BR9914018A - Derivado de cianofenila - Google Patents
Derivado de cianofenilaInfo
- Publication number
- BR9914018A BR9914018A BR9914018-7A BR9914018A BR9914018A BR 9914018 A BR9914018 A BR 9914018A BR 9914018 A BR9914018 A BR 9914018A BR 9914018 A BR9914018 A BR 9914018A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- group
- cyanophenyl derivative
- application
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
Abstract
"DERIVADO DE CIANOFENILA" Novos derivados de cianofenila substituídos por piperazino, nos quais um grupo carbamoíla ou sulfamoíla substituído, contendo um grupo arila ou heterocíclico opcionalmente substituído ou similar, está ligado ao átomo de nitrogênio que constitui o anel de piperazina. Estes derivados exibem atividades antiandrogênio e são, portanto, úteis na prevenção ou no tratamento de câncer prostático, hipertrofia prostática e assim por diante.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26750898 | 1998-09-22 | ||
JP15539899 | 1999-06-02 | ||
PCT/JP1999/005149 WO2000017163A1 (fr) | 1998-09-22 | 1999-09-21 | Derives de cyanophenyle |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914018A true BR9914018A (pt) | 2001-07-03 |
Family
ID=26483414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914018-7A BR9914018A (pt) | 1998-09-22 | 1999-09-21 | Derivado de cianofenila |
Country Status (13)
Country | Link |
---|---|
US (2) | US6673799B1 (pt) |
EP (1) | EP1122242B1 (pt) |
JP (1) | JP3390744B2 (pt) |
KR (1) | KR100660309B1 (pt) |
CN (1) | CN1129581C (pt) |
AT (1) | ATE384048T1 (pt) |
AU (1) | AU754529B2 (pt) |
BR (1) | BR9914018A (pt) |
CA (1) | CA2345146C (pt) |
DE (1) | DE69938005T2 (pt) |
ES (1) | ES2300151T3 (pt) |
PL (1) | PL346795A1 (pt) |
WO (1) | WO2000017163A1 (pt) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU2001264376A1 (en) * | 2000-06-15 | 2001-12-24 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
WO2002008221A2 (en) * | 2000-07-20 | 2002-01-31 | Neurogen Corporation | Capsaicin receptor ligands |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
EP1335907B1 (en) * | 2000-11-20 | 2010-06-09 | Biovitrum AB (publ) | Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5ht-2 receptor |
GB0105895D0 (en) * | 2001-03-09 | 2001-04-25 | Smithkline Beecham Plc | Novel compounds |
MXPA03010612A (es) | 2001-05-22 | 2004-04-02 | Neurogen Corp | Ligandos receptores de la hormona concentradora de melanina: analogos de 1-bencil-4-aril piperazina substiruidos. |
DE60217363T2 (de) | 2001-09-06 | 2007-10-11 | Schering Corp. | 17beta-hydroxysteroid dehydrogenase type 3 inhibitoren zur behandlung von androgen-abhängigen erkrankungen |
JPWO2003029199A1 (ja) * | 2001-09-28 | 2005-01-13 | 武田薬品工業株式会社 | ベンゼン誘導体、その製造法および用途 |
AU2002360932A1 (en) * | 2001-11-23 | 2003-06-10 | Schering Aktiengesellschaft | Piperazine derivatives destabilising androgen receptors |
US6861432B2 (en) | 2001-11-23 | 2005-03-01 | Schering Aktiengesellschaft | Piperazine derivatives that destabilize androgen receptors |
AU2003212882A1 (en) | 2002-02-01 | 2003-09-02 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
AR039156A1 (es) | 2002-03-28 | 2005-02-09 | Novartis Ag | Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide |
ATE384698T1 (de) | 2002-06-28 | 2008-02-15 | Euro Celtique Sa | Therapeutische piperazin-derivate für die behandlung von schmerzen |
WO2004007471A1 (ja) | 2002-07-12 | 2004-01-22 | Yamanouchi Pharmaceutical Co., Ltd. | N−フェニル−(2r,5s)ジメチルピペラジン誘導体 |
US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
US7132539B2 (en) | 2002-10-23 | 2006-11-07 | The Procter & Gamble Company | Melanocortin receptor ligands |
