BRPI0412715A - células precursoras de oligodendrócitos e métodos de obter e cultivar as mesmas - Google Patents
células precursoras de oligodendrócitos e métodos de obter e cultivar as mesmasInfo
- Publication number
- BRPI0412715A BRPI0412715A BRPI0412715-3A BRPI0412715A BRPI0412715A BR PI0412715 A BRPI0412715 A BR PI0412715A BR PI0412715 A BRPI0412715 A BR PI0412715A BR PI0412715 A BRPI0412715 A BR PI0412715A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- precursor cells
- oligodendrocyte precursor
- obtaining
- population
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/395—Thyroid hormones
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
Abstract
"CéLULAS PRECURSORAS DE OLIGODENDRóCITOS E MéTODOS DE OBTER E CULTIVAR AS MESMAS". A presente invenção refere-se uma população fenotipicamente homogênea, de auto-renovação de células precursoras de oligodendrócitos tendo um estágio de desenvolvimento sincronizado e métodos de obtenção de uma população fenotipicamente homogênea, de auto-renovação de células precursoras de oligodendrócitos. Outros métodos incluem métodos de manutenção e armazenamento de uma população homogênea de células precursoras de oligodendrócitos durante um período de tempo prolongado sem mudança nas características das células e métodos de desdiferenciação de células precursoras de oligodendrócitos. A população fenotipicamente homogênea, de auto-renovação, de células precursoras de oligodendrócitos ou população homogênea de oligodendrócitos podem ser utilizáveis par ao tratamento de um paciente tendo uma condição ou distúrbio do sistema nervoso central.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48793303P | 2003-07-18 | 2003-07-18 | |
PCT/IB2004/002670 WO2005007797A2 (en) | 2003-07-18 | 2004-07-19 | Oligodendrocyte precursor cells and methods of obtaining and culturing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412715A true BRPI0412715A (pt) | 2006-09-26 |
Family
ID=34079394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412715-3A BRPI0412715A (pt) | 2003-07-18 | 2004-07-19 | células precursoras de oligodendrócitos e métodos de obter e cultivar as mesmas |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060172415A1 (pt) |
EP (1) | EP1646711A4 (pt) |
JP (1) | JP2007530001A (pt) |
KR (1) | KR20060037346A (pt) |
CN (1) | CN1833021A (pt) |
AR (1) | AR046076A1 (pt) |
AU (1) | AU2004257000B2 (pt) |
BR (1) | BRPI0412715A (pt) |
CA (1) | CA2532216A1 (pt) |
MX (1) | MXPA05014161A (pt) |
SG (1) | SG144166A1 (pt) |
TW (1) | TW200510537A (pt) |
WO (1) | WO2005007797A2 (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060183147A1 (en) * | 2005-02-11 | 2006-08-17 | Elan Pharmaceuticals, Inc. | Methods of identifying genes which modulate myelination |
CA2613551C (en) * | 2005-06-23 | 2017-06-20 | Tissuegene, Inc. | Use of cells for treating a neurodegenerative condition |
ES2323913B1 (es) * | 2006-03-17 | 2010-05-14 | Universidad De Salamanca (Titular Al 65%) | Efecto mitogeno de sonic hedgehog (shh) sobre precursores de oligodendrocitos y su uso en enfermedades desmielinizantes. |
EP2247718B1 (en) | 2008-01-30 | 2019-01-16 | Asterias Biotherapeutics, Inc. | Synthetic surfaces for culturing stem cell derived cardiomyocytes |
CA2714010C (en) * | 2008-01-30 | 2020-06-16 | Corning Incorporated | Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells |
AU2009210765A1 (en) * | 2008-01-30 | 2009-08-13 | Geron Corporation | Synthetic surfaces for culturing cells in chemically defined media |
EP2355826A1 (en) * | 2008-11-07 | 2011-08-17 | The Cleveland Clinic Foundation | Compounds and methods of promoting oligodendrocyte precursor differentiation |
NO2499238T3 (pt) * | 2009-11-12 | 2018-01-27 | ||
CN101735983B (zh) * | 2009-12-29 | 2011-07-27 | 中国人民解放军第三军医大学 | 少突胶质前体细胞的分离纯化方法 |
ES2375860B8 (es) * | 2010-03-31 | 2013-06-10 | Fundación Hospital Nacional De Parapléjicos Para La Investigación Y La Integración (Fuhnpaiin) | Método para la obtención de células precursoras de oligodendrocitos. |
