BRPI0414845B8 - mólecula de ácido nucleico, vetor, célula de levedura, partícula semelhante a vírus, bem como método para produzir a dita partícula semelhante a vírus - Google Patents

mólecula de ácido nucleico, vetor, célula de levedura, partícula semelhante a vírus, bem como método para produzir a dita partícula semelhante a vírus

Info

Publication number
BRPI0414845B8
BRPI0414845B8 BRPI0414845A BRPI0414845A BRPI0414845B8 BR PI0414845 B8 BRPI0414845 B8 BR PI0414845B8 BR PI0414845 A BRPI0414845 A BR PI0414845A BR PI0414845 A BRPI0414845 A BR PI0414845A BR PI0414845 B8 BRPI0414845 B8 BR PI0414845B8
Authority
BR
Brazil
Prior art keywords
virus
particle
hpv45
vector
particles
Prior art date
Application number
BRPI0414845A
Other languages
English (en)
Portuguese (pt)
Inventor
T Bryan Janine
U Jansen Kathrin
D Schultz Loren
K Brownlow Michelle
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc, Schering Corp filed Critical Merck Sharp & Dohme
Publication of BRPI0414845A publication Critical patent/BRPI0414845A/pt
Publication of BRPI0414845B1 publication Critical patent/BRPI0414845B1/pt
Publication of BRPI0414845B8 publication Critical patent/BRPI0414845B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
BRPI0414845A 2003-09-29 2004-09-24 mólecula de ácido nucleico, vetor, célula de levedura, partícula semelhante a vírus, bem como método para produzir a dita partícula semelhante a vírus BRPI0414845B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
US60/506,812 2003-09-29
PCT/US2004/031326 WO2005032586A1 (en) 2003-09-29 2004-09-24 Optimized expression of hpv 45 l1 in yeast

Publications (3)

Publication Number Publication Date
BRPI0414845A BRPI0414845A (pt) 2006-11-21
BRPI0414845B1 BRPI0414845B1 (pt) 2020-10-13
BRPI0414845B8 true BRPI0414845B8 (pt) 2021-06-15

Family

ID=34421558

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414845A BRPI0414845B8 (pt) 2003-09-29 2004-09-24 mólecula de ácido nucleico, vetor, célula de levedura, partícula semelhante a vírus, bem como método para produzir a dita partícula semelhante a vírus

Country Status (33)

Country Link
US (2) US7250170B2 (ref)
EP (1) EP1673106B1 (ref)
JP (4) JP5451960B2 (ref)
KR (1) KR101165278B1 (ref)
CN (1) CN1859923B (ref)
AR (2) AR045804A1 (ref)
AT (1) ATE435029T1 (ref)
AU (1) AU2004277934B2 (ref)
BE (1) BE2015C072I2 (ref)
BR (1) BRPI0414845B8 (ref)
CA (1) CA2539168C (ref)
CY (2) CY1110525T1 (ref)
DE (1) DE602004021828D1 (ref)
DK (1) DK1673106T3 (ref)
ES (1) ES2327530T3 (ref)
FR (1) FR15C0083I2 (ref)
HU (1) HUS1500063I1 (ref)
IL (1) IL174458A (ref)
IS (1) IS2694B (ref)
LT (2) LTC1673106I2 (ref)
LU (1) LU92902I2 (ref)
MX (1) MXPA06003457A (ref)
MY (1) MY140664A (ref)
NL (1) NL300776I2 (ref)
NO (3) NO339932B1 (ref)
NZ (1) NZ545834A (ref)
PL (1) PL1673106T3 (ref)
PT (1) PT1673106E (ref)
RU (1) RU2360001C2 (ref)
SI (1) SI1673106T1 (ref)
TW (1) TWI350853B (ref)
WO (1) WO2005032586A1 (ref)
ZA (1) ZA200601961B (ref)