ATE409065T1 (de) | 2002-12-17 | 2008-10-15 | Schering Corp | Inhibitoren der 17 beta- hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten |
EP1654221A2 (en) * | 2003-06-10 | 2006-05-10 | Smithkline Beecham Corporation | Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators |
CN1856484B (zh) | 2003-07-24 | 2010-09-22 | 欧洲凯尔蒂克公司 | 用于治疗或预防疼痛的杂芳基-四氢吡啶基化合物 |
CA2536349A1 (en) | 2003-08-22 | 2005-03-03 | Ligand Pharmaceuticals Incorporated | 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds |
US20050124625A1 (en) * | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
BRPI0416208A (pt) * | 2003-11-20 | 2006-12-26 | Warner Lambert Co | moduladores de receptores de androgênio |
NZ548209A (en) | 2003-12-19 | 2009-07-31 | Univ California | Methods and materials for assessing prostate cancer thearapies |
WO2005099693A2 (en) | 2004-02-24 | 2005-10-27 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
DE102004022897A1 (de) * | 2004-05-10 | 2005-12-08 | Bayer Cropscience Ag | Azinyl-imidazoazine |
US20080045504A1 (en) * | 2004-05-11 | 2008-02-21 | Pfizer Products Inc. | Benzonitrile Derivatives to Treat Musculoskeletal Frailty |
US20070004679A1 (en) * | 2004-05-17 | 2007-01-04 | Nathalie Schlienger | Androgen receptor modulators and methods of treating disease using the same |
MXPA06013329A (es) * | 2004-05-17 | 2007-02-22 | Acadia Pharm Inc | Moduladores del receptor androgeno, y metodo para tratar enfermedades en el que se utilizan los mismos. |
US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
DK1805158T3 (en) * | 2004-10-29 | 2018-08-06 | Kalypsys Inc | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR |
NZ555974A (en) * | 2005-01-10 | 2010-11-26 | Acadia Pharm Inc | Aminophenyl derivatives as selective androgen receptor modulators |
US20060173037A1 (en) * | 2005-01-10 | 2006-08-03 | Nathalie Schlienger | Aminophenyl derivatives as selective androgen receptor modulators |
KR20230003445A (ko) | 2005-05-13 | 2023-01-05 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴히단토인 화합물 |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
US8193357B2 (en) * | 2005-06-17 | 2012-06-05 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds |
CA2624383C (en) * | 2005-10-25 | 2014-03-11 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
US7825122B2 (en) | 2005-12-14 | 2010-11-02 | Amgen Inc. | Diaza heterocyclic sulfonamide derivatives and their uses |
BRPI0707537A2 (pt) | 2006-02-07 | 2011-05-03 | Wyeth Corp | inibidores de 11-beta hsd1 |
EP2368550B1 (en) | 2006-03-27 | 2013-09-04 | The Regents of the University of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
SG170809A1 (en) | 2006-03-29 | 2011-05-30 | Univ California | Diarylthiohydantoin compounds |
US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
AR060937A1 (es) * | 2006-05-16 | 2008-07-23 | Kalypsys Inc | Compuestos biciclicos sustituidos con sulfonilo como moduladores de ppar |
WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
PE20130325A1 (es) | 2007-04-27 | 2013-03-18 | Purdue Pharma Lp | Derivados de piperidina, piperazina o tetrahidropiridilo como antagonistas de trpv1 |
JP5292390B2 (ja) * | 2007-08-07 | 2013-09-18 | 武田薬品工業株式会社 | アンドロゲン受容体調節剤としてのピロリジン−2−オン誘導体 |
TW201716385A (zh) | 2007-10-26 | 2017-05-16 | 加州大學董事會 | 二芳基乙內醯脲類化合物 |
KR20100099742A (ko) | 2007-12-21 | 2010-09-13 | 아스트라제네카 아베 | 안드로겐 수용체 관련 병태의 치료에서 사용하기 위한 이환식 유도체 |
DE102008041214A1 (de) | 2008-08-13 | 2010-02-18 | Bayer Cropscience Ag | N-substituierte Azinylakyl-azincarboxamide und deren Analoge |
TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
AR078793A1 (es) | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
EP2536708A4 (en) | 2010-02-16 | 2013-05-29 | Aragon Pharmaceuticals Inc | ANDROGEN RECEPTOR MODULATORS AND USES THEREOF |