JP2014528706A (ja) * | 2011-08-07 | 2014-10-30 | カディマステム リミテッド | 成熟、生存及びミエリン形成に作用する薬剤を同定する方法 |
KR101409336B1 (ko) | 2012-02-15 | 2014-06-27 | 중앙대학교 산학협력단 | 희돌기교전구세포를 유효성분으로 포함하는 중추신경계 질환의 치료용 조성물 |
US20150024491A1 (en) * | 2012-03-27 | 2015-01-22 | Okinawa Institute of Science and Technology Graduate University | Neuronal culture medium and method for producing in vivo-like and enhanced synaptogenesis neuron model |
JP6363096B2 (ja) * | 2012-12-19 | 2018-07-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ミエリン形成をアッセイするためのマイクロピラーアレイ |
CN103388007B (zh) * | 2013-07-25 | 2016-08-24 | 宗兆文 | 一种利用真皮来源的间充质干细胞制备组织工程脊髓的方法 |
JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
CN105062956B (zh) * | 2015-08-21 | 2018-02-09 | 北京市虹天济神经科学研究院 | 人嗅粘膜嗅鞘细胞分离、传代、冻存、分化技术 |
CN105695409B (zh) * | 2016-03-22 | 2019-09-27 | 中国人民解放军第二军医大学 | 一种裸鼹鼠少突胶质前体细胞培养方法 |
EP3436567A4 (en) | 2016-03-30 | 2019-10-30 | Asterias Biotherapeutics, Inc. | OLIGODENDROCYTE PROGENITOR CELL COMPOSITIONS |
WO2018053210A1 (en) * | 2016-09-14 | 2018-03-22 | Asterias Biotherapeutics, Inc. | Pluripotent stem cell-derived oligodendrocyte progenitor cells for the treatment of spinal cord injury |
CN109722418B (zh) * | 2017-10-29 | 2023-01-03 | 复旦大学 | 一种获取和纯化新生小鼠少突胶质前体细胞的方法 |
CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
CN113481161A (zh) * | 2021-07-30 | 2021-10-08 | 四川省医学科学院·四川省人民医院 | 一种培养基及少突胶质祖细胞的诱导培养方法以及应用 |
CN115340982A (zh) * | 2022-08-23 | 2022-11-15 | 徐州医科大学 | 一种分离并纯化新生小鼠皮质区少突胶质前体细胞的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
US6361996B1 (en) * | 1997-05-07 | 2002-03-26 | University Of Utah Research Foundation | Neuroepithelial stem cells and glial-restricted intermediate precursors |
US6235527B1 (en) * | 1997-11-29 | 2001-05-22 | University Of Utah Research Foundation | Lineage restricted glial precursors from the central nervous system |
US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US20040029269A1 (en) * | 2002-05-07 | 2004-02-12 | Goldman Steven A | Promoter-based isolation, purification, expansion, and transplantation of neuronal progenitor cells, oligodendrocyte progenitor cells, or neural stem cells from a population of embryonic stem cells |
US7285415B2 (en) * | 2002-07-11 | 2007-10-23 | The Regents Of The University Of California | Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury |
-
2004
- 2004-07-16 AR ARP040102543A patent/AR046076A1/es unknown
- 2004-07-19 CA CA002532216A patent/CA2532216A1/en not_active Abandoned
- 2004-07-19 JP JP2006520045A patent/JP2007530001A/ja not_active Ceased
- 2004-07-19 SG SG200804940-5A patent/SG144166A1/en unknown
- 2004-07-19 CN CNA2004800193757A patent/CN1833021A/zh active Pending
- 2004-07-19 TW TW093121529A patent/TW200510537A/zh unknown
- 2004-07-19 WO PCT/IB2004/002670 patent/WO2005007797A2/en active Application Filing
- 2004-07-19 MX MXPA05014161A patent/MXPA05014161A/es active IP Right Grant
- 2004-07-19 BR BRPI0412715-3A patent/BRPI0412715A/pt not_active IP Right Cessation
- 2004-07-19 AU AU2004257000A patent/AU2004257000B2/en not_active Expired - Fee Related
- 2004-07-19 US US10/564,819 patent/US20060172415A1/en not_active Abandoned
- 2004-07-19 KR KR1020067000833A patent/KR20060037346A/ko not_active Application Discontinuation
- 2004-07-19 EP EP04744291A patent/EP1646711A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AR046076A1 (es) | 2005-11-23 |
AU2004257000A1 (en) | 2005-01-27 |
WO2005007797A2 (en) | 2005-01-27 |
MXPA05014161A (es) | 2006-05-25 |
WO2005007797A3 (en) | 2006-05-11 |
US20060172415A1 (en) | 2006-08-03 |
AU2004257000B2 (en) | 2011-07-21 |
EP1646711A2 (en) | 2006-04-19 |
EP1646711A4 (en) | 2008-03-19 |
KR20060037346A (ko) | 2006-05-03 |
SG144166A1 (en) | 2008-07-29 |
JP2007530001A (ja) | 2007-11-01 |
TW200510537A (en) | 2005-03-16 |
CN1833021A (zh) | 2006-09-13 |
CA2532216A1 (en) | 2005-01-27 |
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