BRPI0416487A - pentafluorossulfanil-benzoilguanidinas, método para produção das mesmas, seu uso como medicamentos ou agentes de diagnóstico e medicamento contendo as mesmas - Google Patents

pentafluorossulfanil-benzoilguanidinas, método para produção das mesmas, seu uso como medicamentos ou agentes de diagnóstico e medicamento contendo as mesmas

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Publication number
BRPI0416487A
BRPI0416487A BRPI0416487-3A BRPI0416487A BRPI0416487A BR PI0416487 A BRPI0416487 A BR PI0416487A BR PI0416487 A BRPI0416487 A BR PI0416487A BR PI0416487 A BRPI0416487 A BR PI0416487A
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BR
Brazil
Prior art keywords
medicaments
pentafluorosulfanyl
production
benzoylguanidines
diagnostic agents
Prior art date
Application number
BRPI0416487-3A
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English (en)
Inventor
Heinz-Werner Kleemann
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0416487A publication Critical patent/BRPI0416487A/pt

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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0404Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P9/12Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

"PENTAFLUOROSSULFANIL-BENZOILGUANIDINAS, MéTODO PARA PRODUçãO DAS MESMAS, SEU USO COMO MEDICAMENTOS OU AGENTES DE DIAGNóSTICO, E MEDICAMENTO CONTENDO AS MESMAS". Pentafluorossulfanil-benzoguanidinas da fórmula (I), na qual R1 a R4 têm os significados indicados nas reivindicações, são apropriadas, por exemplo, como medicamentos antiarrítmicos com componente cardioprotetor, para profilaxia de infarto e tratamento do infarto, bem como para tratamento da angina pectoris. As mesmas também inibem, preventivamente, os processos patofisiológicos na formação de danos induzidos isquêmica e particularmente, no desencadeamento de arrtmias cardíacas induzidas isquemicamente.
BRPI0416487-3A 2003-11-13 2004-11-03 pentafluorossulfanil-benzoilguanidinas, método para produção das mesmas, seu uso como medicamentos ou agentes de diagnóstico e medicamento contendo as mesmas BRPI0416487A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353202A DE10353202A1 (de) 2003-11-13 2003-11-13 Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PCT/EP2004/012393 WO2005047239A1 (de) 2003-11-13 2004-11-03 Pentafluorsulfanyl-benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament

Publications (1)

Publication Number Publication Date
BRPI0416487A true BRPI0416487A (pt) 2007-03-27

Family

ID=34585094

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416487-3A BRPI0416487A (pt) 2003-11-13 2004-11-03 pentafluorossulfanil-benzoilguanidinas, método para produção das mesmas, seu uso como medicamentos ou agentes de diagnóstico e medicamento contendo as mesmas

Country Status (39)

