ATE269154T1 - Lipidnanokapseln, seine herstellungsverfahren sowie verwendung als medizin - Google Patents
Lipidnanokapseln, seine herstellungsverfahren sowie verwendung als medizinInfo
- Publication number
- ATE269154T1 ATE269154T1 AT01911828T AT01911828T ATE269154T1 AT E269154 T1 ATE269154 T1 AT E269154T1 AT 01911828 T AT01911828 T AT 01911828T AT 01911828 T AT01911828 T AT 01911828T AT E269154 T1 ATE269154 T1 AT E269154T1
- Authority
- AT
- Austria
- Prior art keywords
- medicine
- lipidnano
- capsules
- production process
- producing
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002632 lipids Chemical group 0.000 abstract 3
- 239000002088 nanocapsule Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0004—Preparation of sols
- B01J13/0026—Preparation of sols containing a liquid organic phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/017—Mixtures of compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/14—Derivatives of phosphoric acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0002688A FR2805761B1 (fr) | 2000-03-02 | 2000-03-02 | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
PCT/FR2001/000621 WO2001064328A1 (fr) | 2000-03-02 | 2001-03-02 | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE269154T1 true ATE269154T1 (de) | 2004-07-15 |
Family
ID=8847644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01911828T ATE269154T1 (de) | 2000-03-02 | 2001-03-02 | Lipidnanokapseln, seine herstellungsverfahren sowie verwendung als medizin |
Country Status (22)
Country | Link |
---|---|
US (2) | US8057823B2 (de) |
EP (1) | EP1265698B1 (de) |
JP (1) | JP4790187B2 (de) |
KR (1) | KR100638527B1 (de) |
CN (1) | CN1257011C (de) |
AT (1) | ATE269154T1 (de) |
AU (2) | AU2001240753B2 (de) |
BR (1) | BRPI0108921B8 (de) |
CA (1) | CA2401766C (de) |
DE (1) | DE60103863T2 (de) |
DK (1) | DK1265698T3 (de) |
ES (1) | ES2221640T3 (de) |
FR (1) | FR2805761B1 (de) |
HU (1) | HU226483B1 (de) |
IL (1) | IL151560A0 (de) |
MX (1) | MXPA02008638A (de) |
NO (1) | NO334188B1 (de) |
PT (1) | PT1265698E (de) |
SI (1) | SI1265698T1 (de) |
TR (1) | TR200401812T4 (de) |
WO (1) | WO2001064328A1 (de) |
ZA (1) | ZA200206985B (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0104698D0 (en) | 2001-02-26 | 2001-04-11 | Syngenta Ltd | Process for producing microcapsules |
FR2835430A1 (fr) * | 2002-05-31 | 2003-08-08 | Oreal | Composition comprenant des nanocapsules enrobees de lecithine et un polymere d'acrylamide |
FR2840532B1 (fr) * | 2002-06-11 | 2005-05-06 | Ethypharm Sa | Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s) |
EP1531800B1 (de) * | 2002-06-11 | 2011-06-08 | Ethypharm | Stealth lipid-nanokapseln, verfahren zu ihrer herstellung und ihre verwendung als träger von wirkstoff(en) |
JP4886297B2 (ja) * | 2002-11-01 | 2012-02-29 | バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド | ジオデート送達媒体 |
FR2849379B1 (fr) * | 2002-12-26 | 2005-02-11 | Cosnessens | Encapsulation d'actifs liposolubles |
CN1741795A (zh) * | 2003-02-12 | 2006-03-01 | 国家健康科学研究所 | P糖蛋白抑制剂表面活性剂在胶状载体表面上的使用 |
FR2864900B1 (fr) | 2004-01-09 | 2007-10-12 | Oreal | Dispersion aqueuse de nanocapsules a coeur huileux |
US20110135734A1 (en) * | 2004-04-20 | 2011-06-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method For the Preparation of Nanoparticles From Nanoemulsions |
DE102005037844A1 (de) * | 2005-08-04 | 2007-04-05 | Intendis Gmbh | Wasserfreies Mehr-Phasen-Gel-System |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
FR2907012B1 (fr) | 2006-10-12 | 2012-09-21 | Galderma Sa | Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation |
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
EP1955695A1 (de) * | 2007-02-06 | 2008-08-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nanokapseln lipophiler Komplexe von Nukleinsäuren |
FR2916974B1 (fr) * | 2007-06-11 | 2010-11-26 | Univ Angers | Procede de preparation de nanoparticules lipidiques |
FR2916973B1 (fr) | 2007-06-11 | 2010-02-26 | Univ Angers | Nanocapsules a coeur lipidique chargees en actif(s) hydrosoluble(s) ou hydrodispersible(s) |
FR2917976B1 (fr) * | 2007-06-29 | 2010-05-28 | Galderma Sa | Composition dermatologique comprenant des vehicules lipidiques de calcitriol, son procede de preparation et son utilisation |
EP2036577A1 (de) * | 2007-09-14 | 2009-03-18 | mivenion GmbH | Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen |
EP2039352A1 (de) * | 2007-09-18 | 2009-03-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Lipid-Nanokapseln mit wässrigem Kern zur Einkapselung hydrophiler und/oder lipophiler Moleküle |
FR2934953B1 (fr) | 2008-08-14 | 2011-01-21 | Commissariat Energie Atomique | Nanoemulsions de nanocristaux |
FR2934954B1 (fr) | 2008-08-14 | 2011-07-22 | Commissariat Energie Atomique | Emulsion fluorescente de vert d'indocyanine |
FR2934955B1 (fr) * | 2008-08-14 | 2011-07-08 | Commissariat Energie Atomique | Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions |
FR2939699B1 (fr) * | 2008-12-12 | 2011-05-06 | Univ Angers | Procede de preparation de nanoparticules lipidiques |
FR2943544B1 (fr) * | 2009-03-31 | 2012-04-20 | Univ Angers | Procede de preparation de capsules lipidiques fonctionnalisees. |
FR2949063B1 (fr) * | 2009-08-11 | 2011-09-30 | Pf Medicament | Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale |
FR2950253B1 (fr) | 2009-09-24 | 2011-09-23 | Ethypharm Sa | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
IT1396951B1 (it) * | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
AU2012209274A1 (en) * | 2011-01-24 | 2013-09-12 | Anterios, Inc. | Nanoparticle compositions, formulations thereof, and uses therefor |
WO2012114201A1 (en) | 2011-02-25 | 2012-08-30 | Aroma Technologies | Nanocapsulation of essential oils for preventing or curing infectious diseases alone or with an antibiotic |
FR2988609B1 (fr) * | 2012-03-30 | 2015-09-04 | Commissariat Energie Atomique | Formulation pour l'hormonotherapie |
US10511150B2 (en) | 2012-04-06 | 2019-12-17 | Furukawa Electric Co., Ltd. | Wavelength-variable laser |
WO2013178749A1 (fr) | 2012-06-01 | 2013-12-05 | Galderma Research & Development | Nanocapsules lipidiques comprenant un rétinoide, nanodispersion et composition les contenant, leur procédé de préparation et leur utilisation en dermatologie |
CA2897878A1 (en) * | 2013-01-14 | 2014-07-17 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
EP2789619A1 (de) | 2013-04-12 | 2014-10-15 | Kemotech S.r.l. | Pharmazeutische Verbindungen mit angiogenesehemmender Wirkung |
FR3008900B1 (fr) | 2013-07-25 | 2018-03-30 | Centre Nat Rech Scient | Nanoparticules lipidiques multicompartimentees |
WO2015075229A1 (en) * | 2013-11-22 | 2015-05-28 | Dsm Ip Assets B.V. | Process for making an anti-reflective coating composition and a porous coating made therefrom |
AU2014359195B2 (en) * | 2013-12-04 | 2020-02-27 | Galderma Research & Development | Lipid microcapsules preferably comprising a lipophilic active substance and composition containing same, method for the production thereof, and use of same in dermatology and in cosmetics |
FR3017294B1 (fr) | 2014-02-07 | 2021-10-01 | Atlangram | Nanoparticules lipidiques comprenant un antibiotique et leurs utilisations en therapie |
EP3148590A1 (de) * | 2014-05-30 | 2017-04-05 | AbbVie Deutschland GmbH & Co. KG | Poly(alkyl-2-cyanoacrylat)nanokapseln mit hoher wirkstoffladung |
JP2016163851A (ja) * | 2015-03-06 | 2016-09-08 | 国立大学法人福井大学 | コンポジット型可溶化ナノリポソーム及びその製造方法 |
EP3302421B1 (de) | 2015-05-29 | 2021-07-07 | Galderma Research & Development | Zusammensetzungen mit mindestens einem dispergierten wirkstoff und lipid-mikrokapseln |
JP2019535829A (ja) | 2016-11-21 | 2019-12-12 | エイリオン セラピューティクス, インコーポレイテッド | 大型薬剤の経皮送達 |
JPWO2018180966A1 (ja) * | 2017-03-28 | 2019-06-27 | 富士フイルム株式会社 | マイクロカプセル及びその製造方法 |
EP3453386A1 (de) | 2017-09-08 | 2019-03-13 | Universite D'angers | Nanokapseln mit modifizierten nukleobasen und/oder nukleosiden, hydrogele und oleogele damit und verwendungen davon |
GB201721832D0 (en) | 2017-12-22 | 2018-02-07 | Waterford Institute Of Tech | Ocular drug delivery |
WO2020021052A2 (en) | 2018-07-27 | 2020-01-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin |
EP3679928A1 (de) | 2019-01-08 | 2020-07-15 | Atlangram | Pharmazeutische zusammenetzung vom typ gel zur behandlung/vorbeugung einer infektion |
IT201900009258A1 (it) | 2019-06-17 | 2020-12-17 | R Bio Transfer S R L | Metodo per la preparazione di nanoparticelle lipidiche |
FR3099069A1 (fr) * | 2019-07-24 | 2021-01-29 | Université D`Angers | Procede continu de nano-emulsification par inversion de phase en concentration |
