BRPI0411715A - salinosporamidas e métodos para uso das mesmas - Google Patents
salinosporamidas e métodos para uso das mesmasInfo
- Publication number
- BRPI0411715A BRPI0411715A BRPI0411715-8A BRPI0411715A BRPI0411715A BR PI0411715 A BRPI0411715 A BR PI0411715A BR PI0411715 A BRPI0411715 A BR PI0411715A BR PI0411715 A BRPI0411715 A BR PI0411715A
- Authority
- BR
- Brazil
- Prior art keywords
- strains
- cnb476
- marine
- methods
- cnb392
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Abstract
"SALINOSPORAMIDAS E MéTODOS PARA USO DAS MESMAS". A presente invenção refere-se à descoberta de que determinados produtos da fermentação das cepas CNB392 e CNB476 do actinomicete marinho são inibidores eficazes das células hiperproliferativas de mamíferos. As cepas CNB392 e CNB476 estão dentro da família dos Micromonosporaceae, e o epíteto genérico Salinospora foi proposto para esse grupo de obligatos marinhos. Os produtos de reação produzidos por essas cepas são classificados como salinosporamidas, e são especificamente vantajosos para o tratamento de distúrbios neoplásicos, devido ao seu baixo peso molecular, baixos valores de lC~ 50~, alta potência farmacêutica, e seletividade para células de câncer sobre os fungos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/600,854 US7179834B2 (en) | 2002-06-24 | 2003-06-20 | Salinosporamides and methods for use thereof |
US10/600,854 | 2003-06-20 | ||
US10/838,157 | 2004-04-30 | ||
US10/838,157 US7176232B2 (en) | 2002-06-24 | 2004-04-30 | Salinosporamides and methods for use thereof |
PCT/US2004/019453 WO2005003137A1 (en) | 2003-06-20 | 2004-06-18 | Salinosporamides and methods for use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0411715A true BRPI0411715A (pt) | 2006-08-08 |
BRPI0411715B1 BRPI0411715B1 (pt) | 2020-12-01 |
BRPI0411715B8 BRPI0411715B8 (pt) | 2021-05-25 |
Family
ID=33568002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411715A BRPI0411715B8 (pt) | 2003-06-20 | 2004-06-18 | composição farmacêutica compreendendo salinosporamidas |
Country Status (9)
Country | Link |
---|---|
US (9) | US7176232B2 (pt) |
EP (1) | EP1638977A4 (pt) |
JP (1) | JP2007523859A (pt) |
KR (1) | KR101183784B1 (pt) |
AU (1) | AU2004253879A1 (pt) |
BR (1) | BRPI0411715B8 (pt) |
CA (1) | CA2530215A1 (pt) |
MX (1) | MXPA05013985A (pt) |
WO (1) | WO2005003137A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US8217072B2 (en) * | 2003-06-20 | 2012-07-10 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US20050049294A1 (en) * | 2003-06-20 | 2005-03-03 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
US7943567B2 (en) | 2004-01-30 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foam stabilizers |
US7276530B2 (en) * | 2004-04-30 | 2007-10-02 | Nereus Pharmaceuticals, Inc. | [3.2.0] Heterocyclic compounds and methods of using the same |
US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
CN103230394B (zh) * | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的化合物及其用途 |
MX2007006523A (es) * | 2004-12-03 | 2007-09-11 | Nereus Pharmaceuticals Inc | Metodos para utilizar compuestos heterociclicos [3.2.0] y sus analogos. |
WO2006124902A2 (en) * | 2005-05-16 | 2006-11-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of salinosporamide a and analogues thereof |
US7572606B1 (en) * | 2005-09-09 | 2009-08-11 | Nereus Pharmaceuticals, Inc. | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs |
CA2628110A1 (en) * | 2005-11-04 | 2007-05-18 | The Regents Of The University Of California | Methods of sensitizing cancer to therapy-induced cytotoxicity |
DE202006002452U1 (de) * | 2006-02-16 | 2006-05-24 | Lanxess Deutschland Gmbh | Formkörper für den Sanitärbereich |
US7842814B2 (en) | 2006-04-06 | 2010-11-30 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
US8986971B2 (en) * | 2006-09-22 | 2015-03-24 | Triphase Research And Development I Corp. | Salt formulations for the fermentation of marine microorganisms |
