EA200200314A1 - Олигосахаридные производные рибоза-рибит-фосфата и содержащие их вакцины - Google Patents
Олигосахаридные производные рибоза-рибит-фосфата и содержащие их вакциныInfo
- Publication number
- EA200200314A1 EA200200314A1 EA200200314A EA200200314A EA200200314A1 EA 200200314 A1 EA200200314 A1 EA 200200314A1 EA 200200314 A EA200200314 A EA 200200314A EA 200200314 A EA200200314 A EA 200200314A EA 200200314 A1 EA200200314 A1 EA 200200314A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- mixtures
- oligosaccharides
- vaccines
- ribose
- phosphate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Abstract
Настоящее изобретение относится к области медицины, в частности, к химическим синтезам смесей олигосахаридов, полученных из рибоза-рибит-фосфата, используемых в качестве активной основы в вакцинах для профилактики инфекций, вызываемых Haemophilus influenzae типа b (Hib), а также касается вакцин, содержащих указанные смеси олигосахаридов. Смеси олигосахаридов, полученные химическим синтезом по настоящему изобретению, включают повторяющиеся звенья формулы (фосфат-рибоза-рибит)n или (рибоза-рибит-фосфат)n, по меньшей мере, из 5 соединений структур А или В, представляющих повторяющееся звено капсульного полисахарида Haemophilus Influenzae типа b и отличающихся только величиной n, при этом n принимает значения в интервале от 4 до 25 и где Rили Rозначает спейсер для конъюгации с носителем, при условии, что R=спейсер, если R=H, или R=спейсер, если R=H. Изобретение касается также иммуногенов, содержащих указанные смеси олигосахаридов, вакцин, содержащих указанные иммуногены, и способов получения указанных олигосахаридов в виде смесей. Кроме того, настоящее изобретение включает использование вакцин отдельно либо в сочетании с другими вакцинами для профилактики инфекций, вызываемых Haemophilus Influenzae типа b.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU1999121A CU22904A1 (es) | 1999-08-30 | 1999-08-30 | Oligosacáridos derivados de ribosa- ribitol-fosfato, métodos para prepararlos, inmunógenos que los comprenden y vacunas que comprenden dichos inmunógenos |
| PCT/CU2000/000003 WO2001016146A1 (es) | 1999-08-30 | 2000-08-15 | Oligosacáridos derivados de ribosa-ribitol-fosfato y vacunas que los contienen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200314A1 true EA200200314A1 (ru) | 2002-10-31 |
| EA005381B1 EA005381B1 (ru) | 2005-02-24 |
Family
ID=5459405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200314A EA005381B1 (ru) | 1999-08-30 | 2000-08-15 | Олигосахаридные производные рибоза-рибит-фосфата и содержащие их вакцины |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6765091B1 (ru) |
| EP (1) | EP1212334B1 (ru) |
| JP (1) | JP4850377B2 (ru) |
| KR (1) | KR100818163B1 (ru) |
| CN (1) | CN1205217C (ru) |
| AR (1) | AR025435A1 (ru) |
| AT (1) | ATE308551T1 (ru) |
| AU (1) | AU780816B2 (ru) |
| BR (1) | BRPI0013686B8 (ru) |
| CA (1) | CA2382602C (ru) |
| CO (1) | CO5180646A1 (ru) |
| CU (1) | CU22904A1 (ru) |
| CZ (1) | CZ2002721A3 (ru) |
| DE (1) | DE60023722T2 (ru) |
| DK (1) | DK1212334T3 (ru) |
| EA (1) | EA005381B1 (ru) |
| ES (1) | ES2252045T3 (ru) |
| HK (1) | HK1050693A1 (ru) |
| MX (1) | MXPA02002066A (ru) |
| NZ (1) | NZ517464A (ru) |
| SI (1) | SI1212334T1 (ru) |
| UA (1) | UA75579C2 (ru) |
| WO (1) | WO2001016146A1 (ru) |
| ZA (1) | ZA200201667B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005209303A1 (en) * | 2004-01-29 | 2005-08-11 | Biosynexus, Inc. | Use of amino-oxy functional groups in the preparation of vaccines conjugates |
| WO2011017101A2 (en) | 2009-07-27 | 2011-02-10 | Fina Biosolutions, Llc | Method for producing protein-carbohydrate vaccines reduced in free carbohydrate |
| BR112012002230A2 (pt) | 2009-07-31 | 2020-08-18 | National Research Council Canada | epítopo do núcleo externo do lipopolissacarídeo do h. pylori. |
