BRPI0108921B8 - processo de preparação de nanocápsulas - Google Patents

processo de preparação de nanocápsulas

Info

Publication number
BRPI0108921B8
BRPI0108921B8 BRPI0108921A BR0108921A BRPI0108921B8 BR PI0108921 B8 BRPI0108921 B8 BR PI0108921B8 BR PI0108921 A BRPI0108921 A BR PI0108921A BR 0108921 A BR0108921 A BR 0108921A BR PI0108921 B8 BRPI0108921 B8 BR PI0108921B8
Authority
BR
Brazil
Prior art keywords
nanocapsules
preparation process
lipid
room temperature
preparation
Prior art date
Application number
BRPI0108921A
Other languages
English (en)
Other versions
BR0108921A (pt
BR0108921B1 (pt
Inventor
Pech Brigitte
Heurtault Béatrice
Proust Jacques-Emile
Benoit Jean-Pierre
Richard Joël
Saulnier Patrick
Original Assignee
Ethypharm Sa
Mainelab
Univ Angers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa, Mainelab, Univ Angers filed Critical Ethypharm Sa
Publication of BR0108921A publication Critical patent/BR0108921A/pt
Publication of BR0108921B1 publication Critical patent/BR0108921B1/pt
Publication of BRPI0108921B8 publication Critical patent/BRPI0108921B8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0026—Preparation of sols containing a liquid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/017—Mixtures of compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/14—Derivatives of phosphoric acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34—Higher-molecular-weight carboxylic acid esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"nanocápsulas, processo de preparação de nanocápsulas e utilização de nanocápsulas". a presente invenção refere-se a nanocápsulas, em particular com tamanho médio inferior a 50 nm, constituídas de um núcleo essencialmente lipídico ou semi-líquido à temperatura ambiente, revestido com uma película essencialmente lipídica sólida à temperatura ambiente com espessura de 2-10 mn. ela também se refere a um processo para sua preparação que consiste da inversão de fase de uma emulsão óleo/água provocada com diversos ciclos de elevação e redução da temperatura. as nanocápsulas lipídicas da invenção são particularmente destinadas à fabricação de um medicamento.
BRPI0108921A 2000-03-02 2001-03-02 processo de preparação de nanocápsulas BRPI0108921B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0002688A FR2805761B1 (fr) 2000-03-02 2000-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
FR00/02688 2000-03-02
PCT/FR2001/000621 WO2001064328A1 (fr) 2000-03-02 2001-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament

Publications (3)

Publication Number Publication Date
BR0108921A BR0108921A (pt) 2003-01-21
BR0108921B1 BR0108921B1 (pt) 2014-09-30
BRPI0108921B8 true BRPI0108921B8 (pt) 2021-05-25

Family

ID=8847644

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0108921A BRPI0108921B8 (pt) 2000-03-02 2001-03-02 processo de preparação de nanocápsulas

Country Status (22)

