BRPI0410694A - compostos de piperazina tetra e penta-substituìdos e de anel derivado de piperazina - Google Patents

compostos de piperazina tetra e penta-substituìdos e de anel derivado de piperazina

Info

Publication number
BRPI0410694A
BRPI0410694A BRPI0410694-6A BRPI0410694A BRPI0410694A BR PI0410694 A BRPI0410694 A BR PI0410694A BR PI0410694 A BRPI0410694 A BR PI0410694A BR PI0410694 A BRPI0410694 A BR PI0410694A
Authority
BR
Brazil
Prior art keywords
piperazine
compounds
tetra
penta
derived ring
Prior art date
Application number
BRPI0410694-6A
Other languages
English (en)
Inventor
Shubh D Sharma
Yi-Qun Shi
Zhijun Wu
Ramesh Rajpurohit
Annette M Shadiack
Papireddy Purma
Kevin D Burris
Original Assignee
Palatin Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palatin Technologies Inc filed Critical Palatin Technologies Inc
Publication of BRPI0410694A publication Critical patent/BRPI0410694A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS DE PIPERAZINA TETRA E PENTA-SUBSTITUìDOS E DE ANEL DERIVADO DE PIPERAZINA". Composto receptor-específico de melanocortina da fórmula geral de estrutura (I) onde X, R~ 1~, R~ 2a~, R~ 2b~, R~ 3~, R~ 4a~, R~ 4b~, R~ 5~, e R~ 5b~ são conforme definido na especificação, composto que se liga com alta afinidade a um ou mais receptores de melanocortina e que é opcionalmente um agonista, um antagonista, um agonista inverso ou um antagonista de um agonista inverso, e que pode ser empregado para tratamento de condições ou distúrbios associados com receptor de melanocortina e métodos para o uso dos compostos da invenção.
BRPI0410694-6A 2003-05-01 2004-05-03 compostos de piperazina tetra e penta-substituìdos e de anel derivado de piperazina BRPI0410694A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46744203P 2003-05-01 2003-05-01
US54639304P 2004-02-19 2004-02-19
US10/837,519 US7456184B2 (en) 2003-05-01 2004-04-30 Melanocortin receptor-specific compounds
PCT/US2004/013803 WO2004098602A1 (en) 2003-05-01 2004-05-03 Melanocortin receptor-specific compounds

Publications (1)

Publication Number Publication Date
BRPI0410694A true BRPI0410694A (pt) 2006-06-20

Family

ID=33425190

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410694-6A BRPI0410694A (pt) 2003-05-01 2004-05-03 compostos de piperazina tetra e penta-substituìdos e de anel derivado de piperazina

Country Status (10)

Country Link
US (2) US7456184B2 (pt)
EP (1) EP1622618A4 (pt)
JP (1) JP2006525369A (pt)
KR (1) KR20060009285A (pt)
AU (1) AU2004235792A1 (pt)
BR (1) BRPI0410694A (pt)
CO (1) CO5700752A2 (pt)
EA (1) EA012502B1 (pt)
MX (1) MXPA05011729A (pt)
WO (1) WO2004098602A1 (pt)

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US7456184B2 (en) 2008-11-25
EA012502B1 (ru) 2009-10-30
US7964601B2 (en) 2011-06-21
AU2004235792A2 (en) 2008-06-26
KR20060009285A (ko) 2006-01-31
EP1622618A4 (en) 2008-08-27
EP1622618A1 (en) 2006-02-08
JP2006525369A (ja) 2006-11-09
EA200501724A1 (ru) 2006-06-30
US20040224957A1 (en) 2004-11-11
US20080234289A1 (en) 2008-09-25
WO2004098602A1 (en) 2004-11-18
CO5700752A2 (es) 2006-11-30

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