HRP20070364T3 - Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same - Google Patents
Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the sameInfo
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- HRP20070364T3 HRP20070364T3 HR20070364T HRP20070364T HRP20070364T3 HR P20070364 T3 HRP20070364 T3 HR P20070364T3 HR 20070364 T HR20070364 T HR 20070364T HR P20070364 T HRP20070364 T HR P20070364T HR P20070364 T3 HRP20070364 T3 HR P20070364T3
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- 239000003814 drug Substances 0.000 title 2
- GYZTWZKKXGLURP-UHFFFAOYSA-N FS(F)(F)(F)(F)N(C(=N)N)C(C1=CC=CC=C1)=O Chemical class FS(F)(F)(F)(F)N(C(=N)N)C(C1=CC=CC=C1)=O GYZTWZKKXGLURP-UHFFFAOYSA-N 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 19
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 229910052794 bromium Inorganic materials 0.000 abstract 7
- 229910052801 chlorine Inorganic materials 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052740 iodine Inorganic materials 0.000 abstract 7
- 229910052731 fluorine Inorganic materials 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
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Abstract
Spoj, naznačen time, da je isti formule I gdje: R1 jest vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika, alkoksi skupina koja sadrži 1, 2, 3 ili4 atoma ugljika, F, Cl, Br, I, -CN, NR5R6, -Op-(CH2)n-(CF2)o-CF3 ili -(SOm)q-(CH2)r-(CF2)s-CF3; R5 i R6 neovisno jedan o drugome jesu vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika ili -CH2-CF3;m jest nula, 1 ili 2n, o, p, q, r i s neovisno jedan o drugome jesu nula ili 1; R2 jest vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika, alkoksiskupina koja sadrži 1, 2, 3 ili 4 atoma ugljika, F, Cl, Br, I, -CN, NR7R8, -Ot-(CH2)u-(CF2)v-CF3 ili -(SOw)x-(CH2)y-(CF2)z-CF3;R7 i R8 neovisno jedano drugome jesu vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika ili -CH2-CF3;w jest nula, 1 ili2t, u, v, x, y i z neovisno jedan o drugome jesu nula ili 1; R3 jest Cl, Br, I, -CN, -SO2CH3, alkoksi skupina koja sadrži 1, 2, 3 ili 4 atoma ugljika, NR9R10, -Oa-(CH2)b-(CF2)C-CF3, -(SOd)e-(CH2)f-(CF2)g-CF3, alkil koji sadrži 1, 2, 3, 4, 5 ili 6 atoma ugljika ili cikloalkil koji sadrži 3, 4, 5, 6,7 ili 8 atoma ugljika u kojem 1, 2, 3 ili 4 atomavodika mogu biti zamijenjena s atomima fluora; R9i R10 neovisno jedan o drugome jesu vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika ili -CH2-CF3;a, b i c neovisno jedan o drugome jesu nula ili1; d jest nula, 1 ili 2; e jest nula ili 1; f jest nula, 1,2, 3 ili 4; g jest nula ili 1; iliR3 jest -(CH2)h-fenil ili -O-fenilgdje fenilni supstituenti jesu nesupstituirani ili su pak supstituirani s jednim, dva ili tri supstituenta odabrana iz grupe koju tvore F, Cl, Br, I, -Oj-(CH2)k-CF3, alkoksi skupina koja sadrži 1, 2, 3 ili 4 atoma ugljika,alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika i -SO2CH3;j jest nula ili 1; k jest nula, 1, 2 ili 3;h jest nula, 1,2, 3 ili 4; iliR3 jest -(CH2)aa-heteroarilkoji je nesupstituiran ili je pak supstituiran s jednim, dva ili tri supstituenta odabrana iz grupe koju tvore F, Cl, Br, I, -Obb-(CH2)CC-CF3,alkoksi skupina koja sadrži 1, 2, 3 ili 4 atoma ugljika, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika i -SO2CH3;bb jest nula ili 1; cc jest nula, 1,2 ili 3; aa jest nula, 1,2, 3 ili 4; R4 jest vodik, F, Cl, Br, I, -CN, -SO2CH3, alkoksi skupina koja sadrži 1, 2, 3 ili 4 atoma ugljika, NR11R12, -Odd-(CH2)ee-(CF2)ff-CF3, -(SOgg)hh-(CH2)jj-(CF2)kk-CF3, alkil koji sadrži 1, 2, 