WO2008095195A2 (en) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
US8318656B2 (en) | 2007-07-03 | 2012-11-27 | E. I. Du Pont De Nemours And Company | Production processes and systems, compositions, surfactants, monomer units, metal complexes, phosphate esters, glycols, aqueous film forming foams, and foam stabilizers |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
BRPI0909661A2 (pt) | 2008-03-07 | 2015-08-11 | Nereus Pharmaceuticals Inc | Composto e métodos de síntese química e de formação ou preparação de compostos |
US20090285836A1 (en) * | 2008-04-14 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Use of salinosporamide a to inhibit metastasis |
WO2009140287A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
EP3021120A1 (en) | 2009-02-20 | 2016-05-18 | Michael P. Lisanti | Diagnosis, prognosis, therapeutics and methods for treating neoplastic deiseases comprising determining the level of caveolin-1 in a stromal cell sample |
EP2771489B1 (en) | 2011-10-28 | 2018-07-04 | Millennium Pharmaceuticals, Inc. | Biomarkers of response to nae inhibitors |
JP6286358B2 (ja) | 2011-11-11 | 2018-02-28 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤に応答するバイオマーカー |
EP2810066B1 (en) | 2012-01-24 | 2019-07-31 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
CA2886783A1 (en) | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
US10022372B2 (en) | 2013-04-19 | 2018-07-17 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
CN103408503B (zh) * | 2013-08-21 | 2015-03-11 | 中国科学院南海海洋研究所 | 一种生物碱类化合物的制备方法及其在制备抑制钙离子通道药物中的应用 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
US5276182A (en) * | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
DE4028102A1 (de) | 1990-09-05 | 1992-03-12 | Metallgesellschaft Ag | Verfahren zur analyse von metallteilchen |
DE4030414A1 (de) | 1990-09-26 | 1992-04-02 | Winkler Duennebier Kg Masch | Verfahren zum herstellen von selbstklebeumschlaegen |
DE4039602A1 (de) * | 1990-12-12 | 1992-06-17 | Bauer Kurt Heinz Prof Dr | Pharmazeutische formulierungen |
KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
US5683676A (en) * | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
JP2880292B2 (ja) * | 1992-11-27 | 1999-04-05 | ナプロ バイオセラピューティクス,インコーポレイテッド | 注射可能組成物 |
US5654286A (en) * | 1993-05-12 | 1997-08-05 | Hostetler; Karl Y. | Nucleotides for topical treatment of psoriasis, and methods for using same |
RO115412B1 (ro) * | 1993-10-01 | 2000-02-28 | Syntex Inc | Compozitie farmaceutica si procedeu de obtinere a compozitiei farmaceutice |
US5707641A (en) * | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
IE80468B1 (en) * | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
US6838477B2 (en) * | 1995-04-12 | 2005-01-04 | President And Fellows Of Harvard College | Lactacystin analogs |
US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
US5653987A (en) * | 1995-05-16 | 1997-08-05 | Modi; Pankaj | Liquid formulations for proteinic pharmaceuticals |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
US5667809A (en) * | 1995-06-07 | 1997-09-16 | Alliance Pharmaceutical Corp. | Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents |
US5874443A (en) * | 1995-10-19 | 1999-02-23 | Trega Biosciences, Inc. | Isoquinoline derivatives and isoquinoline combinatorial libraries |
US5886210A (en) * | 1996-08-22 | 1999-03-23 | Rohm And Haas Company | Method for preparing aromatic compounds |
NZ337364A (en) * | 1997-02-15 | 2001-06-29 | Millennium Pharm Inc | Treatment of infarcts, ischemia and reperfusion through inhibition of NFkappaB |
US5922683A (en) * | 1997-05-29 | 1999-07-13 | Abbott Laboratories | Multicyclic erythromycin derivatives |
DE69809063T2 (de) * | 1997-08-04 | 2003-06-12 | Taisho Pharmaceutical Co Ltd | Aryloxyanilin-derivate |
US6133308A (en) * | 1997-08-15 | 2000-10-17 | Millennium Pharmaceuticals, Inc. | Synthesis of clasto-lactacystin beta-lactone and analogs thereof |
