BRPI0406749A - Métodos relacionados ao tratamento de distúrbios fincionais do intestino e composição farmacêutica - Google Patents
Métodos relacionados ao tratamento de distúrbios fincionais do intestino e composição farmacêuticaInfo
- Publication number
- BRPI0406749A BRPI0406749A BR0406749-5A BRPI0406749A BRPI0406749A BR PI0406749 A BRPI0406749 A BR PI0406749A BR PI0406749 A BRPI0406749 A BR PI0406749A BR PI0406749 A BRPI0406749 A BR PI0406749A
- Authority
- BR
- Brazil
- Prior art keywords
- functional
- treatment
- present
- patient
- nari
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000014540 Functional gastrointestinal disease Diseases 0.000 title 1
- 201000007637 bowel dysfunction Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 229940113081 5 Hydroxytryptamine 3 receptor antagonist Drugs 0.000 abstract 2
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 2
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 230000003187 abdominal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000010339 dilation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000000117 functional diarrhea Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000966 norepinephrine reuptake Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44007703P | 2003-01-13 | 2003-01-13 | |
| US49248003P | 2003-08-04 | 2003-08-04 | |
| PCT/US2004/000807 WO2004062623A2 (en) | 2003-01-13 | 2004-01-13 | Method of treating functional bowel disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0406749A true BRPI0406749A (pt) | 2005-12-20 |
Family
ID=32718145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0406749-5A BRPI0406749A (pt) | 2003-01-13 | 2004-01-13 | Métodos relacionados ao tratamento de distúrbios fincionais do intestino e composição farmacêutica |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US20040147509A1 (https=) |
| EP (2) | EP2286817A3 (https=) |
| JP (2) | JP2006516976A (https=) |
| KR (1) | KR20050111318A (https=) |
| CN (1) | CN100353946C (https=) |
| AU (1) | AU2004204825B2 (https=) |
| BR (1) | BRPI0406749A (https=) |
| CA (1) | CA2512983A1 (https=) |
| MX (1) | MXPA05007381A (https=) |
| NZ (1) | NZ541008A (https=) |
| PL (1) | PL378367A1 (https=) |
| WO (1) | WO2004062623A2 (https=) |
| ZA (1) | ZA200505817B (https=) |
Families Citing this family (23)
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| GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| JP2006516977A (ja) * | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ,インコーポレイテッド | 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法 |
| MXPA05007381A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para el tratamiento de transtornos funcionales del intestino. |
| JP2006522144A (ja) * | 2003-04-04 | 2006-09-28 | ダイノゲン ファーマシューティカルズ,インコーポレイテッド | 下部尿路障害の治療方法 |
| DE602006012811D1 (de) * | 2005-01-28 | 2010-04-22 | Astellas Pharma Inc | Verfahren zum screening eines therapeutischen wirkstoffs für darmirritationssyndrome |
| WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| WO2007000046A1 (en) * | 2005-06-27 | 2007-01-04 | Holburn Biomedical Corporation | Methods for diagnosing functional bowel disease |
| US20070010543A1 (en) * | 2005-07-01 | 2007-01-11 | Dynogen Pharmaceuticals, Inc. | Compositions and methods for treating gastrointestinal hypomotility and associated disorders |
| US20090175933A1 (en) * | 2005-10-07 | 2009-07-09 | Colocaps Pty Ltd | Preparation for the treatment of diarrhoea |
| GB0524668D0 (en) * | 2005-12-02 | 2006-01-11 | Novartis Ag | Organic compounds |
| EP2251757B1 (en) * | 2005-12-02 | 2011-11-23 | iRobot Corporation | Coverage robot mobility |
| US20070254899A1 (en) * | 2006-03-31 | 2007-11-01 | Dynogen Pharmaceuticals, Inc. | Soluble salts of thieno[2,3-d]pyrimidine derivatives |
| TW200838534A (en) * | 2007-02-07 | 2008-10-01 | Astellas Pharma Inc | Treatment for irritable bowel syndrome |
| US20110158930A1 (en) * | 2008-08-28 | 2011-06-30 | Astellas Pharma Inc. | Method for treatment of irritable bowel syndrome |
| CN105412110B (zh) * | 2011-10-18 | 2018-05-25 | 赫尔森保健股份公司 | 奈妥匹坦和帕洛诺司琼的治疗性组合 |