3, 4, 5 ili 6 atoma ugljika ili cikloalkil koji sadrži 3, 4, 5, 6, 7 ili8 atoma ugljika u kojem 1, 2, 3 ili 4 atoma vodika mogu biti zamijenjena s atomima fluora; R11 i R12 neovisno jedan o drugome jesu vodik, alkil koji sadrži 1, 2, 3 ili 4 atoma ugljika ili -CH2-CF3;dd, ee i ff neovisno jedan o drugome jesu nula ili 1; gg jest nula, 1 ili 2; hh jest nula ili 1; jj jest nula, 1, 2, 3 ili 4; kk jest nula ili 1; iliR4 jest -(CH2)ll-fenil ili -O-fenil, gdje fenilni supstituenti jesu nesupstituirani ili su pak supstituirani s jednim, dva ili tri supstituenta odabrana iz grupe koju tvore F, Cl, Br, I, -Omm-(CH2)nn-CF3, alkoksi skupina koja sadrži 1, 2, 3 ili 4 atoma ugljika, alkilA compound of formula I wherein: R 1 is hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, F, Cl, Br, I, -CN, NR5R6, -Op- (CH2) n- (CF2) o-CF3 or - (SOm) q- (CH2) r- (CF2) s-CF3; R5 and R6 independently of one another are hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms or -CH2-CF3, m is zero, 1 or 2n, o, p, q, ris independently of one another are zero or 1; R 2 is hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, F, Cl, Br, I, -CN, NR7R8, -Ot- (CH2) in - (CF2) v-CF3 or - (SOw) x- (CH2) y- (CF2) z-CF3, R7 and R8 independently of one another are hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms or -CH2 -CF3; w is zero, 1 or 2t, u, v, x, y and independently of one another are zero or 1; R3 is Cl, Br, I, -CN, -SO2CH3, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, NR9R10, -Oa- (CH2) b- (CF2) C-CF3, - (SOd) e - (CH2) f- (CF2) g-CF3, alkyl containing 1, 2, 3, 4, 5 or 6 carbon atoms or cycloalkyl containing 3, 4, 5, 6,7 or 8 carbon atoms in which 1, 2, 3 or 4 hydrogen atoms may be replaced by fluorine atoms; R 9 and R 10 independently of one another are hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms or -CH 2 -CF 3, a, b and c independently of one another are zero or 1; d is zero, 1 or 2; e is zero or 1; f is zero, 1, 2, 3 or 4; g is zero or 1; or R3 is - (CH2) h-phenyl or -O-phenyl wherein the phenyl substituents are unsubstituted or are substituted by one, two or three substituents selected from the group consisting of F, Cl, Br, I, -Oj- (CH2) k- CF3, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, alkyl containing 1, 2, 3 or 4 carbon atoms and -SO2CH3, j is zero or 1; k is zero, 1, 2 or 3, h is zero, 1, 2, 3 or 4; or R 3 is - (CH 2) aa-heteroaryl which is unsubstituted or substituted by one, two or three substituents selected from the group consisting of F, Cl, Br, I, -Obb- (CH 2) CC-CF 3, an alkoxy group containing 1 , 2, 3 or 4 carbon atoms, alkyl containing 1, 2, 3 or 4 carbon atoms and -SO2CH3; bb is zero or 1; cc is zero, 1, 2 or 3; aa is zero, 1, 2, 3 or 4; R4 is hydrogen, F, Cl, Br, I, -CN, -SO2CH3, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, NR11R12, -Odd- (CH2) ee- (CF2) ff-CF3, - (SOgg) hh- (CH2) jj- (CF2) kk-CF3, alkyl containing 1, 2, 3, 4, 5 or 6 carbon atoms or cycloalkyl containing 3, 4, 5, 6, 7 or 8 carbon atoms in wherein 1, 2, 3 or 4 hydrogen atoms may be replaced by fluorine atoms; R 11 and R 12 independently of one another are hydrogen, alkyl containing 1, 2, 3 or 4 carbon atoms or -CH 2 -CF 3; dd, ee and ff independently of one another are zero or 1; gg is zero, 1 or 2; hh is zero or 1; jj is zero, 1, 2, 3 or 4; kk is zero or 1; or R 4 is - (CH 2) 11 -phenyl or -O-phenyl, wherein the phenyl substituents are unsubstituted or are substituted with one, two or three substituents selected from the group consisting of F, Cl, Br, I, -Omm- (CH 2) nn-CF3, an alkoxy group containing 1, 2, 3 or 4 carbon atoms, alkyl