Country Link
EP (1) EP1685096B1 (pt)
JP (1) JP4528304B2 (pt)
KR (1) KR101262065B1 (pt)
CN (1) CN100445265C (pt)
AR (1) AR046620A1 (pt)
AT (1) ATE368029T1 (pt)
AU (1) AU2004288758B2 (pt)
BR (1) BRPI0416487A (pt)
CA (1) CA2551057C (pt)
CR (1) CR8321A (pt)
CY (1) CY1106868T1 (pt)
DE (2) DE10353202A1 (pt)
DK (1) DK1685096T3 (pt)
DO (1) DOP2004001028A (pt)
EC (1) ECSP066563A (pt)
ES (1) ES2287788T3 (pt)
GT (1) GT200400217A (pt)
HK (1) HK1095584A1 (pt)
HN (1) HN2004000474A (pt)
HR (1) HRP20070364T3 (pt)
IL (1) IL175237A (pt)
JO (1) JO2466B1 (pt)
MA (1) MA28161A1 (pt)
MY (1) MY144211A (pt)
NI (1) NI200600112A (pt)
NO (1) NO20062635L (pt)
NZ (1) NZ547172A (pt)
OA (1) OA13285A (pt)
PE (1) PE20051034A1 (pt)
PL (1) PL1685096T3 (pt)
PT (1) PT1685096E (pt)
RS (1) RS50520B (pt)
RU (1) RU2380358C2 (pt)
TN (1) TNSN06116A1 (pt)
TW (1) TWI334411B (pt)
UA (1) UA84307C2 (pt)
UY (1) UY28616A1 (pt)
WO (1) WO2005047239A1 (pt)
ZA (1) ZA200602579B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7317124B2 (en) * 2003-11-13 2008-01-08 Sanofi-Aventis Deutschland Gmbh Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates
WO2009097972A1 (de) 2008-02-05 2009-08-13 Sanofi-Aventis Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
EP2661434A4 (en) * 2011-01-06 2014-07-09 Beta Pharma Canada Inc NEW URGES FOR THE TREATMENT AND PREVENTION OF CANCER
EP3064489A4 (en) 2013-11-01 2017-06-21 Ube Industries, Ltd. Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097409T3 (es) * 1992-09-22 1997-04-01 Hoechst Ag Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos.
DE4417004A1 (de) * 1994-05-13 1995-11-16 Hoechst Ag Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19526381A1 (de) * 1995-07-19 1997-01-23 Hoechst Ag 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19713427A1 (de) * 1997-04-01 1998-10-08 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19950898A1 (de) * 1999-10-22 2001-04-26 Aventis Pharma Gmbh Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10222192A1 (de) * 2002-05-18 2003-11-27 Aventis Pharma Gmbh Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10338554A1 (de) * 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
JP2007513076A (ja) 2007-05-24
NI200600112A (es) 2006-12-12
OA13285A (en) 2007-01-31
ES2287788T3 (es) 2007-12-16
CY1106868T1 (el) 2012-09-26
NO20062635L (no) 2006-08-11
AU2004288758B2 (en) 2011-06-02
ATE368029T1 (de) 2007-08-15
CR8321A (es) 2007-09-14
CA2551057A1 (en) 2005-05-26
MY144211A (en) 2011-08-15
DK1685096T3 (da) 2007-10-22
DOP2004001028A (es) 2005-05-14
AU2004288758A1 (en) 2005-05-26
HK1095584A1 (en) 2007-05-11
EP1685096B1 (de) 2007-07-25
HRP20070364T3 (en) 2008-01-31
ZA200602579B (en) 2007-06-27
EP1685096A1 (de) 2006-08-02
RU2380358C2 (ru) 2010-01-27
CN100445265C (zh) 2008-12-24
WO2005047239A1 (de) 2005-05-26
KR20060122848A (ko) 2006-11-30
PE20051034A1 (es) 2005-12-23
RS50520B (sr) 2010-05-07
TW200530162A (en) 2005-09-16
DE10353202A1 (de) 2005-06-16
RU2006120448A (ru) 2007-12-27
DE502004004460D1 (de) 2007-09-06
CN1878755A (zh) 2006-12-13
IL175237A (en) 2010-12-30
UA84307C2 (ru) 2008-10-10
AR046620A1 (es) 2005-12-14
MA28161A1 (fr) 2006-09-01
UY28616A1 (es) 2005-06-30
IL175237A0 (en) 2006-09-05
ECSP066563A (es) 2006-10-17
KR101262065B1 (ko) 2013-05-08
JP4528304B2 (ja) 2010-08-18
TWI334411B (en) 2010-12-11
NZ547172A (en) 2009-12-24
TNSN06116A1 (en) 2007-11-15
PT1685096E (pt) 2007-09-04
PL1685096T3 (pl) 2007-11-30
HN2004000474A (es) 2009-06-19
JO2466B1 (en) 2009-01-20
GT200400217A (es) 2005-06-23
CA2551057C (en) 2012-10-30

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