WO1999009006A1 (en) | 1997-08-15 | 1999-02-25 | Soucy Francois | SYNTHESIS OF CLASTO-LACTACYSTIN β-LACTONE AND ANALOGS THEREOF |
US20010051654A1 (en) * | 1997-09-25 | 2001-12-13 | Elliott Peter J. | Treatment of inflammatory and autoimmune diseases |
WO1999015183A1 (en) | 1997-09-25 | 1999-04-01 | Proscript Inc. | PROTEASOME INHIBITORS, UBIQUITIN PATHWAY INHIBITORS OR AGENTS THAT INTERFERE WITH THE ACTIVATION OF NF-λB VIA THE UBIQUITIN PROTEASOME PATHWAY TO TREAT INFLAMMATORY AND AUTOIMMUNE DISEASES |
US6831057B2 (en) | 1997-10-28 | 2004-12-14 | The University Of North Carolina At Chapel Hill | Use of NF-κB inhibition in combination therapy for cancer |
CA2219867A1 (en) | 1997-10-31 | 1999-04-30 | Jiangping Wu | The use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock |
EP2201944B1 (en) * | 1997-11-21 | 2012-05-23 | Purdue Neuroscience Company | Use of substituted 2-aminoacetamides for treating, preventing or ameliorating manic depression |
US6617171B2 (en) * | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
PL343249A1 (en) * | 1998-03-26 | 2001-07-30 | Shionogi & Co | Indole derivatives with antiviral activity |
US6509331B1 (en) * | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
KR20010080267A (ko) | 1998-10-20 | 2001-08-22 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아솜 억제제 약물 작용을 모니터링하는 방법 |
FR2784988B1 (fr) * | 1998-10-23 | 2002-09-20 | Adir | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20020049157A1 (en) * | 1999-08-25 | 2002-04-25 | Jiangping Wu | Use of proteasome inhibitors for treating cancer, inflammation, autoimmune disease, graft rejection and septic shock |
DK1326632T3 (da) * | 2000-10-12 | 2007-01-15 | Viromics Gmbh | Protease-inhibitorer til behandling af infektioner af hepatitisvirus |
JP4395549B2 (ja) * | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
WO2003084551A1 (de) * | 2002-04-05 | 2003-10-16 | Viromics Gmbh | Mittel zur behandlung von flaviviridae-infektionen |
US7179834B2 (en) * | 2002-06-24 | 2007-02-20 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
US7176232B2 (en) * | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
WO2004043374A2 (en) | 2002-11-06 | 2004-05-27 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for treating cancer using proteasome inhibitors |
ES2336562T3 (es) | 2003-02-14 | 2010-04-14 | Intermed Discovery Gmbh | Heterociclos sustituidos. |
US20050049294A1 (en) * | 2003-06-20 | 2005-03-03 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
US8217072B2 (en) * | 2003-06-20 | 2012-07-10 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
WO2005094423A2 (en) | 2004-02-26 | 2005-10-13 | President And Fellows Of Harvard College | Selective inhibition of proteasomes of tuberculosis and other bacteria |
US7371875B2 (en) * | 2004-03-12 | 2008-05-13 | Miikana Therapeutics, Inc. | Cytotoxic agents and methods of use |
WO2005099687A2 (en) | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
US7183417B2 (en) * | 2004-04-09 | 2007-02-27 | President And Fellows Of Harvard College | Simple stereocontrolled synthesis of salinosporamide A |
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
US20060264495A1 (en) * | 2004-04-30 | 2006-11-23 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
US7276530B2 (en) * | 2004-04-30 | 2007-10-02 | Nereus Pharmaceuticals, Inc. | [3.2.0] Heterocyclic compounds and methods of using the same |
US7579371B2 (en) * | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
US20080064736A1 (en) | 2004-07-12 | 2008-03-13 | Bayer Cropscience Ag | Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides |
WO2006060819A2 (en) | 2004-12-03 | 2006-06-08 | The Regents Of The University Of California | Dhmeq as a sensitizing agent for chemotherapy and immunotherapy of resistant cancer cells |
MX2007006523A (es) | 2004-12-03 | 2007-09-11 | Nereus Pharmaceuticals Inc | Metodos para utilizar compuestos heterociclicos [3.2.0] y sus analogos. |
