbesartan-containing tablets
CN104997778A (en) * 2015-07-08 2015-10-28 南京正大天晴制药有限公司 Olmesartan medoxomil and amlodipine medicinal composition
JP2017210435A (en) * 2016-05-25 2017-11-30 ダイト株式会社 Method for producing irbesartan and amlodipine besylate-containing tablet
JP6151413B2 (en) * 2016-07-25 2017-06-21 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet
CN106580992A (en) * 2016-11-10 2017-04-26 许昌恒生制药有限公司 Manidipine hydrochloride and irbesartan compound tablet for treating high blood pressure and preparation method
JP2017141299A (en) * 2017-05-24 2017-08-17 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet
JP2018168185A (en) * 2018-07-05 2018-11-01 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition and orally disintegrable tablet with excellent elution
JP2019203031A (en) * 2019-09-06 2019-11-28 大日本住友製薬株式会社 Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395728B2 (en) * 1999-07-08 2002-05-28 Novartis Ag Method of treatment and pharmaceutical composition
JP2003034655A (en) * 2001-05-15 2003-02-07 Takeda Chem Ind Ltd Fast degradable solid tablet
JP2003104888A (en) * 2001-09-28 2003-04-09 Taiyo Yakuhin Kogyo Kk Tablet of dihydropyridine derivative
EG24716A (en) * 2002-05-17 2010-06-07 Novartis Ag Combination of organic compounds
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
JP2008528456A (en) * 2005-01-26 2008-07-31 レツク・フアーマシユーテイカルズ・デー・デー Novel pharmaceutical composition comprising candesartan cilexetil as lipophilic crystalline substance

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103127110A (en) * 2013-03-18 2013-06-05 吉林省博大伟业制药有限公司 Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker

Also Published As

Publication number Publication date
JP5063370B2 (en) 2012-10-31
JP2008543727A (en) 2008-12-04
WO2007001065A3 (en) 2007-05-03
TWI407978B (en) 2013-09-11
WO2007001065A2 (en) 2007-01-04

Similar Documents

Publication Publication Date Title
TW200730200A (en) Method for the preparation of a wet granulated drug product
TW200740459A (en) Pharmaceutical preparation containing an angiotensin II receptor antagonist and a calcium channel blocker
WO2007001067A3 (en) Solid dosage form comprising an angiotensin ii receptor antagonist and a calcium channel blocker
WO2008051942A3 (en) Farnesoid x receptor agonists
TN2009000093A1 (en) Pharmaceutical compositions comprising nilotinib or its salt
MX2009010556A (en) Modified dosage forms of tacrolimus.
WO2006082523A3 (en) Pharmaceutical sustained release composition of metformin
UA99136C2 (en) Improved pharmaceutical composition comprising a calcium channel antagonist such as lercanidipine, process for the preparation thereof
PL2054411T3 (en) Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
WO2007050802A3 (en) Novel opioid antagonists
WO2007076260A3 (en) Farnesoid x receptor agonists
WO2007052289A3 (en) Novel dispersible tablet composition
WO2007044796A3 (en) Pyridazinone compounds as calcilytics
WO2010146179A3 (en) Solid pharmaceutical composition comprising rivaroxaban
MX349221B (en) Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same.
IL195514A (en) Substituted pyridyl compounds, pharmaceutical compositions comprising them, uses thereof as modulators of the histamine h3 receptor and method for their preparation
MX2009010167A (en) Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent.
MY160432A (en) Antihypertensive pharmaceutical composition
WO2009071650A3 (en) Amide compounds as boosters of antivirals
WO2007044251A3 (en) Pharmaceutical compositions
UA95274C2 (en) Solid pharmaceutical composition comprising irbesartan and processes for the manufacture thereof
CL2007003503A1 (en) COMPOUNDS DERIVED FROM INDOL-2-IL-CARBONIL-PIPERIDINA-BENZOIMIDAZOLONA AND INDOL-2-IL-CARBONIL-PIPERIDINA-BENZOXAZOLONA, ANTAGONISTS OF THE V1A RECEIVER; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION; AND USE FOR DISMENORREA TREATMENT
UA105285C2 (en) Solid pharmaceutical composition comprising ramipril and amlodipine besilate and method for its preparation
WO2007029093A3 (en) Pharmaceutical dosage forms of oxcarbazepine
WO2011087765A3 (en) Methods of producing stabilized solid pharmaceutical compositions containing morphinans