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AU2005230907C1 (en) 2004-03-24 2016-07-28 Merck Sharp & Dohme Llc Optimized expression of HPV 52 L1 in yeast
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AU2006236905B2 (en) 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
EA013326B1 (ru) * 2005-04-26 2010-04-30 Глаксосмитклайн Байолоджикалс С.А. Вакцина
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JP5758385B2 (ja) 2009-06-19 2015-08-05 アイジェン インコーポレーテッド 子宮頸がんワクチン
CA2799205A1 (en) 2010-05-25 2011-12-01 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
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CN103215302B (zh) * 2012-01-21 2019-01-15 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv18 l1蛋白的方法
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN104120089B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv45 l1蛋白的方法
CN112280793B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因，及载体，菌株，表达方法
WO2015057541A1 (en) 2013-10-16 2015-04-23 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
WO2016038625A2 (en) * 2014-09-11 2016-03-17 Cadila Healthcare Limited Superior human papilloma virus antigens with superior immunological properties and vaccine containing it
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
BR112022015313A2 (pt) 2020-02-14 2022-09-27 Merck Sharp & Dohme Llc Vacina de hpv
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
EP4380615A1 (en) 2021-08-06 2024-06-12 Merck Sharp & Dohme LLC Hpv vaccine
WO2023023152A1 (en) 2021-08-19 2023-02-23 Merck Sharp & Dohme Llc Thermostable lipid nanoparticle and methods of use thereof
TW202513091A (zh) 2023-06-09 2025-04-01 美商默沙東有限責任公司 用於人類乳突病毒疫苗之奈米乳液佐劑組合物

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Also Published As

Publication number Publication date
US7482015B2 (en) 2009-01-27
KR101165278B1 (ko) 2012-07-23
WO2005032586A1 (en) 2005-04-14
JP2014221052A (ja) 2014-11-27
IL174458A (en) 2014-06-30
EP1673106A1 (en) 2006-06-28
JP2016136947A (ja) 2016-08-04
AR045804A1 (es) 2005-11-16
ATE435029T1 (de) 2009-07-15
US7250170B2 (en) 2007-07-31
RU2360001C2 (ru) 2009-06-27
AU2004277934B2 (en) 2009-09-17
IS8362A (is) 2006-03-20
CY1110525T1 (el) 2015-04-29
CA2539168A1 (en) 2005-04-14
NL300776I1 (ref) 2015-12-29
PT1673106E (pt) 2009-09-22
FR15C0083I2 (fr) 2016-11-25
NO2022051I1 (no) 2022-11-30
RU2006114701A (ru) 2007-11-10
CN1859923A (zh) 2006-11-08
IL174458A0 (en) 2006-08-01
SI1673106T1 (sl) 2009-12-31
NO339932B1 (no) 2017-02-20
PL1673106T3 (pl) 2009-12-31
TWI350853B (en) 2011-10-21
JP5451960B2 (ja) 2014-03-26
CY2015050I2 (el) 2016-06-22
HUS1500063I1 (hu) 2016-02-29
JP2007507207A (ja) 2007-03-29
NL300776I2 (ref) 2015-12-29
US20080138361A1 (en) 2008-06-12
BRPI0414845B1 (pt) 2020-10-13
CA2539168C (en) 2011-05-31
LU92902I2 (fr) 2016-03-08
KR20070029628A (ko) 2007-03-14
FR15C0083I1 (fr) 2016-08-01
MY140664A (en) 2010-01-15
IS2694B (is) 2010-11-15
DE602004021828D1 (de) 2009-08-13
DK1673106T3 (da) 2009-11-09
ES2327530T3 (es) 2009-10-30
EP1673106B1 (en) 2009-07-01
CY2015050I1 (el) 2016-06-22
US20060240040A1 (en) 2006-10-26
LTC1673106I2 (lt) 2017-05-10
NO20061876L (no) 2006-04-28
BE2015C072I2 (ref) 2023-12-14
AU2004277934A1 (en) 2005-04-14
LTPA2015049I1 (lt) 2016-01-11
JP2011152137A (ja) 2011-08-11
BRPI0414845A (pt) 2006-11-21
NO2017012I1 (no) 2017-04-05
ZA200601961B (en) 2007-05-30
NZ545834A (en) 2009-02-28
CN1859923B (zh) 2012-09-05
TW200521233A (en) 2005-07-01
AR077396A2 (es) 2011-08-24
MXPA06003457A (es) 2006-06-05

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