CN103230394B (zh) * | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的化合物及其用途 |
WO2006060609A1 (en) | 2004-12-03 | 2006-06-08 | Honeywell International Inc. | Gas jet control for inertial measurement unit |
WO2006118973A2 (en) | 2005-04-29 | 2006-11-09 | Nereus Pharmaceuticals, Inc. | Methods of using heterobyclic compounds for treatment of rectal cancer |
WO2006124902A2 (en) * | 2005-05-16 | 2006-11-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of salinosporamide a and analogues thereof |
EP1931679A4 (en) | 2005-08-10 | 2009-07-29 | Harvard College | ANALOGUE OF SALINOSPORAMIDE A |
US7572606B1 (en) * | 2005-09-09 | 2009-08-11 | Nereus Pharmaceuticals, Inc. | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs |
US7465720B2 (en) | 2005-09-12 | 2008-12-16 | President And Fellows Of Harvard College | Proteasome inhibiting β-lactam compounds |
CA2628110A1 (en) * | 2005-11-04 | 2007-05-18 | The Regents Of The University Of California | Methods of sensitizing cancer to therapy-induced cytotoxicity |
US20070225250A1 (en) * | 2006-01-26 | 2007-09-27 | Bebaas, Inc. | Cobalamin compositions for the treatment of cancer |
GB0605217D0 (en) * | 2006-03-15 | 2006-04-26 | Novartis Ag | Method and compositions for assessing acute rejection |
US7842814B2 (en) * | 2006-04-06 | 2010-11-30 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
WO2007130404A1 (en) | 2006-05-03 | 2007-11-15 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for the treatment of lung cancer |
DE102006026464A1 (de) | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
US8088923B2 (en) * | 2006-07-07 | 2012-01-03 | The Texas A&M University System | Cyclic-fused beta-lactones and their synthesis |
WO2008124699A1 (en) | 2007-04-06 | 2008-10-16 | Nereus Pharmaceuticals, Inc. | A method of using proteasome inhibitors in combination with histone deacetylase inhibitors to treat cancer |
WO2008137780A2 (en) * | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Use of [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
US7442830B1 (en) * | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
BRPI0909661A2 (pt) * | 2008-03-07 | 2015-08-11 | Nereus Pharmaceuticals Inc | Composto e métodos de síntese química e de formação ou preparação de compostos |
WO2009140287A1 (en) * | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Salinosporamide derivatives as proteasome inhibitors |
-
2004
- 2004-04-30 US US10/838,157 patent/US7176232B2/en not_active Expired - Lifetime
- 2004-06-18 WO PCT/US2004/019453 patent/WO2005003137A1/en active Application Filing
- 2004-06-18 AU AU2004253879A patent/AU2004253879A1/en not_active Abandoned
- 2004-06-18 BR BRPI0411715A patent/BRPI0411715B8/pt active IP Right Grant
- 2004-06-18 EP EP04776728A patent/EP1638977A4/en not_active Withdrawn
- 2004-06-18 CA CA002530215A patent/CA2530215A1/en not_active Abandoned
- 2004-06-18 KR KR1020057024462A patent/KR101183784B1/ko active IP Right Grant
- 2004-06-18 JP JP2006517371A patent/JP2007523859A/ja active Pending
- 2004-06-18 MX MXPA05013985A patent/MXPA05013985A/es active IP Right Grant
-
2005
- 2005-06-07 US US11/147,622 patent/US7176233B2/en not_active Expired - Lifetime
-
2007
- 2007-02-12 US US11/705,694 patent/US7635712B2/en not_active Expired - Lifetime
-
2009
- 2009-12-15 US US12/638,860 patent/US8222289B2/en not_active Expired - Lifetime
-
2012
- 2012-05-22 US US13/477,364 patent/US8637565B2/en not_active Expired - Lifetime
-
2013
- 2013-12-23 US US14/139,692 patent/US9078881B2/en not_active Expired - Lifetime
-
2015
- 2015-07-08 US US14/794,468 patent/US9713607B2/en not_active Expired - Lifetime
-
2017
- 2017-07-20 US US15/655,739 patent/US10314818B2/en not_active Expired - Lifetime
-
2019
- 2019-05-21 US US16/418,801 patent/US10912764B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20140178354A1 (en) | 2014-06-26 |
US8222289B2 (en) | 2012-07-17 |
KR20060069793A (ko) | 2006-06-22 |