CN112773776B (zh) * | 2019-11-11 | 2023-06-20 | 上海胜联医药科技有限公司 | 一种载药纳米粒体系 |
CN115006369B (zh) * | 2021-03-03 | 2023-08-29 | 浙江大学 | 一种脑靶向类脂纳米囊载药系统及其制备方法和应用 |
IT202100023570A1 (it) | 2021-09-13 | 2023-03-13 | Bioema S R L S Biotecnologia Energia Mat Ambiente | Metodo per la preparazione di nanoparticelle lipidiche |
Family Cites Families (23)
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US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US5174930A (en) * | 1986-12-31 | 1992-12-29 | Centre National De La Recherche Scientifique (Cnrs) | Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
ES2085465T3 (es) * | 1989-11-13 | 1996-06-01 | Abraham J Domb | Lipoesferas para la administracion controlada de sustancias. |
FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
ES2034891B1 (es) * | 1991-08-08 | 1993-12-16 | Cusi Lab | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
FR2681248B1 (fr) * | 1991-09-13 | 1995-04-28 | Oreal | Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau. |
IL101387A (en) * | 1992-03-26 | 1999-11-30 | Pharmos Ltd | Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets |
FR2692167B1 (fr) | 1992-06-16 | 1994-09-16 | Centre Nat Rech Scient | Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules. |
ES2070076B1 (es) * | 1993-04-20 | 1996-04-16 | Cusi Lab | Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento. |
US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
DE4337030A1 (de) * | 1993-10-29 | 1995-05-04 | Henkel Kgaa | Verfahren zur Herstellung von Wachsdispersionen |
ES2078190B1 (es) * | 1994-05-20 | 1996-08-01 | Cusi Lab | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
US5578298A (en) * | 1994-05-27 | 1996-11-26 | General Electric Company | Microemulsions for high viscosity amino silicone fluids and gums and their preparation |
FR2725369B1 (fr) * | 1994-10-07 | 1997-01-03 | Oreal | Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire |
US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US5972389A (en) * | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
FR2755856B1 (fr) * | 1996-11-21 | 1999-01-29 | Merck Clevenot Laboratoires | Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules |
CN1113650C (zh) * | 1997-07-29 | 2003-07-09 | 法玛西雅厄普约翰美国公司 | 自体乳化剂形式的亲脂性化合物的药物组合物 |
TWI241915B (en) * | 1998-05-11 | 2005-10-21 | Ciba Sc Holding Ag | A method of preparing a pharmaceutical end formulation using a nanodispersion |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
-
2000
- 2000-03-02 FR FR0002688A patent/FR2805761B1/fr not_active Expired - Lifetime
-
2001
- 2001-03-02 JP JP2001563219A patent/JP4790187B2/ja not_active Expired - Lifetime
- 2001-03-02 EP EP01911828A patent/EP1265698B1/de not_active Expired - Lifetime
- 2001-03-02 HU HU0300209A patent/HU226483B1/hu unknown
- 2001-03-02 US US10/220,506 patent/US8057823B2/en not_active Expired - Fee Related
- 2001-03-02 CA CA002401766A patent/CA2401766C/fr not_active Expired - Lifetime
- 2001-03-02 BR BRPI0108921A patent/BRPI0108921B8/pt not_active IP Right Cessation
- 2001-03-02 CN CNB018071422A patent/CN1257011C/zh not_active Expired - Lifetime
- 2001-03-02 IL IL15156001A patent/IL151560A0/xx active IP Right Grant
- 2001-03-02 WO PCT/FR2001/000621 patent/WO2001064328A1/fr active IP Right Grant
- 2001-03-02 DK DK01911828T patent/DK1265698T3/da active
- 2001-03-02 PT PT01911828T patent/PT1265698E/pt unknown
- 2001-03-02 AU AU2001240753A patent/AU2001240753B2/en not_active Expired
- 2001-03-02 SI SI200130157T patent/SI1265698T1/xx unknown
- 2001-03-02 MX MXPA02008638A patent/MXPA02008638A/es active IP Right Grant
- 2001-03-02 ES ES01911828T patent/ES2221640T3/es not_active Expired - Lifetime
- 2001-03-02 TR TR2004/01812T patent/TR200401812T4/xx unknown
- 2001-03-02 DE DE60103863T patent/DE60103863T2/de not_active Expired - Lifetime
- 2001-03-02 AT AT01911828T patent/ATE269154T1/de active
- 2001-03-02 KR KR1020027011526A patent/KR100638527B1/ko active IP Right Grant
- 2001-03-02 AU AU4075301A patent/AU4075301A/xx active Pending
-
2002
- 2002-08-30 ZA ZA200206985A patent/ZA200206985B/xx unknown
- 2002-09-02 NO NO20024181A patent/NO334188B1/no not_active IP Right Cessation
-
2009
- 2009-05-29 US US12/474,958 patent/US20090238865A1/en not_active Abandoned
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