BRPI0413484A - processo para preparação de n-arilmorfolinonas - Google Patents

processo para preparação de n-arilmorfolinonas

Info

Publication number
BRPI0413484A
BRPI0413484A BRPI0413484-2A BRPI0413484A BRPI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A
Authority
BR
Brazil
Prior art keywords
arylmorpholinones
preparation
preparing
morpholinones
precursors
Prior art date
Application number
BRPI0413484-2A
Other languages
English (en)
Inventor
Dieter Dorsch
Bertram Cezanne
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0413484A publication Critical patent/BRPI0413484A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

"PROCESSO PARA PREPARAçãO DE N-ARIL-MORFOLINONAS". A presente invenção refere-se a um processo para preparação de compostos da fórmula (1) onde X possui o significado indicado na Reivindicação 1 da Patente e precursores do mesmo.
BRPI0413484-2A 2003-08-11 2004-07-16 processo para preparação de n-arilmorfolinonas BRPI0413484A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10336716A DE10336716A1 (de) 2003-08-11 2003-08-11 Verfahren zur Herstellung von N-Aryl-morpholinonen
PCT/EP2004/007938 WO2005016899A1 (de) 2003-08-11 2004-07-16 Verfahren zur herstellung von n-aryl-morpholinonen

Publications (1)

Publication Number Publication Date
BRPI0413484A true BRPI0413484A (pt) 2006-10-17

Family

ID=34177411

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413484-2A BRPI0413484A (pt) 2003-08-11 2004-07-16 processo para preparação de n-arilmorfolinonas

Country Status (20)

Country Link
US (2) US7687624B2 (pt)
EP (1) EP1654240B1 (pt)
JP (1) JP4668903B2 (pt)
KR (1) KR101119940B1 (pt)
CN (1) CN100537549C (pt)
AR (1) AR045244A1 (pt)
AT (1) ATE344252T1 (pt)
AU (1) AU2004265056B2 (pt)
BR (1) BRPI0413484A (pt)
CA (1) CA2535412C (pt)
DE (2) DE10336716A1 (pt)
DK (1) DK1654240T3 (pt)
ES (1) ES2275233T3 (pt)
HK (1) HK1095145A1 (pt)
MX (1) MXPA06001567A (pt)
PL (1) PL1654240T3 (pt)
PT (1) PT1654240E (pt)
RU (1) RU2343149C2 (pt)
WO (1) WO2005016899A1 (pt)
ZA (1) ZA200602068B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211654B (zh) * 2013-08-13 2017-03-29 联化科技（台州）有限公司 一种利伐沙班中间体的制备方法以及中间体
CN103804222A (zh) * 2014-02-25 2014-05-21 湖北迅达药业股份有限公司 一种4-（4-氨基苯基）-3-吗啉酮的合成方法及其中间体
CN103804221B (zh) * 2014-02-25 2016-09-14 湖北迅达药业股份有限公司 一种4-(4-氨基苯基)-3-吗啉酮的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH512247A (de) * 1968-05-02 1971-09-15 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10102322A1 (de) * 2001-01-19 2002-07-25 Merck Patent Gmbh Phenylderivate
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone

Also Published As

Publication number Publication date
ES2275233T3 (es) 2007-06-01
AU2004265056B2 (en) 2011-03-17
JP2007501818A (ja) 2007-02-01
KR101119940B1 (ko) 2012-03-19
EP1654240A1 (de) 2006-05-10
ZA200602068B (en) 2007-05-30
ATE344252T1 (de) 2006-11-15
PL1654240T3 (pl) 2007-02-28
DK1654240T3 (da) 2007-03-26
RU2006107291A (ru) 2007-09-20
RU2343149C2 (ru) 2009-01-10
CA2535412C (en) 2012-08-28
AU2004265056A1 (en) 2005-02-24
CA2535412A1 (en) 2005-02-24
EP1654240B1 (de) 2006-11-02
MXPA06001567A (es) 2006-05-15
PT1654240E (pt) 2007-02-28
CN100537549C (zh) 2009-09-09
JP4668903B2 (ja) 2011-04-13
CN1832933A (zh) 2006-09-13
AR045244A1 (es) 2005-10-19
HK1095145A1 (en) 2007-04-27
KR20060066086A (ko) 2006-06-15
US7687624B2 (en) 2010-03-30
DE10336716A1 (de) 2005-03-10
DE502004001923D1 (de) 2006-12-14
US20100210864A1 (en) 2010-08-19
WO2005016899A1 (de) 2005-02-24
US20060217550A1 (en) 2006-09-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2264 DE 27/05/2014.