Country Link
US (2) US8057823B2 (pt)
EP (1) EP1265698B1 (pt)
JP (1) JP4790187B2 (pt)
KR (1) KR100638527B1 (pt)
CN (1) CN1257011C (pt)
AT (1) ATE269154T1 (pt)
AU (2) AU2001240753B2 (pt)
BR (1) BRPI0108921B8 (pt)
CA (1) CA2401766C (pt)
DE (1) DE60103863T2 (pt)
DK (1) DK1265698T3 (pt)
ES (1) ES2221640T3 (pt)
FR (1) FR2805761B1 (pt)
HU (1) HU226483B1 (pt)
IL (1) IL151560A0 (pt)
MX (1) MXPA02008638A (pt)
NO (1) NO334188B1 (pt)
PT (1) PT1265698E (pt)
SI (1) SI1265698T1 (pt)
TR (1) TR200401812T4 (pt)
WO (1) WO2001064328A1 (pt)
ZA (1) ZA200206985B (pt)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104698D0 (en) * 2001-02-26 2001-04-11 Syngenta Ltd Process for producing microcapsules
FR2835430A1 (fr) * 2002-05-31 2003-08-08 Oreal Composition comprenant des nanocapsules enrobees de lecithine et un polymere d'acrylamide
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
MXPA04012567A (es) * 2002-06-11 2005-04-19 Ethypharm Sa Nanocapsulas lipidicas encubiertas, metodos para la preparacion de las mismas y uso de las mismas como un portador para principios activos.
EP1562557B2 (en) * 2002-11-01 2016-11-16 University of Medicine and Dentistry of New Jersey Geodate delivery vehicles
FR2849379B1 (fr) * 2002-12-26 2005-02-11 Cosnessens Encapsulation d'actifs liposolubles
EP1596840A1 (en) * 2003-02-12 2005-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of p-glycoprotein inhibitor surfactants at the surface of a colloidal carrier
FR2864900B1 (fr) 2004-01-09 2007-10-12 Oreal Dispersion aqueuse de nanocapsules a coeur huileux
WO2005102507A1 (en) * 2004-04-20 2005-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for the preparation of nanoparticles from nanoemulsions
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
FR2907012B1 (fr) 2006-10-12 2012-09-21 Galderma Sa Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
GB0623838D0 (en) 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1955695A1 (en) * 2007-02-06 2008-08-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nanocapsules of lipophilic complexes of nucleic acids
FR2916973B1 (fr) 2007-06-11 2010-02-26 Univ Angers Nanocapsules a coeur lipidique chargees en actif(s) hydrosoluble(s) ou hydrodispersible(s)
FR2916974B1 (fr) * 2007-06-11 2010-11-26 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2917976B1 (fr) * 2007-06-29 2010-05-28 Galderma Sa Composition dermatologique comprenant des vehicules lipidiques de calcitriol, son procede de preparation et son utilisation
EP2036577A1 (de) * 2007-09-14 2009-03-18 mivenion GmbH Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen
EP2039352A1 (en) * 2007-09-18 2009-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934955B1 (fr) * 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2939699B1 (fr) 2008-12-12 2011-05-06 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2943544B1 (fr) 2009-03-31 2012-04-20 Univ Angers Procede de preparation de capsules lipidiques fonctionnalisees.
FR2949063B1 (fr) * 2009-08-11 2011-09-30 Pf Medicament Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale
FR2950253B1 (fr) * 2009-09-24 2011-09-23 Ethypharm Sa Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
SG10201804552WA (en) * 2011-01-24 2018-07-30 Anterios Inc Nanoparticle compositions, formulations thereof, and uses therefor
JP2014507441A (ja) 2011-02-25 2014-03-27 エイド・ファルマ 単独で、または抗生物質と共に感染症を予防または治療するための精油のナノカプセル化
FR2988609B1 (fr) * 2012-03-30 2015-09-04 Commissariat Energie Atomique Formulation pour l'hormonotherapie
US10511150B2 (en) 2012-04-06 2019-12-17 Furukawa Electric Co., Ltd. Wavelength-variable laser
US10702604B2 (en) 2012-06-01 2020-07-07 Galderma Research & Development Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing the same, process for preparing the same and use thereof in dermatology
CA2897878A1 (en) * 2013-01-14 2014-07-17 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
EP2789619A1 (en) 2013-04-12 2014-10-15 Kemotech S.r.l. Pharmaceutical compounds wiht angiogenesis inbhibitory activity
FR3008900B1 (fr) 2013-07-25 2018-03-30 Centre Nat Rech Scient Nanoparticules lipidiques multicompartimentees
BR112016011575A2 (pt) * 2013-11-22 2017-09-12 Dsm Ip Assets Bv processo para preparação de uma composição de revestimento antirreflexiva e um revestimento poroso feito da mesma.
MX2016007067A (es) * 2013-12-04 2016-08-11 Galderma Res & Dev Microcapsulas lipidicas que comprenden de preferencia un retinoide y composicion que las contiene, su procedimiento de preparacion y su uso en dermatologia.
FR3017294B1 (fr) * 2014-02-07 2021-10-01 Atlangram Nanoparticules lipidiques comprenant un antibiotique et leurs utilisations en therapie
SG11201609954VA (en) * 2014-05-30 2016-12-29 Abbvie Deutschland Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules
JP2016163851A (ja) * 2015-03-06 2016-09-08 国立大学法人福井大学 コンポジット型可溶化ナノリポソーム及びその製造方法
EP3302421B1 (fr) 2015-05-29 2021-07-07 Galderma Research & Development Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques
CN110198703A (zh) 2016-11-21 2019-09-03 艾里奥治疗公司 大试剂的透皮递送
CN110325272A (zh) * 2017-03-28 2019-10-11 富士胶片株式会社 微胶囊及其制造方法
EP3453386A1 (en) 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof
GB201721832D0 (en) * 2017-12-22 2018-02-07 Waterford Institute Of Tech Ocular drug delivery
WO2020021052A2 (en) 2018-07-27 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin
EP3679928A1 (fr) 2019-01-08 2020-07-15 Atlangram Composition pharmaceutique de type gel pour traiter/prevenir une infection
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
FR3099069A1 (fr) * 2019-07-24 2021-01-29 Université D`Angers Procede continu de nano-emulsification par inversion de phase en concentration
CN112773776B (zh) * 2019-11-11 2023-06-20 上海胜联医药科技有限公司 一种载药纳米粒体系
CN115006369B (zh) * 2021-03-03 2023-08-29 浙江大学 一种脑靶向类脂纳米囊载药系统及其制备方法和应用
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5174930A (en) * 1986-12-31 1992-12-29 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
AU655162B2 (en) * 1989-11-13 1994-12-08 Nova Pharmaceutical Corporation Lipospheres for controlled delivery of substances
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
FR2692167B1 (fr) 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5578298A (en) * 1994-05-27 1996-11-26 General Electric Company Microemulsions for high viscosity amino silicone fluids and gums and their preparation
FR2725369B1 (fr) * 1994-10-07 1997-01-03 Oreal Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2755856B1 (fr) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules
ES2174462T3 (es) * 1997-07-29 2002-11-01 Upjohn Co Formulacion autoestimulante para compuestos lipofilos.
TWI241915B (en) * 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