| JOP20130213B1 (ar) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
| CA3178035A1 (en) | 2012-12-24 | 2014-07-03 | Neurogastrx, Inc. | Methods for treating gi tract disorders |
| US9844554B2 (en) | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
| CA2962429C (en) * | 2014-09-29 | 2023-01-03 | Takeda Pharmaceutical Company Limited | Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide |
| US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
| WO2022104234A1 (en) * | 2020-11-15 | 2022-05-19 | Castor Trevor P | Methods for assaying and measuring the efficacy of anti-nausea compounds |
| CN113412817B (zh) * | 2021-05-31 | 2022-07-12 | 成都中医药大学附属医院 | 提高成模率减少死亡率的ibs-d实验动物模型方法 |
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| CA2491836C (en) * | 2002-07-10 | 2011-01-25 | Arachnova Therapeutics Ltd. | 4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-d) pyrimidine in the treatment of functional bowel disorder |
| BR0313836A (pt) * | 2002-08-29 | 2005-06-21 | Arachnova Therapeutics Ltd | Novos usos terapêuticos de 4-(2-fluorofenil)-6-metil-2-(1-piperazinil)tieno[2,3-d]pi rimidina |
| JP2006516977A (ja) * | 2003-01-13 | 2006-07-13 | ダイノゲン ファーマシューティカルズ,インコーポレイテッド | 悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法 |
| MXPA05007381A (es) * | 2003-01-13 | 2006-02-10 | Dynogen Pharmaceuticals Inc | Metodo para el tratamiento de transtornos funcionales del intestino. |
-
2004
- 2004-01-13 MX MXPA05007381A patent/MXPA05007381A/es not_active Application Discontinuation
- 2004-01-13 NZ NZ541008A patent/NZ541008A/en unknown
- 2004-01-13 KR KR1020057012930A patent/KR20050111318A/ko not_active Withdrawn
- 2004-01-13 JP JP2006500936A patent/JP2006516976A/ja not_active Ceased
- 2004-01-13 CN CNB2004800042278A patent/CN100353946C/zh not_active Expired - Fee Related
- 2004-01-13 BR BR0406749-5A patent/BRPI0406749A/pt not_active IP Right Cessation
- 2004-01-13 WO PCT/US2004/000807 patent/WO2004062623A2/en not_active Ceased
- 2004-01-13 EP EP10075488A patent/EP2286817A3/en not_active Withdrawn
- 2004-01-13 CA CA002512983A patent/CA2512983A1/en not_active Abandoned
- 2004-01-13 US US10/757,364 patent/US20040147509A1/en not_active Abandoned
- 2004-01-13 AU AU2004204825A patent/AU2004204825B2/en not_active Ceased
- 2004-01-13 PL PL378367A patent/PL378367A1/pl not_active Application Discontinuation
- 2004-01-13 EP EP04701811A patent/EP1558081A4/en not_active Withdrawn
- 2004-05-03 US US10/838,789 patent/US20040254168A1/en not_active Abandoned
- 2004-05-07 US US10/841,319 patent/US20040259862A1/en not_active Abandoned
- 2004-05-07 US US10/841,317 patent/US20040254169A1/en not_active Abandoned
- 2004-05-07 US US10/841,318 patent/US20040254170A1/en not_active Abandoned
- 2004-06-11 US US10/866,593 patent/US20050032780A1/en not_active Abandoned
-
2005
- 2005-04-29 US US11/119,357 patent/US20050192270A1/en not_active Abandoned
- 2005-07-20 ZA ZA200505817A patent/ZA200505817B/en unknown
-
2006
- 2006-05-26 US US11/441,905 patent/US20060217391A1/en not_active Abandoned
-
2011
- 2011-03-18 JP JP2011061194A patent/JP2011157372A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20040147509A1 (en) | 2004-07-29 |
| AU2004204825B2 (en) | 2007-07-19 |
| WO2004062623A2 (en) | 2004-07-29 |
| KR20050111318A (ko) | 2005-11-24 |
| AU2004204825A1 (en) | 2004-07-29 |
| EP2286817A3 (en) | 2011-06-15 |
| EP1558081A4 (en) | 2006-06-14 |
| JP2006516976A (ja) | 2006-07-13 |
| US20040259862A1 (en) | 2004-12-23 |
| EP2286817A2 (en) | 2011-02-23 |
| WO2004062623A3 (en) | 2005-06-09 |
| CA2512983A1 (en) | 2004-07-29 |
| MXPA05007381A (es) | 2006-02-10 |
| US20050192270A1 (en) | 2005-09-01 |
| NZ541008A (en) | 2007-09-28 |
| CN100353946C (zh) | 2007-12-12 |
| JP2011157372A (ja) | 2011-08-18 |
| PL378367A1 (pl) | 2006-04-03 |
| US20060217391A1 (en) | 2006-09-28 |
| US20040254168A1 (en) | 2004-12-16 |
| US20050032780A1 (en) | 2005-02-10 |
| EP1558081A2 (en) | 2005-08-03 |
| US20040254169A1 (en) | 2004-12-16 |
| US20040254170A1 (en) | 2004-12-16 |
| ZA200505817B (en) | 2006-04-26 |
| CN1750759A (zh) | 2006-03-22 |
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