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10353202A DE10353202A1 (en) | 2003-11-13 | 2003-11-13 | Pentafluorsulfuranyl-benzoylguanidine, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| PCT/EP2004/012393 WO2005047239A1 (en) | 2003-11-13 | 2004-11-03 | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070364T3 true HRP20070364T3 (en) | 2008-01-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070364T HRP20070364T3 (en) | 2003-11-13 | 2007-08-23 | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same |
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| EP (1) | EP1685096B1 (en) |
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| KR (1) | KR101262065B1 (en) |
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| AR (1) | AR046620A1 (en) |
| AT (1) | ATE368029T1 (en) |
| AU (1) | AU2004288758B2 (en) |
| BR (1) | BRPI0416487A (en) |
| CA (1) | CA2551057C (en) |
| CR (1) | CR8321A (en) |
| CY (1) | CY1106868T1 (en) |
| DE (2) | DE10353202A1 (en) |
| DK (1) | DK1685096T3 (en) |
| DO (1) | DOP2004001028A (en) |
| EC (1) | ECSP066563A (en) |
| ES (1) | ES2287788T3 (en) |
| GT (1) | GT200400217A (en) |
| HK (1) | HK1095584A1 (en) |
| HN (1) | HN2004000474A (en) |
| HR (1) | HRP20070364T3 (en) |
| IL (1) | IL175237A (en) |
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| MA (1) | MA28161A1 (en) |
| MY (1) | MY144211A (en) |
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| PE (1) | PE20051034A1 (en) |
| PL (1) | PL1685096T3 (en) |
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| RU (1) | RU2380358C2 (en) |
| TN (1) | TNSN06116A1 (en) |
| TW (1) | TWI334411B (en) |
| UA (1) | UA84307C2 (en) |
| UY (1) | UY28616A1 (en) |
| WO (1) | WO2005047239A1 (en) |
| ZA (1) | ZA200602579B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7317124B2 (en) * | 2003-11-13 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates |
| SI2242740T1 (en) | 2008-02-05 | 2013-03-29 | Sanofi | Sf5 derivatives as par1 inhibitors, production thereof, and use as medicaments |
| EP2661434A4 (en) * | 2011-01-06 | 2014-07-09 | Beta Pharma Canada Inc | Novel ureas for the treatment and prevention of cancer |
| EP3064489A4 (en) | 2013-11-01 | 2017-06-21 | Ube Industries, Ltd. | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0589336B1 (en) * | 1992-09-22 | 1997-01-08 | Hoechst Aktiengesellschaft | Benzoylguanidines, process for their preparation and their use as antiarrhythmic agents |
| DE4417004A1 (en) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE19517848A1 (en) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorine-containing benzoylguanidines |
| DE19526381A1 (en) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-fluoroalkyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
| DE19713427A1 (en) * | 1997-04-01 | 1998-10-08 | Hoechst Ag | Ortho-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them |
| DE19950898A1 (en) * | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | New heteroaryl substituted fluoroalkyl-benzoylguanidine derivatives useful for treatment of e.g. ischemias, cardiac infarction, angina, shock, atherosclerosis, cancer and metabolic disorders |
| DE10222192A1 (en) * | 2002-05-18 | 2003-11-27 | Aventis Pharma Gmbh | New pentafluorosulfanylbenzoylguanidine compound useful for treating e.g. infarction, angina pectoris and stroke |
| DE10338554A1 (en) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them |
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