Also Published As

Publication number Publication date
ATE269154T1 (de) 2004-07-15
KR100638527B1 (ko) 2006-10-25
ZA200206985B (en) 2003-10-07
DK1265698T3 (da) 2004-10-25
HU226483B1 (en) 2009-03-02
NO20024181L (no) 2002-10-22
JP2003525257A (ja) 2003-08-26
US20030152635A1 (en) 2003-08-14
DE60103863D1 (de) 2004-07-22
US8057823B2 (en) 2011-11-15
HUP0300209A2 (hu) 2003-06-28
DE60103863T2 (de) 2005-06-30
IL151560A0 (en) 2003-04-10
ES2221640T3 (es) 2005-01-01
NO334188B1 (no) 2014-01-13
KR20030003692A (ko) 2003-01-10
TR200401812T4 (tr) 2004-09-21
US20090238865A1 (en) 2009-09-24
AU2001240753B2 (en) 2005-04-14
PT1265698E (pt) 2004-11-30
EP1265698A1 (fr) 2002-12-18
CN1419472A (zh) 2003-05-21
FR2805761B1 (fr) 2002-08-30
FR2805761A1 (fr) 2001-09-07
HUP0300209A3 (en) 2005-04-28
JP4790187B2 (ja) 2011-10-12
MXPA02008638A (es) 2004-09-06
EP1265698B1 (fr) 2004-06-16
SI1265698T1 (en) 2004-10-31
AU4075301A (en) 2001-09-12
BR0108921A (pt) 2003-01-21
BR0108921B1 (pt) 2014-09-30
CN1257011C (zh) 2006-05-24
CA2401766C (fr) 2009-05-19
WO2001064328A1 (fr) 2001-09-07
NO20024181D0 (no) 2002-09-02
CA2401766A1 (fr) 2001-09-07

Similar Documents

Publication Publication Date Title
BRPI0108921B8 (pt) processo de preparação de nanocápsulas
BR0114186A (pt) Emprego de copolicarbonatos
BRPI0409334A (pt) pelìcula de gel termorreversìvel, homogênea, cápsulas moles, processos para fabricar as pelìculas de gel e cápsulas moles, e, forma sólida
ATE431705T1 (de) Matrix-formende zubereitung, die pektin enthält
BRPI0312398B8 (pt) derivado de 1,3-difenilprop-2-en-1-ona substituído, processo de preparação de compostos, composição farmacêutica e utilização de pelo menos um derivado de 1,3-difenilprop-2-en-1-ona substituído
BR0305488A (pt) Método para produzir um substrato revestido e substrato revestido
BR0207215A (pt) Derivados de pirazolopiriminona tendo ação de inibição de pde7
BR0316918A (pt) Encapsulato de co-acervato complexo, composição alimentìcia e processo para a preparação de um encapsulato de co-acervato complexo
BR0318278A (pt) compostos de éter aminocicloexìlico e usos dos mesmo
EP1103266A3 (de) Curcumin-Formulierungen
BR0215027A (pt) Derivados de 6-aminomorfinano, processo de preparação para o mesmo e sua aplicação
BRPI0516224A (pt) produto alimentìcio contendo um ou vários microorganismos vivos e pelo menos um ingrediente alimentìcio bioativo de interesse, processo de preparação do mesmo, e, utilização de um produto alimentìcio
BR9907655A (pt) Derivados de ácido di-hidróxi-hexanóico
BR0207365A (pt) Composição, composição não-sólida, método para conferir estabilidade fìsica, método para maquilagem, cuidado ou tratamento e kit de multicompartimentos
BRPI0414139A (pt) métodos e composições para tratar infecções por herpes
BR0116077A (pt) Micropartìculas com perfil de liberação aperfeiçoado e processos para produção das mesmas
ITRM990707A0 (it) Composizione per la prevenzione e/o il trattamento di disturbi dovutiad un alterato metabolismo dei lipidi, che comprende propionil l-carni
ITMI931723A1 (it) Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
BR9911024A (pt) Composição de revestimento e método de produção de um revestimento em um substrato.
BR0108096A (pt) Método para manter ou melhorar a sìntese de mucinas
BR0210063A (pt) Composição estável e uso da mesma
DE69801811D1 (de) Alkykendiamin di- oder tri-essigsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in kosmetischen zusammensetzungen
ATE241640T1 (de) Fusidinsäure-derivate
BR0317412A (pt) Composição farmacêutica de liberação prolongada de fenitoìna de sódio e processo para sua preparação
BRPI0501241A (pt) composição cosmética, composição farmacêutica e processo para preparação das referidas composições

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/09/2014, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/03/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 02/03/2021