US20100144826A1 (en) | 2010-06-10 |
US20170319546A1 (en) | 2017-11-09 |
EP1638977A1 (en) | 2006-03-29 |
WO2005003137A1 (en) | 2005-01-13 |
US20150313875A1 (en) | 2015-11-05 |
BRPI0411715B1 (pt) | 2020-12-01 |
US20050239866A1 (en) | 2005-10-27 |
US20040259856A1 (en) | 2004-12-23 |
US10912764B2 (en) | 2021-02-09 |
CA2530215A1 (en) | 2005-01-13 |
US9078881B2 (en) | 2015-07-14 |
US8637565B2 (en) | 2014-01-28 |
KR101183784B1 (ko) | 2012-09-17 |
US7635712B2 (en) | 2009-12-22 |
US10314818B2 (en) | 2019-06-11 |
US7176233B2 (en) | 2007-02-13 |
US20190269651A1 (en) | 2019-09-05 |
US20120230972A1 (en) | 2012-09-13 |
AU2004253879A1 (en) | 2005-01-13 |
US20070155815A1 (en) | 2007-07-05 |
BRPI0411715B8 (pt) | 2021-05-25 |
EP1638977A4 (en) | 2008-07-23 |
US7176232B2 (en) | 2007-02-13 |
JP2007523859A (ja) | 2007-08-23 |
MXPA05013985A (es) | 2006-03-17 |
US9713607B2 (en) | 2017-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0411715A (pt) | salinosporamidas e métodos para uso das mesmas | |
BRPI0613859A8 (pt) | compostos derivados de nitrocatecol, seu uso e seu processo de preparação, bem como composição farmacêutica | |
BRPI0712631A8 (pt) | compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações | |
BR112012027062B8 (pt) | composto, processo para a preparação de um composto e usos do mesmo | |
BRPI0612125A2 (pt) | compostos da fórmula (i), processo para a fabricação destes, composto da fórmula iiia, composições farmacêuticas, método para o tratamento e/ou profilaxia de doenças associadas à modulação dos receptores cb1 e uso de compostos | |
BR112012017269A2 (pt) | compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos | |
WO2008095040A3 (en) | 2-5a derivatives and their use as anti-cancer, anti-viral and anti-parasitic agents | |
BR0313266A (pt) | Compostos, respectivos processos de preparação e uso, formulação farmacêutica e métodos de prevenção e/ou tratamento de um distúrbio mediado pelo receptor de mglur5 e de inibição da ativação de receptores de mglur5 | |
CY1114340T1 (el) | Συνθεσεις και χρησεις για θεραπεια σκληρυνσης κατα πλακας | |
BRPI0512974A (pt) | novos derivados de hidantoìna para o tratamento de doenças obstrutivas das vias aéreas | |
BR0309964A (pt) | Derivados anticonvulsivos de sulfamoto substituìdo | |
BRPI0512986A (pt) | novos derivados de hidantoìna | |
UY30759A1 (es) | Compuestos quimicos | |
BRPI0709581A8 (pt) | compostos de bicicloeteroarila como moduladores de px27 e seu uso | |
BRPI1011540A2 (pt) | anticorpos anticxcr4 para o tratamento de of hiv | |
BRPI0407734A (pt) | derivados de adamantano, processo para sua preparação e composições farmacêuticas os contendo | |
BRPI0713443A2 (pt) | Derivados de piperazinila úteis no tratamento de doenças medianas por receptor gpr38, uso e composição farmacêutica contendo tais compostos e processos para preparação dos mesmos | |
BRPI0508177A (pt) | composto, processo para a produção do composto, composição farmacêutica, uso do composto método para o tratamento de uma doença e produto de combinação | |
BR0313043A (pt) | Conjugados efetores, processo para sua produção e seu uso farmacêutico | |
BRPI0606636A2 (pt) | compostos macrocìclicos úteis como inibidores de bace | |
BR112014003063A2 (pt) | "3,4-di-hidro-1h-[1,8]naftiridinonas substituídas com ciclopenta[c]pirrol antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso". | |
BRPI0410906A (pt) | triazolopirimidinas | |
BRPI0909737A2 (pt) | compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos | |
BR0309753A (pt) | Processo para a preparação de derivados de 6-alquilideno penem | |
BRPI0820258B8 (pt) | composto, composições de vacina, e, uso de um composto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal: appeal against refusal | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/12/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/06/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |