BRPI0013686B8 - procedimento para sintetizar uma mistura de oligossacarídeos - Google Patents
procedimento para sintetizar uma mistura de oligossacarídeosInfo
- Publication number
- BRPI0013686B8 BRPI0013686B8 BRPI0013686A BR0013686A BRPI0013686B8 BR PI0013686 B8 BRPI0013686 B8 BR PI0013686B8 BR PI0013686 A BRPI0013686 A BR PI0013686A BR 0013686 A BR0013686 A BR 0013686A BR PI0013686 B8 BRPI0013686 B8 BR PI0013686B8
- Authority
- BR
- Brazil
- Prior art keywords
- oligosaccharides
- mixture
- vaccines
- ribose
- mixtures
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Abstract
"mistura de oligossacarídeos, procedimento para sintetizar uma mistura de oligossacarídeos, imunógeno que contém uma mistura de oligossacarídeos, vacina que contém imunógeno, dissacarídeo, derivados dissacarídeos, métodos para a síntese do dissacarídeo intermediário e para preparar dissacarídeos, uso dos dissacarídeos, macromoléculas que contém mistura de oligossacarídeos, e, uso de macromoléculas". a presente invenção refere-se ao campo da medicina, em particular à síntese química de misturas de oligossacarídeos derivados de ribose-ribitol-fosfato, que são empregadas como princípio ativo em vacinas para a prevenção de infecções causadas por haemophilus influenzae tipo b (hib), bem como às vacinas que compreendem a referida mistura de oligossacarídeos. as misturas de oligossacarídeos obtidas por síntese química da presente invenção compreendem unidades repetitivas de fórmula (fosfato-ribose-ribitol)n ou (ribose-ribitol-fosfato)n de pelo menos 5 compostos com estrutura a ou b, que representam a unidade repetitiva do polissacarídeo capsular do haemophilus influenzae tipo b e que diferem apenas em n, sendo que n <242> 4 e <243> 25), e que r~ 1~ ou r~ 2~ é um espaçador para a conjugação a um veículo, com a condição de que r~ 1~ = espaçador se r~ 2~ = h, ou r~ 2~ = espaçador se r~ 1~ = h. a invenção também se refere aos imunógenos que contêm estas misturas oligossacarídicas, às vacinas que contêm estes imunógenos e aos processos para preparar estes oligossacarídeos em forma de misturas. além disso, a invenção refere-se ao uso das vacinas, quer sejam sozinhas ou em combinação com outras vacinas, para a prevenção das infecções causadas pelo haemophilus influenzae tipo b.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU1999121A CU22904A1 (es) | 1999-08-30 | 1999-08-30 | Oligosacáridos derivados de ribosa- ribitol-fosfato, métodos para prepararlos, inmunógenos que los comprenden y vacunas que comprenden dichos inmunógenos |
| PCT/CU2000/000003 WO2001016146A1 (es) | 1999-08-30 | 2000-08-15 | Oligosacáridos derivados de ribosa-ribitol-fosfato y vacunas que los contienen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0013686A BR0013686A (pt) | 2002-08-13 |
| BRPI0013686B1 BRPI0013686B1 (pt) | 2016-07-26 |
| BRPI0013686B8 true BRPI0013686B8 (pt) | 2021-05-25 |
Family
ID=5459405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0013686A BRPI0013686B8 (pt) | 1999-08-30 | 2000-08-15 | procedimento para sintetizar uma mistura de oligossacarídeos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6765091B1 (pt) |
| EP (1) | EP1212334B1 (pt) |
| JP (1) | JP4850377B2 (pt) |
| KR (1) | KR100818163B1 (pt) |
| CN (1) | CN1205217C (pt) |
| AR (1) | AR025435A1 (pt) |
| AT (1) | ATE308551T1 (pt) |
| AU (1) | AU780816B2 (pt) |
| BR (1) | BRPI0013686B8 (pt) |
| CA (1) | CA2382602C (pt) |
| CO (1) | CO5180646A1 (pt) |
| CU (1) | CU22904A1 (pt) |
| CZ (1) | CZ2002721A3 (pt) |
| DE (1) | DE60023722T2 (pt) |
| DK (1) | DK1212334T3 (pt) |
| EA (1) | EA005381B1 (pt) |
| ES (1) | ES2252045T3 (pt) |
| HK (1) | HK1050693A1 (pt) |
| MX (1) | MXPA02002066A (pt) |
| NZ (1) | NZ517464A (pt) |
| SI (1) | SI1212334T1 (pt) |
| UA (1) | UA75579C2 (pt) |
| WO (1) | WO2001016146A1 (pt) |
| ZA (1) | ZA200201667B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007519746A (ja) * | 2004-01-29 | 2007-07-19 | バイオシネクサス インコーポレーティッド | ワクチン調製におけるアミノ−オキシ官能基の使用 |
| US8647621B2 (en) | 2009-07-27 | 2014-02-11 | Fina Biosolutions, Llc | Method of producing protein-carbohydrate vaccines reduced in free carbohydrate |
| EP2459708B1 (en) | 2009-07-31 | 2016-06-22 | National Research Council of Canada | H. pylori lipopolysaccharide outer core epitope |
| EP2513056B1 (en) | 2009-12-17 | 2022-05-04 | Serum Institute of India Pvt. Ltd. | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
| ES2743156T3 (es) | 2010-04-23 | 2020-02-18 | Serum Institute Of India Pvt Ltd | Método simple para eliminación simultánea de múltiples impurezas a partir de sobrenadantes de cultivo a niveles ultrabajos |
| US11014952B2 (en) | 2016-07-28 | 2021-05-25 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against Haemophilus influenzae type b |
| KR20200141053A (ko) * | 2018-03-23 | 2020-12-17 | 코라넥스 캐피탈 | 치료 도구로서의 정밀 당 접합체 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ223009A (en) * | 1986-12-31 | 1990-06-26 | Nl Rivm Of Thoven | Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens |
| EP0320942A3 (en) * | 1987-12-18 | 1989-10-04 | American Cyanamid Company | Novel polysaccharides novel macromolecular conjugates of the polysaccharides |
| US5843463A (en) * | 1990-12-21 | 1998-12-01 | Antexbiologics, Inc. | Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae |
-
1999
- 1999-08-30 CU CU1999121A patent/CU22904A1/es unknown
-
2000
- 2000-08-15 CN CNB008134731A patent/CN1205217C/zh not_active Expired - Lifetime
- 2000-08-15 JP JP2001519710A patent/JP4850377B2/ja not_active Expired - Fee Related
- 2000-08-15 MX MXPA02002066A patent/MXPA02002066A/es active IP Right Grant
- 2000-08-15 AU AU68173/00A patent/AU780816B2/en not_active Ceased
- 2000-08-15 SI SI200030780T patent/SI1212334T1/sl unknown
- 2000-08-15 AT AT00956040T patent/ATE308551T1/de active
- 2000-08-15 ES ES00956040T patent/ES2252045T3/es not_active Expired - Lifetime
- 2000-08-15 NZ NZ517464A patent/NZ517464A/en not_active IP Right Cessation
- 2000-08-15 DK DK00956040T patent/DK1212334T3/da active
- 2000-08-15 CA CA2382602A patent/CA2382602C/en not_active Expired - Fee Related
- 2000-08-15 CZ CZ2002721A patent/CZ2002721A3/cs unknown
- 2000-08-15 EA EA200200314A patent/EA005381B1/ru not_active IP Right Cessation
- 2000-08-15 KR KR1020027002706A patent/KR100818163B1/ko not_active IP Right Cessation
- 2000-08-15 UA UA2002021613A patent/UA75579C2/uk unknown
- 2000-08-15 WO PCT/CU2000/000003 patent/WO2001016146A1/es active IP Right Grant
- 2000-08-15 DE DE60023722T patent/DE60023722T2/de not_active Expired - Lifetime
- 2000-08-15 US US10/070,101 patent/US6765091B1/en not_active Expired - Lifetime
- 2000-08-15 BR BRPI0013686A patent/BRPI0013686B8/pt not_active IP Right Cessation
- 2000-08-15 EP EP00956040A patent/EP1212334B1/en not_active Expired - Lifetime
- 2000-08-28 CO CO00064095A patent/CO5180646A1/es active IP Right Grant
- 2000-08-29 AR ARP000104496A patent/AR025435A1/es not_active Application Discontinuation
-
2002
- 2002-02-27 ZA ZA200201667A patent/ZA200201667B/en unknown
-
2003
- 2003-04-23 HK HK03102864A patent/HK1050693A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2252045T3 (es) | 2006-05-16 |
| JP2003528032A (ja) | 2003-09-24 |
| ATE308551T1 (de) | 2005-11-15 |
| CU22904A1 (es) | 2004-01-23 |
| JP4850377B2 (ja) | 2012-01-11 |
| US6765091B1 (en) | 2004-07-20 |
| CZ2002721A3 (cs) | 2002-07-17 |
| CA2382602C (en) | 2010-02-16 |
| SI1212334T1 (sl) | 2006-04-30 |
| BRPI0013686B1 (pt) | 2016-07-26 |
| EP1212334B1 (en) | 2005-11-02 |
| DE60023722D1 (de) | 2005-12-08 |
| UA75579C2 (en) | 2006-05-15 |
| MXPA02002066A (es) | 2004-07-30 |
| HK1050693A1 (en) | 2003-07-04 |
| EA005381B1 (ru) | 2005-02-24 |
| CN1205217C (zh) | 2005-06-08 |
| DK1212334T3 (da) | 2006-03-20 |
| EP1212334A1 (en) | 2002-06-12 |
| KR100818163B1 (ko) | 2008-03-31 |
| CO5180646A1 (es) | 2002-07-30 |
| ZA200201667B (en) | 2003-08-27 |
| CN1376158A (zh) | 2002-10-23 |
| AR025435A1 (es) | 2002-11-27 |
| CA2382602A1 (en) | 2001-03-08 |
| DE60023722T2 (de) | 2006-07-20 |
| AU780816B2 (en) | 2005-04-21 |
| NZ517464A (en) | 2004-03-26 |
| WO2001016146A1 (es) | 2001-03-08 |
| BR0013686A (pt) | 2002-08-13 |
| EA200200314A1 (ru) | 2002-10-31 |
| AU6817300A (en) | 2001-03-26 |
| KR20020068501A (ko) | 2002-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07B | Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette] |
Free format text: REF. A RPI NO 2125 DE 27/09/2011. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/07/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 15/08/2020 |