ES2533990T3 (es) * | 2010-02-24 | 2015-04-16 | Research Triangle Institute | Antagonistas de receptores opioides de arilpiperazina |
BR112013009274A2 (pt) * | 2010-10-22 | 2018-05-02 | Astellas Pharma Inc. | antagonista para receptor de andrógeno mutante |
ES2541295T3 (es) | 2011-04-21 | 2015-07-17 | Orion Corporation | Carboxamidas que modulan el receptor de andrógenos |
EP3173411B1 (en) | 2011-06-22 | 2018-05-09 | Purdue Pharma L.P. | Trpv1 antagonists including dihydroxy substituent and uses thereof |
US20140275105A1 (en) * | 2011-10-21 | 2014-09-18 | Astellas Pharma Inc. | Crystal of androgen receptor antagonistic compound |
CN104661658A (zh) | 2012-09-26 | 2015-05-27 | 阿拉贡药品公司 | 用于治疗非转移性去势抵抗性前列腺癌的抗雄激素 |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
JP2016516005A (ja) | 2013-02-25 | 2016-06-02 | ノバルティス アーゲー | 新規のアンドロゲンレセプター変異 |
CN103965159B (zh) * | 2014-05-17 | 2017-04-12 | 广州医科大学 | 醚类芳基哌嗪衍生物及其盐、制备方法和用途 |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
CA3015285A1 (en) * | 2016-03-24 | 2017-09-28 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer |
EP3500310A1 (en) | 2016-08-20 | 2019-06-26 | FTF Pharma Private Limited | Pharmaceutical composition comprising an androgen receptor inhibitor |
WO2019025153A1 (de) | 2017-07-31 | 2019-02-07 | Bayer Cropscience Aktiengesellschaft | Verwendung von substituierten n-sulfonyl-n'-aryldiaminoalkanen und n-sulfonyl-n'-heteroaryldiaminoalkanen oder deren salzen zur steigerung der stresstoleranz in pflanzen |
CN111479560A (zh) | 2017-10-16 | 2020-07-31 | 阿拉贡药品公司 | 用于治疗非转移性去势难治性前列腺癌的抗雄激素 |
LT3786160T (lt) | 2017-10-27 | 2022-09-26 | Boehringer Ingelheim International Gmbh | Piridino dariniai ir jų terapinis panaudojimas kaip trpc6 inhibitorių |
CN114761003B (zh) | 2019-09-23 | 2023-12-29 | 冰洲石生物科技公司 | 具有雄激素受体降解活性的新型脲类及其用途 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL248308A (pt) * | 1958-09-30 | |||
DE1239940B (de) * | 1962-07-24 | 1967-05-03 | Kalle Ag | Lichtempfindliches Aufzeichnungsmaterial fuer Reproduktionszwecke |
DE3063878D1 (en) * | 1979-07-13 | 1983-07-28 | Thomae Gmbh Dr K | Derivatives of carboxylic acids, their preparation and medicaments containing them |
GB8619472D0 (en) * | 1986-08-09 | 1986-09-17 | Pfizer Ltd | Anti-arrhythmia agents |
US5411981A (en) | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
WO1993010091A2 (en) * | 1991-11-14 | 1993-05-27 | Glaxo Group Limited | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
DE4234295A1 (de) | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
GB9326373D0 (en) | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Chemical compounds |
US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
FR2722788B1 (fr) | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
CZ288002B6 (cs) | 1995-01-11 | 2001-03-14 | Samjin Pharmaceutical Co., Ltd. | Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující |
AU6318896A (en) | 1995-07-06 | 1997-02-05 | Japan Tobacco Inc. | Benzamidoxime derivatives and medicinal use thereof |
TW357143B (en) | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
ZA968661B (en) | 1995-11-17 | 1998-04-14 | Upjohn Co | Oxazolidinone antibacterial agent with tricyclic substituents. |
EP0850222B1 (en) | 1996-06-29 | 2003-05-28 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
CA2264549C (en) * | 1996-08-26 | 2004-09-14 | Pfizer Inc. | Spirocyclic dopamine receptor subtype ligands |
FR2761066B1 (fr) | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
AU735144B2 (en) * | 1997-07-23 | 2001-07-05 | Yamanouchi Pharmaceutical Co., Ltd. | Novel hexahydro-1,4-diazepine derivatives or their salts |
ID24372A (id) * | 1997-10-27 | 2000-07-13 | Agouron Pharma | SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs |
-
1999
- 1999-09-21 KR KR1020017003629A patent/KR100660309B1/ko not_active IP Right Cessation
- 1999-09-21 JP JP2000574073A patent/JP3390744B2/ja not_active Expired - Fee Related
- 1999-09-21 DE DE69938005T patent/DE69938005T2/de not_active Expired - Lifetime
- 1999-09-21 EP EP99943446A patent/EP1122242B1/en not_active Expired - Lifetime
- 1999-09-21 ES ES99943446T patent/ES2300151T3/es not_active Expired - Lifetime
- 1999-09-21 AU AU56544/99A patent/AU754529B2/en not_active Ceased
- 1999-09-21 WO PCT/JP1999/005149 patent/WO2000017163A1/ja active IP Right Grant
- 1999-09-21 AT AT99943446T patent/ATE384048T1/de not_active IP Right Cessation
- 1999-09-21 CN CN99811198A patent/CN1129581C/zh not_active Expired - Fee Related
- 1999-09-21 US US09/787,672 patent/US6673799B1/en not_active Expired - Fee Related
- 1999-09-21 PL PL99346795A patent/PL346795A1/xx not_active Application Discontinuation
- 1999-09-21 CA CA2345146A patent/CA2345146C/en not_active Expired - Fee Related
- 1999-09-21 BR BR9914018-7A patent/BR9914018A/pt not_active IP Right Cessation
-
2003
- 2003-06-30 US US10/608,341 patent/US20040010037A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2345146A1 (en) | 2000-03-30 |
PL346795A1 (en) | 2002-02-25 |
US20040010037A1 (en) | 2004-01-15 |
EP1122242A1 (en) | 2001-08-08 |
WO2000017163A1 (fr) | 2000-03-30 |
CA2345146C (en) | 2010-02-23 |
EP1122242B1 (en) | 2008-01-16 |
KR100660309B1 (ko) | 2006-12-22 |
ATE384048T1 (de) | 2008-02-15 |
EP1122242A4 (en) | 2004-12-01 |
DE69938005D1 (de) | 2008-03-06 |
KR20010075268A (ko) | 2001-08-09 |
US6673799B1 (en) | 2004-01-06 |
DE69938005T2 (de) | 2009-01-15 |
CN1319091A (zh) | 2001-10-24 |
ES2300151T3 (es) | 2008-06-01 |
AU754529B2 (en) | 2002-11-21 |
AU5654499A (en) | 2000-04-10 |
JP3390744B2 (ja) | 2003-03-31 |
CN1129581C (zh) | 2003-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9914018A (pt) | Derivado de cianofenila | |
NL350077I1 (nl) | Cyprosulfamide | |
TR200000059T2 (tr) | Piridin türevleri | |
BG105557A (en) | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants | |
DE69910831D1 (de) | Epothilonderivate und ihre verwendung als antitumormittel | |
YU21401A (sh) | Tetrahidropiridoetri | |
DE69821985D1 (de) | Ortho-anthranilamide derivate als antikoagulantien | |
DK0981341T3 (da) | Anvendelse af betulinsyrederivater til behandling og forebyggelse af melanom | |
DE69929463D1 (de) | Polyhydroxylierte heterocyclische derivate als antikoagulanten | |
BG104597A (en) | Inhibition of raf kinase using substituted heterocyclic ureas | |
DK1070056T3 (da) | Phthalazinon-PDE III/IV-inhibitorer | |
ATE290382T1 (de) | Heterozyklische kalium-kanal inhibitoren | |
BG102003A (en) | PYRIDO/2,3-d/PYRIMIDINES FOR THE INHIBITION OF CELLULAR PROLIFERATION CAUSED BY PROTEINTHYROSIKINASE | |
DK0946507T3 (da) | Substituerede pyrrolylforbindelser til behandling af inflammation | |
WO1994004541A3 (en) | Protein kinase inhibitors and related compounds combined with taxol | |
MX9700557A (es) | Dihidrobenzofuranos. | |
TR199802767T2 (xx) | Trombin �nleyiciler olarak yeni amidino t�revleri. | |
DK0889886T5 (da) | Hidtil ukendte, i 6-stilling substituerede phenanthridiner | |
NO924121L (no) | Substituerte pyrimidiner | |
CY1107149T1 (el) | Νεα παραγωγα αμιδινοβενζυλαμινης και χρηση τους ως αναστολεων θρομβινης | |
DE69821530D1 (de) | Dihydrobenzifurane | |
ATE287403T1 (de) | 6-phenylbenzonaphthyidine | |
DE60036558D1 (de) | Phthalazinon-derivate als pde 4 hemmer | |
MX9304626A (es) | Derivados heterociclicos utiles en el tratamiento de enfermedades cardiovasculares. | |
BG106599A (en) | Wood treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1947 DE 29 - 04 - 2008. |