| SG181750A1 (en) | 2009-12-17 | 2012-07-30 | Fina Biosolutions Llc | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
| NZ602971A (en) * | 2010-04-23 | 2014-11-28 | Serum Inst India Ltd | Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels |
| CN109843899B (zh) | 2016-07-28 | 2022-04-19 | 马克斯·普朗克科学促进学会 | 用作对流感嗜血杆菌b型的疫苗的稳定耐水解的合成的聚核糖基核糖醇磷酸衍生物 |
| EP3768309A4 (en) * | 2018-03-23 | 2021-12-01 | Koranex Capital | PRECISION GLYCOCONJUGATES AS THERAPEUTIC TOOLS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ223009A (en) * | 1986-12-31 | 1990-06-26 | Nl Rivm Of Thoven | Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens |
| EP0320942A3 (en) * | 1987-12-18 | 1989-10-04 | American Cyanamid Company | Novel polysaccharides novel macromolecular conjugates of the polysaccharides |
| US5843463A (en) * | 1990-12-21 | 1998-12-01 | Antexbiologics, Inc. | Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae |
-
1999
- 1999-08-30 CU CU1999121A patent/CU22904A1/es unknown
-
2000
- 2000-08-15 CA CA2382602A patent/CA2382602C/en not_active Expired - Fee Related
- 2000-08-15 UA UA2002021613A patent/UA75579C2/uk unknown
- 2000-08-15 AU AU68173/00A patent/AU780816B2/en not_active Ceased
- 2000-08-15 CZ CZ2002721A patent/CZ2002721A3/cs unknown
- 2000-08-15 US US10/070,101 patent/US6765091B1/en not_active Expired - Lifetime
- 2000-08-15 SI SI200030780T patent/SI1212334T1/sl unknown
- 2000-08-15 BR BRPI0013686A patent/BRPI0013686B8/pt not_active IP Right Cessation
- 2000-08-15 MX MXPA02002066A patent/MXPA02002066A/es active IP Right Grant
- 2000-08-15 DK DK00956040T patent/DK1212334T3/da active
- 2000-08-15 EA EA200200314A patent/EA005381B1/ru not_active IP Right Cessation
- 2000-08-15 WO PCT/CU2000/000003 patent/WO2001016146A1/es active IP Right Grant
- 2000-08-15 DE DE60023722T patent/DE60023722T2/de not_active Expired - Lifetime
- 2000-08-15 AT AT00956040T patent/ATE308551T1/de active
- 2000-08-15 NZ NZ517464A patent/NZ517464A/en not_active IP Right Cessation
- 2000-08-15 ES ES00956040T patent/ES2252045T3/es not_active Expired - Lifetime
- 2000-08-15 KR KR1020027002706A patent/KR100818163B1/ko not_active IP Right Cessation
- 2000-08-15 EP EP00956040A patent/EP1212334B1/en not_active Expired - Lifetime
- 2000-08-15 JP JP2001519710A patent/JP4850377B2/ja not_active Expired - Fee Related
- 2000-08-15 CN CNB008134731A patent/CN1205217C/zh not_active Expired - Lifetime
- 2000-08-28 CO CO00064095A patent/CO5180646A1/es active IP Right Grant
- 2000-08-29 AR ARP000104496A patent/AR025435A1/es not_active Application Discontinuation
-
2002
- 2002-02-27 ZA ZA200201667A patent/ZA200201667B/en unknown
-
2003
- 2003-04-23 HK HK03102864A patent/HK1050693A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA75579C2 (en) | 2006-05-15 |
| DE60023722D1 (de) | 2005-12-08 |
| KR20020068501A (ko) | 2002-08-27 |
| CN1376158A (zh) | 2002-10-23 |
| DE60023722T2 (de) | 2006-07-20 |
| BRPI0013686B1 (pt) | 2016-07-26 |
| EP1212334B1 (en) | 2005-11-02 |
| CA2382602C (en) | 2010-02-16 |
| AU780816B2 (en) | 2005-04-21 |
| CZ2002721A3 (cs) | 2002-07-17 |
| SI1212334T1 (sl) | 2006-04-30 |
| BRPI0013686B8 (pt) | 2021-05-25 |
| EP1212334A1 (en) | 2002-06-12 |
| HK1050693A1 (en) | 2003-07-04 |
| KR100818163B1 (ko) | 2008-03-31 |
| US6765091B1 (en) | 2004-07-20 |
| AU6817300A (en) | 2001-03-26 |
| NZ517464A (en) | 2004-03-26 |
| AR025435A1 (es) | 2002-11-27 |
| CU22904A1 (es) | 2004-01-23 |
| MXPA02002066A (es) | 2004-07-30 |
| ES2252045T3 (es) | 2006-05-16 |
| ATE308551T1 (de) | 2005-11-15 |
| EA005381B1 (ru) | 2005-02-24 |
| DK1212334T3 (da) | 2006-03-20 |
| ZA200201667B (en) | 2003-08-27 |
| JP2003528032A (ja) | 2003-09-24 |
| CN1205217C (zh) | 2005-06-08 |
| CA2382602A1 (en) | 2001-03-08 |
| BR0013686A (pt) | 2002-08-13 |
| JP4850377B2 (ja) | 2012-01-11 |
| CO5180646A1 (es) | 2002-07-30 |
| WO2001016146A1 (es) | 2001-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |